BRPI0910550A2 - ensaio para confôrmeros patogênicos - Google Patents

ensaio para confôrmeros patogênicos

Info

Publication number
BRPI0910550A2
BRPI0910550A2 BRPI0910550A BRPI0910550A BRPI0910550A2 BR PI0910550 A2 BRPI0910550 A2 BR PI0910550A2 BR PI0910550 A BRPI0910550 A BR PI0910550A BR PI0910550 A BRPI0910550 A BR PI0910550A BR PI0910550 A2 BRPI0910550 A2 BR PI0910550A2
Authority
BR
Brazil
Prior art keywords
assay
pathogenic conformers
conformers
pathogenic
Prior art date
Application number
BRPI0910550A
Other languages
English (en)
Inventor
Alice Yam
Anthony Lau
David Peretz
Man Carol Gao
Ping Wu
Xuemei Wang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0910550A2 publication Critical patent/BRPI0910550A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
BRPI0910550A 2008-04-30 2009-04-29 ensaio para confôrmeros patogênicos BRPI0910550A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4939608P 2008-04-30 2008-04-30
PCT/US2009/042185 WO2009134942A1 (en) 2008-04-30 2009-04-29 Assay for pathogenic conformers

Publications (1)

Publication Number Publication Date
BRPI0910550A2 true BRPI0910550A2 (pt) 2015-09-29

Family

ID=40863365

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0910550A BRPI0910550A2 (pt) 2008-04-30 2009-04-29 ensaio para confôrmeros patogênicos

Country Status (8)

Country Link
US (1) US20110189692A1 (pt)
EP (1) EP2282753A1 (pt)
JP (1) JP2011520108A (pt)
CN (1) CN102083450A (pt)
AU (1) AU2009243060A1 (pt)
BR (1) BRPI0910550A2 (pt)
CA (1) CA2721982A1 (pt)
WO (1) WO2009134942A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2781952A1 (en) * 2009-11-30 2011-06-03 Novartis Ag Amyloid beta aggregates in cerebro spinal fluid as biomarkers for alzheimer's disease
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
GB201513444D0 (en) * 2015-07-30 2015-09-16 Univ Durham Peptoid
GB201518675D0 (en) 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
JP2018538302A (ja) * 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体
WO2017156324A1 (en) 2016-03-09 2017-09-14 Mike-Ann, Llc Peptoid affinity ligands
KR20210146915A (ko) * 2019-03-29 2021-12-06 세키스이 메디칼 가부시키가이샤 면역 측정 시약 및 면역 측정 방법

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006117A (en) * 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US3843443A (en) * 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
US4244721A (en) * 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
JP3355351B2 (ja) * 1989-02-24 2002-12-09 ユーロジェン・ホールディング・ソシエテ・アノニム 遺伝的に工作されたイムノグロブリン
US5231167A (en) * 1989-09-08 1993-07-27 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5306812A (en) * 1989-09-08 1994-04-26 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US6075121A (en) * 1990-05-15 2000-06-13 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
ATE197646T1 (de) * 1990-08-06 2000-12-15 Chiron Corp Verfahren zum nachweis von cytokinkonvertasehemmern
CA2099574A1 (en) * 1991-01-04 1992-07-05 Noubar B. Afeyan Sulfonamide bonded hydrophilic coatings
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
TW327194B (en) * 1992-05-01 1998-02-21 American Cyanamid Co Novel amyloid precursor proteins and methods of using same
US5831005A (en) * 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5908969A (en) * 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6376170B1 (en) * 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
US5639581A (en) * 1994-10-24 1997-06-17 Fuji Xerox Co., Ltd. Charge transporting polymer, process for producing the same, and organic electronic device containing the same
US5854215A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
DE852011T1 (de) * 1995-09-14 2001-10-11 Univ California Für natives prp-sc spezifische antikörper
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
WO1998006437A2 (en) * 1996-08-13 1998-02-19 Chiron Corporation Compositions and methods for polynucleotide delivery
EP1015013A4 (en) * 1997-01-10 2002-07-24 Massachusetts Inst Technology TREATMENT OF NEUROTOXICITY IN ALZHEIMER'S DISEASE BY BETA-AMYLOID PEPTIDES
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
EP0861900A1 (en) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
US6787319B2 (en) * 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
US7005295B1 (en) * 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
EP0979236B1 (en) * 1997-04-28 2009-07-29 Novartis Vaccines and Diagnostics, Inc. Apparatus for synthesis of oligomers, especially peptoids, with reagent recycling
US5962669A (en) * 1997-06-02 1999-10-05 The Regents Of The University Of California Nucleic acid encoding prion protein variant
DE59805338D1 (de) * 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
DE69926742T2 (de) * 1998-04-14 2006-06-14 Sugen Inc Ste20-verwandte proteinkinasen
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
EP1267904A4 (en) * 2000-02-16 2006-02-08 Univ Northwestern POLYPEPTIDE PULMONAL TENSIDES
IL152116A0 (en) * 2000-04-05 2003-05-29 Vi Technologies Inc Prion-binding ligands and methods of using same
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
WO2001097785A2 (en) * 2000-06-20 2001-12-27 Caprion Pharmaceuticals Inc. Basic copolymers for the treatment of prion-related-disease
CN1176407C (zh) * 2000-06-22 2004-11-17 京瓷株式会社 彩色图像形成装置及其方法
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
US6721761B2 (en) * 2000-12-20 2004-04-13 American Management Systems, Inc. System for assigning digital identifiers to telephone numbers and IP numbers
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
WO2003045128A2 (en) * 2001-11-21 2003-06-05 New York University SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID β, PRION PROTEIN, AMYLIN, α-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
BRPI0307976B8 (pt) * 2002-02-28 2021-07-27 Microsens Biophage Ltd processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra
EP1572937B1 (en) * 2002-04-09 2012-02-08 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US20040208919A1 (en) * 2002-06-13 2004-10-21 Nicolau Yves C. Vaccination against prion diseases
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
NZ560410A (en) * 2002-12-03 2008-12-24 Univ North Carolina State Prion protein ligands and methods of use
PL1615992T3 (pl) * 2003-04-04 2014-03-31 Pathogen Removal And Diagnostic Tech Inc Materiały wiążące białko prionowe i sposoby ich zastosowania
US7745569B2 (en) * 2003-04-07 2010-06-29 The Regents Of The University Of California Amyloid specific binding peptides and detecting abeta peptide
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US7439041B2 (en) * 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
JP3910569B2 (ja) * 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7482172B2 (en) * 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
MX2007008497A (es) * 2005-01-13 2007-09-14 Novartis Vaccines & Diagnostic Ensayos inmunosorbentes enlazados a enzimas usando reactivos de peptidos especificos de prion.
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic ISOLATION OF PATHOGENIC PRIONS
NZ594844A (en) * 2005-09-09 2013-04-26 Novartis Ag Prion-specific peptoid reagents
WO2008134034A1 (en) * 2007-04-26 2008-11-06 Yale University Prion protein as a receptor for amyloid-beta oligomers

Also Published As

Publication number Publication date
AU2009243060A1 (en) 2009-11-05
JP2011520108A (ja) 2011-07-14
CN102083450A (zh) 2011-06-01
CA2721982A1 (en) 2009-11-05
EP2282753A1 (en) 2011-02-16
WO2009134942A1 (en) 2009-11-05
US20110189692A1 (en) 2011-08-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.