IL132426A0 - An amyloid binding compound and pharmaceutical compositions containing the same - Google Patents
An amyloid binding compound and pharmaceutical compositions containing the sameInfo
- Publication number
- IL132426A0 IL132426A0 IL13242698A IL13242698A IL132426A0 IL 132426 A0 IL132426 A0 IL 132426A0 IL 13242698 A IL13242698 A IL 13242698A IL 13242698 A IL13242698 A IL 13242698A IL 132426 A0 IL132426 A0 IL 132426A0
- Authority
- IL
- Israel
- Prior art keywords
- same
- pharmaceutical compositions
- compositions containing
- binding compound
- amyloid binding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/14—Styryl dyes
- C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/837,494 US6168776B1 (en) | 1994-07-19 | 1997-04-18 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
PCT/US1998/007889 WO1998047969A1 (en) | 1997-04-18 | 1998-04-20 | Alkyl, alkenyl and alkynyl chrysamine g derivatives for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
Publications (1)
Publication Number | Publication Date |
---|---|
IL132426A0 true IL132426A0 (en) | 2001-03-19 |
Family
ID=25274617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13242698A IL132426A0 (en) | 1997-04-18 | 1998-04-20 | An amyloid binding compound and pharmaceutical compositions containing the same |
Country Status (19)
Country | Link |
---|---|
US (3) | US6168776B1 (no) |
EP (1) | EP0977815A1 (no) |
JP (1) | JP2002500634A (no) |
KR (1) | KR20010006552A (no) |
CN (1) | CN1261906A (no) |
AR (1) | AR012845A1 (no) |
AU (1) | AU7136998A (no) |
BR (1) | BR9809580A (no) |
CA (1) | CA2286607A1 (no) |
EE (1) | EE9900503A (no) |
HU (1) | HUP0003804A3 (no) |
IL (1) | IL132426A0 (no) |
NO (1) | NO995088L (no) |
NZ (1) | NZ500714A (no) |
PL (1) | PL336321A1 (no) |
SK (1) | SK144099A3 (no) |
TR (1) | TR199903115T2 (no) |
WO (1) | WO1998047969A1 (no) |
ZA (1) | ZA983301B (no) |
Families Citing this family (80)
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US6417178B1 (en) * | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
BR0016652A (pt) * | 1999-12-23 | 2002-11-19 | Neurochem Inc | Métodos para inibir angiopatia amilóide cerebral, para tratar um estado de doença caracterizado por angiopatia amilóide cerebral em um indivìduo, e para diagnosticar angiopatia amilóide cerebral em um indivìduo |
US7640062B2 (en) | 2000-05-08 | 2009-12-29 | Brainsgate Ltd. | Methods and systems for management of alzheimer's disease |
EP2151187A1 (en) * | 2000-08-21 | 2010-02-10 | The General Hospital Corporation | Methods for diagnosing a neurodegenerative condition |
US7297326B2 (en) * | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
HU230375B1 (hu) | 2000-08-24 | 2016-03-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
US6589504B1 (en) | 2000-09-22 | 2003-07-08 | Pharmacia & Upjohn Company | Compounds and methods for diagnosing and treating amyloid-related conditions |
US7668586B2 (en) * | 2000-11-02 | 2010-02-23 | Cornell Research Foundation, Inc. | In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease |
US6379650B1 (en) | 2001-03-19 | 2002-04-30 | Wesley Scott Ashton | Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging |
CN100422180C (zh) | 2001-04-23 | 2008-10-01 | 宾夕法尼亚州大学理事会 | 淀粉样斑块聚集抑制剂和诊断成像剂 |
EP1420830B1 (en) * | 2001-04-27 | 2011-03-09 | The General Hospital Corporation | Ocular diagnosis of alzheimer's disease |
US20030211459A1 (en) * | 2001-10-25 | 2003-11-13 | The General Hospital Corporation | Drug development by rapid neuroimaging of neural cells |
US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
US7407778B2 (en) | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
NZ536054A (en) * | 2002-04-09 | 2009-10-30 | Scripps Research Inst | Motif-grafted hybrid polypeptides and uses thereof |
US7684859B2 (en) | 2002-04-25 | 2010-03-23 | Brainsgate Ltd. | Stimulation of the OTIC ganglion for treating medical conditions |
TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
US7692011B2 (en) | 2002-10-04 | 2010-04-06 | Prana Biotechnology Limited | 8-hydroxy and 8-mercapto quinazolinones |
JP2006515999A (ja) | 2002-11-14 | 2006-06-15 | ブレインズゲート リミティド | 刺激のための外科用ツール及び技法 |
US20040204344A1 (en) * | 2003-01-22 | 2004-10-14 | Xudong Huang | Amyloid-binding, metal-chelating agents |
GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
EP1631561B1 (en) | 2003-05-07 | 2010-08-18 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
JP2007504283A (ja) * | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
WO2004110963A2 (en) * | 2003-05-29 | 2004-12-23 | Pettegrew Jay W | Glycerophosphocholine and its derivatives for medical imaging neuropsychiatric disorders |
US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
US20050214222A1 (en) * | 2004-02-13 | 2005-09-29 | Mckinnon Stuart J | In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes |
US8055347B2 (en) | 2005-08-19 | 2011-11-08 | Brainsgate Ltd. | Stimulation for treating brain events and other conditions |
US9233245B2 (en) | 2004-02-20 | 2016-01-12 | Brainsgate Ltd. | SPG stimulation |
US8010189B2 (en) * | 2004-02-20 | 2011-08-30 | Brainsgate Ltd. | SPG stimulation for treating complications of subarachnoid hemorrhage |
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EP1893245A4 (en) * | 2005-06-24 | 2009-06-24 | Univ Pennsylvania | RADIOACTIVELY MARKED PEGYLATION OF LIGANDS FOR USE AS A CONTRAST |
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WO2007047815A2 (en) * | 2005-10-18 | 2007-04-26 | The Brigham And Women's Hospital, Inc. | Diagnosis of transmissible spongiform encephalopathy |
US20090142269A1 (en) * | 2005-12-01 | 2009-06-04 | University Of Oittsburgh-Of The Commonwealth System Of Higher Education | Isotoypically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
JP5170783B2 (ja) | 2006-04-11 | 2013-03-27 | コグノプティックス, インコーポレイテッド | 眼の画像化 |
DK2012789T3 (da) | 2006-04-14 | 2013-12-16 | Prana Biotechnology Ltd | Fremgangsmåde til behandling af aldersrelateret makulær degeneration (AMD) |
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JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. | ブロモドメイン阻害剤としての新規複素環式化合物 |
CU20130027A7 (es) | 2013-02-28 | 2014-10-30 | Ct De Neurociencias De Cuba | Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales |
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JP2016534063A (ja) | 2013-10-22 | 2016-11-04 | ザ ジェネラル ホスピタル コーポレイション | クロモリン誘導体ならびに関連するイメージングおよび治療方法 |
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CH566420B5 (en) | 1967-10-03 | 1975-09-15 | Ciba Geigy Ag | Bis-stilbene compds for use as optical brighteners |
CH547243A (de) | 1970-07-23 | 1974-03-29 | Ciba Geigy Ag | Verfahren zur herstellung von styrylverbindungen. |
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DE2364396A1 (de) | 1973-12-22 | 1975-07-10 | Basf Ag | Neue bisstyrylarylverbindungen |
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WO1992016239A1 (en) | 1991-03-13 | 1992-10-01 | The Regents Of The University Of Minnesota | Radiopharmaceutical agents for the detection of alzheimer's disease |
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-
1997
- 1997-04-18 US US08/837,494 patent/US6168776B1/en not_active Expired - Lifetime
-
1998
- 1998-04-20 SK SK1440-99A patent/SK144099A3/sk unknown
- 1998-04-20 WO PCT/US1998/007889 patent/WO1998047969A1/en not_active Application Discontinuation
- 1998-04-20 PL PL98336321A patent/PL336321A1/xx unknown
- 1998-04-20 HU HU0003804A patent/HUP0003804A3/hu unknown
- 1998-04-20 BR BR9809580-3A patent/BR9809580A/pt unknown
- 1998-04-20 JP JP54622398A patent/JP2002500634A/ja active Pending
- 1998-04-20 KR KR1019997009642A patent/KR20010006552A/ko not_active Application Discontinuation
- 1998-04-20 CA CA002286607A patent/CA2286607A1/en not_active Abandoned
- 1998-04-20 TR TR1999/03115T patent/TR199903115T2/xx unknown
- 1998-04-20 IL IL13242698A patent/IL132426A0/xx unknown
- 1998-04-20 ZA ZA9803301A patent/ZA983301B/xx unknown
- 1998-04-20 EE EEP199900503A patent/EE9900503A/xx unknown
- 1998-04-20 AR ARP980101817A patent/AR012845A1/es not_active Application Discontinuation
- 1998-04-20 NZ NZ500714A patent/NZ500714A/en unknown
- 1998-04-20 AU AU71369/98A patent/AU7136998A/en not_active Abandoned
- 1998-04-20 EP EP98918448A patent/EP0977815A1/en not_active Withdrawn
- 1998-04-20 CN CN98806318A patent/CN1261906A/zh active Pending
- 1998-11-09 US US09/188,200 patent/US6133259A/en not_active Expired - Fee Related
- 1998-11-09 US US09/188,244 patent/US6114175A/en not_active Expired - Fee Related
-
1999
- 1999-10-18 NO NO995088A patent/NO995088L/no not_active Application Discontinuation
Also Published As
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MX9909557A (es) | 2002-12-13 |
US6114175A (en) | 2000-09-05 |
TR199903115T2 (xx) | 2000-05-22 |
EP0977815A1 (en) | 2000-02-09 |
EE9900503A (et) | 2000-06-15 |
AU7136998A (en) | 1998-11-13 |
CA2286607A1 (en) | 1998-10-29 |
NO995088L (no) | 1999-12-17 |
HUP0003804A3 (en) | 2002-09-30 |
AR012845A1 (es) | 2000-11-22 |
JP2002500634A (ja) | 2002-01-08 |
NO995088D0 (no) | 1999-10-18 |
PL336321A1 (en) | 2000-06-19 |
HUP0003804A2 (hu) | 2001-06-28 |
US6168776B1 (en) | 2001-01-02 |
KR20010006552A (ko) | 2001-01-26 |
US6133259A (en) | 2000-10-17 |
WO1998047969A1 (en) | 1998-10-29 |
ZA983301B (en) | 1999-10-20 |
NZ500714A (en) | 2001-09-28 |
SK144099A3 (en) | 2000-07-11 |
CN1261906A (zh) | 2000-08-02 |
BR9809580A (pt) | 2001-06-19 |
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