IL127782A - תהליך להכנת -17אסטרים של 9a, 21 - דיהלו - פרגנן - 11b, 17a דיאול - 20 אונים - Google Patents

תהליך להכנת -17אסטרים של 9a, 21 - דיהלו - פרגנן - 11b, 17a דיאול - 20 אונים

Info

Publication number
IL127782A
IL127782A IL12778297A IL12778297A IL127782A IL 127782 A IL127782 A IL 127782A IL 12778297 A IL12778297 A IL 12778297A IL 12778297 A IL12778297 A IL 12778297A IL 127782 A IL127782 A IL 127782A
Authority
IL
Israel
Prior art keywords
epoxy
methyl
dione
pregnadien
chloride
Prior art date
Application number
IL12778297A
Other languages
English (en)
Other versions
IL127782A0 (en
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of IL127782A0 publication Critical patent/IL127782A0/xx
Publication of IL127782A publication Critical patent/IL127782A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12778297A 1996-06-28 1997-06-25 תהליך להכנת -17אסטרים של 9a, 21 - דיהלו - פרגנן - 11b, 17a דיאול - 20 אונים IL127782A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67286196A 1996-06-28 1996-06-28
PCT/US1997/010121 WO1998000437A1 (en) 1996-06-28 1997-06-25 PROCESS FOR THE PREPARATION OF 17-ESTERS OF 9α,21-DIHALO-PREGNANE-11β,17αDIOL-20-ONES

Publications (2)

Publication Number Publication Date
IL127782A0 IL127782A0 (en) 1999-10-28
IL127782A true IL127782A (he) 2004-06-20

Family

ID=24700321

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12778297A IL127782A (he) 1996-06-28 1997-06-25 תהליך להכנת -17אסטרים של 9a, 21 - דיהלו - פרגנן - 11b, 17a דיאול - 20 אונים

Country Status (21)

Country Link
EP (1) EP0923599B1 (he)
JP (3) JP4269110B2 (he)
KR (1) KR100441187B1 (he)
CN (1) CN1158296C (he)
AR (1) AR007485A1 (he)
AT (1) ATE212035T1 (he)
AU (1) AU725606B2 (he)
BR (1) BR9710081A (he)
CA (1) CA2258681C (he)
CZ (1) CZ293944B6 (he)
DE (1) DE69709655T2 (he)
DK (1) DK0923599T3 (he)
ES (1) ES2166549T3 (he)
HK (1) HK1017899A1 (he)
IL (1) IL127782A (he)
NO (1) NO312367B1 (he)
NZ (1) NZ333410A (he)
PL (1) PL185637B1 (he)
PT (1) PT923599E (he)
SK (1) SK283666B6 (he)
WO (1) WO1998000437A1 (he)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT102343B (pt) * 1999-08-02 2003-11-28 Hovione Farmaciencia Sa Processo para a preparacao de furoato mometasona
PT102405A (pt) * 2000-01-20 2001-07-31 Hovione Farmaciencia Sa Processo para a preparacao de mometasona
CN100436473C (zh) * 2005-12-09 2008-11-26 天津药业集团有限公司 糠酸莫美他松中间体21-酯及制法
CN100389121C (zh) * 2005-12-09 2008-05-21 天津药业集团有限公司 糠酸莫美他松中间体21-羟的制备方法
CN105566437B (zh) * 2015-12-30 2018-07-20 山东京卫制药有限公司 一种8dm衍生物及利用其合成糠酸莫米松的方法
CN107266519B (zh) * 2016-04-08 2021-06-29 天津金耀集团有限公司 一种9β，11β-环氧-17α-羟基-16α-甲基-21-氯代-1，4孕甾二烯-3，20-二酮新晶型及其制备方法
CN107266518B (zh) * 2016-04-08 2021-03-30 天津金耀集团有限公司 一种糠酸莫米松晶型及其制备方法
CN106279340B (zh) * 2016-08-10 2018-07-20 山东京卫制药有限公司 一种合成糠酸莫米松或其一水合物的方法
CN107951893B (zh) * 2016-10-18 2022-04-26 天津金耀集团有限公司 一种糠酸莫米松粉吸入剂组合物
CN109206468B (zh) * 2017-06-30 2023-06-27 天津药业研究院股份有限公司 一种糠酸莫米松的制备方法
CN109206466B (zh) * 2017-06-30 2022-08-09 天津药业研究院股份有限公司 一种甾体21位羟基氯代或溴代方法
CN109517019B (zh) * 2017-09-18 2021-12-07 华东师范大学 一种3β-乙酰氧基雄甾-5-烯-17-酮加成反应副产物的再利用方法
CN112110972B (zh) * 2019-06-21 2022-03-18 河南利华制药有限公司 一种氯倍他索丙酸酯的制备方法
CN112110975A (zh) * 2019-06-21 2020-12-22 河南利华制药有限公司 一种一勺烩工艺合成糠酸莫米松的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2713587A (en) * 1952-03-08 1955-07-19 Searle & Co 11, 17-dihydroxy-4-pregnene-3, 20-dione
US2793207A (en) * 1954-11-01 1957-05-21 Searle & Co Steroidal thiazole derivatives
US3440252A (en) * 1965-06-23 1969-04-22 Glaxo Lab Ltd Preparation of 21-deoxy steroids
US3502700A (en) * 1967-01-19 1970-03-24 Squibb & Sons Inc 17-esters of 9alpha,21-dihalo-11beta,17alpha-dihydroxyprogesterones
CY1359A (en) * 1981-02-02 1987-08-07 Schering Corp Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NZ333410A (en) 2000-06-23
AU3483597A (en) 1998-01-21
WO1998000437A1 (en) 1998-01-08
DK0923599T3 (da) 2002-04-22
JP2009035552A (ja) 2009-02-19
CZ293944B6 (cs) 2004-08-18
PL185637B1 (pl) 2003-06-30
EP0923599A1 (en) 1999-06-23
AR007485A1 (es) 1999-10-27
NO986086L (no) 1999-02-16
DE69709655T2 (de) 2002-09-12
KR20000022547A (ko) 2000-04-25
NO312367B1 (no) 2002-04-29
JP2012149076A (ja) 2012-08-09
SK283666B6 (sk) 2003-11-04
CA2258681C (en) 2006-11-14
JP4269110B2 (ja) 2009-05-27
PL330843A1 (en) 1999-06-07
DE69709655D1 (de) 2002-02-21
PT923599E (pt) 2002-06-28
KR100441187B1 (ko) 2004-11-03
HK1017899A1 (en) 1999-12-03
BR9710081A (pt) 1999-08-10
ES2166549T3 (es) 2002-04-16
CA2258681A1 (en) 1998-01-08
NO986086D0 (no) 1998-12-23
JP2000514058A (ja) 2000-10-24
CZ417798A3 (cs) 1999-05-12
IL127782A0 (en) 1999-10-28
CN1158296C (zh) 2004-07-21
EP0923599B1 (en) 2002-01-16
JP5061061B2 (ja) 2012-10-31
AU725606B2 (en) 2000-10-12
CN1228782A (zh) 1999-09-15
SK177898A3 (en) 2000-04-10
ATE212035T1 (de) 2002-02-15

Similar Documents

Publication Publication Date Title
JP5061061B2 (ja) ９α，２１−ジハロ−プレグナン−１１β，１７α−ジオール−２０−オンの１７−エステルの調製のためのプロセス
US5886200A (en) Process for the preparation of 17-esters of 9 α, 21-dihalo-pregnane-11 β, 17 α-diol-20-ones
EP0336521B1 (en) 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
US20070129332A1 (en) Processes to prepare eplerenone
US7417140B2 (en) 7α-Hydroxyacetyl and 7α-Hydroperoxyacetyl-substituted steroid compounds
EP2596007B1 (en) Process for the preparation of 17-desoxy-corticosteroids
JPH0710877B2 (ja) プレグナン誘導体の製造方法
JPH036158B2 (he)
KR800000555B1 (ko) 스테로이드의 레티온산 에스테르의 제조방법
RU2339642C2 (ru) Способы получения эплеренона
EP0053845A1 (en) 17-Beta-ethynylsteroids and process for preparing same
JPS6118559B2 (he)

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees