IL133100A - Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent - Google Patents

Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent

Info

Publication number
IL133100A
IL133100A IL13310098A IL13310098A IL133100A IL 133100 A IL133100 A IL 133100A IL 13310098 A IL13310098 A IL 13310098A IL 13310098 A IL13310098 A IL 13310098A IL 133100 A IL133100 A IL 133100A
Authority
IL
Israel
Prior art keywords
vwd
dihydroxypropyl
amino
isophthalamide
bis
Prior art date
Application number
IL13310098A
Other languages
English (en)
Hebrew (he)
Other versions
IL133100A0 (en
Inventor
Dick Malthe-Sorenssen
Audun Aukrust
Original Assignee
Amersham Health As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health As filed Critical Amersham Health As
Publication of IL133100A0 publication Critical patent/IL133100A0/xx
Publication of IL133100A publication Critical patent/IL133100A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Polyamides (AREA)
IL13310098A 1997-05-23 1998-05-22 Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent IL133100A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9710726.2A GB9710726D0 (en) 1997-05-23 1997-05-23 Compound
US4917697P 1997-06-10 1997-06-10
PCT/GB1998/001492 WO1998052911A1 (en) 1997-05-23 1998-05-22 Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (2)

Publication Number Publication Date
IL133100A0 IL133100A0 (en) 2001-03-19
IL133100A true IL133100A (en) 2004-07-25

Family

ID=10812988

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13310098A IL133100A (en) 1997-05-23 1998-05-22 Yellow polymorphic 5-amino - 2,4,6-triiodo-n, n'-bis (2,3-dihydroxypropyl)-isophthalamide, a process for its preparation, and the use thereof in the production of an iodinated x-ray contrast agent

Country Status (18)

Country Link
US (1) US6337422B1 (cs)
EP (1) EP0983230B1 (cs)
JP (1) JP4476366B2 (cs)
KR (1) KR100543856B1 (cs)
CN (1) CN1161324C (cs)
AT (1) ATE256101T1 (cs)
AU (1) AU725565B2 (cs)
BR (1) BRPI9809153B8 (cs)
CA (1) CA2290544A1 (cs)
CZ (1) CZ297243B6 (cs)
DE (1) DE69820435T2 (cs)
GB (1) GB9710726D0 (cs)
HU (1) HU224128B1 (cs)
IL (1) IL133100A (cs)
NO (1) NO327490B1 (cs)
PL (1) PL190905B1 (cs)
PT (1) PT983230E (cs)
WO (1) WO1998052911A1 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
WO2007094683A1 (en) 2006-02-15 2007-08-23 Ge Healthcare As Contrast agents
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
CN102271715A (zh) 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
EP2281807A1 (en) * 2009-07-21 2011-02-09 GE Healthcare AS Decolorizing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, a contrast media intermediate
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
SMT202100546T1 (it) 2011-09-19 2021-11-12 Orexo Ab Compresse per via sublinguale resistenti all'abuso comprendenti buprenorfina e naloxone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
WO1989008101A1 (en) * 1988-03-01 1989-09-08 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
DE69524088T2 (de) * 1994-06-21 2002-08-29 Mallinckrodt, Inc. Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
DE69609963T2 (de) * 1995-05-24 2001-04-12 Nycomed Imaging As, Oslo Verfahren zur iodierung

Also Published As

Publication number Publication date
KR20010012794A (ko) 2001-02-26
CA2290544A1 (en) 1998-11-26
ATE256101T1 (de) 2003-12-15
AU725565B2 (en) 2000-10-12
DE69820435D1 (en) 2004-01-22
CN1161324C (zh) 2004-08-11
KR100543856B1 (ko) 2006-01-23
EP0983230B1 (en) 2003-12-10
PL190905B1 (pl) 2006-02-28
NO995676D0 (no) 1999-11-19
US6337422B1 (en) 2002-01-08
BRPI9809153B1 (pt) 2017-11-14
HUP0003637A1 (hu) 2001-02-28
CZ297243B6 (cs) 2006-10-11
DE69820435T2 (de) 2004-10-07
CZ417199A3 (cs) 2000-05-17
AU7540798A (en) 1998-12-11
NO327490B1 (no) 2009-07-13
BRPI9809153A (pt) 2000-08-01
HUP0003637A3 (en) 2001-06-28
CN1257479A (zh) 2000-06-21
BRPI9809153B8 (pt) 2021-07-06
PT983230E (pt) 2004-04-30
GB9710726D0 (en) 1997-07-16
PL336848A1 (en) 2000-07-17
WO1998052911A1 (en) 1998-11-26
IL133100A0 (en) 2001-03-19
EP0983230A1 (en) 2000-03-08
JP4476366B2 (ja) 2010-06-09
HU224128B1 (hu) 2005-05-30
JP2001526678A (ja) 2001-12-18
NO995676L (no) 1999-11-19

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Owner name: GE HEALTHCARE AS

Free format text: FORMER NAME:AMERSHAM HEALTH AS

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