ATE515265T1 - Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen - Google Patents
Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungenInfo
- Publication number
- ATE515265T1 ATE515265T1 AT99914109T AT99914109T ATE515265T1 AT E515265 T1 ATE515265 T1 AT E515265T1 AT 99914109 T AT99914109 T AT 99914109T AT 99914109 T AT99914109 T AT 99914109T AT E515265 T1 ATE515265 T1 AT E515265T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- drug
- vitamin
- analogues
- tumors
- Prior art date
Links
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 4
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 2
- 230000000148 hypercalcaemia Effects 0.000 abstract 2
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 2
- 208000017520 skin disease Diseases 0.000 abstract 2
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 229960005084 calcitriol Drugs 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7969698P | 1998-03-27 | 1998-03-27 | |
| PCT/US1999/006442 WO1999049870A1 (en) | 1998-03-27 | 1999-03-25 | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515265T1 true ATE515265T1 (de) | 2011-07-15 |
Family
ID=22152202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99914109T ATE515265T1 (de) | 1998-03-27 | 1999-03-25 | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6521608B1 (de) |
| EP (2) | EP1064000B1 (de) |
| JP (1) | JP2002509888A (de) |
| AT (1) | ATE515265T1 (de) |
| AU (1) | AU762481C (de) |
| CA (1) | CA2326117A1 (de) |
| ES (1) | ES2368824T3 (de) |
| WO (1) | WO1999049870A1 (de) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
| US20040167106A1 (en) * | 1993-06-04 | 2004-08-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US5763429A (en) * | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US6242434B1 (en) * | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
| CA2279590A1 (en) * | 1997-02-13 | 1998-08-20 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin d compounds |
| US6087350A (en) * | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| ES2368824T3 (es) * | 1998-03-27 | 2011-11-22 | Oregon Health & Science University | Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos. |
| JP2003525254A (ja) * | 2000-03-02 | 2003-08-26 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 併用化学療法 |
| JP4803939B2 (ja) * | 2000-04-19 | 2011-10-26 | 中外製薬株式会社 | ビタミンd誘導体 |
| CA2409759A1 (en) * | 2000-05-09 | 2001-11-15 | Children's Medical Center Corporation | Method and composition for the treatment of angiogenesis |
| EP2070911A2 (de) | 2000-07-18 | 2009-06-17 | Bone Care International, Inc. | Stabilisiertes 1-alpha-Hydroxy-Vitamin D |
| US20040087559A1 (en) * | 2000-09-22 | 2004-05-06 | Schwartz Gary G. | Methods for prevention and treatment of cancer |
| EP1270026A1 (de) * | 2001-06-22 | 2003-01-02 | Erik Andersen | Stents mit Vitamin D-Analogen zur Verhinderung von Restenosen |
| KR20050044655A (ko) * | 2001-12-03 | 2005-05-12 | 노바세아, 인크. | 활성 비타민 d 화합물을 함유하는 약제학적 조성물 |
| EP1552837A1 (de) * | 2002-08-01 | 2005-07-13 | Chugai Seiyaku Kabushiki Kaisha | Antipsoriasis-mittel |
| US20040170621A1 (en) * | 2002-08-30 | 2004-09-02 | Roodman G. David | Method of resisting osteoclast formation |
| US20040138162A1 (en) * | 2002-08-30 | 2004-07-15 | Roodman G. David | Method of resisting osteoclast formation |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| EP1562606A4 (de) * | 2002-11-06 | 2006-05-24 | Novacea Inc | Verfahren zur verwendung von vitamin d-verbindungen bei der behandlung myelodysplastischer syndrome |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| AU2003295773A1 (en) * | 2002-11-21 | 2004-06-18 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2521221A1 (en) * | 2003-04-02 | 2004-10-14 | Genix Therapeutics, Inc. | Method for the treatment of prostate cancer |
| US20050020546A1 (en) * | 2003-06-11 | 2005-01-27 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| AU2004247109A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of cancer with active vitamin D compounds in combination with radiotherapeutic agents and treatments |
| CA2528378A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of immune-mediated disorders with active vitamin d compounds alone or in combination with other therapeutic agents |
| WO2005097128A1 (en) * | 2004-03-30 | 2005-10-20 | Novacea, Inc. | 1,4-bis-n-oxide azaanthracenediones and the use thereof |
| AU2005244061A1 (en) * | 2004-05-10 | 2005-11-24 | Novacea, Inc. | Prevention of arterial restenosis with active vitamin D compounds |
| WO2005117542A2 (en) * | 2004-05-10 | 2005-12-15 | Novacea, Inc. | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| WO2005110464A2 (en) * | 2004-05-14 | 2005-11-24 | Oregon Health & Science University | Irx5 inhibition as treatment for hyperproliferative disorders |
| PL1765391T3 (pl) * | 2004-06-07 | 2013-08-30 | Qu Biologics Inc | Kompozycje bakteryjne do leczenia nowotworów |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US20060003950A1 (en) * | 2004-06-30 | 2006-01-05 | Bone Care International, Inc. | Method of treating prostatic diseases using a combination of vitamin D analogues and other agents |
| US7094775B2 (en) * | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
| MX2007006546A (es) * | 2004-11-22 | 2007-08-17 | Wisconsin Alumni Res Found | Analogos de 17,20(e)-deshidro vitamina d y sus usos. |
| JP2008526856A (ja) * | 2005-01-05 | 2008-07-24 | ノバセア インコーポレイティッド | 活性ビタミンd化合物またはその模倣体による血栓性疾患の予防 |
| US20080069814A1 (en) * | 2005-01-05 | 2008-03-20 | Novacea, Inc. | Prevention of Thrombotic Disorders with Active Vitamin D Compounds or Mimics Thereof |
| US20100144671A1 (en) | 2005-03-04 | 2010-06-10 | Women And Infants Hospital Of Ri, Inc. | Compositions and Methods for Cancer Treatment |
| CN101198336A (zh) * | 2005-03-23 | 2008-06-11 | 拜奥艾克塞尔股份公司 | 20-烷基双生维生素d3化合物及其使用方法 |
| EP1879596A4 (de) * | 2005-03-23 | 2009-01-21 | Bioxell Spa | 20-alkyl, gemini-vitamin-d3-verbindungen und anwendungsverfahren dafür |
| BRPI0610077A2 (pt) * | 2005-04-22 | 2010-05-25 | Novacea Inc | tratamento, prevenção e atenuação de distúrbios pulmonares associados à quimioterapia ou radioterapia com compostos de vitamina d ativos ou miméticos destes |
| GB0513984D0 (en) * | 2005-07-07 | 2005-08-17 | Teva Pharma | Dosage form |
| CA2882048C (en) | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| EP2679228B1 (de) * | 2006-06-21 | 2018-03-21 | Opko Ireland Global Holdings, Ltd. | Therapie mit Vitamin-D-Sättigungsmittel und Vitamin-D-Hormonersatzmittel |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| CN101528309A (zh) | 2006-08-25 | 2009-09-09 | 库伽尔生物科技公司 | 包括给予维生素d化合物和另外的治疗剂的治疗癌症的方法 |
| TW200833345A (en) * | 2006-11-01 | 2008-08-16 | Novacea Inc | Use of vitamin D compounds and mimics thereof to enhance delivery of therapeutics and oxygen to tumors and other tissues |
| WO2009047644A2 (en) | 2007-04-25 | 2009-04-16 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| KR101759244B1 (ko) | 2007-04-25 | 2017-07-18 | 사이토크로마 인코포레이티드 | 비타민 d 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| EP3225243B1 (de) | 2007-04-25 | 2025-09-03 | Opko Renal, LLC | Verfahren zur sicheren und effektiven behandlung und vorbeugung von sekundärem hyperparathyroidismus für chronische nierenerkrankung |
| MX2010007263A (es) * | 2007-12-28 | 2011-03-15 | Wisconsin Alumni Res Foundation Star | Análogos de vitamina d-2-metilen-(20s, 25s)-19, 26-dinor. |
| US20090221538A1 (en) * | 2008-02-01 | 2009-09-03 | Hayes Colleen E | Methods of treating multiple sclerosis by administering pulse dose calcitriol |
| CN106853250A (zh) | 2008-04-02 | 2017-06-16 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| KR20170096238A (ko) * | 2009-01-27 | 2017-08-23 | 베르그 엘엘씨 | 화학요법과 연관된 부작용을 경감시키기 위한 비타민 d3 및 이의 유사물 |
| US8470304B2 (en) * | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
| MX338746B (es) | 2009-08-14 | 2016-04-29 | Berg Llc | Vitamina d3 y analogos de la misma para tratar alopecia. |
| SI2552484T1 (sl) | 2010-03-29 | 2020-07-31 | Opko Ireland Global Holdings, Ltd. | Postopki in sestavki za znižanje ravni paratiroidnega hormona |
| SG10201604175XA (en) | 2010-07-26 | 2016-07-28 | Qu Biolog Inc | Immunogenic anti-inflammatory compositions |
| US9008389B2 (en) * | 2012-09-28 | 2015-04-14 | Robert D. Williams | System and method for determining the amount of vitamin D generated by a user |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
| CA2913543C (en) | 2013-05-29 | 2024-01-09 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| ES2536256B2 (es) | 2013-11-20 | 2016-02-01 | Universidade De Santiago De Compostela | Análogos de vitamina d con interés farmacéutico |
| SG10201808645TA (en) | 2013-12-16 | 2018-11-29 | Massachusetts Inst Technology | Fortified Micronutrient Salt Formulations |
| CA3254723A1 (en) | 2014-05-02 | 2025-04-15 | Qu Biologics Inc. | ANTIMICROBIAL IMMUNOMODULATION |
| WO2016011397A1 (en) * | 2014-07-17 | 2016-01-21 | Mayo Foundation For Medical Education And Research | Methods and materials for reducing development of stenosis of arteriovenous fistulas |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CA3018019A1 (en) | 2016-03-28 | 2017-10-26 | Opko Ireland Global Holdings, Limited | Methods of vitamin d treatment |
| ES3014630T3 (en) | 2016-07-29 | 2025-04-23 | Janssen Pharmaceutica Nv | Niraparib for use in a method of treating prostate cancer |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2383446A (en) * | 1941-06-04 | 1945-08-28 | Du Pont | Antirachitic materials and processes for their production |
| US3741996A (en) * | 1971-12-02 | 1973-06-26 | Wisconsin Alumni Res Found | 1{60 -hydroxycholecalciferol |
| US4670190A (en) * | 1973-01-10 | 1987-06-02 | Hesse Robert H | 1-α-hydroxy vitamin D compounds and process for preparing same |
| US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4195027A (en) * | 1978-01-16 | 1980-03-25 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4260549A (en) * | 1979-05-21 | 1981-04-07 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
| US4160803A (en) * | 1978-03-23 | 1979-07-10 | Corning Glass Works | Self packaged test kit |
| JPS57149224A (en) | 1981-03-13 | 1982-09-14 | Chugai Pharmaceut Co Ltd | Tumor-suppressing agent |
| US4508651A (en) * | 1983-03-21 | 1985-04-02 | Hoffmann-La Roche Inc. | Synthesis of 1α,25-dihydroxyergocalciferol |
| US4689180A (en) * | 1984-01-30 | 1987-08-25 | Wisconsin Alumni Research Foundation | 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound |
| US5120722A (en) | 1984-02-08 | 1992-06-09 | Hoffmann-La Roche Inc. | Trihydroxy-cholecacliferol and trihydroxy-ergocalciferol for treating leukemia |
| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| US4857518A (en) | 1984-10-04 | 1989-08-15 | Wisconsin Alumni Research Foundation | Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same |
| US5037816A (en) * | 1984-11-02 | 1991-08-06 | The General Hospital Corporation | Method of treating psoriasis |
| US4728643A (en) * | 1984-11-02 | 1988-03-01 | The General Hospital Corporation | Method of treating psoriasis |
| US4717721A (en) | 1985-05-30 | 1988-01-05 | Howard W. Bremer | Sidechain homo-vitamin D compounds with preferential anti-cancer activity |
| US4661294A (en) * | 1985-03-18 | 1987-04-28 | The General Hospital Corporation | Biologically active 1-thio derivatives of vitamin D |
| EP0227826B1 (de) | 1985-08-02 | 1989-10-25 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Neue vitamin-d-analoga |
| JPS62185015A (ja) * | 1986-02-08 | 1987-08-13 | Taisho Pharmaceut Co Ltd | 分化誘導剤 |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US4833125A (en) * | 1986-12-05 | 1989-05-23 | The General Hospital Corporation | Method of increasing bone mass |
| DE3865544D1 (de) | 1987-06-23 | 1991-11-21 | Yamanouchi Pharma Co Ltd | Vitamin d3-derivate. |
| US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
| US5145846A (en) | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| US5087619A (en) * | 1988-01-20 | 1992-02-11 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| US4804502A (en) | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| KR0144358B1 (ko) * | 1988-04-21 | 1998-07-15 | 피. 라이달 크리스텐슨 | 비타민 d 동족체 |
| US5354744A (en) | 1988-04-29 | 1994-10-11 | Wisconsin Alumni Research Foundation | Side chain unsaturated 1 alpha-hydroxyvitamin D analogs |
| US4927815A (en) | 1988-04-29 | 1990-05-22 | Wisconsin Alumni Research Foundation | Compounds effective in inducing cell differentiation and process for preparing same |
| US5232836A (en) * | 1988-05-04 | 1993-08-03 | Ire-Medgenix S.A. | Vitamin D derivatives: therapeutic applications and applications to assays of metabolites of vitamin D |
| US4851401A (en) | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US5098899A (en) * | 1989-03-06 | 1992-03-24 | Trustees Of Boston University | Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5321018A (en) * | 1989-03-09 | 1994-06-14 | Wisconsin Alumni Research Foundation | Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis |
| GB8915770D0 (en) | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| US5219528A (en) * | 1989-07-28 | 1993-06-15 | Pierce Chemical Company | Apparatus for rapid immunoassays |
| CA2073448A1 (en) * | 1990-01-12 | 1991-07-13 | Raymond D. Youssefyeh | 1-azetidyl and 1-hexamethylenimine alkyl of aryl bisphosphonic acids and their use as pharmacological agents |
| GB9007236D0 (en) | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| DE4011682A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | 24-oxa-derivate in der vitamin d-reihe |
| US5194248A (en) * | 1990-06-21 | 1993-03-16 | Trustees Of Boston University | Compositions comprising vitamin D analog precursors and the use thereof |
| US5141719A (en) * | 1990-07-18 | 1992-08-25 | Bio-Rad Laboratories, Inc. | Multi-sample filtration plate assembly |
| GB9017890D0 (en) | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| US5763428A (en) * | 1990-09-21 | 1998-06-09 | Bone Care International, Inc. | Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof |
| US5798345A (en) | 1990-09-21 | 1998-08-25 | Bone Care International, Inc. | Method of inhibiting the hyperproliferation of malignant cells |
| US6025346A (en) * | 1990-09-21 | 2000-02-15 | Bone Care International, Inc. | 1α-hydroxy vitamin D4 and novel intermediates and analogues |
| WO1992005130A1 (en) * | 1990-09-21 | 1992-04-02 | Lunar Corporation | NOVEL 1α-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES |
| DE69229103T2 (de) * | 1991-01-08 | 1999-10-14 | Bone Care International Inc. | Verfahren zur herstellung und verwendung von 1alpha,24-dihydroxy vitamin-d2 |
| US5789397A (en) | 1991-01-08 | 1998-08-04 | Bone Care International, Inc. | Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2 |
| US6538037B2 (en) * | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
| DE4101953A1 (de) * | 1991-01-19 | 1992-07-23 | Schering Ag | 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel |
| US5417923A (en) * | 1991-04-24 | 1995-05-23 | Pfizer Inc. | Assay tray assembly |
| ATE168114T1 (de) * | 1991-05-15 | 1998-07-15 | Yamanouchi Pharma Co Ltd | (-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8- azaspiro(4,5)decan l-tartrat |
| AU650751B2 (en) * | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5486509A (en) * | 1991-06-28 | 1996-01-23 | University Of Miami | Method of preventing and treating chemotherapy-induced alopecia |
| EP0521550B1 (de) | 1991-07-05 | 1996-09-18 | Duphar International Research B.V | Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür |
| US5205989A (en) * | 1991-09-18 | 1993-04-27 | Minnesota Mining And Manufacturing Company | Multi-well filtration apparatus |
| DE4141746A1 (de) | 1991-12-13 | 1993-06-17 | Schering Ag | 20-methyl-substituierte vitamin d-derivate |
| US5403832A (en) * | 1992-03-12 | 1995-04-04 | The Johns Hopkins University | Vitamin D3 analogues |
| GB9206648D0 (en) | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| TW258729B (de) * | 1992-06-22 | 1995-10-01 | Ciba Geigy | |
| ATE211387T1 (de) | 1992-06-22 | 2002-01-15 | Bone Care Int Inc | Oral 1alpha-hydroxyprevitamin d |
| US5795882A (en) | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| DE69325253T2 (de) * | 1992-08-28 | 1999-12-02 | Bone Care International Inc., Madison | 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung |
| CA2096105A1 (en) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Vitamin d3 fluorinated analogs |
| US5753638A (en) * | 1992-10-07 | 1998-05-19 | Hoffmann-La Roche Inc. | Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs |
| TW270927B (de) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
| US5547947A (en) | 1993-03-11 | 1996-08-20 | Hoffmann-La Roche Inc. | Methods of treatment |
| ES2147238T3 (es) * | 1993-07-09 | 2000-09-01 | Theramex | Nuevos analogos estructurales de la vitamina d. |
| ATE195431T1 (de) * | 1993-09-01 | 2000-09-15 | Teijin Ltd | Emulsion auf der basis von 1-alpha,24-dihydroxy- vitamin d3 |
| US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
| US5597575A (en) * | 1994-06-06 | 1997-01-28 | Breitbarth; Richard | Composition for stimulating and inducing hair growth |
| IL110117A0 (en) | 1994-06-24 | 1994-10-07 | Univ Ben Gurion | Pharmaceutical compositions comprising vitamin-d analogs |
| US6040300A (en) * | 1995-04-07 | 2000-03-21 | Arch Development Corporation | Method of preventing colon cancer with vitamin D3 analogues |
| US6221911B1 (en) * | 1995-06-07 | 2001-04-24 | Karo Bio Ab | Uses for thyroid hormone compounds or thyroid hormone-like compounds |
| US5739271A (en) * | 1995-06-07 | 1998-04-14 | Gen-Probe Incorporated | Thiocationic lipids |
| PT771789E (pt) * | 1995-10-30 | 2000-05-31 | Hoffmann La Roche | 1 alfa 26-di-hidroxi-d-homo-vitamina d3 |
| US6869940B2 (en) * | 1995-12-28 | 2005-03-22 | Chugai Seiyaku Kabushiki Kaisha | Malignant tumor metastasis inhibitors |
| CA2240278A1 (en) * | 1995-12-28 | 1997-07-10 | Chugai Seiyaku Kabushiki Kaisha | Malignant tumor metastasis inhibitors |
| AU710931B2 (en) * | 1996-02-28 | 1999-09-30 | Sumitomo Pharmaceuticals Company, Limited | Crystalline vitamin D derivative |
| DE19619036A1 (de) | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US5939456A (en) | 1996-07-26 | 1999-08-17 | Perrine; Susan P. | Pulsed administration of compositions for the treatment of blood disorders |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6573256B2 (en) * | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
| US6599513B2 (en) * | 1997-05-27 | 2003-07-29 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6372234B1 (en) * | 1997-05-27 | 2002-04-16 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6087350A (en) | 1997-08-29 | 2000-07-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of pretreatment chemicals to enhance efficacy of cytotoxic agents |
| ES2368824T3 (es) * | 1998-03-27 | 2011-11-22 | Oregon Health & Science University | Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos. |
| US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| US20010002396A1 (en) * | 1998-07-16 | 2001-05-31 | Charles Achkar | Compositions and methods of treating skin conditions |
| US6552009B2 (en) * | 1998-07-16 | 2003-04-22 | Gentrix Llc | Compositions and methods of treating abnormal cell proliferation |
| US6218430B1 (en) * | 1998-08-24 | 2001-04-17 | Ligand Pharmaceuticals Incorporated | Vitamin D3 mimics |
| AU758792B2 (en) * | 1998-10-23 | 2003-03-27 | Teijin Limited | Vitamin D3 derivatives and remedies for inflammatory respiratory diseases containing the same |
| PL356968A1 (en) | 1999-04-13 | 2004-07-12 | Leo Pharmaceutical Products Ltd.A/S | Solubilized pharmaceutical composition for parenteral administration |
| US6524594B1 (en) * | 1999-06-23 | 2003-02-25 | Johnson & Johnson Consumer Companies, Inc. | Foaming oil gel compositions |
| US6566554B1 (en) * | 1999-07-16 | 2003-05-20 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Aminobenzophenones as inhibitors of IL-1β and TNF-α |
| DE60014393T2 (de) * | 1999-07-16 | 2006-02-16 | Leo Pharma A/S | Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha |
| FR2798855B1 (fr) * | 1999-09-28 | 2003-04-25 | Oreal | Utilisation de complexes inorganiques-organiques dans une composition a usage topique |
| US6369098B1 (en) * | 1999-10-05 | 2002-04-09 | Bethesda Pharmaceuticals, Inc. | Dithiolane derivatives |
| CA2393312C (en) * | 1999-12-06 | 2011-07-12 | Leo Pharma A/S | Aminobenzophenones as inhibitors of il-1.beta. and tnf-.alpha. |
| JP2003525254A (ja) | 2000-03-02 | 2003-08-26 | ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション | 併用化学療法 |
| US6395784B1 (en) * | 2000-06-07 | 2002-05-28 | Bristol-Myers Squibb Company | Benzamide ligands for the thyroid receptor |
-
1999
- 1999-03-25 ES ES99914109T patent/ES2368824T3/es not_active Expired - Lifetime
- 1999-03-25 EP EP99914109A patent/EP1064000B1/de not_active Expired - Lifetime
- 1999-03-25 AT AT99914109T patent/ATE515265T1/de not_active IP Right Cessation
- 1999-03-25 CA CA002326117A patent/CA2326117A1/en not_active Abandoned
- 1999-03-25 WO PCT/US1999/006442 patent/WO1999049870A1/en not_active Ceased
- 1999-03-25 JP JP2000540833A patent/JP2002509888A/ja not_active Ceased
- 1999-03-25 US US09/647,075 patent/US6521608B1/en not_active Expired - Lifetime
- 1999-03-25 EP EP10184333A patent/EP2340840B1/de not_active Expired - Lifetime
- 1999-03-25 AU AU32022/99A patent/AU762481C/en not_active Ceased
-
2002
- 2002-11-21 US US10/302,654 patent/US20030119795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2340840B1 (de) | 2012-08-29 |
| AU3202299A (en) | 1999-10-18 |
| AU762481C (en) | 2004-08-19 |
| WO1999049870A1 (en) | 1999-10-07 |
| JP2002509888A (ja) | 2002-04-02 |
| CA2326117A1 (en) | 1999-10-07 |
| EP1064000B1 (de) | 2011-07-06 |
| US6521608B1 (en) | 2003-02-18 |
| AU762481B2 (en) | 2003-06-26 |
| EP1064000A1 (de) | 2001-01-03 |
| EP1064000A4 (de) | 2002-01-02 |
| ES2368824T3 (es) | 2011-11-22 |
| US20030119795A1 (en) | 2003-06-26 |
| EP2340840A1 (de) | 2011-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE515265T1 (de) | Vitamin d und dessen analoge zur behandlung vom tumoren und anderen hyperproliferativen erkrankungen | |
| NL990012I1 (nl) | Geneesmiddelen die salmeterol en fluticason bevatten. | |
| ES2162615T3 (es) | Metodo para tratar o prevenir diabetes de tipo 1 mediante la administracion oral de insulina. | |
| ES2141706T3 (es) | Formulaciones y su empleo en el tratamiento de enfermedades neurologicas. | |
| PT97552A (pt) | Processo para a preparacao de formas de dosagem para administracao de farmacos para o tratamento da doenca de parkison | |
| DE3382641D1 (de) | Arzneimittel fuer die therapeutische behandlung von alopezie. | |
| BR9306841A (pt) | Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico | |
| SE9703191D0 (sv) | Medicament for improvement of duration of muscle function or treatment of muscle disorders or diseases | |
| DK0416950T3 (da) | Medikamenter | |
| NO994165L (no) | Anvendelse av deskarboetoksyloratadin for fremstilling av et medikament for behandling av urininkontinens, reisesyke og svimmelhet | |
| DE69200711D1 (de) | Pharmazeutische Zusammensetzungen enthaltend Fluticasonpropionat und Oxikonazol oder dessen Salz zur lokalen Anwendung. | |
| DE60018409D1 (de) | Verwendung von antiseptika zur herstelllung von arzneimitteln zur prophylaxe und behandlung von infektionen und/ oder funktionellen gewebeumformungen im körperinneren | |
| BR0116653A (pt) | Medicamento contendo uma poliamina como substância ativa | |
| GR3032224T3 (en) | Therapeutic agent for threatened abortion. | |
| CA2516458A1 (en) | Use of kahalalide compounds for the manufacture of a medicament for the treatment of psoriasis | |
| DE3688787D1 (de) | Herstellung eines arzneimittels gegen arthritis und rheumatismus. | |
| GB8923254D0 (en) | Medicaments | |
| AR109456A2 (es) | Uso de et743 para la preparación de un medicamento para el tratamiento de un paciente humano afectado por cáncer mediante terapia de combinación | |
| Fujita et al. | A clinical experience of fosfomycin tablet on cystitis | |
| Sánchez et al. | Meclofenamate sodium, phenylbutazone, and naproxen in the treatment of degenerative joint disease. Report of a placebo-controlled double-blind clinical comparison | |
| IL110888A0 (en) | Pharmaceutical compositions for the treatment of liver diseases comprising a benzothiazepine derivative | |
| PT1265629E (pt) | Utilizacao da hormona de crescimento em dose baixa | |
| MY111155A (en) | Medicaments | |
| RU2002129097A (ru) | Комбинированные терапии с использованием активности, повреждающей сосуды | |
| UA30251A (uk) | Спосіб лікування гіпертонії сфінктера одді у хворих на хронічний безкам'яний холецистит при поєднанні з підвищенням тонусу симпатичної нервової системи |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |