DE69820435T2 - Gelbe polymorphe Form von 5-Amino-2,4,6-triiodo-N,N'-bis (2,3-dihydroxypropyl)isophthalamid - Google Patents

Gelbe polymorphe Form von 5-Amino-2,4,6-triiodo-N,N'-bis (2,3-dihydroxypropyl)isophthalamid Download PDF

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Publication number
DE69820435T2
DE69820435T2 DE69820435T DE69820435T DE69820435T2 DE 69820435 T2 DE69820435 T2 DE 69820435T2 DE 69820435 T DE69820435 T DE 69820435T DE 69820435 T DE69820435 T DE 69820435T DE 69820435 T2 DE69820435 T2 DE 69820435T2
Authority
DE
Germany
Prior art keywords
triiodo
isophthalamide
dihydroxypropyl
bis
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820435T
Other languages
English (en)
Other versions
DE69820435D1 (en
Inventor
Dick Malthe-Sorenssen
Audun Aukrust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Application granted granted Critical
Publication of DE69820435D1 publication Critical patent/DE69820435D1/de
Publication of DE69820435T2 publication Critical patent/DE69820435T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Polyamides (AREA)
  • Indole Compounds (AREA)
DE69820435T 1997-05-23 1998-05-22 Gelbe polymorphe Form von 5-Amino-2,4,6-triiodo-N,N'-bis (2,3-dihydroxypropyl)isophthalamid Expired - Lifetime DE69820435T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9710726.2A GB9710726D0 (en) 1997-05-23 1997-05-23 Compound
PCT/GB1998/001492 WO1998052911A1 (en) 1997-05-23 1998-05-22 Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (2)

Publication Number Publication Date
DE69820435D1 DE69820435D1 (en) 2004-01-22
DE69820435T2 true DE69820435T2 (de) 2004-10-07

Family

ID=10812988

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820435T Expired - Lifetime DE69820435T2 (de) 1997-05-23 1998-05-22 Gelbe polymorphe Form von 5-Amino-2,4,6-triiodo-N,N'-bis (2,3-dihydroxypropyl)isophthalamid

Country Status (18)

Country Link
US (1) US6337422B1 (de)
EP (1) EP0983230B1 (de)
JP (1) JP4476366B2 (de)
KR (1) KR100543856B1 (de)
CN (1) CN1161324C (de)
AT (1) ATE256101T1 (de)
AU (1) AU725565B2 (de)
BR (1) BRPI9809153B8 (de)
CA (1) CA2290544A1 (de)
CZ (1) CZ297243B6 (de)
DE (1) DE69820435T2 (de)
GB (1) GB9710726D0 (de)
HU (1) HU224128B1 (de)
IL (1) IL133100A (de)
NO (1) NO327490B1 (de)
PL (1) PL190905B1 (de)
PT (1) PT983230E (de)
WO (1) WO1998052911A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
ATE496881T1 (de) 2006-02-15 2011-02-15 Ge Healthcare As Kontrastmittel
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
US20110256068A1 (en) 2009-01-09 2011-10-20 Wistand Lars-Goeran Contrast media compositions
EP2281807A1 (de) * 2009-07-21 2011-02-09 GE Healthcare AS Entfärben von 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamid, ein Kontrastmittelzwischenprodukt
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
CN103813785B (zh) 2011-09-19 2017-02-15 奥瑞克索股份公司 新的治疗阿片样物质依赖的抗滥用药物组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
WO1989008101A1 (en) * 1988-03-01 1989-09-08 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
EP0762900B1 (de) * 1994-06-21 2001-11-21 Mallinckrodt Inc. Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
EP0828705B1 (de) * 1995-05-24 2000-08-23 Nycomed Imaging As Verfahren zur iodierung

Also Published As

Publication number Publication date
ATE256101T1 (de) 2003-12-15
KR20010012794A (ko) 2001-02-26
NO327490B1 (no) 2009-07-13
EP0983230B1 (de) 2003-12-10
PL336848A1 (en) 2000-07-17
US6337422B1 (en) 2002-01-08
GB9710726D0 (en) 1997-07-16
BRPI9809153B8 (pt) 2021-07-06
WO1998052911A1 (en) 1998-11-26
CZ297243B6 (cs) 2006-10-11
CZ417199A3 (cs) 2000-05-17
PT983230E (pt) 2004-04-30
CN1257479A (zh) 2000-06-21
AU7540798A (en) 1998-12-11
BRPI9809153B1 (pt) 2017-11-14
KR100543856B1 (ko) 2006-01-23
NO995676L (no) 1999-11-19
BRPI9809153A (pt) 2000-08-01
IL133100A0 (en) 2001-03-19
IL133100A (en) 2004-07-25
JP2001526678A (ja) 2001-12-18
CA2290544A1 (en) 1998-11-26
AU725565B2 (en) 2000-10-12
HUP0003637A1 (hu) 2001-02-28
PL190905B1 (pl) 2006-02-28
HUP0003637A3 (en) 2001-06-28
EP0983230A1 (de) 2000-03-08
NO995676D0 (no) 1999-11-19
HU224128B1 (hu) 2005-05-30
JP4476366B2 (ja) 2010-06-09
DE69820435D1 (en) 2004-01-22
CN1161324C (zh) 2004-08-11

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8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R082 Change of representative

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Country of ref document: EP

Representative=s name: J D REYNOLDS & CO., GB