IL111596A - Process for the preparation of Claudront and pharmaceutical preparations containing it - Google Patents

Process for the preparation of Claudront and pharmaceutical preparations containing it

Info

Publication number
IL111596A
IL111596A IL11159694A IL11159694A IL111596A IL 111596 A IL111596 A IL 111596A IL 11159694 A IL11159694 A IL 11159694A IL 11159694 A IL11159694 A IL 11159694A IL 111596 A IL111596 A IL 111596A
Authority
IL
Israel
Prior art keywords
weight
clodronate
process according
disodium
disodium clodronate
Prior art date
Application number
IL11159694A
Other languages
English (en)
Hebrew (he)
Other versions
IL111596A0 (en
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of IL111596A0 publication Critical patent/IL111596A0/xx
Publication of IL111596A publication Critical patent/IL111596A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Ceramic Products (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Glanulating (AREA)
  • Glass Compositions (AREA)
IL11159694A 1993-11-12 1994-11-10 Process for the preparation of Claudront and pharmaceutical preparations containing it IL111596A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI935019A FI94926C (fi) 1993-11-12 1993-11-12 Menetelmä klodronaattivalmisteen valmistamiseksi

Publications (2)

Publication Number Publication Date
IL111596A0 IL111596A0 (en) 1995-01-24
IL111596A true IL111596A (en) 1998-12-06

Family

ID=8538945

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11159694A IL111596A (en) 1993-11-12 1994-11-10 Process for the preparation of Claudront and pharmaceutical preparations containing it

Country Status (25)

Country Link
US (1) US5776499A (el)
EP (1) EP0727983B1 (el)
JP (1) JPH09504800A (el)
KR (1) KR100352155B1 (el)
CN (1) CN1040945C (el)
AT (1) ATE202700T1 (el)
AU (1) AU679586B2 (el)
CA (1) CA2175994A1 (el)
CZ (1) CZ286132B6 (el)
DE (1) DE69427648T2 (el)
DK (1) DK0727983T3 (el)
ES (1) ES2160688T3 (el)
FI (1) FI94926C (el)
GR (1) GR3036470T3 (el)
HU (1) HU220633B1 (el)
IL (1) IL111596A (el)
NO (1) NO312938B1 (el)
NZ (1) NZ275833A (el)
PL (1) PL176658B1 (el)
PT (1) PT727983E (el)
RU (1) RU2141323C1 (el)
SK (1) SK280552B6 (el)
TW (1) TW436297B (el)
WO (1) WO1995013054A1 (el)
ZA (1) ZA948974B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
AR021347A1 (es) * 1999-10-20 2002-07-17 Cipla Ltd Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma
RO121891B1 (ro) 2001-07-04 2008-07-30 Sindan S.R.L. Compoziţie farmaceutică pentru profilaxia şi tratamentul dereglărilor metabolismului calciului şi procedeu de preparare
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
GB0616794D0 (en) * 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
JP6864955B2 (ja) * 2015-12-22 2021-04-28 ストック カンパニー“チェペトスキー メカニカル プラント” チタン合金から棒材を製造する方法
EP3713581A1 (en) 2017-11-22 2020-09-30 Inbiomotion S.L. Therapeutic treatment of breast cancer based on c-maf
TWI806467B (zh) 2022-03-03 2023-06-21 金兆豐數位科技股份有限公司 金融商品提昇報酬率多維度決策方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2040733T3 (es) * 1986-12-20 1993-11-01 Boehringer Mannheim Gmbh Medicamentos que contienen clodronato y procedimiento para su preparacion.
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
CA2162470C (en) 1993-05-15 1998-06-16 Walter Preis Tablet with improved bioavailability containing dichloromethylenediphosphonic acid as the active substance

Also Published As

Publication number Publication date
HU220633B1 (hu) 2002-03-28
HU9601257D0 (en) 1996-07-29
CZ286132B6 (cs) 2000-01-12
CA2175994A1 (en) 1995-05-18
CZ132796A3 (en) 1996-10-16
KR960705548A (ko) 1996-11-08
US5776499A (en) 1998-07-07
SK60696A3 (en) 1997-02-05
FI94926B (fi) 1995-08-15
EP0727983B1 (en) 2001-07-04
IL111596A0 (en) 1995-01-24
AU8108794A (en) 1995-05-29
ZA948974B (en) 1995-11-21
PT727983E (pt) 2001-11-30
AU679586B2 (en) 1997-07-03
HUT75228A (en) 1997-04-28
TW436297B (en) 2001-05-28
DE69427648T2 (de) 2002-04-18
NO312938B1 (no) 2002-07-22
CN1134664A (zh) 1996-10-30
NO961906L (no) 1996-05-23
ATE202700T1 (de) 2001-07-15
PL176658B1 (pl) 1999-07-30
WO1995013054A1 (en) 1995-05-18
PL314299A1 (en) 1996-09-02
DE69427648D1 (de) 2001-08-09
EP0727983A1 (en) 1996-08-28
KR100352155B1 (ko) 2002-12-31
JPH09504800A (ja) 1997-05-13
FI935019A0 (fi) 1993-11-12
NZ275833A (en) 1997-10-24
ES2160688T3 (es) 2001-11-16
RU2141323C1 (ru) 1999-11-20
DK0727983T3 (da) 2001-09-24
NO961906D0 (no) 1996-05-10
CN1040945C (zh) 1998-12-02
GR3036470T3 (en) 2001-11-30
FI94926C (fi) 1995-11-27
FI935019A (fi) 1995-05-13
SK280552B6 (sk) 2000-03-13

Similar Documents

Publication Publication Date Title
CA2301185C (en) Pharmaceutical preparation comprising clodronate as active ingredient and silicified microcrystalline cellulose as excipient
US5211958A (en) Pharmaceutical composition and process for its preparation
US4632843A (en) Process for the preparation of solid pharmaceutical products
EP0301006B1 (en) Methylprednisolone/sodium carboxymethyl starch tablet composition
JP2008531737A (ja) アリピプラゾールの湿式造粒医薬組成物
JP6759390B2 (ja) トホグリフロジンを含有する固形製剤及びその製造方法
US5460829A (en) Pharmaceutical compositions based on ebastine or analogues thereof
US5776499A (en) Process for preparing a clodronate preparation
EA008585B1 (ru) Капсулы флуконазола с улучшенным высвобождением
JP2019530727A (ja) ラモトリギンを含む経口懸濁液用の粉末
EP0319074A1 (en) Pharmaceutical composition and process for its preparation
CN105407875A (zh) 包含异烟肼颗粒和利福喷汀颗粒的呈包衣片剂形式的抗结核病的稳定的药物组合物及其制备方法
KR20190047239A (ko) 바제독시펜 또는 그의 약제학적으로 허용가능한 염 및 콜레칼시페롤 또는 그의 약제학적으로 허용가능한 염을 포함하는, 습식과립법을 이용하여 제조되는 복합제제
WO2024030098A1 (en) A tablet of tolvaptan and at least one binder processed with spray granulation

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed