IL104074A - 20-methyl-substituted vitamin d derivatives and process for the preparation thereof - Google Patents

20-methyl-substituted vitamin d derivatives and process for the preparation thereof

Info

Publication number
IL104074A
IL104074A IL104074A IL10407492A IL104074A IL 104074 A IL104074 A IL 104074A IL 104074 A IL104074 A IL 104074A IL 10407492 A IL10407492 A IL 10407492A IL 104074 A IL104074 A IL 104074A
Authority
IL
Israel
Prior art keywords
methyl
group
vitamin
dihydroxy
hydroxy
Prior art date
Application number
IL104074A
Other languages
English (en)
Other versions
IL104074A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL104074A0 publication Critical patent/IL104074A0/xx
Publication of IL104074A publication Critical patent/IL104074A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL104074A 1991-12-13 1992-12-13 20-methyl-substituted vitamin d derivatives and process for the preparation thereof IL104074A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4141746A DE4141746A1 (de) 1991-12-13 1991-12-13 20-methyl-substituierte vitamin d-derivate

Publications (2)

Publication Number Publication Date
IL104074A0 IL104074A0 (en) 1993-05-13
IL104074A true IL104074A (en) 1998-01-04

Family

ID=6447341

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104074A IL104074A (en) 1991-12-13 1992-12-13 20-methyl-substituted vitamin d derivatives and process for the preparation thereof

Country Status (24)

Country Link
US (1) US5446035A (cs)
EP (1) EP0637299B1 (cs)
JP (1) JP3280975B2 (cs)
KR (1) KR100271462B1 (cs)
CN (1) CN1035177C (cs)
AT (1) ATE138366T1 (cs)
AU (1) AU670585B2 (cs)
CA (1) CA2125476C (cs)
CZ (1) CZ286579B6 (cs)
DE (2) DE4141746A1 (cs)
DK (1) DK0637299T3 (cs)
ES (1) ES2089585T3 (cs)
FI (1) FI108226B (cs)
GR (1) GR3020097T3 (cs)
HU (1) HUT68263A (cs)
IL (1) IL104074A (cs)
MX (1) MX9207101A (cs)
NO (1) NO305949B1 (cs)
NZ (1) NZ246052A (cs)
PL (1) PL171403B1 (cs)
SK (1) SK280450B6 (cs)
TW (1) TW275060B (cs)
WO (1) WO1993012081A1 (cs)
ZA (1) ZA929650B (cs)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9220272D0 (en) * 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
GB9315253D0 (en) * 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5981597A (en) * 1995-02-13 1999-11-09 Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
EP0880362B1 (en) * 1996-02-13 2005-05-25 G.D. SEARLE & CO. Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b 4 receptor antagonist
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
JP4219553B2 (ja) 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
ATE515265T1 (de) 1998-03-27 2011-07-15 Univ Oregon Health & Science Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen
US6443856B1 (en) 1999-11-01 2002-09-03 Callaway Golf Company Contoured scorelines for the face of a golf club
US20030188756A1 (en) * 2002-08-19 2003-10-09 Cantorna Margherita T Treatment of inflammatory bowel disease with vitamin d compounds
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20030220307A1 (en) * 2000-08-17 2003-11-27 Akira Kawase Remedial agent for osteoporosis
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AU2004265288A1 (en) * 2003-07-30 2005-02-24 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
ES2525410T3 (es) * 2005-05-10 2014-12-22 Dermipsor Ltd Composiciones y métodos para el tratamiento de enfermedades hiperproliferativas dérmicas
JP2008540513A (ja) * 2005-05-10 2008-11-20 ダーミプソル リミテッド スキンケアのための組成物及び方法
CA2607901C (en) 2005-06-13 2016-08-16 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
PL1734251T3 (pl) * 2005-06-17 2007-05-31 Magneti Marelli Powertrain Spa Wtryskiwacz paliwa
EP2004597B1 (en) * 2006-04-10 2011-01-26 Wisconsin Alumni Research Foundation 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds with a 1,1-dimethylpropyl side chain
WO2008024485A2 (en) 2006-08-25 2008-02-28 Cougar Biotechnology, Inc. Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080051380A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
WO2009009132A1 (en) * 2007-07-12 2009-01-15 Cougar Biotechnology, Inc. Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer
MX339746B (es) * 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
ES2742750T3 (es) 2009-08-14 2020-02-17 Berg Llc Vitamina D3 y análogos de la misma para tratar la alopecia
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
KR20240115925A (ko) 2016-07-29 2024-07-26 얀센 파마슈티카 엔브이 전립선암의 치료 방법
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
US11903952B2 (en) 2020-05-27 2024-02-20 Northwestern University Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

Also Published As

Publication number Publication date
KR940703806A (ko) 1994-12-12
FI942766A7 (fi) 1994-06-10
DE4141746A1 (de) 1993-06-17
HU9401456D0 (en) 1994-08-29
AU4035693A (en) 1993-07-19
CN1073677A (zh) 1993-06-30
CZ141694A3 (en) 1995-01-18
WO1993012081A1 (de) 1993-06-24
CZ286579B6 (cs) 2000-05-17
NO942178D0 (no) 1994-06-10
MX9207101A (es) 1993-08-01
DK0637299T3 (da) 1996-09-30
PL171403B1 (pl) 1997-04-30
SK280450B6 (sk) 2000-02-14
IL104074A0 (en) 1993-05-13
EP0637299B1 (de) 1996-05-22
AU670585B2 (en) 1996-07-25
ATE138366T1 (de) 1996-06-15
EP0637299A1 (de) 1995-02-08
FI108226B (fi) 2001-12-14
JP3280975B2 (ja) 2002-05-13
FI942766A0 (fi) 1994-06-10
CA2125476A1 (en) 1993-06-24
ES2089585T3 (es) 1996-10-01
US5446035A (en) 1995-08-29
CN1035177C (zh) 1997-06-18
JPH07505132A (ja) 1995-06-08
KR100271462B1 (ko) 2000-11-15
NO305949B1 (no) 1999-08-23
CA2125476C (en) 2003-02-11
GR3020097T3 (en) 1996-08-31
ZA929650B (en) 1993-06-09
SK66194A3 (en) 1995-02-08
DE59206393D1 (de) 1996-06-27
NO942178L (cs) 1994-06-10
NZ246052A (en) 1995-07-26
HUT68263A (en) 1995-06-28
TW275060B (cs) 1996-05-01

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Legal Events

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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees