MX9207101A - Derivados de vitamina d sustituidos con metilo en posicion 20 - Google Patents

Derivados de vitamina d sustituidos con metilo en posicion 20

Info

Publication number
MX9207101A
MX9207101A MX9207101A MX9207101A MX9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A MX 9207101 A MX9207101 A MX 9207101A
Authority
MX
Mexico
Prior art keywords
vitamin
methyl
derivatives replaced
derivatives
preparation
Prior art date
Application number
MX9207101A
Other languages
English (en)
Inventor
Gunter Neef
Andreas Steinmeyer
Gerald Kirsch
Katica Schwarz
Ruth Thieroffekerdt
Herbert Wiesinger
Martin Haberey
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX9207101A publication Critical patent/MX9207101A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen los nuevos derivados de vitamina D sustituidos con metilo en posición 20, y un procedimiento para su preparación. Los nuevos compuestos tienen frente al calcitriol una inducción muy mejorada de la diferenciación celular (HL-60) y son apropiados para la preparación de medicamentos.
MX9207101A 1991-12-13 1992-12-08 Derivados de vitamina d sustituidos con metilo en posicion 20 MX9207101A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4141746A DE4141746A1 (de) 1991-12-13 1991-12-13 20-methyl-substituierte vitamin d-derivate

Publications (1)

Publication Number Publication Date
MX9207101A true MX9207101A (es) 1993-08-01

Family

ID=6447341

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9207101A MX9207101A (es) 1991-12-13 1992-12-08 Derivados de vitamina d sustituidos con metilo en posicion 20

Country Status (24)

Country Link
US (1) US5446035A (es)
EP (1) EP0637299B1 (es)
JP (1) JP3280975B2 (es)
KR (1) KR100271462B1 (es)
CN (1) CN1035177C (es)
AT (1) ATE138366T1 (es)
AU (1) AU670585B2 (es)
CA (1) CA2125476C (es)
CZ (1) CZ286579B6 (es)
DE (2) DE4141746A1 (es)
DK (1) DK0637299T3 (es)
ES (1) ES2089585T3 (es)
FI (1) FI108226B (es)
GR (1) GR3020097T3 (es)
HU (1) HUT68263A (es)
IL (1) IL104074A (es)
MX (1) MX9207101A (es)
NO (1) NO305949B1 (es)
NZ (1) NZ246052A (es)
PL (1) PL171403B1 (es)
SK (1) SK280450B6 (es)
TW (1) TW275060B (es)
WO (1) WO1993012081A1 (es)
ZA (1) ZA929650B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9220272D0 (en) * 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) * 1993-06-04 2004-08-26 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of a Vitamin D compound
GB9315253D0 (en) * 1993-07-23 1993-09-08 Res Inst Medicine Chem Chemical compounds
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US5981597A (en) * 1995-02-13 1999-11-09 Trustees Of The University Of Pennsylvania Differentiating agents for the treatment of inflammatory intestinal diseases
ATE296114T1 (de) * 1996-02-13 2005-06-15 Searle & Co Zubereitungen, enthaltend einen cyclooxygenase-2- inhibitor und einen leukotrien-b4-rezeptor- antagonisten
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
JP4219553B2 (ja) 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
AU762481C (en) 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
US20030188756A1 (en) * 2002-08-19 2003-10-09 Cantorna Margherita T Treatment of inflammatory bowel disease with vitamin d compounds
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
WO2002013832A1 (fr) * 2000-08-17 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Agent therapeutique destine au traitement de l'osteoporose
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
NZ545270A (en) * 2003-07-30 2010-04-30 Rigel Pharmaceuticals Inc 2,4-Pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US9173835B2 (en) 2005-05-10 2015-11-03 Dermipsor Ltd. Compositions and methods for treating hyperproliferative epidermal diseases
US8034788B2 (en) * 2005-05-10 2011-10-11 Dermipsor Ltd. Composition and methods for skin care
WO2006135915A2 (en) 2005-06-13 2006-12-21 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders
EP1734251B1 (en) * 2005-06-17 2007-01-24 MAGNETI MARELLI POWERTRAIN S.p.A. Fuel injector
MX2008012674A (es) * 2006-04-10 2008-10-15 Wisconsin Alumni Res Found Compuestos de 1 a-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitamina d con una cadena lateral 1,1-dimetilpropilo.
US20080051375A1 (en) * 2006-08-25 2008-02-28 Auerbach Alan H Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
CA2838089A1 (en) 2006-08-25 2008-02-28 Cougar Biotechnology, Inc. Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20090124587A1 (en) * 2007-07-12 2009-05-14 Auerbach Alan H METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS
MX339746B (es) 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
CA3031705A1 (en) 2016-07-29 2018-02-01 Janssen Pharmaceutica Nv Treatment of prostate cancer with niraparib
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
US11903952B2 (en) 2020-05-27 2024-02-20 Northwestern University Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

Also Published As

Publication number Publication date
EP0637299A1 (de) 1995-02-08
IL104074A0 (en) 1993-05-13
GR3020097T3 (en) 1996-08-31
NO942178D0 (no) 1994-06-10
JP3280975B2 (ja) 2002-05-13
HUT68263A (en) 1995-06-28
ATE138366T1 (de) 1996-06-15
AU4035693A (en) 1993-07-19
WO1993012081A1 (de) 1993-06-24
NZ246052A (en) 1995-07-26
SK66194A3 (en) 1995-02-08
CZ141694A3 (en) 1995-01-18
EP0637299B1 (de) 1996-05-22
TW275060B (es) 1996-05-01
ES2089585T3 (es) 1996-10-01
DE4141746A1 (de) 1993-06-17
PL171403B1 (pl) 1997-04-30
US5446035A (en) 1995-08-29
NO305949B1 (no) 1999-08-23
NO942178L (es) 1994-06-10
FI942766A0 (fi) 1994-06-10
CZ286579B6 (cs) 2000-05-17
CA2125476A1 (en) 1993-06-24
SK280450B6 (sk) 2000-02-14
KR100271462B1 (ko) 2000-11-15
DK0637299T3 (da) 1996-09-30
HU9401456D0 (en) 1994-08-29
KR940703806A (ko) 1994-12-12
FI108226B (fi) 2001-12-14
ZA929650B (en) 1993-06-09
AU670585B2 (en) 1996-07-25
CN1073677A (zh) 1993-06-30
JPH07505132A (ja) 1995-06-08
IL104074A (en) 1998-01-04
DE59206393D1 (de) 1996-06-27
CA2125476C (en) 2003-02-11
FI942766A (fi) 1994-06-10
CN1035177C (zh) 1997-06-18

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees