IL124537A - History of benzimidazole converted to naphthalene and pharmaceutical preparations containing them - Google Patents

History of benzimidazole converted to naphthalene and pharmaceutical preparations containing them

Info

Publication number
IL124537A
IL124537A IL12453796A IL12453796A IL124537A IL 124537 A IL124537 A IL 124537A IL 12453796 A IL12453796 A IL 12453796A IL 12453796 A IL12453796 A IL 12453796A IL 124537 A IL124537 A IL 124537A
Authority
IL
Israel
Prior art keywords
optionally substituted
methyl
halo
alkyl
hydroxy
Prior art date
Application number
IL12453796A
Other languages
English (en)
Hebrew (he)
Other versions
IL124537A0 (en
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Publication of IL124537A0 publication Critical patent/IL124537A0/xx
Publication of IL124537A publication Critical patent/IL124537A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
IL12453796A 1995-12-08 1996-12-05 History of benzimidazole converted to naphthalene and pharmaceutical preparations containing them IL124537A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/570,057 US5849759A (en) 1995-12-08 1995-12-08 Naphthyl-substituted benzimidazole derivatives as anti-coagulants
PCT/IB1996/001496 WO1997021437A1 (en) 1995-12-08 1996-12-05 Naphthyl-substituted benzimidazole derivatives as anticoagulants

Publications (2)

Publication Number Publication Date
IL124537A0 IL124537A0 (en) 1998-12-06
IL124537A true IL124537A (en) 2002-04-21

Family

ID=24278023

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12453796A IL124537A (en) 1995-12-08 1996-12-05 History of benzimidazole converted to naphthalene and pharmaceutical preparations containing them

Country Status (23)

Country Link
US (1) US5849759A (ru)
EP (1) EP0865281B1 (ru)
JP (1) JP2000502082A (ru)
KR (1) KR19990071974A (ru)
CN (1) CN1110305C (ru)
AT (1) ATE215371T1 (ru)
CZ (1) CZ177698A3 (ru)
DE (1) DE69620443T2 (ru)
DK (1) DK0865281T3 (ru)
ES (1) ES2175179T3 (ru)
HK (1) HK1018208A1 (ru)
HU (1) HUP9904066A3 (ru)
IL (1) IL124537A (ru)
MX (1) MX9804597A (ru)
NO (1) NO312673B1 (ru)
NZ (1) NZ325449A (ru)
PL (1) PL327169A1 (ru)
PT (1) PT865281E (ru)
RU (1) RU98112597A (ru)
SK (1) SK282767B6 (ru)
UA (1) UA49869C2 (ru)
WO (1) WO1997021437A1 (ru)
ZA (1) ZA9610315B (ru)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69630214T2 (de) 1995-03-10 2004-07-15 Berlex Laboratories, Inc., Richmond Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
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US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
ES2241151T3 (es) * 1997-06-26 2005-10-16 Eli Lilly And Company Agentes antitromboticos.
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
DE19753522A1 (de) * 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
WO1999032477A1 (en) 1997-12-19 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
PL195682B1 (pl) * 1997-12-24 2007-10-31 Sanofi Aventis Deutschland Pochodne indolu, sposób ich wytwarzania, środek farmaceutyczny oraz zastosowanie pochodnych indolu
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Also Published As

Publication number Publication date
PT865281E (pt) 2002-09-30
ATE215371T1 (de) 2002-04-15
HK1018208A1 (en) 1999-12-17
US5849759A (en) 1998-12-15
NO982606L (no) 1998-08-10
EP0865281A4 (en) 1999-07-28
AU700894B2 (en) 1999-01-14
HUP9904066A2 (hu) 2000-03-28
NZ325449A (en) 2000-01-28
DK0865281T3 (da) 2002-07-29
PL327169A1 (en) 1998-11-23
CN1110305C (zh) 2003-06-04
ZA9610315B (en) 1997-06-17
DE69620443T2 (de) 2002-11-28
HUP9904066A3 (en) 2001-11-28
CZ177698A3 (cs) 1998-09-16
NO312673B1 (no) 2002-06-17
IL124537A0 (en) 1998-12-06
JP2000502082A (ja) 2000-02-22
SK282767B6 (sk) 2002-12-03
MX9804597A (es) 1998-10-31
EP0865281B1 (en) 2002-04-03
CN1209062A (zh) 1999-02-24
AU1395697A (en) 1997-07-03
RU98112597A (ru) 2000-10-20
UA49869C2 (ru) 2002-10-15
ES2175179T3 (es) 2002-11-16
NO982606D0 (no) 1998-06-05
SK74698A3 (en) 1998-12-02
EP0865281A1 (en) 1998-09-23
WO1997021437A1 (en) 1997-06-19
KR19990071974A (ko) 1999-09-27
DE69620443D1 (de) 2002-05-08

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