IL103710A - R(-)-enantiomers of n-trityl- 4-oxo-5-phosphonovalinate derivatives - Google Patents

R(-)-enantiomers of n-trityl- 4-oxo-5-phosphonovalinate derivatives

Info

Publication number
IL103710A
IL103710A IL103710A IL10371092A IL103710A IL 103710 A IL103710 A IL 103710A IL 103710 A IL103710 A IL 103710A IL 10371092 A IL10371092 A IL 10371092A IL 103710 A IL103710 A IL 103710A
Authority
IL
Israel
Prior art keywords
oxo
derivatives
phosphononorvaline
formula
trityl
Prior art date
Application number
IL103710A
Other languages
English (en)
Other versions
IL103710A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL103710A0 publication Critical patent/IL103710A0/xx
Publication of IL103710A publication Critical patent/IL103710A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL103710A 1991-11-15 1992-11-11 R(-)-enantiomers of n-trityl- 4-oxo-5-phosphonovalinate derivatives IL103710A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79283491A 1991-11-15 1991-11-15

Publications (2)

Publication Number Publication Date
IL103710A0 IL103710A0 (en) 1993-04-04
IL103710A true IL103710A (en) 1998-02-08

Family

ID=25158215

Family Applications (1)

Application Number Title Priority Date Filing Date
IL103710A IL103710A (en) 1991-11-15 1992-11-11 R(-)-enantiomers of n-trityl- 4-oxo-5-phosphonovalinate derivatives

Country Status (16)

Country Link
EP (1) EP0613459B1 (ja)
JP (1) JP3168563B2 (ja)
KR (1) KR100241480B1 (ja)
AT (1) ATE134989T1 (ja)
AU (1) AU667845B2 (ja)
CA (1) CA2121835A1 (ja)
DE (1) DE69208888T2 (ja)
DK (1) DK0613459T3 (ja)
ES (1) ES2087555T3 (ja)
FI (1) FI942248A0 (ja)
GR (1) GR3019587T3 (ja)
HU (1) HU214055B (ja)
IL (1) IL103710A (ja)
MX (1) MX9206448A (ja)
NO (1) NO305314B1 (ja)
WO (1) WO1993010075A1 (ja)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2025326C (en) * 1989-09-19 2001-04-24 Jeffrey P. Whitten Nmda antagonists

Also Published As

Publication number Publication date
EP0613459A1 (en) 1994-09-07
HU214055B (en) 1997-12-29
DE69208888T2 (de) 1996-08-01
MX9206448A (es) 1993-05-01
ATE134989T1 (de) 1996-03-15
IL103710A0 (en) 1993-04-04
ES2087555T3 (es) 1996-07-16
HUT70551A (en) 1995-10-30
CA2121835A1 (en) 1993-05-27
DK0613459T3 (da) 1996-04-01
NO941820D0 (no) 1994-05-13
DE69208888D1 (de) 1996-04-11
NO941820L (no) 1994-05-13
FI942248A (fi) 1994-05-13
WO1993010075A1 (en) 1993-05-27
KR100241480B1 (ko) 2000-03-02
FI942248A0 (fi) 1994-05-13
GR3019587T3 (en) 1996-07-31
AU2864292A (en) 1993-06-15
HU9401469D0 (en) 1994-08-29
NO305314B1 (no) 1999-05-10
EP0613459B1 (en) 1996-03-06
JP3168563B2 (ja) 2001-05-21
JPH07501523A (ja) 1995-02-16
AU667845B2 (en) 1996-04-18

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH1 Patent not in force
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PARMACEUTICALS, INC.