IL123298A0 - Quiescent cell populations for nuclear transfer - Google Patents

Quiescent cell populations for nuclear transfer

Info

Publication number
IL123298A0
IL123298A0 IL12329896A IL12329896A IL123298A0 IL 123298 A0 IL123298 A0 IL 123298A0 IL 12329896 A IL12329896 A IL 12329896A IL 12329896 A IL12329896 A IL 12329896A IL 123298 A0 IL123298 A0 IL 123298A0
Authority
IL
Israel
Prior art keywords
nuclear transfer
cell populations
quiescent cell
quiescent
cell
Prior art date
Application number
IL12329896A
Other languages
English (en)
Original Assignee
Roslin Inst Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roslin Inst Edinburgh filed Critical Roslin Inst Edinburgh
Publication of IL123298A0 publication Critical patent/IL123298A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8773—Ovine embryos

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
IL12329896A 1995-08-31 1996-08-30 Quiescent cell populations for nuclear transfer IL123298A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9517780.4A GB9517780D0 (en) 1995-08-31 1995-08-31 Biological manipulation
PCT/GB1996/002099 WO1997007669A1 (en) 1995-08-31 1996-08-30 Quiescent cell populations for nuclear transfer

Publications (1)

Publication Number Publication Date
IL123298A0 true IL123298A0 (en) 1998-09-24

Family

ID=10779998

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12329896A IL123298A0 (en) 1995-08-31 1996-08-30 Quiescent cell populations for nuclear transfer

Country Status (24)

Country Link
US (5) US6147276A (ko)
EP (3) EP0849990B1 (ko)
JP (2) JP4081613B2 (ko)
KR (4) KR100793220B1 (ko)
CN (3) CN1769431A (ko)
AT (1) ATE199115T1 (ko)
AU (1) AU716956C (ko)
BR (1) BR9610034B1 (ko)
CA (1) CA2229568C (ko)
CZ (1) CZ60898A3 (ko)
DE (1) DE69611793T2 (ko)
DK (1) DK0849990T3 (ko)
ES (1) ES2155197T3 (ko)
GB (2) GB9517780D0 (ko)
HK (2) HK1004938A1 (ko)
HU (1) HUP9900234A3 (ko)
IL (1) IL123298A0 (ko)
NO (1) NO980845L (ko)
NZ (3) NZ316149A (ko)
PL (1) PL325331A1 (ko)
SG (1) SG75155A1 (ko)
SI (1) SI0849990T1 (ko)
WO (1) WO1997007669A1 (ko)
ZA (1) ZA967390B (ko)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480772A (en) 1993-02-03 1996-01-02 Brandeis University In vitro activation of a nucleus
US7304204B2 (en) 1995-08-31 2007-12-04 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US6077697A (en) 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US7696404B2 (en) 1996-08-19 2010-04-13 Advanced Cell Technology, Inc. Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
US6271436B1 (en) 1996-10-11 2001-08-07 The Texas A & M University System Cells and methods for the generation of transgenic pigs
AU8154398A (en) * 1997-01-10 1999-01-25 University Of Massachusetts Cloning using donor nuclei from non-serum starved, differentiated cells
US6215041B1 (en) * 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
GB9703550D0 (en) * 1997-02-20 1997-04-09 Ppl Therapeutics Scotland Ltd Cell mediated transgenesis
US6011197A (en) 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
EP0981604B1 (en) * 1997-04-24 2009-01-07 University of Washington Targeted gene modification by parvoviral vectors
EP0989995A2 (en) 1997-06-19 2000-04-05 The General Hospital Corporation Torsin, torsin genes, and methods of use
US6921814B2 (en) 1997-06-19 2005-07-26 The General Hospital Corporation Torsin, torsin-related genes and methods of detecting neuronal disease
WO1999005266A2 (en) * 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
CA2300972A1 (en) * 1997-08-22 1999-03-04 Biotechnology And Biological Sciences Research Council Use of mariner transposan in the production of transgenic animals
CA2302480A1 (en) * 1997-09-02 1999-03-11 Cancer Research Campaign Technology Limited A cell-free replication system and uses thereof
WO1999021415A1 (en) * 1997-10-28 1999-05-06 Stem Cell Sciences Pty. Ltd. Nuclear transfer for production of transgenic animal embryo
AU739902B2 (en) * 1998-01-16 2001-10-25 Agrobiogen Gmbh Efficient nuclear transfer using fetal fibroblasts
US6331659B1 (en) 1998-01-21 2001-12-18 University Of Hawaii Cumulus cells as nuclear donors
WO1999046982A1 (en) * 1998-03-16 1999-09-23 Relag Pty Ltd Porcine nuclear transfer
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
GB9809178D0 (en) * 1998-04-29 1998-07-01 Univ Edinburgh Nuclear reprogramming of somatic cells
WO2000022098A1 (en) 1998-10-12 2000-04-20 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
EP1375654A3 (en) * 1998-11-02 2008-01-16 GTC Biotherapeutics, Inc. Transgenic and cloned mammals
AU2003204830B2 (en) * 1998-11-02 2007-08-30 Gtc Biotherapeutics, Inc. Transgenic and cloned mammals
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
US6580017B1 (en) 1998-11-02 2003-06-17 Genzyme Transgenics Corporation Methods of reconstructed goat embryo transfer
CA2350233A1 (en) * 1998-11-02 2000-05-11 Genzyme Transgenics Corp. Transgenic and cloned mammals
WO2000030436A1 (en) 1998-11-19 2000-06-02 Ppl Therapeutics (Scotland) Ltd. Stabilisation of milk from transgenic animals
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US6258998B1 (en) 1998-11-24 2001-07-10 Infigen, Inc. Method of cloning porcine animals
JP2002534118A (ja) * 1999-01-13 2002-10-15 ピーピーエル セラピューティクス （スコットランド） リミテッド 二重核移植法及びその結果物
GB9903804D0 (en) * 1999-02-20 1999-04-14 Univ Sheffield Pluripotential cells-2
GB9903805D0 (en) * 1999-02-20 1999-04-14 Univ Sheffield Pluripotential cells-1
WO2000050443A2 (en) 1999-02-26 2000-08-31 Millennium Pharmaceutcals, Inc. Secreted proteins and uses thereof
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
EP2199392A3 (en) * 1999-03-04 2010-12-15 Revivicor, Inc. Genetic modification of somatic cells and uses thereof
CA2370385A1 (en) * 1999-04-28 2000-11-02 Universite De Montreal Telophase enucleated oocytes for nuclear transfer
EP1191840B1 (en) * 1999-06-04 2007-01-17 Istituto Zootecnico E Caseario per La Sardegna Process for reconstructing a non-human animal embryo by nuclear transfer and preparing the animal therefrom.
AU5553600A (en) 1999-06-23 2001-01-31 Ppl Therapeutics (Scotland) Ltd Fusion proteins incorporating lysozyme
CN1304444A (zh) * 1999-06-30 2001-07-18 黄禹锡 一种通过用种间核转移技术生产人类克隆胚胎的方法
AU782286B2 (en) * 1999-06-30 2005-07-14 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
CA2334382A1 (en) 1999-06-30 2001-01-04 Woo-Suk Hwang Method for producing cloned cows
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
JP2003503045A (ja) * 1999-06-30 2003-01-28 ワン，ウー−サク 異種間核移植技術を用いたクローントラの生産方法
AU7072700A (en) 1999-08-23 2001-03-19 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
EP2275559A3 (en) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimized messenger RNA
CN1402781A (zh) * 1999-09-30 2003-03-12 根茨美转基因公司 克隆和转基因哺乳动物的生产方法
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US6635802B1 (en) * 2000-01-10 2003-10-21 The Texas A&M University System Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
GB0001401D0 (en) * 2000-01-22 2000-03-08 Univ Edinburgh Methods for amplifying genetic material and use thereof
US6906238B2 (en) 2000-03-15 2005-06-14 University Of Georgia Research Foundation, Inc. Effective nuclear reprogramming in mammals using CDK2 inhibitors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
GB2360522A (en) 2000-03-24 2001-09-26 Geron Corp A strategy for maintaining pregnancy
WO2001088096A2 (en) * 2000-05-15 2001-11-22 Geron Corporation Ovine tissue for xenotransplantation
JP2004510411A (ja) 2000-06-05 2004-04-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｉ型糖尿病の同定およびモジュレーションのための組成物、キット、および方法
CA2413857C (en) 2000-06-28 2010-04-27 Genetics Institute, Llc. Pd-l2 molecules: pd-1 ligands and uses therefor
WO2002009510A2 (en) * 2000-08-01 2002-02-07 Xy Genetics, Llc Methods of selecting and cloning animals
MXPA03001915A (es) 2000-08-03 2004-09-10 Therapeutic Human Polyclonals Produccion de anticuerpos humanizados en animales transgenicos.
US6677500B2 (en) 2000-08-15 2004-01-13 Board Of Trustees Of The University Of Illinois Ungulates expressing exogenous IGF-I in their milk
AU2001291558A1 (en) * 2000-09-06 2002-03-22 Nexia Biotechnologies, Inc. Generation of transgenic animals using nuclear transfer and oocytes at the germinal vesicle stage
US20040029825A1 (en) * 2001-10-03 2004-02-12 Davies Christopher J Methods of minimizing immunological rejection of a nuclear transfer fetus
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
EP2295606A1 (en) 2000-11-28 2011-03-16 Wyeth LLC Expression analysis of KIAA nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
JP2004526425A (ja) 2000-11-28 2004-09-02 ワイス 前立腺癌の診断および治療に有用なｆｋｂｐ核酸およびポリペプチドの発現分析
ATE466089T1 (de) 2000-12-22 2010-05-15 Agronomique Inst Nat Rech Positionsunabhängige und gewebespezifische expression eines transgens in der milch eines transgen-tieres
US7491534B2 (en) 2000-12-22 2009-02-17 Kirin Holdings Kabushiki Kaisha Methods for altering cell fate to generate T-cells specific for an antigen of interest
US20020142397A1 (en) 2000-12-22 2002-10-03 Philippe Collas Methods for altering cell fate
WO2002051997A1 (en) * 2000-12-22 2002-07-04 Aurox Llc Methods for cloning mammals using reprogrammed donor chromatin or donor cells
EP1860199B1 (en) 2001-01-12 2014-03-05 Exelixis, Inc. Modulating insulin receptor signaling
US20050177883A1 (en) 2001-01-30 2005-08-11 Rebholtz Paul C. Systems of transferring embryos and managing recipients
AU2002250020A1 (en) * 2001-02-02 2002-08-19 Erik Forsberg Method of cloning transgenic mammalian animals using pseudonuclei
DK1572862T3 (da) * 2001-02-20 2012-11-26 Intrexon Corp Kimære, retinoide x-receptorer og deres anvendelse i et hidtil ukendt ecdysonrecepttorbaseret inducerbart genekspressionssystem
EP1434988A4 (en) 2001-02-23 2005-12-14 Elan Pharm Inc TRANSGENIC ANIMALS KNOCKOUT WITH GENE BACE-1 INACTIVE
JP2002262716A (ja) * 2001-03-07 2002-09-17 National Agricultural Research Organization 株化細胞を用いて家畜個体を作出する方法
AU2002258477A1 (en) * 2001-03-08 2002-09-24 Advanced Cell Technology, Inc. Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture
AUPR363701A0 (en) 2001-03-09 2001-04-05 Garelag Pty Ltd Method for the production of nuclear transfer embryos
US8981061B2 (en) 2001-03-20 2015-03-17 Novo Nordisk A/S Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
US7126039B2 (en) * 2001-03-21 2006-10-24 Geron Corporation Animal tissue with carbohydrate antigens compatible for human transplantation
AU2002242854A1 (en) * 2001-03-21 2002-10-03 Geron Corporation Use of telomerase reverse transcriptase to create homozygous knockout animals
CA2442066C (en) 2001-04-02 2005-11-01 Wyeth Pd-1, a receptor for b7-4, and uses therefor
US20030027330A1 (en) * 2001-04-02 2003-02-06 Robert Lanza Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
KR100886095B1 (ko) 2001-04-16 2009-02-27 와이어쓰 홀딩스 코포레이션 폴리펩티드 항원을 암호화하는 신규한 스트렙토코쿠스 뉴모니애 개방형 판독 프레임 및 이를 포함하는 조성물
WO2002092791A1 (en) * 2001-05-14 2002-11-21 Stell Tissues or organs for use in xenotransplantation
US20030153044A1 (en) * 2001-05-14 2003-08-14 Monika Liljedahl Tissues or organs for use in xenotransplantation
WO2003005810A2 (en) * 2001-07-09 2003-01-23 Alexion Pharmaceuticals Inc. Cloned non-human mammals from contact inhibited donor cells
US7691995B2 (en) 2001-07-12 2010-04-06 University Of Massachusetts In vivo production of small interfering RNAS that mediate gene silencing
EP1900815B1 (en) 2001-07-12 2016-09-07 University of Massachusetts In vivo production of small interfering RNAs that mediate gene silencing
US20030051264A1 (en) * 2001-07-31 2003-03-13 Monika Liljedahl Genetically modified cows having reduced susceptibility to mad cow disease
US20030211603A1 (en) * 2001-08-14 2003-11-13 Earp David J. Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells
JP2005514921A (ja) 2001-11-09 2005-05-26 ダナ−ファーバー キャンサー インスティチュート インク ＰＧＣ−１β、新規ＰＧＣ−１相同体およびその用途
US20050170506A1 (en) * 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030134422A1 (en) * 2002-01-16 2003-07-17 Sayre Chauncey Bigelow Stem cell maturation for all tissue lines
US20050090004A1 (en) * 2003-01-16 2005-04-28 Sayre Chauncey B. Stem cell maturation for all tissue lines
JP4968498B2 (ja) * 2002-01-23 2012-07-04 ユニバーシティ オブ ユタ リサーチ ファウンデーション ジンクフィンガーヌクレアーゼを用いる、標的化された染色体変異誘発
KR100502695B1 (ko) * 2002-02-28 2005-07-25 한국생명공학연구원 형질전환 효율이 향상된 복제수정란의 대량 생산 방법
US20030232410A1 (en) * 2002-03-21 2003-12-18 Monika Liljedahl Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
GB0207299D0 (en) * 2002-03-28 2002-05-08 Franks Christopher R Stem cell therapy
US20030204860A1 (en) * 2002-04-01 2003-10-30 David Melican Method for selecting cell lines to be used for nuclear transfer in mammalian species
US20030207448A1 (en) * 2002-05-06 2003-11-06 Revera Gregory Henry Methodologies for the creation of pluripotent or multipotent human stem cells without creating or destroying a human embryo
GB0211904D0 (en) * 2002-05-23 2002-07-03 Medical Res Council Nuclear transfer
US7410797B2 (en) * 2002-06-11 2008-08-12 Ogle Roy C Meningeal-derived stem cells
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
EP1565581B1 (en) 2002-08-20 2011-08-10 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
JP2006502748A (ja) 2002-09-05 2006-01-26 カリフォルニア インスティテュート オブ テクノロジー 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法
CA2501752A1 (en) 2002-10-10 2004-04-22 Wyeth Compositions, organisms and methodologies employing a novel human kinase
US20040077077A1 (en) * 2002-10-18 2004-04-22 Xiangzhong Yang Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same
US7208306B2 (en) 2002-10-24 2007-04-24 Wyeth Compositions employing a novel human protein phosphatase
AU2003290689A1 (en) 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
US7611839B2 (en) 2002-11-21 2009-11-03 Wyeth Methods for diagnosing RCC and other solid tumors
US7297525B2 (en) 2002-11-27 2007-11-20 Wyeth Composition employing a novel human kinase
US20040148648A1 (en) * 2002-12-10 2004-07-29 Esmail Behboodi Method and system for utilizing somatic cell nuclear transfer embryos as cell donors for additional nuclear transfer
EP2474631B1 (en) 2002-12-20 2014-02-12 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
DE602004015064D1 (de) 2003-01-06 2008-08-28 Wyeth Corp Zusammensetzungen und verfahren zur diagnose und behandlung von kolonkrebs
FR2855183B1 (fr) 2003-05-23 2005-08-12 Agronomique Inst Nat Rech Procede de clonage du rat par transfert nucleaire
AU2004248136B2 (en) 2003-06-02 2011-09-15 University Of Massachusetts Methods and compositions for controlling efficacy of RNA silencing
US8309704B2 (en) 2003-06-02 2012-11-13 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNAi
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) * 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US20080050313A1 (en) 2003-08-14 2008-02-28 Exelixis, Inc. Sulfs as Modifiers of the Beta-Catenin Pathway and Methods of Use
CA2761987A1 (en) 2003-10-07 2005-04-21 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
US7951532B2 (en) 2003-11-12 2011-05-31 Children's Hospital Medical Center Method of screening a midkine modulating agent
EP2386659B1 (en) 2003-11-26 2014-01-15 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7420099B2 (en) * 2004-04-22 2008-09-02 Kirin Holdings Kabushiki Kaisha Transgenic animals and uses thereof
EP2423327B1 (en) 2004-05-07 2014-01-08 Celera Corporation Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
JP2006081542A (ja) * 2004-08-18 2006-03-30 Institute Of Physical & Chemical Research クローン哺乳動物の作成方法
JP2008517931A (ja) 2004-10-22 2008-05-29 ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 脂質関連疾患および障害を処置するための、ＰＧＣ−１βを調節するための方法および組成物
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
CN1274829C (zh) 2004-12-10 2006-09-13 四川大学华西医院 抗eb病毒所致肿瘤多肽及其应用与制备方法
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20060286666A1 (en) * 2005-06-17 2006-12-21 Kang Ji Y Methods and apparatuses for culturing stem cell using biomaterial shell
WO2007052096A2 (en) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production of bone morphogenic proteins (bmps) in transgenic mammals
KR100733012B1 (ko) 2005-07-26 2007-06-28 재단법인서울대학교산학협력재단 복제된 개과 동물 및 이의 생산 방법
NZ565711A (en) 2005-08-09 2011-10-28 Revivicor Inc Transgenic ungulates expressing a porcine CTLA4 peptide fused to an immunoglobulin
JP2009507835A (ja) 2005-09-09 2009-02-26 ジョンズ ホプキンス ユニバーシティ 抗体、アゴニストおよびアンタゴニストを用いてニューリチン遺伝子をターゲティングすることによる調節性ｔ細胞およびｄｃの機能の操作
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
WO2007124019A2 (en) 2006-04-21 2007-11-01 Gtc Biotherapeutics, Inc. Methods and products related to the transfer of molecules from blood to the mammary gland
SG174053A1 (en) 2006-09-01 2011-09-29 Therapeutic Human Polyclonals Inc Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
EP2636754B1 (en) 2006-09-11 2015-03-04 Celera Corporation Genetic polymorphisms associated with psoriasis, methods of detection and uses thereof
WO2008051511A2 (en) 2006-10-20 2008-05-02 Applera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
KR101398220B1 (ko) * 2006-10-30 2014-05-22 건국대학교 산학협력단 형질전환 배아 생성방법
WO2008085891A1 (en) * 2007-01-05 2008-07-17 Worcester Polytechnic Institute Oocyte spindle-associated factors improve somatic cell cloning
KR100829426B1 (ko) 2007-01-17 2008-05-15 재단법인서울대학교산학협력재단 복제개의 생산 방법
US20080222745A1 (en) * 2007-03-07 2008-09-11 Utah State University Colcemid-Treatment of Oocytes to enhance Nuclear Transfer Cloning
KR100868245B1 (ko) 2007-05-29 2008-11-11 강원대학교산학협력단 데메콜친 처리에 의한 효율적인 복제 동물의 생산방법
WO2009055656A2 (en) 2007-10-26 2009-04-30 Centocor, Inc. Vectors, host cells, and methods of production and uses
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
KR101105248B1 (ko) 2008-01-04 2012-01-17 재단법인서울대학교산학협력재단 형질전환된 복제개의 생산방법
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
WO2009114185A2 (en) 2008-03-12 2009-09-17 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
US8288094B2 (en) 2008-04-09 2012-10-16 Institut Pasteur APOBEC3 mediated DNA editing
US8557773B2 (en) 2008-05-02 2013-10-15 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Treatment of bleeding with low half-life fibrinogen
CN102144027B (zh) * 2008-07-07 2016-04-06 宝生物工程株式会社 生产多能干细胞的方法
US8216786B2 (en) 2008-07-09 2012-07-10 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
US9181315B2 (en) 2009-01-08 2015-11-10 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
US8722964B2 (en) 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
EP2267153A1 (en) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers
US9314005B2 (en) 2009-07-01 2016-04-19 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (SCID)
EP2456876A2 (en) 2009-07-24 2012-05-30 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for cytokine-cytokine signaling pathways
US20110145936A1 (en) 2009-07-30 2011-06-16 Ostertag Eric M Genetically Modified Rat Models for Pharmacokinetics
US20110035816A1 (en) 2009-08-05 2011-02-10 Ostertag Eric M Genetically Modified Rat Models for Drug Metabolism
WO2011022634A2 (en) 2009-08-20 2011-02-24 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pain
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
US10429384B2 (en) 2010-01-22 2019-10-01 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US9631018B2 (en) 2010-03-26 2017-04-25 The Trustees Of Dartmouth College Vista regulatory T cell mediator protein, vista binding agents and use thereof
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
ES2738476T3 (es) 2010-08-11 2020-01-23 Inst Nat Sante Rech Med Cocultivos de células del cúmulo y embriones durante procedimientos de fertilización in vitro
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US8748178B2 (en) 2010-11-23 2014-06-10 The New York Stem Cell Foundation Method for producing pluripotent stem cells
NZ759163A (en) 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
WO2012129198A1 (en) 2011-03-23 2012-09-27 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for obesity and diabetes
HUE039793T2 (hu) 2011-05-16 2019-02-28 Univ Missouri Sertés reproduktív és légzési szindróma vírus rezisztens állatok
CA2848368C (en) 2011-09-13 2023-02-14 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using fndc5
CN102391989A (zh) * 2011-10-12 2012-03-28 扬州大学 转基因动物重组产物精确分析检验方法
PL2814844T3 (pl) 2012-02-15 2017-12-29 Novo Nordisk A/S Przeciwciała wiążące i blokujące receptor aktywujący wykazujący ekspresję na komórkach szpikowych -1 (trem-1)
US9550830B2 (en) 2012-02-15 2017-01-24 Novo Nordisk A/S Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
WO2013120554A1 (en) 2012-02-15 2013-08-22 Novo Nordisk A/S Antibodies that bind peptidoglycan recognition protein 1
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
FI3421486T3 (fi) 2012-06-22 2023-12-15 Dartmouth College Uusia vista-ig-rakenteita ja vista-ig:n käyttö autoimmuuni-, allergia- ja tulehdushäiriöiden hoitamiseksi
CN109793893B (zh) 2012-09-07 2023-05-26 达特茅斯大学理事会 用于诊断和治疗癌症的vista调节剂
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
JP2016508515A (ja) 2013-02-13 2016-03-22 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 高ガラクトシル化抗ＴＮＦ−α抗体およびその使用
EP2956003A2 (en) 2013-02-13 2015-12-23 Laboratoire Français du Fractionnement et des Biotechnologies Proteins with modified glycosylation and methods of production thereof
WO2014178485A1 (ko) 2013-04-30 2014-11-06 건국대학교 산학협력단 Ｃｍｐ-아세틸뉴라미닌산 히드록실라아제 타겟팅 벡터, 그 벡터가 도입된 이종간 이식용 형질전환 동물 및 그 제조방법
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
MX369173B (es) 2013-12-24 2019-10-30 Janssen Pharmaceutica Nv Anticuerpos y fragmentos anti-vista.
CA2935804A1 (en) 2014-01-14 2015-07-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
WO2015191881A2 (en) 2014-06-11 2015-12-17 Green Kathy A Use of vista agonists and antagonists to suppress or enhance humoral immunity
PL3172232T3 (pl) 2014-07-17 2024-06-24 Novo Nordisk A/S Ukierunkowana miejscowo mutageneza przeciwciał trem-1 dla zmniejszania lepkości
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
JP2018505911A (ja) 2014-12-05 2018-03-01 イミュネクスト，インコーポレーテッド 推定上のｖｉｓｔａ受容体としてのｖｓｉｇ８の同定と、ｖｉｓｔａ／ｖｓｉｇ８調節剤を産生するためのその使用
KR102316842B1 (ko) 2014-12-09 2021-10-25 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 274 유전자를 갖는 비인간 동물
CN104823921A (zh) * 2015-05-21 2015-08-12 蒙汉勤 一种用于人体烧伤皮肤移植及医学实验的小型香猪的饲养技术
US11009509B2 (en) 2015-06-24 2021-05-18 Janssen Pharmaceutica Nv Anti-VISTA antibodies and fragments
DK3331355T3 (en) 2015-08-06 2024-07-08 Univ Missouri Porcine reproductive and respiratory syndrome virus (prrsv)-resistant porcine and cells having modified cd163 genes
CA3002676A1 (en) 2015-10-29 2017-05-04 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
MX2018009800A (es) 2016-02-12 2018-11-09 Janssen Pharmaceutica Nv Anticuerpos y fragmentos anti-vista, usos de los mismos y procedimientos de identificacion de los mismos.
MA44776A (fr) 2016-04-15 2019-03-06 Immunext Inc Anticorps anti-vista humain et leur utilisation
CA3092387A1 (en) 2018-04-02 2019-10-10 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
KR20200141470A (ko) 2018-04-06 2020-12-18 칠드런'즈 메디컬 센터 코포레이션 체세포 재프로그래밍 및 각인의 조정을 위한 조성물 및 방법
US11160260B2 (en) 2018-04-17 2021-11-02 The Curators Of The University Of Missouri Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
WO2020041360A1 (en) 2018-08-21 2020-02-27 Quidel Corporation Dbpa antibodies and uses thereof
CA3161024A1 (en) 2019-12-19 2021-06-24 Quidel Corporation Monoclonal antibody fusions
AU2021385081A1 (en) 2020-11-20 2023-06-29 Revivicor, Inc. Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation
JP2024534702A (ja) 2021-09-20 2024-09-20 レバイビコア，インコーポレイティド 異種移植のための１０個の遺伝子改変を含むマルチトランスジェニックブタ

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890003947B1 (ko) * 1985-12-11 1989-10-13 가부시기가이샤 시마즈세이사구쇼 세포융합장치
US5057420A (en) * 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
GB8714426D0 (en) * 1987-06-19 1987-07-22 Agricultural & Food Res Culture technique
CA2059199A1 (en) * 1992-01-10 1993-07-11 Steen Willadsen Method for producing mature reconstituted mammalian eggs by nuclear transplantation
GB2265909B (en) * 1992-04-01 1996-03-20 Inst Of Animal Physiology And Fusion of donor nucleus with recipient cytoplast in the absence of calcium ion
EP0661969B1 (en) * 1992-09-22 2003-03-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Taxol for treating lymphomas and breast cancer and for reducing multi-drug resistance to taxol
CA2092258A1 (en) * 1992-12-30 1994-07-01 Steven L. Stice Synchronized donor cells for bovine nuclear transfer
US5496720A (en) * 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
PT1118325E (pt) * 1993-07-29 2006-05-31 Us Health Utilizacao de paclitaxel e seus derivados na preparacao de um medicamento para o tratamento de restenose
AU1439295A (en) * 1993-12-17 1995-07-03 Abs Global, Inc. Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates
WO1995017500A1 (en) * 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
GB9417831D0 (en) * 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US7304204B2 (en) * 1995-08-31 2007-12-04 Roslin Institute Ungulates produced by nuclear transfer of G1 cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US6215041B1 (en) * 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US6235969B1 (en) * 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6011197A (en) * 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
WO1999005266A2 (en) * 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
US6225243B1 (en) * 1998-08-03 2001-05-01 Bba Nonwovens Simpsonville, Inc. Elastic nonwoven fabric prepared from bi-component filaments
WO2000022098A1 (en) * 1998-10-12 2000-04-20 Geron Bio-Med Limited Porcine oocytes with improved developmental competence
US20050156424A1 (en) * 2000-02-29 2005-07-21 Thyssenkrupp Presta Ag Steering column and manufacturing method thereof

Also Published As

Publication number Publication date
GB9517780D0 (en) 1995-11-01
KR20070047848A (ko) 2007-05-07
KR20060053008A (ko) 2006-05-19
US7514258B2 (en) 2009-04-07
CA2229568A1 (en) 1997-03-06
GB9802915D0 (en) 1998-04-08
DK0849990T3 (da) 2001-04-17
HUP9900234A3 (en) 2000-03-28
CN1202084A (zh) 1998-12-16
HK1004938A1 (en) 1998-12-18
HUP9900234A2 (hu) 1999-05-28
ES2155197T3 (es) 2001-05-01
NZ334288A (en) 2000-06-23
EP0849990A1 (en) 1998-07-01
EP1005789A3 (en) 2005-03-02
HK1090089A1 (en) 2006-12-15
KR19990044148A (ko) 1999-06-25
JP2000506722A (ja) 2000-06-06
CN1230533C (zh) 2005-12-07
NO980845L (no) 1998-04-29
US20070033664A1 (en) 2007-02-08
NO980845D0 (no) 1998-02-27
AU716956B2 (en) 2000-03-09
AU716956C (en) 2002-03-28
KR100793220B1 (ko) 2008-01-10
SI0849990T1 (en) 2001-06-30
KR100533476B1 (ko) 2006-04-21
EP0849990B1 (en) 2001-02-14
ZA967390B (en) 1998-03-02
CN1769432A (zh) 2006-05-10
CZ60898A3 (cs) 1998-07-15
WO1997007669A1 (en) 1997-03-06
US7355094B2 (en) 2008-04-08
PL325331A1 (en) 1998-07-20
KR20050088163A (ko) 2005-09-01
CN100422317C (zh) 2008-10-01
ATE199115T1 (de) 2001-02-15
CN1769431A (zh) 2006-05-10
GB2318578A (en) 1998-04-29
US6147276A (en) 2000-11-14
US20070028313A1 (en) 2007-02-01
NZ337311A (en) 2008-05-30
CA2229568C (en) 2011-11-22
EP0930009A1 (en) 1999-07-21
NZ316149A (en) 1999-10-28
DE69611793T2 (de) 2001-09-20
SG75155A1 (en) 2000-09-19
US20050010966A1 (en) 2005-01-13
US7232938B2 (en) 2007-06-19
EP1005789A2 (en) 2000-06-07
GB2318578B (en) 2000-01-19
BR9610034A (pt) 1999-12-21
JP2006217913A (ja) 2006-08-24
AU6831096A (en) 1997-03-19
US20060156424A1 (en) 2006-07-13
DE69611793D1 (de) 2001-03-22
BR9610034B1 (pt) 2011-03-09
JP4081613B2 (ja) 2008-04-30

Similar Documents

Publication Publication Date Title
GB2318578B (en) Quiescent cell populations for nuclear transfer
ZA918965B (en) Nucleic acid amplification by two-enzyme,self-sustained sequence replication
IL108144A0 (en) Non-reducing saccharideforming enzyme, its preparation and uses
DE3167468D1 (en) Method for preparing 2,5-diketo-d-gluconic acid and microorganisms for carrying out the method
EP0311385A3 (en) Optically active hydroxybenzylamine derivative, optically active amine-boron compound containing said derivative, and process for producing optically active compound by using said compound
AU6300198A (en) Production of transgenic donor cells for nuclear transfer
GB9016114D0 (en) A method of,and system for,altering the rate at which digital circuitry operates
GB2207711B (en) Method for harnessing tidal energy.
GB2331751B (en) Quiescent cell populations for nuclear transfer
GB9325804D0 (en) An aid to recovery from disease caused by bacteria,viruses and malignant cells
EP0626852A4 (en) Method for making universal donor cells.
FR2607458B1 (fr) Dispositif individuel destine au transport de bacs en particulier de bacs a vendanges
HK1019394A1 (en) Quiescent cell populations for nuclear transfer
EP0651795A4 (en) INSULATION PROCEDURE FOR MUTANT CELLS.
YU67083A (en) Device for carrying out a method of combusting of waste parts of corn,particularly straw
GB8728942D0 (en) Hydraulic accumulator multiple tubed turbine system
GB2321840B (en) Recovery of cryopreserved plant cells
DZ1948A1 (fr) Système de récupération et d'alimentation énergétique, système hydro-électrique.
AU8208082A (en) Carrying bag, particularly for bicycles
ZA856226B (en) Method for recovering purified growth hormones from genetically engineered microorganisms
AR241958A1 (es) Central de fuerza motriz de energia solar
PL310367A1 (en) Apparatus for separating and thickening mechanical suspensions carried by water, especially in hydraulic slag and ash transport systems at power and/orheat generating plants
IT1157790B (it) Sistema integrato modulare costituito da un convertitore accumulatore termico per reattori termonucleari a fusione