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Thermostable DNA polymerase enzymes their preparation and their use

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C12Q1/6848 Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
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IL121441A

Israel

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1997 CZ TW ES DE EP AT DK IL CA HU UA NO KR US CN PL MX BR JP RU AU
Application IL12144197A events
1997-07-31
Application filed by Hoffmann La Roche
1998-01-04
Publication of IL121441A0
2000-07-16
Publication of IL121441A
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Patent citations (5)
Cited by (67)
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Patent Citations (5)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
US5466591A * 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US4889818A * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5912155A * 1994-09-30 1999-06-15 Life Technologies, Inc. Cloned DNA polymerases from Thermotoga neapolitana
DE655506T1 * 1994-10-17 1995-09-28 President And Fellows Of Harvard College, Cambridge, Mass. DNS Polymerase mit Veränderten Nukleotiden Bindungstelle.
US5614365A * 1994-10-17 1997-03-25 President & Fellow Of Harvard College DNA polymerase having modified nucleotide binding site for DNA sequencing
* Cited by examiner, † Cited by third party

Cited By (67)

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Family To Family Citations
WO1998023733A2 * 1996-11-27 1998-06-04 University Of Washington Thermostable polymerases having altered fidelity
US20030215857A1 * 1996-12-20 2003-11-20 Roche Diagnostics Gmbh Method for the direct, exponential amplification and sequencing of DNA molecules and its application
DE69841023D1 * 1997-03-12 2009-09-10 Applied Biosystems Llc DNA Polymerasen mit verbesserten Fähigkeiten zum Einbau von markierten Nukleotiden
CA2243985C 1997-09-11 2004-08-10 F. Hoffmann-La Roche Ag Thermostable dna polymerases incorporating nucleoside triphosphates labeled with fluorescein family dyes
US6458945B1 1998-10-01 2002-10-01 Variagenics, Inc. Method for analyzing polynucleotides
US6777188B2 1998-10-01 2004-08-17 Variagenics, Inc. Genotyping by mass spectrometric analysis of allelic fragments
US6500650B1 1998-10-01 2002-12-31 Variagenics, Inc. Method for identifying polymorphisms
US6855500B2 1998-10-01 2005-02-15 Sequenom, Inc. Fluorescence-based genotyping
US6566059B1 1998-10-01 2003-05-20 Variagenics, Inc. Method for analyzing polynucleotides
US6440705B1 1998-10-01 2002-08-27 Vincent P. Stanton, Jr. Method for analyzing polynucleotides
US6610492B1 1998-10-01 2003-08-26 Variagenics, Inc. Base-modified nucleotides and cleavage of polynucleotides incorporating them
US6994998B1 1998-10-01 2006-02-07 Sequenom, Inc. Base-modified nucleotides and their use for polymorphism detection
AU5008900A * 1999-05-12 2000-11-21 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
GB9921318D0 * 1999-09-09 1999-11-10 Kristensen Tom Chimeric molecules
US6329178B1 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US7179590B2 2000-04-18 2007-02-20 Roche Molecular Systems, Inc High temperature reverse transcription using mutant DNA polymerases
US6214557B1 * 2000-06-06 2001-04-10 Washington University Cold sensitive mutant DNA polymerases
WO2002010750A2 * 2000-07-31 2002-02-07 Maxygen, Inc. Biosensors, reagents and diagnostic applications of directed evolution
JP4741170B2 * 2000-10-11 2011-08-03 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー アニオン性リンカーを有する蛍光核酸塩基結合体
NZ525336A * 2000-10-20 2006-03-31 Expression Diagnostics Inc Leukocyte expression profiling
WO2002073504A1 * 2001-03-14 2002-09-19 Gene Logic, Inc. A system and method for retrieving and using gene expression data from multiple sources
US6905827B2 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6887690B2 * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
EP1436385A4 * 2001-09-14 2005-12-14 Invitrogen Corp DNA POLYMERASES AND MUTANTS CORRESPONDING
US20050042629A1 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
WO2003048308A2 2001-11-30 2003-06-12 Applera Corporation Thermus brockianus nucleic acid polymerases
US6723546B2 * 2002-03-26 2004-04-20 New England Biolabs, Inc. Method for cloning and expression of BsaI restriction endonuclease and BsaI methylase in E. coli
US7148049B2 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
US7820030B2 2003-04-16 2010-10-26 Handylab, Inc. System and method for electrochemical detection of biological compounds
US7892745B2 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7572581B2 * 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
US7947817B2 * 2003-06-30 2011-05-24 Roche Molecular Systems, Inc. Synthesis and compositions of 2'-terminator nucleotides
EP1493824A1 * 2003-07-02 2005-01-05 Consortium National de Recherche en Genomique (CNRG) Method for detection of mutations in DNA
JP4127204B2 * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
US20080311627A1 * 2004-06-17 2008-12-18 Epigenomics Ag Compositions and Methods for Preventing Carry-Over Contamination in Nucleic Acid Amplification Reactions
US7745125B2 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
WO2006029184A2 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
US7890268B2 * 2004-12-28 2011-02-15 Roche Molecular Systems, Inc. De-novo sequencing of nucleic acids
JP2008546424A * 2005-06-28 2008-12-25 アジェンコート パーソナル ジェノミクス コーポレイション 修飾ポリヌクレオチドを作製する方法および配列決定する方法
US20060292578A1 * 2005-06-28 2006-12-28 Weidong Zheng DNA polymerase blends and mutant DNA polymerases
EP1762629B1 2005-09-12 2009-11-11 Roche Diagnostics GmbH Detection of biological DNA
US20070154894A1 * 2005-12-30 2007-07-05 Affymetrix, Inc. Labeling and non-enzymatic fragmentation of cDNA using a ribonucleoside triphosphate analog
US7993832B2 2006-08-14 2011-08-09 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008140484A2 2006-11-09 2008-11-20 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080242560A1 * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US10150990B2 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
WO2011123246A2 2010-04-01 2011-10-06 Illumina, Inc. Solid-phase clonal amplification and related methods
CN106244695B 2010-11-24 2019-12-13 株式会社钟化 扩增核酸的检测方法和检测装置
WO2012146260A1 2011-04-23 2012-11-01 Biolytix Ag Herstellung und verwendung von proteinen in der molekularbiologie
US9783844B2 * 2012-04-27 2017-10-10 Kaneka Corporation Method for amplifying nucleic acid and method for detecting amplified nucleic acid
TWI487789B 2012-12-24 2015-06-11 Ind Tech Res Inst 單離的脫氧核糖核酸聚合酶、套組與其應用
EP2970366B1 2013-03-15 2019-01-16 Ibis Biosciences, Inc. Nucleotide analogs for sequencing
US9932623B2 2013-08-19 2018-04-03 Abbott Molecular Inc. Nucleotide analogs
US10392652B2 2013-11-22 2019-08-27 Kaneka Corporation Micro RNA detection method using two primers to produce an amplified double stranded DNA fragment having a single stranded region at one end
CN103966182A * 2014-04-30 2014-08-06 厦门安普利生物工程有限公司 一种提取纯化Tth DNA聚合酶的方法
US11180522B2 2015-05-08 2021-11-23 Centrillion Technology Holdings Corporation Disulfide-linked reversible terminators
WO2019014359A2 * 2017-07-12 2019-01-17 The Scripps Research Institute POLYMERASE CHAIN TRANSCRIPTION (PCT): EXPONENTIAL SYNTHESIS OF RNA AND MODIFIED RNA
WO2019060418A1 2017-09-20 2019-03-28 Regeneron Pharmaceuticals, Inc. IMMUNOTHERAPY METHODS FOR PATIENTS WITH TUMORS TRANSPORTING HIGH PASSENGER GENE MUTATION CHARGE
CN108130318B * 2018-02-28 2020-07-14 深圳市艾伟迪生物科技有限公司 突变型Taq DNA聚合酶、免核酸提取直接PCR扩增的试剂盒及其应用
WO2020069424A1 2018-09-28 2020-04-02 Centrillion Technologies, Inc. Disulfide-linked reversible terminators
NZ774828A 2018-10-29 2025-08-29 Codexis Inc Engineered dna polymerase variants
CN110093410A * 2019-05-21 2019-08-06 通用生物系统（安徽）有限公司 一种dna测序反应试剂及其制备方法
GB202007428D0 2020-05-19 2020-07-01 Fabricnano Ltd Polynucleotide synthesis
CN112322715B * 2020-11-17 2022-11-25 清华大学 一种核酸测序方法
GB202114105D0 2021-10-01 2021-11-17 Fabricnano Ltd Nucleotide synthesis
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Priority And Related Applications

Applications Claiming Priority (1)

Application Filing date Title
US2337696P 1996-08-06

Legal Events

Date Code Title Description
2000-11-21 FF Patent granted
2003-10-31 KB Patent renewed
2007-08-19 KB Patent renewed
2011-07-31 KB Patent renewed
2016-03-31 MM9K Patent not in force due to non-payment of renewal fees
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