IL136093A0 - Biodegradable polymer scaffold - Google Patents

Biodegradable polymer scaffold

Info

Publication number
IL136093A0
IL136093A0 IL13609398A IL13609398A IL136093A0 IL 136093 A0 IL136093 A0 IL 136093A0 IL 13609398 A IL13609398 A IL 13609398A IL 13609398 A IL13609398 A IL 13609398A IL 136093 A0 IL136093 A0 IL 136093A0
Authority
IL
Israel
Prior art keywords
polymer
scaffold
polymer scaffold
particles
solvent
Prior art date
Application number
IL13609398A
Other languages
English (en)
Original Assignee
Bonetec Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonetec Corp filed Critical Bonetec Corp
Publication of IL136093A0 publication Critical patent/IL136093A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3821Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843Connective tissue
    • A61L27/3847Bones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
IL13609398A 1997-11-14 1998-11-13 Biodegradable polymer scaffold IL136093A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002221195A CA2221195A1 (en) 1997-11-14 1997-11-14 Biodegradable polymer matrix
PCT/CA1998/001052 WO1999025391A2 (en) 1997-11-14 1998-11-13 Biodegradable polymer scaffold

Publications (1)

Publication Number Publication Date
IL136093A0 true IL136093A0 (en) 2001-05-20

Family

ID=4161772

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13609398A IL136093A0 (en) 1997-11-14 1998-11-13 Biodegradable polymer scaffold

Country Status (15)

Country Link
US (1) US6379962B1 (pt)
EP (1) EP1030697B1 (pt)
JP (1) JP4636684B2 (pt)
KR (1) KR100664772B1 (pt)
CN (1) CN1212866C (pt)
AT (1) ATE247994T1 (pt)
AU (2) AU749041B2 (pt)
BR (1) BR9814036B1 (pt)
CA (2) CA2221195A1 (pt)
DE (1) DE69817600T2 (pt)
DK (1) DK1030697T3 (pt)
ES (1) ES2207861T3 (pt)
IL (1) IL136093A0 (pt)
NZ (1) NZ504973A (pt)
WO (1) WO1999025391A2 (pt)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR876M (pt) 1960-10-12 1961-10-16
US7022522B2 (en) * 1998-11-13 2006-04-04 Limin Guan Macroporous polymer scaffold containing calcium phosphate particles
WO2000067811A1 (en) * 1999-05-07 2000-11-16 Salviac Limited Biostable polyether polyurethane product
AU4606700A (en) * 1999-05-07 2000-11-21 Salviac Limited A tissue engineering scaffold
JP3421741B2 (ja) * 2000-05-18 2003-06-30 筑波大学長 人工骨髄、血球細胞の増殖方法
US6835390B1 (en) * 2000-11-17 2004-12-28 Jon Vein Method for producing tissue engineered meat for consumption
DE10126137C1 (de) * 2001-05-29 2002-11-07 Andreas Haisch Verfahren zur Herstellung von Zellen, Geweben und Organen
WO2003004254A1 (en) * 2001-07-03 2003-01-16 The Regents Of The University Of California Microfabricated biopolymer scaffolds and method of making same
DE60215895T2 (de) * 2001-09-13 2007-05-31 Akira Myoi, Toyonaka Poröse Calciumphosphat-Keramik für in vivo-Anwendungen
US9969980B2 (en) 2001-09-21 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
NL1019888C2 (nl) * 2002-02-01 2003-08-25 Univ Twente Werkwijze voor het vervaardigen van een poreuze polymeerstructuur.
US20030215941A1 (en) * 2002-03-12 2003-11-20 Stewart Campbell Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US20030181978A1 (en) 2002-03-25 2003-09-25 Brown Kelly R. Channeled biomedical foams and method for producing same
DE10392444T5 (de) * 2002-03-28 2005-05-25 Japan As Represented By President Of National Cardiovascular Center, Suita-Shi Stützgerüst für die Gewebsverarbeitung, künstliches Blutgefäß, Manschette und biologisches Implantat abdeckendes Glied
WO2004006840A2 (en) * 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
EP1594908B1 (en) 2003-02-19 2012-08-01 Orteq B.V. Method for the preparation of new segmented polyurethanes with high tear and tensile strengths and method for making porous scaffolds
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
GB0311221D0 (en) * 2003-05-15 2003-06-18 Orthogem Ltd Biomaterial
DE602004018163D1 (de) * 2003-08-29 2009-01-15 Mayo Foundation Hydrogel-porenbildner zur herstellung von biologisch abbaubaren gerüsten
CA2558661C (en) 2004-02-06 2012-09-04 Georgia Tech Research Corporation Load bearing biocompatible device
WO2005077013A2 (en) 2004-02-06 2005-08-25 Georgia Tech Research Corporation Surface directed cellular attachment
US7446131B1 (en) 2004-06-10 2008-11-04 The United States Of America As Represented By The Secretary Of Agriculture Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
WO2006020240A2 (en) * 2004-07-16 2006-02-23 The Forsyth Institute Methods and compositions for bioengineering a tooth
US8541028B2 (en) 2004-08-04 2013-09-24 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
ATE536750T1 (de) * 2004-09-17 2011-12-15 Jon Vein Gewebegezüchtetes fleisch zum verzehr und herstellungsverfahren für gewebegezüchtetes fleisch zum verzehr
EP1809678B1 (en) * 2004-11-12 2013-05-22 Mayo Foundation for Medical Education and Research Photocrosslinkable poly(caprolactone fumarate)
WO2006055940A2 (en) * 2004-11-18 2006-05-26 Mayo Foundation For Medical Education And Research Block copolymers of polycaprolactone and poly (propylene fumarate)
CA2603773A1 (en) * 2005-04-26 2006-11-02 Rimon Therapeutics Ltd. Pro-angiogenic polymer scaffolds
EP1874525B1 (en) * 2005-04-29 2011-06-01 Mayo Foundation for Medical Education and Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
CN100453124C (zh) * 2006-04-28 2009-01-21 武汉理工大学 多孔、分层、三维空间多级结构的组织支架材料及其制备方法
US8197930B1 (en) 2007-05-10 2012-06-12 Hrl Laboratories, Llc Three-dimensional ordered open-cellular structures
US8287895B1 (en) 2008-04-24 2012-10-16 Hrl Laboratories, Llc Three-dimensional biological scaffold compromising polymer waveguides
US8048857B2 (en) * 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US20080177378A1 (en) * 2007-01-19 2008-07-24 Civention Ag Partially bioabsorbable implant
WO2008112821A2 (en) * 2007-03-12 2008-09-18 University Of Washington Solid-state cellular and noncellular thermoplastic materials: processing, properties, and applications
US20090069904A1 (en) * 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
DE102008042401A1 (de) * 2008-09-26 2010-04-08 Forschungszentrum Karlsruhe Gmbh Bandscheibenimplantat sowie Verfahren zur Herstellung eines solchen
US20110076396A1 (en) * 2009-09-28 2011-03-31 Limin Guan Method of forming a calcium phosphate coating within a porous material
JP2013528175A (ja) * 2010-05-28 2013-07-08 ガーネット バイオセラピューティクス インコーポレイテッド インビトロで培養し、増殖させた自己複製コロニー形成細胞由来の成分を有する、生存しているおよび生存していない生理活性デバイスの組成物ならびにそれらの使用法
ES2662331T3 (es) * 2010-08-10 2018-04-06 Lifecell Corporation Matrices tisulares regenerativas
CA2837303C (en) 2011-05-26 2019-08-20 Cartiva, Inc. Tapered joint implant and related tools
US9415562B1 (en) * 2011-08-17 2016-08-16 Hrl Laboratories, Llc Ultra-light micro-lattices and a method for forming the same
ES2681443T3 (es) 2011-11-29 2018-09-13 The Regents Of The University Of California Andamiaje de glucomanano para el cultivo e ingeniería de tejidos tridimensionales
US9539773B2 (en) 2011-12-06 2017-01-10 Hrl Laboratories, Llc Net-shape structure with micro-truss core
US8485820B1 (en) 2011-12-22 2013-07-16 Mohamed Ikbal Ali Devices and methods for enhancing bone growth
EP2793962B1 (en) * 2011-12-23 2016-04-27 Dang Quang Svend Le Process for modifying the surface morphology of a medical device
US9017806B2 (en) 2012-03-23 2015-04-28 Hrl Laboratories, Llc High airflow micro-truss structural apparatus
US10350072B2 (en) 2012-05-24 2019-07-16 Cartiva, Inc. Tooling for creating tapered opening in tissue and related methods
KR101304015B1 (ko) * 2012-06-15 2013-09-04 단국대학교 산학협력단 조직 공학용 하이드로겔-다공성 생체세라믹 융합형 스캐폴드 및 이의 제조방법
CN102961781B (zh) * 2012-12-18 2015-08-05 中国科学院长春应用化学研究所 一种组织工程支架材料的制备方法
EA035413B1 (ru) 2013-06-13 2020-06-10 Ордженисис Лтд. Популяции клеток, способы трансдифференцировки и способы их применения
WO2016072017A1 (ja) * 2014-11-07 2016-05-12 オリンパス株式会社 生体組織接合材および生体組織接合方法
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
ES2578705B1 (es) * 2015-01-28 2017-08-04 Universitat Politècnica De Catalunya Andamio macroporoso para ingeniería de tejidos óseos, método de diseño tridimensional y aplicaciones
AU2016243659B2 (en) 2015-03-31 2020-04-23 Cartiva, Inc. Hydrogel implants with porous materials and methods
EP3277228B1 (en) 2015-03-31 2020-01-15 Cartiva, Inc. Carpometacarpal (cmc) implants
US10729548B2 (en) 2016-05-02 2020-08-04 Howmedica Osteonics Corp. Bioactive soft tissue implant and methods of manufacture and use thereof
US11331191B2 (en) 2015-08-12 2022-05-17 Howmedica Osteonics Corp. Bioactive soft tissue implant and methods of manufacture and use thereof
CA2938576A1 (en) * 2015-08-12 2017-02-12 Howmedica Osteonics Corp. Methods for forming scaffolds
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
WO2018061846A1 (ja) 2016-09-27 2018-04-05 富士フイルム株式会社 細胞組織の製造方法、及び多孔フィルム
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. TRANSDIFFERENTIAL CELL POPULATIONS AND METHOD OF USING THEM
EP3621654A4 (en) 2017-05-10 2021-02-17 Graybug Vision, Inc. PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY
KR102198398B1 (ko) * 2017-09-22 2021-01-05 고려대학교 산학협력단 비용매상분리법을 이용한 다공성 코어-치밀성 쉘 구조형 스캐폴드 제조 기술
WO2023142599A1 (zh) * 2022-01-27 2023-08-03 华东理工大学 一种从电极剥离的胶原材料的制备方法及其该胶原材料的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
DE4120325A1 (de) 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
US5277811A (en) * 1992-04-14 1994-01-11 Millipore Corporation Process for forming porous polymeric product from a nonporous polymeric composition and product
US5228994A (en) * 1992-10-13 1993-07-20 Millipore Corporation Composite microporous membranes
US5514378A (en) 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
GB2301362B (en) * 1995-05-30 1999-01-06 Johnson & Johnson Medical Absorbable implant materials having controlled porosity

Also Published As

Publication number Publication date
US6379962B1 (en) 2002-04-30
CN1285757A (zh) 2001-02-28
KR100664772B1 (ko) 2007-01-04
DK1030697T3 (da) 2003-12-29
EP1030697A2 (en) 2000-08-30
WO1999025391A2 (en) 1999-05-27
WO1999025391A3 (en) 1999-08-26
AU1138099A (en) 1999-06-07
CA2310070A1 (en) 1999-05-27
CN1212866C (zh) 2005-08-03
ATE247994T1 (de) 2003-09-15
NZ504973A (en) 2003-07-25
CA2221195A1 (en) 1999-05-14
BR9814036B1 (pt) 2011-07-26
KR20010015819A (ko) 2001-02-26
AU749041B2 (en) 2002-06-20
EP1030697B1 (en) 2003-08-27
AU2002300496B2 (en) 2005-04-21
DE69817600D1 (de) 2003-10-02
DE69817600T2 (de) 2004-06-24
BR9814036A (pt) 2000-11-21
JP2001523483A (ja) 2001-11-27
ES2207861T3 (es) 2004-06-01
JP4636684B2 (ja) 2011-02-23
CA2310070C (en) 2008-01-08

Similar Documents

Publication Publication Date Title
IL136093A0 (en) Biodegradable polymer scaffold
EP0857072B1 (en) Implantable bioresorbable membrane and method for the preparation thereof
Shapiro et al. Novel alginate sponges for cell culture and transplantation
Schugens et al. Polylactide macroporous biodegradable implants for cell transplantation. II. Preparation of polylactide foams by liquid‐liquid phase separation
JP2001523483A5 (pt)
US9028857B2 (en) Method for preparing porous scaffold for tissue engineering
CA2256327C (en) Polysaccharide sponges for cell culture and transplantation
EP1468676A3 (en) Poly (vinyl alcohol) cryogel
IT1247472B (it) Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
CA2370810A1 (en) Porous polymer scaffolds for tissue engineering
CA2271884A1 (en) Improved porous biomaterials and methods for their manufacture
AU3155700A (en) New biomaterials
CA2701858A1 (en) Method for preparing porous scaffold for tissue engineering, cell culture and cell delivery
ZA914098B (en) Biocompatible perforated membranes,processes for their preparation,their use as a support in the in vitro growth of epithelial cells,the artificial skin obtained in this manner,and its use in skin grafts
WO2000018318A1 (en) Fibrillar matrices
EP0277678A1 (en) A graft suitable for treatment by reconstructive surgery and having tissue-specific porosity, and a process for making such graft
Mittal et al. Integration of porosity and bio-functionalization to form a 3D scaffold: cell culture studies and in vitro degradation
AU3639301A (en) Biodegradable polymer/ceramic implant material with bimodal degradation profile
WO2003053216A3 (en) Biodegradable, porous structures useful for growing living tissue, and methods of manufacture
AU2016213743A1 (en) Methods for forming scaffolds
Koupaei et al. Porous crosslinked polycaprolactone hydroxyapatite networks for bone tissue engineering
IL139715A (en) Method for preparing biocompatible scaffold
CN113546221A (zh) 一种镁基复合材料及其制备方法和应用
IL150042A (en) Cytosene particles with large constituents, a method for their preparation and use in a method for producing living cells or plant cells
SE1251042A1 (sv) Metod för att producera en alginatbelagd titandioxidscaffold

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees