JP4476366B2 - ５−アミノ−２，４，６−トリヨード−ｎ，ｎ´−ビス（２，３−ジヒドロキシプロピル）−イソフタルアミドの黄色多形 - Google Patents

５−アミノ−２，４，６−トリヨード−ｎ，ｎ´−ビス（２，３−ジヒドロキシプロピル）−イソフタルアミドの黄色多形 Download PDF

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Publication number
JP4476366B2
JP4476366B2 JP55014098A JP55014098A JP4476366B2 JP 4476366 B2 JP4476366 B2 JP 4476366B2 JP 55014098 A JP55014098 A JP 55014098A JP 55014098 A JP55014098 A JP 55014098A JP 4476366 B2 JP4476366 B2 JP 4476366B2
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Japan
Prior art keywords
isophthalamide
bis
triiodo
amino
dihydroxypropyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP55014098A
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Japanese (ja)
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JP2001526678A (ja
Inventor
マルテ−セーレンセン，ディック
アウクルスト，アウデュン
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Indole Compounds (AREA)
JP55014098A 1997-05-23 1998-05-22 ５−アミノ−２，４，６−トリヨード−ｎ，ｎ´−ビス（２，３−ジヒドロキシプロピル）−イソフタルアミドの黄色多形 Expired - Lifetime JP4476366B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9710726.2 1997-05-23
GBGB9710726.2A GB9710726D0 (en) 1997-05-23 1997-05-23 Compound
PCT/GB1998/001492 WO1998052911A1 (en) 1997-05-23 1998-05-22 Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide

Publications (2)

Publication Number Publication Date
JP2001526678A JP2001526678A (ja) 2001-12-18
JP4476366B2 true JP4476366B2 (ja) 2010-06-09

Family

ID=10812988

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55014098A Expired - Lifetime JP4476366B2 (ja) 1997-05-23 1998-05-22 ５−アミノ−２，４，６−トリヨード−ｎ，ｎ´−ビス（２，３−ジヒドロキシプロピル）−イソフタルアミドの黄色多形

Country Status (18)

Country Link
US (1) US6337422B1 (cs)
EP (1) EP0983230B1 (cs)
JP (1) JP4476366B2 (cs)
KR (1) KR100543856B1 (cs)
CN (1) CN1161324C (cs)
AT (1) ATE256101T1 (cs)
AU (1) AU725565B2 (cs)
BR (1) BRPI9809153B8 (cs)
CA (1) CA2290544A1 (cs)
CZ (1) CZ297243B6 (cs)
DE (1) DE69820435T2 (cs)
GB (1) GB9710726D0 (cs)
HU (1) HU224128B1 (cs)
IL (1) IL133100A (cs)
NO (1) NO327490B1 (cs)
PL (1) PL190905B1 (cs)
PT (1) PT983230E (cs)
WO (1) WO1998052911A1 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524515B2 (en) * 2003-01-10 2009-04-28 Mutual Pharmaceuticals, Inc. Pharmaceutical safety dosage forms
DE602007012208D1 (de) 2006-02-15 2011-03-10 Ge Healthcare As Kontrastmittel
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
CN102271715A (zh) 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
US20110021833A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Crystallization of an intermediate for synthesizing non-ionic x-ray contrast agents
US20110021834A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous process of preparing intermediate for non-ionic x-ray contrast agents
EP2281807A1 (en) * 2009-07-21 2011-02-09 GE Healthcare AS Decolorizing 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, a contrast media intermediate
ME02153B (me) 2011-09-19 2015-10-20 Orexo Ab Nove farmaceutske kompozicije, otporne na zloupotrebu, za tretman zavisnosti od opioida

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
AU612510B2 (en) * 1988-03-01 1991-07-11 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5013865A (en) * 1988-04-06 1991-05-07 Mallinckrodt, Inc. Process for the preparation of 2,4,6-triiodo-5-amino-N-alkylisophthalamic acid and 2,4,6-triiodo-5-amino-isophthalamide compounds
US5256393A (en) * 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
EP0762900B1 (en) * 1994-06-21 2001-11-21 Mallinckrodt Inc. Improved synthesis of ioversol using phosphoric acid modified co-addition
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
WO1996037461A1 (en) * 1995-05-24 1996-11-28 Nycomed Imaging A.S Iodination process

Also Published As

Publication number Publication date
PT983230E (pt) 2004-04-30
JP2001526678A (ja) 2001-12-18
HUP0003637A3 (en) 2001-06-28
CZ297243B6 (cs) 2006-10-11
CN1161324C (zh) 2004-08-11
ATE256101T1 (de) 2003-12-15
US6337422B1 (en) 2002-01-08
BRPI9809153B8 (pt) 2021-07-06
CZ417199A3 (cs) 2000-05-17
PL336848A1 (en) 2000-07-17
HUP0003637A1 (hu) 2001-02-28
NO995676D0 (no) 1999-11-19
DE69820435T2 (de) 2004-10-07
NO995676L (no) 1999-11-19
IL133100A (en) 2004-07-25
AU725565B2 (en) 2000-10-12
DE69820435D1 (en) 2004-01-22
EP0983230A1 (en) 2000-03-08
BRPI9809153B1 (pt) 2017-11-14
PL190905B1 (pl) 2006-02-28
AU7540798A (en) 1998-12-11
BRPI9809153A (pt) 2000-08-01
KR20010012794A (ko) 2001-02-26
WO1998052911A1 (en) 1998-11-26
NO327490B1 (no) 2009-07-13
CN1257479A (zh) 2000-06-21
EP0983230B1 (en) 2003-12-10
KR100543856B1 (ko) 2006-01-23
HU224128B1 (hu) 2005-05-30
CA2290544A1 (en) 1998-11-26
IL133100A0 (en) 2001-03-19
GB9710726D0 (en) 1997-07-16

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