IL143243A0 - A cultured tissue construct containing fibroblast cells and methods for the production thereof - Google Patents

A cultured tissue construct containing fibroblast cells and methods for the production thereof

Info

Publication number
IL143243A0
IL143243A0 IL14324399A IL14324399A IL143243A0 IL 143243 A0 IL143243 A0 IL 143243A0 IL 14324399 A IL14324399 A IL 14324399A IL 14324399 A IL14324399 A IL 14324399A IL 143243 A0 IL143243 A0 IL 143243A0
Authority
IL
Israel
Prior art keywords
tissue constructs
cultured tissue
production
methods
fibroblast cells
Prior art date
Application number
IL14324399A
Other languages
English (en)
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of IL143243A0 publication Critical patent/IL143243A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698Skin equivalents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/09Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323Adult fibroblasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL14324399A 1998-11-19 1999-11-19 A cultured tissue construct containing fibroblast cells and methods for the production thereof IL143243A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10924798P 1998-11-19 1998-11-19
US33963299A 1999-06-24 1999-06-24
PCT/US1999/027505 WO2000029553A1 (en) 1998-11-19 1999-11-19 Bioengineered tissue constructs and methods for producing and using them

Publications (1)

Publication Number Publication Date
IL143243A0 true IL143243A0 (en) 2002-04-21

Family

ID=26806787

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14324399A IL143243A0 (en) 1998-11-19 1999-11-19 A cultured tissue construct containing fibroblast cells and methods for the production thereof

Country Status (15)

Country Link
US (2) US7824913B2 (zh)
EP (3) EP1131410B1 (zh)
JP (2) JP2002530069A (zh)
CN (2) CN102051343A (zh)
AT (1) ATE305967T1 (zh)
AU (3) AU769637B2 (zh)
BR (1) BR9915476A (zh)
CA (1) CA2351396C (zh)
DE (1) DE69927600T2 (zh)
DK (1) DK1131410T3 (zh)
ES (2) ES2249928T3 (zh)
HK (1) HK1040740A1 (zh)
IL (1) IL143243A0 (zh)
PT (1) PT1612265E (zh)
WO (1) WO2000029553A1 (zh)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1131410B1 (en) * 1998-11-19 2005-10-05 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US20040018226A1 (en) * 1999-02-25 2004-01-29 Wnek Gary E. Electroprocessing of materials useful in drug delivery and cell encapsulation
US20020081732A1 (en) * 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
WO2002015952A1 (en) * 2000-08-08 2002-02-28 Bioamide, Inc. Scaffolds for tissue engineered hair
EP1315756A2 (en) * 2000-09-01 2003-06-04 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed fibrin-based matrices and tissues
WO2002022185A2 (en) * 2000-09-18 2002-03-21 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
EP1832300A3 (en) * 2000-09-18 2008-02-27 Organogenesis Inc. Method for treating a patient using a cultured connective tissue construct
JP4366075B2 (ja) * 2000-09-21 2009-11-18 株式会社資生堂 角質細胞の成熟度の評価方法
FR2828206B1 (fr) * 2001-08-03 2004-09-24 Centre Nat Rech Scient Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
JP4822635B2 (ja) * 2001-09-05 2011-11-24 株式会社 資生堂 人工毛球部及びその製造方法、並びに、人工毛球部を用いた薬剤の評価方法
KR100777993B1 (ko) * 2001-10-15 2007-11-28 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 정상 재생조직의 형성방법과 정상 재생조직 및 감수성등의 검정방법
FR2833610B1 (fr) * 2001-12-14 2007-01-26 Natural Implant Construits cellulaires cultives in vitro, preparation et utilisations
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
DE10220472A1 (de) * 2002-05-07 2003-11-27 Hans-Guenther Machens Bioartifizielle Haut
EP1521821A2 (en) * 2002-07-16 2005-04-13 Biogentis Inc. Method for preparing engineered tissue
GB0304918D0 (en) * 2003-03-05 2003-04-09 Celltran Ltd Cell culture
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
EP1644011A1 (en) 2003-06-25 2006-04-12 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
KR101156797B1 (ko) * 2003-10-06 2012-06-18 가부시키가이샤 시세이도 재생된 모포를 담지하는 동물
JP2005218445A (ja) * 2004-01-09 2005-08-18 Technology Seed Incubation Co Ltd 培養皮膚細胞とこれを原料として用いた移植用材及び遺伝子解析用材並びに培養皮膚細胞の製造方法
CA2559275C (en) * 2004-03-09 2020-02-18 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
AU2005300263A1 (en) * 2004-03-09 2006-05-11 Jan-Eric W. Ahlfors Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8206448B2 (en) 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US8796015B2 (en) 2004-11-09 2014-08-05 Proxy Biomedical Limited Tissue scaffold
US8518436B2 (en) * 2005-05-16 2013-08-27 Purdue Research Foundation Engineered extracellular matrices
CA2626199A1 (en) * 2005-10-17 2007-04-26 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
US8268361B2 (en) 2005-10-26 2012-09-18 Ahlfors Jan-Eric W Acellular bioabsorbable tissue regeneration matrices
AR057629A1 (es) 2005-11-22 2007-12-05 Aderans Res Inst Inc Injerto de foliculos pilosos de piel obtenida por ingenieria de tejidos
AU2007212002B2 (en) * 2006-02-07 2013-05-16 Organogenesis, Inc. Bioengineered tissue constructs and cardiac uses thereof
EP2520324A2 (en) * 2006-02-09 2012-11-07 Aderans Research Institute, Inc. Micrometer assisted fluid delivery device
WO2007100870A2 (en) * 2006-02-28 2007-09-07 The Trustees Of Columbia University In The City Of New York Methods for compact aggregation of dermal cells
AU2007223276B2 (en) * 2006-03-03 2012-12-20 Organogenesis, Inc. Oral tissue regeneration and repair
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
GB2453452B (en) * 2006-05-16 2010-12-01 Purdue Research Foundation Three dimensional purified collagen matrices
US20070269476A1 (en) * 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
FR2903702B1 (fr) 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
AU2007297611B2 (en) 2006-09-21 2013-02-07 Purdue Research Foundation Collagen preparation and method of isolation
EP2082030A2 (en) * 2006-10-20 2009-07-29 Keracure, Inc. Devices with cells cultured on flexible supports
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
CN106390200A (zh) * 2006-10-23 2017-02-15 库克生物科技公司 组分特性增强的处理的ecm材料
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
EP2130915A4 (en) 2007-02-28 2010-04-21 Senju Pharma Co CELL THAT CAN EXPRESS A LARGE QUANTITY OF LACRITIN
US7985537B2 (en) 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
CA2706855A1 (en) * 2007-11-28 2009-06-04 Organogenesis, Inc. Bioengineered tissue constructs and methods for production and use
CA2708615C (en) * 2007-12-10 2019-12-31 Purdue Research Foundation Collagen-based matrices with stem cells
US8613776B2 (en) * 2007-12-27 2013-12-24 The Trustees Of Columbia University In The City Of New York Systems and methods for forming patterned extracellular matrix materials
CN102066558B (zh) * 2008-01-30 2017-02-08 希斯托金公司 胞外基质组合物
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
US8852637B2 (en) 2008-11-14 2014-10-07 Histogen, Inc. Extracellular matrix compositions for the treatment of cancer
US20100166822A1 (en) * 2008-12-31 2010-07-01 Howmedica Osteonics Corp. Adhesive cartilage implant
ES2599828T3 (es) 2009-06-04 2017-02-03 The General Hospital Corporation Pulmón bioartificial
US8986377B2 (en) 2009-07-21 2015-03-24 Lifecell Corporation Graft materials for surgical breast procedures
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US20110046639A1 (en) * 2009-08-24 2011-02-24 Konstantinos Giotis Method of direct hair implantation
CA2781309A1 (en) * 2009-12-04 2011-06-09 Euclid Systems Corporation Composition and methods for the prevention and treatment of macular degeneration, diabetic retinopathy, and diabetic macular edema
WO2011088365A1 (en) 2010-01-14 2011-07-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
EP2561087A4 (en) * 2010-04-20 2013-10-16 Int Stem Cell Corp PHYSIOLOGICAL METHODS FOR ISOLATING CELLULAR POPULATIONS OF HIGH PURITY
WO2011160055A2 (en) * 2010-06-18 2011-12-22 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Hair follicle neogenesis
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
GB201112922D0 (en) * 2011-07-27 2011-09-14 Univ Durham Micro-organ
DK2756073T3 (da) * 2011-09-12 2021-03-22 Organovo Inc Manipuleret væv til in vitro-forskningsanvendelser, anordninger deraf og fremgangsmåder til fremstilling deraf
CN103958665A (zh) * 2011-11-11 2014-07-30 基本药品有限责任公司 包含血清替代物和不稳定因子的试剂盒
EP3400900B1 (en) 2012-01-13 2020-05-20 LifeCell Corporation Methods of manufacturing breast prostheses
KR20150009521A (ko) * 2012-03-07 2015-01-26 파이브로셀 테크놀로지스, 인코퍼레이티드 국소피부제제 및 개인맞춤형 피부치료방법
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
EP2841010B1 (en) 2012-04-24 2023-08-23 Harvard Apparatus Regenerative Technology, Inc. Supports for engineered tissue scaffolds
AU2013277350B2 (en) 2012-06-21 2017-06-29 Lifecell Corporation Implantable prosthesis having acellular tissue attachments
US9956072B2 (en) 2012-10-04 2018-05-01 Lifecell Corporation Surgical template and delivery device
DE102012223061A1 (de) 2012-12-13 2014-06-18 Henkel Ag & Co. Kgaa Altershautmodell
WO2014110300A1 (en) 2013-01-09 2014-07-17 Harvard Apparatus Regenerative Technology Synthetic scaffolds
CN109251883B (zh) 2013-02-12 2022-08-26 复制细胞生命科学公司 治疗和修复肌腱的组合物和方法
WO2014179559A1 (en) 2013-05-03 2014-11-06 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
CN103497892B (zh) * 2013-09-03 2015-12-02 中山大学 一种细胞培养基材及其制备方法和应用
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
TW201538730A (zh) 2014-02-12 2015-10-16 Replicel Life Sciences Inc 用於治療骨骼、關節及軟骨之組合物及方法
JP6829078B2 (ja) 2014-03-14 2021-02-10 ザ ジェネラル ホスピタル コーポレイション 肺バイオリアクタ
JP6218238B2 (ja) * 2014-07-10 2017-10-25 国立大学法人大阪大学 人工皮膚及びその製造方法
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
WO2016172365A1 (en) 2015-04-21 2016-10-27 Purdue Research Foundation Office Of Technology Commercialization Cell-collagen-silica composites and methods of making and using the same
US10307237B2 (en) 2015-05-15 2019-06-04 Lifecell Corporation Tissue matrices and methods of treatment
CA2989768A1 (en) * 2015-06-25 2016-12-29 Auckland Uniservices Limited An apparatus comprising a gas permeable material and methods for growth of epidermal cells and tissue
WO2017024090A1 (en) * 2015-08-06 2017-02-09 The Johns Hopkins University Tissue-derived scaffolds for corneal reconstruction
AU2016310471B2 (en) 2015-08-21 2021-05-20 Lifecell Corporation Breast treatment device
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
CN109689071B (zh) 2016-05-16 2023-05-30 通用医疗公司 肺上皮工程中的人气道干细胞
RU2749991C2 (ru) 2016-08-31 2021-06-21 Лайфселл Корпорейшн Устройство для коррекции молочной железы
MX2016012375A (es) * 2016-09-23 2018-03-22 Univ Mexico Nac Autonoma Metodo para preparar un suplemento a partir de cultivos de celulas mesenquimales de gelatina de wharton y usos del mismo.
CN106544281B (zh) * 2016-12-07 2019-07-02 哈尔滨工业大学 一种基于蛋白质和多糖构筑生物体保护层的制备方法
WO2018200750A1 (en) 2017-04-25 2018-11-01 Purdue Research Foundation 3-dimensional (3d) tissue-engineered muscle for tissue restoration
CN109663148A (zh) * 2018-12-17 2019-04-23 太阳雨林(厦门)生物医药有限公司 一种细胞外基质高分子材料生物复合血管
WO2020227095A1 (en) 2019-05-03 2020-11-12 Lifecell Corporation Breast treatment device
WO2020257281A1 (en) 2019-06-18 2020-12-24 United Therapeutics Corporation Mitochondrial treatment of organs for transplantation
CN111100838B (zh) * 2019-12-27 2023-05-09 广东博溪生物科技有限公司 低温保存运输培养基
US20230357684A1 (en) * 2020-09-18 2023-11-09 University Of Virginia Patent Foundation 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication
WO2024030601A1 (en) * 2022-08-05 2024-02-08 The Texas A&M University System Fabricated engineered skin dermis compositions and methods thereof

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
DE3317550C2 (de) 1983-05-13 1985-08-22 Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5026649A (en) 1986-03-20 1991-06-25 Costar Corporation Apparatus for growing tissue cultures in vitro
US5510254A (en) 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
JPS6410983A (en) * 1987-02-19 1989-01-13 Takeda Chemical Industries Ltd Artificial tissue and production thereof
EP0282746A1 (en) * 1987-02-19 1988-09-21 Takeda Chemical Industries, Ltd. Method for producing artificial cultured tissue
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JPH051280Y2 (zh) 1987-10-12 1993-01-13
IL94611A (en) 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
IL95429A (en) * 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
IL102929A (en) * 1992-08-24 1996-11-14 Interpharm Lab Ltd Serum-free medium for mammalian cells
US5374515A (en) 1992-11-13 1994-12-20 Organogenesis, Inc. In vitro cornea equivalent model
US5827641A (en) * 1992-11-13 1998-10-27 Parenteau; Nancy L. In vitro cornea equivalent model
US5366893A (en) 1993-01-13 1994-11-22 Becton, Dickinson And Company Culture vessel
JPH07178A (ja) * 1993-06-11 1995-01-06 New Japan Chem Co Ltd 細胞培養用担体
US5518878A (en) 1993-09-15 1996-05-21 Organogenesis Inc. Cryopreservation of cultured skin or cornea equivalents with agitation
US5891617A (en) 1993-09-15 1999-04-06 Organogenesis Inc. Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
US5741701A (en) * 1994-04-25 1998-04-21 Becton, Dickinson And Company Cell culture substrates and methods of use
JPH10500305A (ja) * 1994-05-11 1998-01-13 オーガノジェネシス インコーポレイテッド 細胞培養由来コラーゲン
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5618718A (en) 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5830708A (en) * 1995-06-06 1998-11-03 Advanced Tissue Sciences, Inc. Methods for production of a naturally secreted extracellular matrix
US5665391A (en) * 1995-10-12 1997-09-09 Spectral Diagnostics Inc. Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes
US5689961A (en) 1996-01-30 1997-11-25 Organogenesis Inc. Ice seeding apparatus for cryopreservation systems
US5766937A (en) 1996-02-15 1998-06-16 Becton Dickinson And Company Culture vessel and assembly
CA2253724A1 (en) * 1996-04-26 1997-11-06 Case Western Reserve University Skin regeneration using mesenchymal stem cells
EP1131410B1 (en) * 1998-11-19 2005-10-05 Organogenesis Inc. Bioengineered tissue constructs and methods for producing and using them
US6733530B1 (en) * 1999-08-02 2004-05-11 Eric Sun-Yin Chan Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin
CN100345452C (zh) * 2003-10-16 2007-10-24 华为技术有限公司 一种确定移动通信系统中用于加密同步的计数器检查发起时机的方法

Also Published As

Publication number Publication date
JP2010187680A (ja) 2010-09-02
CN102051343A (zh) 2011-05-11
EP1612265A3 (en) 2006-03-01
JP5484975B2 (ja) 2014-05-07
BR9915476A (pt) 2002-01-02
US20020172705A1 (en) 2002-11-21
US20080108134A1 (en) 2008-05-08
AU2010201787B2 (en) 2012-09-13
EP1612265A2 (en) 2006-01-04
PT1612265E (pt) 2013-03-14
DE69927600T2 (de) 2006-07-06
EP2295540A1 (en) 2011-03-16
EP1612265B1 (en) 2013-01-16
HK1040740A1 (zh) 2002-06-21
CN1333818A (zh) 2002-01-30
WO2000029553A1 (en) 2000-05-25
JP2002530069A (ja) 2002-09-17
AU1917100A (en) 2000-06-05
EP1131410A1 (en) 2001-09-12
DE69927600D1 (de) 2005-11-10
AU2010201787A1 (en) 2010-05-27
CA2351396A1 (en) 2000-05-25
CA2351396C (en) 2012-08-14
US7824913B2 (en) 2010-11-02
EP1131410B1 (en) 2005-10-05
DK1131410T3 (da) 2005-10-31
ES2402739T3 (es) 2013-05-08
AU769637B2 (en) 2004-01-29
WO2000029553A9 (en) 2000-11-09
AU2004201787A1 (en) 2004-05-27
ES2249928T3 (es) 2006-04-01
ATE305967T1 (de) 2005-10-15

Similar Documents

Publication Publication Date Title
IL143243A0 (en) A cultured tissue construct containing fibroblast cells and methods for the production thereof
WO2003092471A3 (en) Cell-seeded extracellular matrix grafts
MY120511A (en) New pesticides
DE69527540T2 (de) Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen
AU4330597A (en) Serum-free mammalian cell culture medium, and uses thereof
DE69535328D1 (de) In-vitro wachstum von langerhans'schen inseln und ihre verwendungen
WO2001024842A3 (en) Hybrid matrices and hybrid matrix mixtures
BR0312920A (pt) células tronco hematopoéticas e métodos de tratamento de doenças oculares neovasculares com as mesmas
HUT63374A (en) Process for producing new benzoic acid derivatives having cardiovascular activity and pharmaceutical compositions comprising such active ingredient
EP1616960A3 (en) Human pancreatic cell lines: developments and uses
GB9825096D0 (en) Cells,culture methods and their uses
PT967888E (pt) Composicao edulcorane soluvel contendo fibras alimentares e sua utilizacao
DE69031606D1 (de) Kern-Schale-Polymer, Herstellung und dessen Verwendung
DE3889980D1 (de) Reaktivfarbstoffe, deren Herstellung und Verwendung.
AU2002221526A1 (en) Method for producing vital, biological substitute tissue in vitro using cell cultures and a support
DE69803383D1 (de) Selektive inhibitoren des faktors x, eine azepinonstruktur enthaltend
CA2151123A1 (fr) Cellules modifiees au niveau du catabolisme de la betaine, preparation et utilisations, notamment pour la production de metabolites ou d'enzymes
AU2002250934A1 (en) Bioartificial primarily vascularized tissue matrix, bioartificial primarily vascularized tissue, method for the production thereof and use of the same
DE69906989T2 (de) Gelatinöse zusammensatzug aus fisch zur verwendung als bestandteil von tabletten
WO2004001024A3 (en) Genetically engineered keratinocytes expressing at least one growth factor and/or activated egf receptor, skin equivalent comprising said keratinocytes and toxicity assay using said keratinocytes
DE69012472D1 (de) Dialkylperoxide, Verfahren zu ihrer Herstellung und ihre Verwendung.
DE69025308D1 (de) Enzyme die teilnehmen an c-endamidierung, herstellung und verwendung
ATE359372T1 (de) Vektoren zur inhibierung von viralem und tumorwachstum
DE59700297D1 (de) Disazofarbstoffe, deren Herstellung und Verwendung
IL158526A0 (en) Method and composition for skin grafts