IL133100A - Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent - Google Patents

Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent

Info

Publication number
IL133100A
IL133100A IL13310098A IL13310098A IL133100A IL 133100 A IL133100 A IL 133100A IL 13310098 A IL13310098 A IL 13310098A IL 13310098 A IL13310098 A IL 13310098A IL 133100 A IL133100 A IL 133100A
Authority
IL
Israel
Prior art keywords
vwd
dihydroxypropyl
amino
isophthalamide
bis
Prior art date
Application number
IL13310098A
Other languages
English (en)
Hebrew (he)
Other versions
IL133100A0 (en
Inventor
Dick Malthe-Sorenssen
Audun Aukrust
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of IL133100A0 publication Critical patent/IL133100A0/xx
Publication of IL133100A publication Critical patent/IL133100A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Polyamides (AREA)
IL13310098A 1997-05-23 1998-05-22 Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent IL133100A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9710726.2A GB9710726D0 (en) 1997-05-23 1997-05-23 Compound
US4917697P 1997-06-10 1997-06-10
PCT/GB1998/001492 WO1998052911A1 (en) 1997-05-23 1998-05-22 Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (2)

Publication Number Publication Date
IL133100A0 IL133100A0 (en) 2001-03-19
IL133100A true IL133100A (en) 2004-07-25

Family

ID=10812988

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13310098A IL133100A (en) 1997-05-23 1998-05-22 Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent

Country Status (18)

Country Link
US (1) US6337422B1 (cs)
EP (1) EP0983230B1 (cs)
JP (1) JP4476366B2 (cs)
KR (1) KR100543856B1 (cs)
CN (1) CN1161324C (cs)
AT (1) ATE256101T1 (cs)
AU (1) AU725565B2 (cs)
BR (1) BRPI9809153B8 (cs)
CA (1) CA2290544A1 (cs)
CZ (1) CZ297243B6 (cs)
DE (1) DE69820435T2 (cs)
GB (1) GB9710726D0 (cs)
HU (1) HU224128B1 (cs)
IL (1) IL133100A (cs)
NO (1) NO327490B1 (cs)
PL (1) PL190905B1 (cs)
PT (1) PT983230E (cs)
WO (1) WO1998052911A1 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
US8124806B2 (en) 2006-02-15 2012-02-28 Ge Healthcare As Contrast agents
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
EP2385845A1 (en) 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
EP2281807A1 (en) * 2009-07-21 2011-02-09 GE Healthcare AS Decolorizing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, a contrast media intermediate
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
PH12014500316B1 (en) 2011-09-19 2018-10-03 Orexo Ab New abuse-resistant pharmaceutical composition for the treatment of opioid dependence

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
AU612510B2 (en) * 1988-03-01 1991-07-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
WO1995035122A1 (en) * 1994-06-21 1995-12-28 Mallinckrodt Medical, Inc. Improved synthesis of ioversol using phosphoric acid modified co-addition
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
JP3985034B2 (ja) * 1995-05-24 2007-10-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ ヨウ素化方法

Also Published As

Publication number Publication date
CN1161324C (zh) 2004-08-11
EP0983230A1 (en) 2000-03-08
BRPI9809153B8 (pt) 2021-07-06
JP2001526678A (ja) 2001-12-18
NO327490B1 (no) 2009-07-13
DE69820435T2 (de) 2004-10-07
PL190905B1 (pl) 2006-02-28
WO1998052911A1 (en) 1998-11-26
CA2290544A1 (en) 1998-11-26
KR100543856B1 (ko) 2006-01-23
BRPI9809153B1 (pt) 2017-11-14
EP0983230B1 (en) 2003-12-10
PT983230E (pt) 2004-04-30
HUP0003637A1 (hu) 2001-02-28
BRPI9809153A (pt) 2000-08-01
AU725565B2 (en) 2000-10-12
AU7540798A (en) 1998-12-11
CZ417199A3 (cs) 2000-05-17
PL336848A1 (en) 2000-07-17
CZ297243B6 (cs) 2006-10-11
CN1257479A (zh) 2000-06-21
HU224128B1 (hu) 2005-05-30
NO995676D0 (no) 1999-11-19
US6337422B1 (en) 2002-01-08
NO995676L (no) 1999-11-19
HUP0003637A3 (en) 2001-06-28
JP4476366B2 (ja) 2010-06-09
ATE256101T1 (de) 2003-12-15
GB9710726D0 (en) 1997-07-16
DE69820435D1 (en) 2004-01-22
IL133100A0 (en) 2001-03-19
KR20010012794A (ko) 2001-02-26

Similar Documents

Publication Publication Date Title
RU2273629C2 (ru) Способы получения кристаллов натеглинида
US20040132828A1 (en) Polymorphic forms of sertraline hydrochloride
AU725565B2 (en) Yellow polymorph of 5-amino-2,4,6-triiodo-N,N'-bis (2,3-dihydroxypropyl)-isophthalamide
JP4249273B2 (ja) 特定の結晶化形態のジルパテロール塩酸塩、その製造方法及び使用される中間体物質
SK14212002A3 (sk) Spôsob prípravy (+)-cis-sertralínu
JP3780002B2 (ja) イオヘキソールの製法
CA2351717C (en) A process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide
DE69721052T2 (de) Alpha-aminosäureamide, ihre herstellung und ihre therapeutische anwendung
KR100544932B1 (ko) 트리요오도 벤젠 화합물의 제법
KR20110009052A (ko) 비-이온성 ｘ-선 조영제에 대한 중간체의 연속 제조 방법
US6137006A (en) Preparation of tri-iodo benzene compounds
PT101982B (pt) PROCESSO PARA A PREPARACAO DE S-N, N'-BIS-{2-HIDROXI-(1-HIDROXIMETIL) ETIL}- 5-(2-ACETOXI-PROPIONILAMINO)-2,4,6-TRIIODO-ISOFTALAMIDA E SUA UTILIZACãO NA PREPARACãO DO IOPAMIDOL
CN103228620B (zh) 造影剂的制备方法
KR101076126B1 (ko) 초음파를 이용한 요오딕사놀의 결정화
JP4476365B2 (ja) トリヨードベンゼン化合物の製造
RU2743999C2 (ru) Способ разделения солей баклофена
CA2710642C (en) Crystallization of iodixanol using ultrasound
CA2710582A1 (en) Decolorizing contrast media intermediates

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
HC Change of name of proprietor(s)

Owner name: GE HEALTHCARE AS

Free format text: FORMER NAME:AMERSHAM HEALTH AS

KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired