DE69208888D1 - N-trityl asparaginsäurederivate zur herstellung von phosphonat nmda antagonisten - Google Patents
N-trityl asparaginsäurederivate zur herstellung von phosphonat nmda antagonistenInfo
- Publication number
- DE69208888D1 DE69208888D1 DE69208888T DE69208888T DE69208888D1 DE 69208888 D1 DE69208888 D1 DE 69208888D1 DE 69208888 T DE69208888 T DE 69208888T DE 69208888 T DE69208888 T DE 69208888T DE 69208888 D1 DE69208888 D1 DE 69208888D1
- Authority
- DE
- Germany
- Prior art keywords
- trityl
- production
- acid derivatives
- nmda antagonists
- asparagic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical class OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 title 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 title 1
- HYHXAZMLKDGXEI-JOCHJYFZSA-N dimethyl (2r)-2-(tritylamino)butanedioate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(N[C@H](CC(=O)OC)C(=O)OC)C1=CC=CC=C1 HYHXAZMLKDGXEI-JOCHJYFZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79283491A | 1991-11-15 | 1991-11-15 | |
| PCT/US1992/008739 WO1993010075A1 (en) | 1991-11-15 | 1992-10-13 | N-trityl aspartic acid derivatives for preparing phosphonate nmda antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69208888D1 true DE69208888D1 (de) | 1996-04-11 |
| DE69208888T2 DE69208888T2 (de) | 1996-08-01 |
Family
ID=25158215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69208888T Expired - Fee Related DE69208888T2 (de) | 1991-11-15 | 1992-10-13 | N-trityl asparaginsäurederivate zur herstellung von phosphonat nmda antagonisten |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0613459B1 (de) |
| JP (1) | JP3168563B2 (de) |
| KR (1) | KR100241480B1 (de) |
| AT (1) | ATE134989T1 (de) |
| AU (1) | AU667845B2 (de) |
| CA (1) | CA2121835A1 (de) |
| DE (1) | DE69208888T2 (de) |
| DK (1) | DK0613459T3 (de) |
| ES (1) | ES2087555T3 (de) |
| FI (1) | FI942248A (de) |
| GR (1) | GR3019587T3 (de) |
| HU (1) | HU214055B (de) |
| IL (1) | IL103710A (de) |
| MX (1) | MX9206448A (de) |
| NO (1) | NO305314B1 (de) |
| WO (1) | WO1993010075A1 (de) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU632362B2 (en) * | 1989-09-19 | 1992-12-24 | Merrell Dow Pharmaceuticals Inc. | Nmda antagonists |
-
1992
- 1992-10-13 CA CA002121835A patent/CA2121835A1/en not_active Abandoned
- 1992-10-13 AU AU28642/92A patent/AU667845B2/en not_active Ceased
- 1992-10-13 WO PCT/US1992/008739 patent/WO1993010075A1/en active IP Right Grant
- 1992-10-13 AT AT92921774T patent/ATE134989T1/de not_active IP Right Cessation
- 1992-10-13 HU HU9401469A patent/HU214055B/hu not_active IP Right Cessation
- 1992-10-13 JP JP50924593A patent/JP3168563B2/ja not_active Expired - Fee Related
- 1992-10-13 KR KR1019940701634A patent/KR100241480B1/ko not_active IP Right Cessation
- 1992-10-13 DK DK92921774.3T patent/DK0613459T3/da active
- 1992-10-13 EP EP92921774A patent/EP0613459B1/de not_active Expired - Lifetime
- 1992-10-13 ES ES92921774T patent/ES2087555T3/es not_active Expired - Lifetime
- 1992-10-13 DE DE69208888T patent/DE69208888T2/de not_active Expired - Fee Related
- 1992-11-10 MX MX9206448A patent/MX9206448A/es not_active IP Right Cessation
- 1992-11-11 IL IL103710A patent/IL103710A/en not_active IP Right Cessation
-
1994
- 1994-05-13 NO NO941820A patent/NO305314B1/no not_active IP Right Cessation
- 1994-05-13 FI FI942248A patent/FI942248A/fi unknown
-
1996
- 1996-04-09 GR GR960400979T patent/GR3019587T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL103710A (en) | 1998-02-08 |
| MX9206448A (es) | 1993-05-01 |
| FI942248A0 (fi) | 1994-05-13 |
| ES2087555T3 (es) | 1996-07-16 |
| HU9401469D0 (en) | 1994-08-29 |
| NO941820D0 (no) | 1994-05-13 |
| NO305314B1 (no) | 1999-05-10 |
| WO1993010075A1 (en) | 1993-05-27 |
| ATE134989T1 (de) | 1996-03-15 |
| EP0613459B1 (de) | 1996-03-06 |
| JP3168563B2 (ja) | 2001-05-21 |
| CA2121835A1 (en) | 1993-05-27 |
| KR100241480B1 (ko) | 2000-03-02 |
| NO941820L (no) | 1994-05-13 |
| DE69208888T2 (de) | 1996-08-01 |
| AU667845B2 (en) | 1996-04-18 |
| JPH07501523A (ja) | 1995-02-16 |
| HUT70551A (en) | 1995-10-30 |
| EP0613459A1 (de) | 1994-09-07 |
| GR3019587T3 (en) | 1996-07-31 |
| DK0613459T3 (da) | 1996-04-01 |
| FI942248A (fi) | 1994-05-13 |
| IL103710A0 (en) | 1993-04-04 |
| AU2864292A (en) | 1993-06-15 |
| HU214055B (en) | 1997-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |