IL117265A - Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them - Google Patents

Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117265A
IL117265A IL11726596A IL11726596A IL117265A IL 117265 A IL117265 A IL 117265A IL 11726596 A IL11726596 A IL 11726596A IL 11726596 A IL11726596 A IL 11726596A IL 117265 A IL117265 A IL 117265A
Authority
IL
Israel
Prior art keywords
benzoxazepine
benzothiazepine
benzazepine
preparation
acetic acid
Prior art date
Application number
IL11726596A
Other languages
English (en)
Other versions
IL117265A0 (en
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of IL117265A0 publication Critical patent/IL117265A0/xx
Publication of IL117265A publication Critical patent/IL117265A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11726596A 1995-03-23 1996-02-26 Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them IL117265A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19510566A DE19510566A1 (de) 1995-03-23 1995-03-23 Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
IL117265A0 IL117265A0 (en) 1996-06-18
IL117265A true IL117265A (en) 2000-07-16

Family

ID=7757471

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11726596A IL117265A (en) 1995-03-23 1996-02-26 Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5677297A (cs)
EP (1) EP0733642B1 (cs)
JP (1) JP3942670B2 (cs)
KR (1) KR100482499B1 (cs)
CN (1) CN1059436C (cs)
AR (1) AR023289A1 (cs)
AT (1) ATE197801T1 (cs)
AU (1) AU701271B2 (cs)
CA (1) CA2172354C (cs)
CZ (1) CZ289245B6 (cs)
DE (2) DE19510566A1 (cs)
DK (1) DK0733642T3 (cs)
DZ (1) DZ2003A1 (cs)
ES (1) ES2152444T3 (cs)
GR (1) GR3035410T3 (cs)
HU (1) HU226064B1 (cs)
IL (1) IL117265A (cs)
NO (1) NO305904B1 (cs)
NZ (1) NZ286224A (cs)
PL (1) PL184336B1 (cs)
PT (1) PT733642E (cs)
RU (1) RU2159768C2 (cs)
SK (1) SK281079B6 (cs)
UA (1) UA44712C2 (cs)
ZA (1) ZA961243B (cs)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2781483A1 (fr) * 1998-07-21 2000-01-28 Hoechst Marion Roussel Inc Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
US20020052370A1 (en) * 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
PL367093A1 (en) * 2001-05-18 2005-02-21 Solvay Pharmaceuticals Gmbh Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments
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SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
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US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
DE10344848A1 (de) * 2003-09-26 2005-04-14 Solvay Pharmaceuticals Gmbh Amidomethyl-substituierte l-(Carboxyalkyl)-cyclopentylcarbonylamino-benzazepin-N-essigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enhaltende Arzneimittel
DE602004010172T2 (de) 2003-11-18 2008-09-11 Solvay Pharmaceuticals Gmbh Pharmazeutische zusammensetzungen zur behandlung von nierenfunktionsstörungen
US7232813B2 (en) * 2004-01-12 2007-06-19 Solvay Pharmaceuticals B.V. Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders
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RU2715241C2 (ru) 2015-02-19 2020-02-26 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
CN105017154B (zh) * 2015-07-07 2017-10-10 浙江博聚新材料有限公司 一种3‑溴‑1,3,4,5‑四氢‑2h‑1‑苯并氮杂卓‑2‑酮制备方法
JP7306828B2 (ja) 2016-03-08 2023-07-11 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー 結晶性（２ｓ，４ｒ）－５－（５’－クロロ－２’－フルオロ－［１，１’－ビフェニル］－４－イル）－２－（エトキシメチル）－４－（３－ヒドロキシイソオキサゾール－５－カルボキサミド）－２－メチルペンタン酸およびその使用
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JP7401442B2 (ja) 2018-01-31 2023-12-19 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規使用
PL424452A1 (pl) 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
PL424453A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)
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Also Published As

Publication number Publication date
NZ286224A (en) 1997-09-22
PL184336B1 (pl) 2002-10-31
CN1147506A (zh) 1997-04-16
HUP9600680A2 (en) 1997-01-28
HUP9600680A3 (en) 1998-07-28
CA2172354C (en) 2002-10-08
PT733642E (pt) 2001-03-30
HU9600680D0 (en) 1996-05-28
DE19510566A1 (de) 1996-09-26
EP0733642B1 (de) 2000-11-29
CZ86396A3 (en) 1996-10-16
DK0733642T3 (da) 2001-01-15
AR023289A1 (es) 2002-09-04
CA2172354A1 (en) 1996-09-24
CZ289245B6 (cs) 2001-12-12
ZA961243B (en) 1996-08-27
UA44712C2 (uk) 2002-03-15
EP0733642A1 (de) 1996-09-25
SK35496A3 (en) 1997-02-05
ATE197801T1 (de) 2000-12-15
KR960034178A (ko) 1996-10-22
NO961181L (no) 1996-09-24
GR3035410T3 (en) 2001-05-31
KR100482499B1 (ko) 2006-08-23
IL117265A0 (en) 1996-06-18
PL313433A1 (en) 1996-09-30
HU226064B1 (en) 2008-04-28
DE59606160D1 (de) 2001-01-04
JPH08269011A (ja) 1996-10-15
ES2152444T3 (es) 2001-02-01
JP3942670B2 (ja) 2007-07-11
RU2159768C2 (ru) 2000-11-27
CN1059436C (zh) 2000-12-13
AU4821096A (en) 1996-10-03
NO961181D0 (no) 1996-03-22
SK281079B6 (sk) 2000-11-07
AU701271B2 (en) 1999-01-21
NO305904B1 (no) 1999-08-16
DZ2003A1 (fr) 2002-07-20
US5677297A (en) 1997-10-14

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