KR950700314A - 루이스형 당쇄 유도체(Lewis-type sugar chain derivative) - Google Patents

루이스형 당쇄 유도체(Lewis-type sugar chain derivative)

Info

Publication number
KR950700314A
KR950700314A KR1019940702604A KR19940702604A KR950700314A KR 950700314 A KR950700314 A KR 950700314A KR 1019940702604 A KR1019940702604 A KR 1019940702604A KR 19940702604 A KR19940702604 A KR 19940702604A KR 950700314 A KR950700314 A KR 950700314A
Authority
KR
South Korea
Prior art keywords
lewis
sugar chain
following formula
chain derivative
derivatives represented
Prior art date
Application number
KR1019940702604A
Other languages
English (en)
Inventor
아키라 하세가와
마코토 기소
요시아키 요시쿠니
Original Assignee
아키라 하세가와
아반 히데아키
니뽄 신야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아키라 하세가와, 아반 히데아키, 니뽄 신야쿠 가부시키가이샤 filed Critical 아키라 하세가와
Publication of KR950700314A publication Critical patent/KR950700314A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명의 목적은 의약으로서 유용하며, 또한 모라놀린을 함유하는 하기 일반식(Ⅰ)로 표시되는 신규한 SLe형 당쇄 유도체를 제공하기 위한 것이다.
상기 식에서, R1은 수소, 저급 알킬, 저급 알케닐 또는 저급 알키닐을 나타내며, R2및 R2는 각각 서로 다르며, 갈락토실, 시알릴갈락토실 또는 푸코실기를 나타내며, R4는 히드록시 또는 아세트아미노기를 나타낸다.
본 발명은 모라놀린을 함유하는 신규한 구조를 갖는 당쇄 유도체로 구성된다. 본 화합물은 세포 접착 저해 활성을 갖고 있어서, 셀렉틴을 길항적으로 저해시킴으로써 염증이나 염증을 수반하는 혈전 형성, 천식, 류마티즘의 치료, 면역질환 및 암의 예방, 치료등에 유용하다.

Description

루이스형 당쇄 유도체(Lewis-type sugar chain derivative)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(Ⅰ)로 표시되는 루이스형 당쇄 유도체 :
    상기 식에서, R1은 수소, 저급 알킬, 저급 알케닐 또는 저급 알키닐을 나타내며, R2및 R3는 각각 서로 다르며, 갈락토실, 시알릴갈락토실 또는 푸코실기를 나타내며, R4는 히드록시 또는 아세트아미노기를 나타낸다.
  2. 하기 식으로 표시되는 루이스 X 유도체 :
  3. 하기 식으로 표시되는 루이스 X 유도체 :
  4. 하기 식으로 표시되는 루이스 X 유도체 :
  5. 하기 식으로 표시되는 루이스 A 유도체 :
  6. 하기 식으로 표시되는 루이스 A 유도체 :
  7. 하기 식으로 표시되는 루이스 A 유도체 :
  8. 하기 식으로 표시되는 루이스 A 유도체 :
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940702604A 1992-01-31 1993-01-29 루이스형 당쇄 유도체(Lewis-type sugar chain derivative) KR950700314A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP92-46081 1992-01-31
JP4608192 1992-01-31
JP92-93431 1992-03-18
JP9343192 1992-03-18
JP92-273615 1992-09-16
JP27361592 1992-09-16
PCT/JP1993/000106 WO1993015098A1 (en) 1992-01-31 1993-01-29 Lewis-type sugar chain derivative

Publications (1)

Publication Number Publication Date
KR950700314A true KR950700314A (ko) 1995-01-16

Family

ID=27292504

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702604A KR950700314A (ko) 1992-01-31 1993-01-29 루이스형 당쇄 유도체(Lewis-type sugar chain derivative)

Country Status (5)

Country Link
US (1) US5498604A (ko)
EP (1) EP0627442A4 (ko)
KR (1) KR950700314A (ko)
CA (1) CA2129140A1 (ko)
WO (1) WO1993015098A1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750508A (en) * 1993-06-16 1998-05-12 Glycomed Incorporated Sialic acid/fucose based medicaments
US5679321A (en) * 1993-06-17 1997-10-21 Glycomed Incorporated Sialic acid/fucose based medicaments
WO1995006057A1 (fr) * 1993-08-23 1995-03-02 Nippon Shinyaku Co., Ltd. Derive de galactosylmoraniline
JPH07126278A (ja) * 1993-09-10 1995-05-16 Daikin Ind Ltd フッ素化ガングリオシドｇｍ３
WO1995013068A1 (fr) * 1993-11-12 1995-05-18 Nippon Shinyaku Co., Ltd. Composition medicamenteuse pour la circulation
DE4408248A1 (de) * 1994-03-11 1995-09-14 Hoechst Ag Physiologisch verträgliche und physiologisch abbaubare Kohlenhydrat-Mimetika, ein Verfahren zur Herstellung und ihre Verwendung
WO1995026969A1 (fr) * 1994-03-31 1995-10-12 Nippon Shinyaku Co., Ltd. Derive de moranoline
US5700918A (en) * 1994-04-01 1997-12-23 Nippon Shinyaku Co., Ltd. Moranoline derivative
JPH08109134A (ja) * 1994-10-11 1996-04-30 Sanwa Kagaku Kenkyusho Co Ltd 細胞変成抑制並びに臓器毒性軽減剤
WO1997000881A1 (en) * 1995-06-22 1997-01-09 Nippon Shinyaku Co., Ltd. Moranoline derivatives
BR9608873A (pt) * 1995-06-29 1999-07-06 Texas Biotechnology Corp Inibidores de selectina de moléculas pequenas di e trivalentes
WO1997002278A1 (fr) * 1995-06-30 1997-01-23 Nippon Shinyaku Co., Ltd. Derives formant une chaine saccharidique et procede pour les produire
CZ89098A3 (cs) * 1995-09-29 1998-09-16 Glycim Oy Syntetické polylaktosaminy obsahující až multivalentní sLEX a metody pro jejich použití
WO1998024453A1 (fr) * 1996-12-05 1998-06-11 Nippon Shinyaku Co., Ltd. Medicaments pour la myelopathie
WO1998036757A1 (en) * 1997-02-21 1998-08-27 Nippon Shinyaku Co., Ltd. Remedy for peptic ulcer
JPH10251152A (ja) * 1997-03-14 1998-09-22 Nippon Shinyaku Co Ltd 虚血再灌流障害治療剤
US6191271B1 (en) 1997-09-05 2001-02-20 Glycim Oy Synthetic divalent sLex containing polylactosamines and methods for use
US7292232B2 (en) * 2004-04-30 2007-11-06 Microsoft Corporation Data input devices and methods for detecting movement of a tracking surface by a laser speckle pattern
CN108299525B (zh) * 2018-01-05 2021-03-26 佛山科学技术学院 路易斯寡糖-x的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
JPS62174095A (ja) * 1985-10-12 1987-07-30 Nippon Shinyaku Co Ltd グルコシルモラノリン誘導体
JPS62242692A (ja) * 1986-04-15 1987-10-23 Nippon Shinyaku Co Ltd モラノリン誘導体の製造法

Also Published As

Publication number Publication date
CA2129140A1 (en) 1993-08-05
EP0627442A1 (en) 1994-12-07
WO1993015098A1 (en) 1993-08-05
EP0627442A4 (en) 1995-01-11
US5498604A (en) 1996-03-12

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