DE69025334T2 - Herstellungsverfahren für proteinmikrosphären - Google Patents
Herstellungsverfahren für proteinmikrosphärenInfo
- Publication number
- DE69025334T2 DE69025334T2 DE69025334T DE69025334T DE69025334T2 DE 69025334 T2 DE69025334 T2 DE 69025334T2 DE 69025334 T DE69025334 T DE 69025334T DE 69025334 T DE69025334 T DE 69025334T DE 69025334 T2 DE69025334 T2 DE 69025334T2
- Authority
- DE
- Germany
- Prior art keywords
- microspheres
- proteins
- mixture
- protein
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43278589A | 1989-11-06 | 1989-11-06 | |
US55755190A | 1990-07-24 | 1990-07-24 | |
PCT/US1990/006430 WO1991006286A1 (en) | 1989-11-06 | 1990-11-06 | Method for producing protein microspheres |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69025334D1 DE69025334D1 (de) | 1996-03-21 |
DE69025334T2 true DE69025334T2 (de) | 1996-08-01 |
Family
ID=27029628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69025334T Expired - Fee Related DE69025334T2 (de) | 1989-11-06 | 1990-11-06 | Herstellungsverfahren für proteinmikrosphären |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0499619B1 (de) |
JP (2) | JPH04506931A (de) |
AT (1) | ATE133856T1 (de) |
AU (1) | AU634606B2 (de) |
CA (1) | CA2071840C (de) |
DE (1) | DE69025334T2 (de) |
ES (1) | ES2084712T3 (de) |
GR (1) | GR3018939T3 (de) |
WO (1) | WO1991006286A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2571874B2 (ja) * | 1989-11-06 | 1997-01-16 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | タンパク質マイクロスフェア組成物 |
CA2046830C (en) | 1990-07-19 | 1999-12-14 | Patrick P. Deluca | Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer |
US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
DE4221880A1 (de) * | 1992-07-03 | 1994-01-05 | Alfatec Pharma Gmbh | Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen |
US5324351A (en) * | 1992-08-13 | 1994-06-28 | Euroceltique | Aqueous dispersions of zein and preparation thereof |
GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
GB2281861B (en) * | 1993-09-21 | 1997-08-20 | Johnson & Johnson Medical | Bioabsorbable wound implant materials containing microspheres |
DE69429820T3 (de) * | 1993-11-19 | 2013-02-28 | Alkermes Controlled Therapeutics, Inc. | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
WO1995018602A1 (en) * | 1994-01-11 | 1995-07-13 | Alkermes Controlled Therapeutics, Inc. | ORAL DOSAGE FORM OF DESMOPRESSIN (dDAVP) |
US5436355A (en) * | 1994-02-03 | 1995-07-25 | Merck & Co., Inc. | Process for making avermectin/zein compositions |
DE4419724A1 (de) * | 1994-06-06 | 1995-12-07 | Omnitechnik Mikroverkapselungs | Lagerstabiles und diffusionsdichtes Mikrokapselwandmaterial |
GB9420355D0 (en) * | 1994-10-10 | 1994-11-23 | Univ Nottingham | Preparation of protein microspheres, films and coatings |
GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
US5681819A (en) * | 1994-12-01 | 1997-10-28 | Oklahoma Medical Research Foundation | Method and compositions for reducing cholesterol absorption |
US5821226A (en) * | 1994-12-01 | 1998-10-13 | Oklahoma Medical Research Foundation | BAL C-tail drug delivery molecules |
US5696087A (en) * | 1994-12-01 | 1997-12-09 | Oklahoma Medical Research Foundation | Method and compositions for reducing cholesterol absorption |
US5985312A (en) * | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
US6368586B1 (en) | 1996-01-26 | 2002-04-09 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
US6342218B1 (en) | 1997-02-14 | 2002-01-29 | Oklahoma Medical Research Foundation | Method for treatment of SLE |
GB2311027B (en) * | 1996-03-15 | 1999-10-27 | Johnson & Johnson Medical | Coated bioabsorbable beads for wound treatment |
US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
WO2000006243A2 (en) | 1998-07-28 | 2000-02-10 | Innerdyne, Inc. | Absorbable brachytherapy and chemotherapy delivery devices and methods |
US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
FR2786098B1 (fr) | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
US9669113B1 (en) | 1998-12-24 | 2017-06-06 | Devicor Medical Products, Inc. | Device and method for safe location and marking of a biopsy cavity |
US6356782B1 (en) | 1998-12-24 | 2002-03-12 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
US6371904B1 (en) | 1998-12-24 | 2002-04-16 | Vivant Medical, Inc. | Subcutaneous cavity marking device and method |
FR2801226B1 (fr) | 1999-11-23 | 2002-01-25 | Flamel Tech Sa | Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation |
FR2814952B1 (fr) | 2000-10-06 | 2004-01-02 | Flamel Tech Sa | Suspension colloidale de particules submicromiques de vectorisation de principes actifs et leur mode de preparation |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
FR2820323B1 (fr) * | 2001-02-07 | 2004-10-08 | Innoform Sa | Composition dietetique et cosmetique a base de polymeres vegetaux immobilisant des actifs |
CA2441108A1 (en) * | 2001-04-05 | 2002-10-17 | Universite Laval | Process for making delivery matrix and uses thereof |
US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
PT1492511E (pt) | 2002-04-09 | 2009-04-09 | Flamel Tech Sa | Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s) |
FR2840614B1 (fr) | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
JP3742842B2 (ja) * | 2002-06-17 | 2006-02-08 | 独立行政法人産業技術総合研究所 | 生分解性ポリ乳酸樹脂組成物 |
CN1727471B (zh) * | 2002-09-20 | 2013-03-06 | 中国科学院上海有机化学研究所 | 植物源性醇溶蛋白基质薄膜的用途 |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
US20080160084A1 (en) | 2004-12-22 | 2008-07-03 | Colarome, Inc. | Natural Water-Insoluble Encapsulation Compositions and Processes for Preparing Same |
WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
FR2906464B1 (fr) * | 2006-09-29 | 2011-07-29 | Europ Finances | Composition active pour prevenir l'accoutumance a l'absorption des boissons alcoolisees |
EP2134830A2 (de) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oszillations-zellkultur-bioreaktor |
WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
ES2627292T3 (es) | 2007-10-12 | 2017-07-27 | Massachusetts Institute Of Technology | Nanotecnología de vacunas |
EP2348879B1 (de) | 2008-10-07 | 2013-12-18 | University Of Pretoria | Verfahren zur herstellung von proteinmikropartikeln |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
WO2012000757A1 (en) | 2010-06-30 | 2012-01-05 | Unilever Nv | Particles comprising hydrophobic polymer and hydrophobic phenolic compound |
CN102516778A (zh) * | 2011-11-29 | 2012-06-27 | 上海交通大学 | 一种基于谷物蛋白的、用于大规模培养细胞的微载体,制备方法及用途 |
WO2013084207A1 (pt) | 2011-12-07 | 2013-06-13 | Universidade Do Minho | Formulações micelares proteicas e respectivo método de produção |
EP2625966A1 (de) * | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanopartikel mit einem pflanzlichen hydrophoben Protein und wassermischbare nichtflüchtige organische Lösung sowie Verwendungen davon |
CN106434799A (zh) * | 2016-09-28 | 2017-02-22 | 华南理工大学 | 一种蛋白质纳米颗粒及其制备方法 |
CN113116785A (zh) * | 2021-05-08 | 2021-07-16 | 何平蓉 | 一种清洁按摩沐浴露及其制备方法 |
CN113230147A (zh) * | 2021-06-01 | 2021-08-10 | 何平蓉 | 一种温和低刺激性的清洁按摩型洁面膏及其制备方法 |
CN113509450A (zh) * | 2021-07-09 | 2021-10-19 | 浙江海洋大学 | 一种递送槲皮素的钙离子稳定的复合纳米颗粒制备方法 |
WO2023164487A1 (en) * | 2022-02-22 | 2023-08-31 | Brown University | Compositions and methods to achieve systemic uptake of particles following oral or mucosal administration |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
US4357259A (en) * | 1977-08-01 | 1982-11-02 | Northwestern University | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
DE68912336T2 (de) * | 1988-09-19 | 1994-08-11 | Opta Food Ingredients Inc | Hydrophobe proteinmikroteilchen und verfahren zur herstellung. |
-
1990
- 1990-11-06 AU AU67562/90A patent/AU634606B2/en not_active Ceased
- 1990-11-06 WO PCT/US1990/006430 patent/WO1991006286A1/en active IP Right Grant
- 1990-11-06 ES ES90917274T patent/ES2084712T3/es not_active Expired - Lifetime
- 1990-11-06 JP JP3500503A patent/JPH04506931A/ja active Pending
- 1990-11-06 DE DE69025334T patent/DE69025334T2/de not_active Expired - Fee Related
- 1990-11-06 EP EP90917274A patent/EP0499619B1/de not_active Expired - Lifetime
- 1990-11-06 AT AT90917274T patent/ATE133856T1/de not_active IP Right Cessation
- 1990-11-06 CA CA002071840A patent/CA2071840C/en not_active Expired - Fee Related
-
1995
- 1995-04-05 JP JP7080618A patent/JP2711231B2/ja not_active Expired - Fee Related
-
1996
- 1996-02-08 GR GR960400286T patent/GR3018939T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU634606B2 (en) | 1993-02-25 |
CA2071840C (en) | 1997-02-04 |
DE69025334D1 (de) | 1996-03-21 |
JP2711231B2 (ja) | 1998-02-10 |
EP0499619B1 (de) | 1996-02-07 |
EP0499619A1 (de) | 1992-08-26 |
GR3018939T3 (en) | 1996-05-31 |
ES2084712T3 (es) | 1996-05-16 |
ATE133856T1 (de) | 1996-02-15 |
JPH04506931A (ja) | 1992-12-03 |
CA2071840A1 (en) | 1991-05-07 |
WO1991006286A1 (en) | 1991-05-16 |
AU6756290A (en) | 1991-05-31 |
JPH0853369A (ja) | 1996-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |