BR9809580A - Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide - Google Patents

Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide

Info

Publication number
BR9809580A
BR9809580A BR9809580-3A BR9809580A BR9809580A BR 9809580 A BR9809580 A BR 9809580A BR 9809580 A BR9809580 A BR 9809580A BR 9809580 A BR9809580 A BR 9809580A
Authority
BR
Brazil
Prior art keywords
derivatives
diagnosis
alzheimer
disease
crisamine
Prior art date
Application number
BR9809580-3A
Other languages
English (en)
Inventor
William E Klunk
Jay W Pettegrew
Chester A Mathis Jr
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Publication of BR9809580A publication Critical patent/BR9809580A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/66—Polycyclic acids with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/141—Bis styryl dyes containing two radicals C6H5-CH=CH-
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

Patente de Invenção: <B>"DERIVADOS DE ALQUIL, ALQUENIL E ALQUINIL CRISAMINA G PARA A DIAGNOSE ANTEMORTE DA DOENçA DE ALZHEIMER E DIAGNóSTICO ATRAVéS DE IMAGEM IN VIVO E PREVENçãO DE DEPOSIçãO DE AMILóIDE"<D>. Os compostos de ligação de amilóide que não são derivados azo de G Crisamina, contendo composições farmacêuticas e métodos usando tais compostos para identificar cérebro com a doença de Alzheimer in vivo e para diagnosticar outras condições patológicas caracterizadas por amiloidoses, tal como Síndrome de Down são descritos. Composições farmacêuticas contendo derivados não azo de G Crisamina e métodos usando tais composições para prevenir a degeneração de célula e toxicidade induzida por amilóide em condições associadas a amiloidoses são também descritas. Métodos usando derivados não azo de G Crisamina para tingir ou detectar depósitos de amilóide em biópsia ou tecido após a morte são também descritos. Métodos usando derivados não azo de G Crisamina para quantificar os depósitos de amilóide em homogenatos de biópsia e tecido após a morte são também descritos.
BR9809580-3A 1997-04-18 1998-04-20 Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide BR9809580A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/837,494 US6168776B1 (en) 1994-07-19 1997-04-18 Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
PCT/US1998/007889 WO1998047969A1 (en) 1997-04-18 1998-04-20 Alkyl, alkenyl and alkynyl chrysamine g derivatives for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition

Publications (1)

Publication Number Publication Date
BR9809580A true BR9809580A (pt) 2001-06-19

Family

ID=25274617

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9809580-3A BR9809580A (pt) 1997-04-18 1998-04-20 Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide

Country Status (19)

Country Link
US (3) US6168776B1 (pt)
EP (1) EP0977815A1 (pt)
JP (1) JP2002500634A (pt)
KR (1) KR20010006552A (pt)
CN (1) CN1261906A (pt)
AR (1) AR012845A1 (pt)
AU (1) AU7136998A (pt)
BR (1) BR9809580A (pt)
CA (1) CA2286607A1 (pt)
EE (1) EE9900503A (pt)
HU (1) HUP0003804A3 (pt)
IL (1) IL132426A0 (pt)
NO (1) NO995088L (pt)
NZ (1) NZ500714A (pt)
PL (1) PL336321A1 (pt)
SK (1) SK144099A3 (pt)
TR (1) TR199903115T2 (pt)
WO (1) WO1998047969A1 (pt)
ZA (1) ZA983301B (pt)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417178B1 (en) * 1994-07-19 2002-07-09 University Of Pittsburgh Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits
IL150374A0 (en) * 1999-12-23 2002-12-01 Neurochem Inc Compounds and methods for modulating cerebral amyloid angiopathy
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US6849249B2 (en) 2001-04-27 2005-02-01 The Brigham And Women's Hospital, Inc. Ocular diagnosis of Alzheimer's Disease
EP2151187A1 (en) * 2000-08-21 2010-02-10 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
US7297326B2 (en) * 2000-08-21 2007-11-20 The General Hospital Corporation Ocular diagnosis of Alzheimer's disease
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU2001286702B2 (en) * 2000-08-24 2008-03-13 University Of Pittsburgh Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease
US6589504B1 (en) 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions
DE60128138T2 (de) * 2000-11-02 2008-01-03 Cornell Research Foundation, Inc. In vivo multiphoton diagnostische detektion und bilddarstellung einer neurodegenerativen erkrankung
US6379650B1 (en) 2001-03-19 2002-04-30 Wesley Scott Ashton Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging
AU2002258915B2 (en) * 2001-04-23 2007-11-15 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregation inhibitors and diagnostic imaging agents
US20030211459A1 (en) * 2001-10-25 2003-11-13 The General Hospital Corporation Drug development by rapid neuroimaging of neural cells
US7407778B2 (en) 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
NZ536054A (en) * 2002-04-09 2009-10-30 Scripps Research Inst Motif-grafted hybrid polypeptides and uses thereof
US7684859B2 (en) 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
TW200413009A (en) * 2002-10-04 2004-08-01 Univ Pennsylvania Biphenyls and fluorenes as imaging agents in alzheimer's disease
EP2210892A3 (en) * 2002-10-04 2010-10-27 Prana Biotechnology Limited Neurologically-active compounds
AU2003283786A1 (en) 2002-11-14 2004-06-03 Brainsgate Ltd. Surgical tools and techniques for stimulation
CN1774267A (zh) * 2003-01-22 2006-05-17 综合医院有限公司 与淀粉样物质结合的金属螯合剂
GB0307855D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Organic compounds
WO2004100998A2 (en) 2003-05-07 2004-11-25 General Electric Company Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
US20070053831A1 (en) * 2003-05-20 2007-03-08 Barrio Jorge R Methods for binding agents to b-amyloid plaques
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
US7815894B2 (en) * 2003-05-29 2010-10-19 Jay W. Pettegrew Compounds, compositions and methods for medical imaging of neuropsychiatric disorders
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
US20050214222A1 (en) * 2004-02-13 2005-09-29 Mckinnon Stuart J In vivo imaging of amyloid plaques in glaucoma using intravenous injectable dyes
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
GB0405193D0 (en) * 2004-03-08 2004-04-21 Medical Res Council Compounds
US8093273B2 (en) * 2004-10-20 2012-01-10 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
WO2007002540A2 (en) * 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
EP2314295B1 (en) * 2005-07-29 2015-01-28 Resverlogix, Inc Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
US20070224593A1 (en) * 2005-10-18 2007-09-27 Goldstein Lee E Diagnosis of transmissible spongiform encephalopathy
RU2008126463A (ru) * 2005-12-01 2010-01-10 Юнивесити оф Питсбэг-оф зе Комонвэлс Систем оф Хайэ Эдюкэйшн (US) Связывающие амилоид бензотиазоловые соединения (варианты), фармацевтическая композиция на их основе, способ детекции отложений амилоида (варианты), способ отличения пораженного болезнью альцгеймера мозга от нормального, способ измерения количества амилоида, способ избирательного связывания с амилоидными бляшками (варианты) и способ выявления продромальной стадии заболевания, связанного с отложениями амилоида с их помощью
ES2617061T3 (es) 2006-04-11 2017-06-15 Cognoptix, Inc Procesamiento de imágenes oculares
ES2437997T3 (es) 2006-04-14 2014-01-15 Prana Biotechnology Limited Método de tratamiento de la degeneración macular relacionada con la edad (AMD)
WO2008118122A2 (en) * 2006-05-08 2008-10-02 Molecular Neuroimaging, Llc Compounds and amyloid probes thereof for therapeutic and imaging uses
WO2007139777A2 (en) * 2006-05-26 2007-12-06 Merck & Co., Inc. Methods for the diagnosis and prognosis of alzheimer's disease using csf protein profiling
US7745222B2 (en) * 2006-10-13 2010-06-29 General Electric Company Amyloid binding assays
US7858663B1 (en) * 2007-10-31 2010-12-28 Pisgah Laboratories, Inc. Physical and chemical properties of thyroid hormone organic acid addition salts
US7910579B2 (en) 2006-12-25 2011-03-22 Tohoku University Benzoxazole derivatives
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
AU2008254428A1 (en) * 2007-05-21 2008-11-27 Neuroptix Corporation Ophthalmic formulations of Amyloid-beta contrast agents and methods of use thereof
JP5172229B2 (ja) * 2007-07-04 2013-03-27 住友化学株式会社 アゾ化合物又はその塩
EP2198040B1 (en) * 2007-08-31 2018-08-15 Case Western Reserve University In vivo imaging of myelin
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
JP5501339B2 (ja) 2008-03-21 2014-05-21 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物
AU2009243060A1 (en) * 2008-04-30 2009-11-05 Novartis Ag. Assay for pathogenic conformers
WO2009146388A1 (en) 2008-05-28 2009-12-03 The Trustees Of Columbia University In The City Of New York Voxel-based methods for assessing subjects using positron emission tomography
JP5602728B2 (ja) 2008-06-26 2014-10-08 レスバーロジックス コーポレイション キナゾリノン誘導体の製造方法
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US9925282B2 (en) 2009-01-29 2018-03-27 The General Hospital Corporation Cromolyn derivatives and related methods of imaging and treatment
KR101709492B1 (ko) 2009-03-18 2017-02-23 리스버로직스 코퍼레이션 신규한 소염제
CU23844B1 (es) 2009-04-17 2012-10-15 Ct De Neurociencias De Cuba Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer
SI2421533T1 (sl) 2009-04-22 2019-01-31 Resverlogix Corp. Nova protivnetna sredstva
US8455836B2 (en) * 2009-10-28 2013-06-04 Roy Stockdale Sensor system for constantly monitoring an irradiance level of a UV lamp and for being operated by power from a sensor thereof
US9555130B2 (en) * 2010-02-25 2017-01-31 Case Western Reserve University Compositions and methods for in vivo imaging of myelin in the peripheral nervous system
KR101905436B1 (ko) 2010-08-16 2018-10-08 코그놉틱스, 인코포레이티드 아밀로이드 단백질을 검출하기 위한 시스템 및 방법
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
US10058530B2 (en) 2012-10-25 2018-08-28 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US9855276B2 (en) 2012-10-25 2018-01-02 The General Hospital Corporation Combination therapies for the treatment of Alzheimer's disease and related disorders
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
CU20130027A7 (es) 2013-02-28 2014-10-30 Ct De Neurociencias De Cuba Chaperoninas químicas como nuevos moduladores moleculares de la beta agregación proteica presente en las enfermedades conformacionales
US10525005B2 (en) 2013-05-23 2020-01-07 The General Hospital Corporation Cromolyn compositions and methods thereof
CN110305095A (zh) 2013-10-22 2019-10-08 综合医院公司 色甘酸衍生物以及成像和治疗的相关方法
TW201609183A (zh) 2013-10-31 2016-03-16 康諾普堤克斯公司 眼用調配物之製備方法及其用途
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator
KR101943706B1 (ko) * 2016-08-25 2019-01-29 성균관대학교산학협력단 유비퀴틴 활성 저해용 조성물
AU2017321782B2 (en) 2016-08-31 2022-03-10 The General Hospital Corporation Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases
MX2020000577A (es) 2017-07-20 2020-09-10 Aztherapies Inc Formulaciones en polvo de cromolina sodica e ibuprofeno.
EP3817739A4 (en) 2018-07-02 2022-04-13 The General Hospital Corporation SODIUM CROMOGLYCATE AND ?-LACTOSE POWDER FORMULATIONS

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US401024A (en) 1889-04-09 Benfabriken
US394841A (en) 1888-12-18 Carl duisberg
US329638A (en) 1885-11-03 Fabriken
US622961A (en) 1899-04-11 Ivan levinstein and carl mensching
US1979534A (en) 1931-10-15 1934-11-06 Farastan Company Disazo compound for therapeutic use
CH554848A (de) 1967-10-03 1974-10-15 Ciba Geigy Ag Verfahren zur herstellung neuer stilben-derivate.
CH566420B5 (en) 1967-10-03 1975-09-15 Ciba Geigy Ag Bis-stilbene compds for use as optical brighteners
CH540958A (de) 1970-07-23 1973-08-31 Ciba Geigy Ag Verwendung von Styrylverbindungen als optische Aufhellmittel für organische Materialien ausserhalb der Textilindustrie
DE2039993A1 (de) 1970-08-12 1972-02-17 Basf Ag Optische Aufheller der Bisstyrylbenzolreihe
CH574950A5 (pt) 1972-06-30 1976-04-30 Ciba Geigy Ag
US4016156A (en) 1972-06-30 1977-04-05 Ciba-Geigy Corporation Distyryl compounds
DE2364396A1 (de) 1973-12-22 1975-07-10 Basf Ag Neue bisstyrylarylverbindungen
LU75628A1 (pt) 1976-08-19 1978-04-13
US5039511A (en) 1987-04-08 1991-08-13 Salutar, Inc. Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
JPS63290858A (ja) 1987-04-08 1988-11-28 サルター・インコーポレーテツド アミロイド症及びアルツハイマー病の診断分析法及びそのための試薬
US4933156A (en) 1987-04-08 1990-06-12 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
US5008099A (en) 1987-04-08 1991-04-16 Salutar, Inc. Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor
US5231000A (en) 1987-10-08 1993-07-27 The Mclean Hospital Antibodies to A4 amyloid peptide
JP2641529B2 (ja) * 1988-10-26 1997-08-13 三菱化学株式会社 新規有機高分子
AU654013B2 (en) 1991-03-13 1994-10-20 Regents Of The University Of Minnesota 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane
US5297562A (en) 1991-04-01 1994-03-29 President And Fellows Of Harvard College Method for detecting and treating Alzheimer's disease
US5434050A (en) 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
US5276059A (en) 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
NZ307369A (en) 1995-05-01 1999-11-29 Univ Pittsburgh Azocompounds for the antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition

Also Published As

Publication number Publication date
CN1261906A (zh) 2000-08-02
IL132426A0 (en) 2001-03-19
HUP0003804A2 (hu) 2001-06-28
JP2002500634A (ja) 2002-01-08
PL336321A1 (en) 2000-06-19
US6114175A (en) 2000-09-05
EP0977815A1 (en) 2000-02-09
TR199903115T2 (xx) 2000-05-22
CA2286607A1 (en) 1998-10-29
EE9900503A (et) 2000-06-15
AR012845A1 (es) 2000-11-22
HUP0003804A3 (en) 2002-09-30
US6168776B1 (en) 2001-01-02
MX9909557A (es) 2002-12-13
ZA983301B (en) 1999-10-20
SK144099A3 (en) 2000-07-11
NO995088L (no) 1999-12-17
NO995088D0 (no) 1999-10-18
KR20010006552A (ko) 2001-01-26
US6133259A (en) 2000-10-17
WO1998047969A1 (en) 1998-10-29
AU7136998A (en) 1998-11-13
NZ500714A (en) 2001-09-28

Similar Documents

Publication Publication Date Title
BR9809580A (pt) Derivados de alquil, alquenil e alquinil g crisamina para o diagnóstico antes da morte da doença de alzheimer e diagnóstico in vivo através de imagem e prevenção de deposição de amilóide
BR9812776A (pt) Composto para o dignóstico antemortem de doença de alzheimer e diagnóstico por imagens in vivo e prevenção de deposição amilóide
FR2377376A1 (fr) Derives d&#39;hexahydroterphenyle et leur application en tant que cristaux liquides
NZ307369A (en) Azocompounds for the antemortem diagnosis of alzheimer&#39;s disease and in vivo imaging and prevention of amyloid deposition
AR030816A1 (es) Derivados de glucopiranosiloxibencilbenceno y composiciones farmaceuticas que comprenden los mismos
HUP0302956A2 (hu) Tioflavinszármazékok az Alzheimer-kór antemortem diagnózisában történő alkalmazásra, eljárás a vegyületek előállítására és ezeket tartalmazó gyógyszerkészítmények
DE69937198D1 (de) Behandlung der alzheimer-krankheit durch erhöhung des cytidin-spiegels in vivo
PT907379E (pt) Agentes de contraste bioactivados para imagiologia de diagnostico
TNSN01035A1 (fr) Derives d&#39;ethers de pyrazole nouveaux, et compositions pharmaceutiques les contenant.
FR2406020A1 (fr) Composition de conditionnement d&#39;etoffes contenant un constituant parfumant
NO20032007D0 (no) Radiofarmasöytiske midler for diagnose av Alzheimer&#39;s sykdom
KR950700314A (ko) 루이스형 당쇄 유도체(Lewis-type sugar chain derivative)
SI1667947T1 (sl) Postopki 11C-radiooznačevanja fenotiazina in fenotiazinu podobnih spojin
BR0011728A (pt) Método de inibir a agregação de proteìna amilóide e imagem de depósitos de amilóide
Mattle et al. Isolated muscle hypertrophy as a sign of radicular or peripheral nerve injury.
DE69200311D1 (de) Acylaminophenolderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
FR2393798A1 (fr) Derives des tetrahydro-1,3,5-thiadiazine-4-one utilisables en tant que compositions insecticides et miticides
DK1107751T3 (da) Lægemiddel indeholdende platinkompleksforbindelser samt anvendelse deraf
FR2410640A1 (fr) Derives de phenoxyalcanolamines, leur preparation et leurs utilisations therapeutiques
Zimmerman et al. Hepatic toxicity of antimicrobial agents.
ES2071793T3 (es) Nuevos derivados de la pirrolidona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DE58906637D1 (de) Phlegmatisierte Chinondiazid-Verbindungen.
FR2648135B1 (fr) Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique
Pototskaya et al. The process of forming of intertissue cooperation in myocardium of rat during ontogenesis.
ES2053590T3 (es) 3-fenil-7h-tiazolo(3,2-b)(1,2,4)triazin-7-onas sustituidas, procedimiento para su preparacion, medicamentos que las contienen y su empleo, asi como algunos productos intermedios formados durante la preparacion de los compuestos mencionados.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES.