IL101564A - Process for making sterile powder containing microcapsules suitable for use in ultrasound imaging and microcapsules obtained by it - Google Patents
Process for making sterile powder containing microcapsules suitable for use in ultrasound imaging and microcapsules obtained by itInfo
- Publication number
- IL101564A IL101564A IL10156492A IL10156492A IL101564A IL 101564 A IL101564 A IL 101564A IL 10156492 A IL10156492 A IL 10156492A IL 10156492 A IL10156492 A IL 10156492A IL 101564 A IL101564 A IL 101564A
- Authority
- IL
- Israel
- Prior art keywords
- microcapsules
- process according
- protein
- wall
- powder
- Prior art date
Links
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- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 230000001057 ionotropic effect Effects 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000009549 lung scintigraphy Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011490 mineral wool Substances 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 210000004115 mitral valve Anatomy 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
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- 229940035035 polydextrose Drugs 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
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- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
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- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
- Y10S516/928—Mixing combined with non-mixing operation or step, successively or simultaneously, e.g. heating, cooling, ph change, ageing, milling
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Ink Jet Recording Methods And Recording Media Thereof (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919107628A GB9107628D0 (en) | 1991-04-10 | 1991-04-10 | Preparation of diagnostic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
IL101564A0 IL101564A0 (en) | 1992-12-30 |
IL101564A true IL101564A (en) | 1999-06-20 |
Family
ID=10693031
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10156492A IL101564A (en) | 1991-04-10 | 1992-04-10 | Process for making sterile powder containing microcapsules suitable for use in ultrasound imaging and microcapsules obtained by it |
IL12303898A IL123038A0 (en) | 1991-04-10 | 1998-01-23 | Sterile hollow microcapsules |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12303898A IL123038A0 (en) | 1991-04-10 | 1998-01-23 | Sterile hollow microcapsules |
Country Status (24)
Country | Link |
---|---|
US (3) | US5518709A (fr) |
EP (6) | EP1829557A3 (fr) |
JP (2) | JP2865866B2 (fr) |
KR (1) | KR0129861B1 (fr) |
CN (1) | CN1066977A (fr) |
AT (3) | ATE246519T1 (fr) |
AU (2) | AU655016B2 (fr) |
CA (1) | CA2083260A1 (fr) |
DE (3) | DE69233489T2 (fr) |
DK (3) | DK0512693T3 (fr) |
ES (3) | ES2150908T3 (fr) |
FI (1) | FI925600A0 (fr) |
GB (2) | GB9107628D0 (fr) |
GR (1) | GR3034462T3 (fr) |
HK (1) | HK1006538A1 (fr) |
HU (1) | HUT62805A (fr) |
IE (1) | IE921140A1 (fr) |
IL (2) | IL101564A (fr) |
MX (1) | MX9201694A (fr) |
NZ (1) | NZ242328A (fr) |
PT (2) | PT512693E (fr) |
RU (1) | RU2109521C1 (fr) |
WO (1) | WO1992018164A1 (fr) |
ZA (1) | ZA922636B (fr) |
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US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
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GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
NZ257212A (en) * | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
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DE69434119T3 (de) † | 1993-07-30 | 2011-05-05 | Imcor Pharmaceutical Co., San Diego | Stabilisierte mikrogasbläschen-zusammensetzungen für echographie |
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IN172208B (fr) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
FR2660864A1 (fr) | 1990-04-13 | 1991-10-18 | Guerbet Sa | Composition de contraste, procede de preparation de cette composition et application a l'imagerie. |
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DE4100470A1 (de) * | 1991-01-09 | 1992-07-16 | Byk Gulden Lomberg Chem Fab | Echokontrastmittel |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
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GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
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IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
US5674468A (en) * | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
CA2115444C (fr) * | 1992-06-12 | 2000-10-03 | Yuji Makino | Preparation pour administration intratracheobronchique |
WO1993025198A1 (fr) * | 1992-06-12 | 1993-12-23 | Teijin Limited | Poudre ultra-fine pour inhalation et production de cette poudre |
GB9221329D0 (en) | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
US5955108A (en) | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
US6017310A (en) | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
EP0949932A1 (fr) | 1996-10-19 | 1999-10-20 | Quadrant Healthcare (UK) Limited | Utilisation de microcapsules creuses a des fins diagnostiques et therapeutiques |
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1991
- 1991-04-10 GB GB919107628A patent/GB9107628D0/en active Pending
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1992
- 1992-04-09 IE IE114092A patent/IE921140A1/en unknown
- 1992-04-10 DK DK92303236T patent/DK0512693T3/da active
- 1992-04-10 EP EP07075443A patent/EP1829557A3/fr not_active Withdrawn
- 1992-04-10 DK DK99203198T patent/DK0972526T3/da active
- 1992-04-10 MX MX9201694A patent/MX9201694A/es unknown
- 1992-04-10 ZA ZA922636A patent/ZA922636B/xx unknown
- 1992-04-10 DK DK95110723T patent/DK0681843T3/da active
- 1992-04-10 EP EP99203198A patent/EP0972526B1/fr not_active Revoked
- 1992-04-10 IL IL10156492A patent/IL101564A/en not_active IP Right Cessation
- 1992-04-10 US US07/956,875 patent/US5518709A/en not_active Expired - Lifetime
- 1992-04-10 CN CN92103376A patent/CN1066977A/zh active Pending
- 1992-04-10 DE DE69233489T patent/DE69233489T2/de not_active Expired - Fee Related
- 1992-04-10 EP EP92303236A patent/EP0512693B1/fr not_active Expired - Lifetime
- 1992-04-10 ES ES92303236T patent/ES2150908T3/es not_active Expired - Lifetime
- 1992-04-10 ES ES99203198T patent/ES2242355T3/es not_active Expired - Lifetime
- 1992-04-10 CA CA002083260A patent/CA2083260A1/fr not_active Abandoned
- 1992-04-10 AT AT95110723T patent/ATE246519T1/de not_active IP Right Cessation
- 1992-04-10 EP EP05075544A patent/EP1547619A3/fr not_active Withdrawn
- 1992-04-10 DE DE69233148T patent/DE69233148T2/de not_active Expired - Fee Related
- 1992-04-10 NZ NZ242328A patent/NZ242328A/en not_active IP Right Cessation
- 1992-04-10 KR KR1019920703116A patent/KR0129861B1/ko not_active IP Right Cessation
- 1992-04-10 PT PT92303236T patent/PT512693E/pt unknown
- 1992-04-10 PT PT95110723T patent/PT681843E/pt unknown
- 1992-04-10 WO PCT/GB1992/000643 patent/WO1992018164A1/fr not_active Application Discontinuation
- 1992-04-10 AT AT92303236T patent/ATE194082T1/de not_active IP Right Cessation
- 1992-04-10 AU AU15891/92A patent/AU655016B2/en not_active Ceased
- 1992-04-10 JP JP4508032A patent/JP2865866B2/ja not_active Expired - Fee Related
- 1992-04-10 AT AT99203198T patent/ATE290405T1/de not_active IP Right Cessation
- 1992-04-10 EP EP92908598A patent/EP0533886A1/fr active Pending
- 1992-04-10 ES ES95110723T patent/ES2203626T3/es not_active Expired - Lifetime
- 1992-04-10 HU HU9203891A patent/HUT62805A/hu unknown
- 1992-04-10 EP EP95110723A patent/EP0681843B2/fr not_active Expired - Lifetime
- 1992-04-10 DE DE69231195T patent/DE69231195T2/de not_active Expired - Fee Related
- 1992-10-29 RU RU92016571A patent/RU2109521C1/ru active
- 1992-12-09 GB GB9225716A patent/GB2260745B/en not_active Expired - Fee Related
- 1992-12-09 FI FI925600A patent/FI925600A0/fi unknown
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1994
- 1994-10-07 AU AU74483/94A patent/AU691196B2/en not_active Ceased
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1995
- 1995-08-22 US US08/517,590 patent/US6022525A/en not_active Expired - Fee Related
-
1998
- 1998-01-23 IL IL12303898A patent/IL123038A0/xx unknown
- 1998-06-17 HK HK98105577A patent/HK1006538A1/xx not_active IP Right Cessation
- 1998-08-19 JP JP10233181A patent/JPH11128232A/ja active Pending
-
1999
- 1999-09-28 US US09/407,370 patent/US6569405B1/en not_active Expired - Fee Related
-
2000
- 2000-09-21 GR GR20000402151T patent/GR3034462T3/el not_active IP Right Cessation
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