IL119750A - 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates - Google Patents

7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates

Info

Publication number
IL119750A
IL119750A IL11975093A IL11975093A IL119750A IL 119750 A IL119750 A IL 119750A IL 11975093 A IL11975093 A IL 11975093A IL 11975093 A IL11975093 A IL 11975093A IL 119750 A IL119750 A IL 119750A
Authority
IL
Israel
Prior art keywords
alkyl
group
group selected
methyl
straight
Prior art date
Application number
IL11975093A
Other languages
English (en)
Hebrew (he)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL119750A publication Critical patent/IL119750A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/20—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C247/18—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/60—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups having oxygen atoms of carbamate groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11975093A 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates IL119750A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92859892A 1992-08-13 1992-08-13
IL106677A IL106677A (en) 1992-08-13 1993-08-12 N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines

Publications (1)

Publication Number Publication Date
IL119750A true IL119750A (en) 1998-09-24

Family

ID=25456505

Family Applications (4)

Application Number Title Priority Date Filing Date
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL11975093A IL119750A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates
IL106677A IL106677A (en) 1992-08-13 1993-08-12 N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11975193A IL119751A (en) 1992-08-13 1993-08-12 7-) Transformed (-8-) Transformed-9-) Amino-Transformed (-6-Demethyl-6-DioxytetracyclinesNew Intermediates

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL106677A IL106677A (en) 1992-08-13 1993-08-12 N) -7 and Tamar (-8-) Transformed-9-) Amino Transformed (-6-Demethyl-6-Deoxytetracyclines
IL11975096A IL119750A0 (en) 1992-08-13 1996-12-03 Novel 7-(substituted) -8- (substituted) -9- (substituted amino) -6- demethyl -6- deoxytetracycline intermediates

Country Status (24)

Country Link
US (4) US5430162A (no)
EP (1) EP0582810B1 (no)
JP (1) JP3639313B2 (no)
KR (1) KR100309540B1 (no)
CN (1) CN1048719C (no)
AT (1) ATE215530T1 (no)
AU (1) AU674524B2 (no)
CA (1) CA2103861C (no)
CZ (1) CZ289195B6 (no)
DE (1) DE69331774T2 (no)
DK (1) DK0582810T3 (no)
ES (1) ES2173876T3 (no)
FI (1) FI933567A (no)
HU (2) HU213269B (no)
IL (4) IL119751A (no)
NO (1) NO302568B1 (no)
NZ (1) NZ248359A (no)
PH (1) PH31210A (no)
PL (4) PL175487B1 (no)
PT (1) PT582810E (no)
RU (1) RU2127255C1 (no)
SG (1) SG47520A1 (no)
SK (1) SK281871B6 (no)
ZA (1) ZA935892B (no)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
EP2327687A3 (en) * 1999-09-14 2012-08-15 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
HUP0300082A2 (en) * 2000-03-31 2003-05-28 Paratek Pharmaceuticals 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them
WO2001093891A1 (en) * 2000-06-02 2001-12-13 Yu Liu Non-antibacterial tetracycline as anti-fungal agents
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001271556A1 (en) * 2000-07-07 2002-01-21 Trustees Of Tufts College 7,8 and 9-substituted tetracycline compounds
EP1679305B1 (en) * 2000-07-07 2012-02-08 Trustees Of Tufts College 9-Substituted minocycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR101027625B1 (ko) * 2000-07-07 2011-04-06 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
WO2002072506A2 (en) 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
ATE404528T1 (de) 2001-03-13 2008-08-15 Paratek Pharm Innc 7,9 substituierte tetracyclinverbindungen
US20040092490A1 (en) * 2001-04-24 2004-05-13 Michael Draper Substituted tetracycline compounds for the treatment of malaria
EP2301550A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
KR101014918B1 (ko) * 2002-03-08 2011-02-15 파라테크 파마슈티컬스, 인크. 아미노-메틸 치환된 테트라시클린 화합물
IL164180A0 (en) * 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
AU2003243205A1 (en) * 2002-05-06 2003-11-17 Collagenex Pharmaceuticals, Inc. Methods of simultaneously treating mucositis and fungal infection
US20040029843A1 (en) * 2002-06-20 2004-02-12 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
EP2277504A1 (en) * 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
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EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
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AU2005299294B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
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PT2225253E (pt) 2007-11-29 2012-09-19 Actelion Pharmaceuticals Ltd Derivados de ácido fosfónico e respetiva utilização como antagonistas do recetor p2y12
MX2011001367A (es) 2008-08-08 2011-06-28 Tetraphase Pharmaceuticals Inc Compuestos de tetraciclina sustituidos con fluor en c7.
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
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CN110582486B (zh) 2016-10-19 2024-01-12 四相制药公司 艾若威四环素的结晶形式

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Also Published As

Publication number Publication date
IL106677A (en) 1998-06-15
PL174127B1 (pl) 1998-06-30
AU4460193A (en) 1994-02-17
JPH06228072A (ja) 1994-08-16
PL175487B1 (pl) 1999-01-29
ES2173876T3 (es) 2002-11-01
US5495018A (en) 1996-02-27
US5512553A (en) 1996-04-30
DE69331774T2 (de) 2002-11-14
DK0582810T3 (da) 2002-06-03
SG47520A1 (en) 1998-04-17
HU9302333D0 (en) 1993-10-28
SK85793A3 (en) 1994-04-06
US5886175A (en) 1999-03-23
HUT64945A (en) 1994-03-28
US5430162A (en) 1995-07-04
IL119750A0 (en) 1997-03-18
ATE215530T1 (de) 2002-04-15
NO302568B1 (no) 1998-03-23
NO932872L (no) 1994-02-14
CN1090267A (zh) 1994-08-03
FI933567A (fi) 1994-02-14
KR940003925A (ko) 1994-03-14
PL300066A1 (en) 1994-02-21
SK281871B6 (sk) 2001-08-06
IL106677A0 (en) 1993-12-08
RU2127255C1 (ru) 1999-03-10
HU211303A9 (en) 1995-11-28
FI933567A0 (fi) 1993-08-12
CZ157593A3 (en) 1994-02-16
PT582810E (pt) 2002-08-30
EP0582810A1 (en) 1994-02-16
CA2103861A1 (en) 1994-02-14
PL174022B1 (pl) 1998-06-30
CZ289195B6 (cs) 2001-11-14
NZ248359A (en) 1996-03-26
PL174230B1 (pl) 1998-07-31
ZA935892B (en) 1994-03-10
CN1048719C (zh) 2000-01-26
CA2103861C (en) 2004-07-27
KR100309540B1 (ko) 2002-04-24
HU213269B (en) 1997-04-28
DE69331774D1 (de) 2002-05-08
IL119751A (en) 1998-09-24
NO932872D0 (no) 1993-08-12
EP0582810B1 (en) 2002-04-03
PH31210A (en) 1998-05-05
AU674524B2 (en) 1997-01-02
JP3639313B2 (ja) 2005-04-20

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