IL138829A0 - Method for increasing bone toughness and stiffness and reducing fractures - Google Patents

Method for increasing bone toughness and stiffness and reducing fractures

Info

Publication number
IL138829A0
IL138829A0 IL13882999A IL13882999A IL138829A0 IL 138829 A0 IL138829 A0 IL 138829A0 IL 13882999 A IL13882999 A IL 13882999A IL 13882999 A IL13882999 A IL 13882999A IL 138829 A0 IL138829 A0 IL 138829A0
Authority
IL
Israel
Prior art keywords
stiffness
increasing bone
reducing fractures
bone toughness
toughness
Prior art date
Application number
IL13882999A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL138829(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL138829A0 publication Critical patent/IL138829A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
IL13882999A 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures IL138829A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10
PCT/US1999/018961 WO2000010596A1 (en) 1998-08-19 1999-08-19 Method of increasing bone toughness and stiffness and reducing fractures

Publications (1)

Publication Number Publication Date
IL138829A0 true IL138829A0 (en) 2001-10-31

Family

ID=26792729

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13882999A IL138829A0 (en) 1998-08-19 1999-08-19 Method for increasing bone toughness and stiffness and reducing fractures
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL138829A IL138829A (en) 1998-08-19 2000-10-03 Use of a parathyroid hormone containing the 34-1 amino acid sequence of human parathyroid hormone in the preparation of a drug to increase bone strength and reduce the risk of bone fracture

Country Status (32)

Country Link
US (2) US6977077B1 (cs)
EP (3) EP1059933B1 (cs)
JP (5) JP2002523375A (cs)
KR (1) KR100454207B1 (cs)
CN (1) CN1205997C (cs)
AR (1) AR033639A1 (cs)
AT (1) ATE231000T1 (cs)
AU (1) AU746277B2 (cs)
BR (1) BR9909445A (cs)
CA (1) CA2325371C (cs)
CO (1) CO5130020A1 (cs)
CY (2) CY1113343T1 (cs)
CZ (1) CZ301017B6 (cs)
DE (2) DE69904918T2 (cs)
DK (4) DK1769804T3 (cs)
DZ (1) DZ2873A1 (cs)
EA (1) EA003362B1 (cs)
ES (4) ES2621653T3 (cs)
HR (1) HRP20000755A2 (cs)
HU (2) HU230697B1 (cs)
ID (1) ID29039A (cs)
IL (2) IL138829A0 (cs)
MY (1) MY129227A (cs)
NO (2) NO323984B1 (cs)
NZ (1) NZ507056A (cs)
PE (1) PE20001089A1 (cs)
PL (1) PL201688B1 (cs)
PT (4) PT1769804E (cs)
TR (1) TR200003455T2 (cs)
TW (1) TW576747B (cs)
UA (1) UA72205C2 (cs)
WO (1) WO2000010596A1 (cs)

Families Citing this family (40)

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US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
AR033639A1 (es) * 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
AU7362900A (en) * 1999-09-20 2001-04-24 Eli Lilly And Company Method for monitoring treatment with a parathyroid hormone
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
JP2005525312A (ja) * 2002-01-10 2005-08-25 オステオトロフィン エルエルシー 骨同化物質を用いた骨疾患の治療方法
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
BRPI0414518A (pt) * 2003-09-19 2006-11-07 Pfizer Prod Inc composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e hormÈnio paratireoidiano
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
MXPA06012980A (es) * 2004-05-10 2007-06-12 Nastech Pharm Co Composiciones y metodos para el suministro mucosal mejorado de la hormona paratiroidea.
MXPA06013168A (es) 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
EP1879608A4 (en) * 2005-05-11 2009-11-11 Unigene Lab Inc METHOD FOR STIMULATING BONE FORMATION AND PRESERVATION
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
US7994129B2 (en) * 2005-11-10 2011-08-09 Michigan Technological University Methods of using black bear parathyroid hormone
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
CA2685807C (en) 2007-04-13 2016-04-12 Kuros Biosurgery Ag Polymeric tissue sealant
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
WO2009072119A2 (en) * 2007-12-04 2009-06-11 Ben-Gurion University Of The Negev Research And Development Authority Amphiphilic peptide matrices for treatment of osteoporosis
WO2009083544A2 (en) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
JPWO2011030774A1 (ja) 2009-09-09 2013-02-07 旭化成ファーマ株式会社 １回当たり１００〜２００単位のｐｔｈが週１回投与されることを特徴とする、ｐｔｈ含有骨粗鬆症治療／予防剤
AU2009356227A1 (en) 2009-12-07 2012-06-21 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
EP2686027B1 (en) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmaceutical formulation for use in spinal fusion
ES2833535T3 (es) 2011-06-07 2021-06-15 Asahi Kasei Pharma Corp Preparación liofilizada que contiene PTH de alta pureza y método para producirla
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
CN108601833B (zh) * 2016-02-01 2022-11-15 伊莱利利公司 甲状旁腺激素-抗rankl抗体融合化合物
EP3576774A4 (en) * 2017-02-01 2020-10-07 The Johns Hopkins University PARATHYROID HORMONE AND REGENERATION OF DEGENERATIVE DISCS
CN116898955A (zh) * 2017-09-22 2023-10-20 旭化成制药株式会社 稳定性优异的含有特立帕肽的液态药物组合物
CN111447943A (zh) 2018-10-29 2020-07-24 旭化成制药株式会社 以按每周2次的频率给予特立帕肽或其盐为特征的骨质疏松症的预防或治疗方法
EP4010360A1 (en) 2019-08-09 2022-06-15 Flagship Pioneering Innovations VI, LLC Modulators of parathyroid hormone receptor (pthr1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
US5556940A (en) 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
WO1996019246A1 (en) * 1994-12-19 1996-06-27 Beth Israel Hospital Association Continuous low-dose administration of parathyroid hormone or its agonist
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
JPH10511090A (ja) * 1994-12-22 1998-10-27 アストラ・アクチエボラーグ 副甲状腺ホルモン，ｐｔｈ含有吸入用治療製剤
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
WO1999012561A2 (en) * 1997-09-09 1999-03-18 F. Hoffman-La Roche Ag FRACTURE HEALING USING PTHrP ANALOGS
MY120063A (en) 1997-12-09 2005-08-30 Lilly Co Eli Stabilized teriparatide solutions
US20040033950A1 (en) * 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
AR033639A1 (es) * 1998-08-19 2004-01-07 Lilly Co Eli Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
EP2949301B1 (en) 2014-05-27 2018-04-18 The Procter and Gamble Company Absorbent core with curved and straight absorbent material areas

Also Published As

Publication number Publication date
CO5130020A1 (es) 2002-02-27
NO323984B1 (no) 2007-07-30
KR100454207B1 (ko) 2004-10-26
AU5575099A (en) 2000-03-14
US7163684B2 (en) 2007-01-16
ID29039A (id) 2001-07-26
IL138829A (en) 2011-01-31
PL201688B1 (pl) 2009-04-30
EP2266598A1 (en) 2010-12-29
CN1205997C (zh) 2005-06-15
AU746277B2 (en) 2002-04-18
JP2002523375A (ja) 2002-07-30
DK2907522T3 (en) 2017-10-23
US20050197294A1 (en) 2005-09-08
EP2907522A1 (en) 2015-08-19
DE69904918D1 (de) 2003-02-20
DK1059933T3 (da) 2003-04-07
CN1308545A (zh) 2001-08-15
EP2907522B1 (en) 2017-08-02
ATE231000T1 (de) 2003-02-15
CY1113343T1 (el) 2016-06-22
DK2266598T3 (en) 2017-05-15
HUP0101594A2 (hu) 2001-11-28
JP2017190332A (ja) 2017-10-19
CY1119552T1 (el) 2018-03-07
TR200003455T2 (tr) 2001-06-21
ES2549551T3 (es) 2017-11-27
NZ507056A (en) 2003-10-31
PT1769804E (pt) 2012-11-13
NO20005947D0 (no) 2000-11-24
JP2015028065A (ja) 2015-02-12
KR20010072763A (ko) 2001-07-31
DK2907522T1 (da) 2015-10-19
HK1030545A1 (en) 2001-05-11
HU230697B1 (hu) 2017-09-28
HK1212602A1 (en) 2016-06-17
TW576747B (en) 2004-02-21
CZ301017B6 (cs) 2009-10-14
UA72205C2 (uk) 2005-02-15
JP6177718B2 (ja) 2017-08-09
DE15152726T1 (de) 2015-12-10
EP1059933B1 (en) 2003-01-15
NO20072983L (no) 2000-11-24
PT2266598T (pt) 2017-05-02
JP2014139220A (ja) 2014-07-31
NO20005947L (no) 2000-11-24
CZ20004134A3 (cs) 2001-08-15
HK1102496A1 (en) 2007-11-23
AR033639A1 (es) 2004-01-07
ES2549551T1 (es) 2015-10-29
PT1059933E (pt) 2003-06-30
EP1059933A1 (en) 2000-12-20
ES2190244T3 (es) 2003-07-16
PT2907522T (pt) 2017-10-23
HUP0101594A3 (en) 2002-01-28
DK1769804T3 (da) 2012-10-15
DZ2873A1 (fr) 2003-12-15
HRP20000755A2 (en) 2001-02-28
BR9909445A (pt) 2000-12-12
EP2266598B1 (en) 2017-02-22
HU1200430D0 (hu) 2001-11-28
ES2393200T3 (es) 2012-12-19
DE69904918T2 (de) 2003-11-13
US6977077B1 (en) 2005-12-20
PL343595A1 (en) 2001-08-27
WO2000010596A1 (en) 2000-03-02
EA003362B1 (ru) 2003-04-24
CA2325371A1 (en) 2000-03-02
EA200001015A1 (ru) 2001-02-26
PE20001089A1 (es) 2000-11-04
CA2325371C (en) 2004-08-17
JP2011021035A (ja) 2011-02-03
MY129227A (en) 2007-03-30
ES2621653T3 (es) 2017-07-04

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