ES2084712T3 - Metodo para producir microesferas proteicas. - Google Patents

Metodo para producir microesferas proteicas.

Info

Publication number
ES2084712T3
ES2084712T3 ES90917274T ES90917274T ES2084712T3 ES 2084712 T3 ES2084712 T3 ES 2084712T3 ES 90917274 T ES90917274 T ES 90917274T ES 90917274 T ES90917274 T ES 90917274T ES 2084712 T3 ES2084712 T3 ES 2084712T3
Authority
ES
Spain
Prior art keywords
microspheres
proteins
mixture
range
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917274T
Other languages
English (en)
Inventor
Edith Mathiowitz
Howard Bernstein
Eric Morrel
Kirsten Schwaller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ES2084712T3 publication Critical patent/ES2084712T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin

Abstract

LAS MICROESFERAS DE PROTEINA SE FORMAN MEDIANTE LA SEPARACION DE FASE EN UN IN-SOLVENTE SEGUIDO DE LA EXTRACCION DEL SOLVENTE. LAS PROTEINAS PREFERIDAS SON PROLAMINAS, TALES COMO ZEINA, QUE SON HIDROFOBICAS, BIODEGRADABLES Y QUE SE PUEDEN MODIFICAR PROTEOLITICAMENTE O QUIMICAMENTE PARA DOTARLAS DE LAS PROPIEDADES DESEABLES, COMO UN INDICE DE DEGRADACION SELECCIONADO. LAS MICROESFERAS COMPUESTAS SE PUEDEN PREPARAR DE UNA MEZCLA DE PROTEINAS O DE UNA MEZCLA DE PROTEINAS CON UNO O MAS MATERIALES POLIMERICOS BIODEGRADABLES TALES COMO POLILACTIDOS. TAMBIEN SE PUEDEN HACER REVESTIMIENTO DE PROTEINAS. LOS COMPUESTOS SE INCORPORAN FACILMENTE EN LAS MICROESFERAS PARA LA SUBSIGUIENTE LIBERACION. EL PROCESO NO INCLUYE AGENTES QUE DEGRADAN LA MAYORIA DE LAS PROTEINAS LABILES. LAS MICROESFERAS TIENEN UNA GAMA DE TAMAÑOS Y MULTIPLES APLICACIONES, INCLUYENDO LA LIBERACION DE DROGAS Y LA LIBERACION RETRASADA DE PESTICIDAS, FERTILIZANTES Y AGENTES PARA LIMPIEZA MEDIOAMBIENTAL. LA SELECCION DEL TAMAÑO DE MICROESFERAS EN LA GAMA MENOR DE CINCO MICRONES Y EL MODO DE ADMINISTRACION SE PUEDEN UTILIZAR PARA MARCAR LAS MICROPARTICULAS A LAS CELULAS DEL SISTEMA RETICULOENDOTELIAL, O A LAS MEMBRANAS MUCOSAS DE LA BOCA O TRACTO GASTROINTESTINAL. TAMBIEN SE PUEDEN UTILIZAR GRANDES IMPLANTES FORMADOS DE LAS MICROESFERAS, ESPECIALMENTE PARA APLICACIONES AGRICOLAS.
ES90917274T 1989-11-06 1990-11-06 Metodo para producir microesferas proteicas. Expired - Lifetime ES2084712T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43278589A 1989-11-06 1989-11-06
US55755190A 1990-07-24 1990-07-24

Publications (1)

Publication Number Publication Date
ES2084712T3 true ES2084712T3 (es) 1996-05-16

Family

ID=27029628

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917274T Expired - Lifetime ES2084712T3 (es) 1989-11-06 1990-11-06 Metodo para producir microesferas proteicas.

Country Status (9)

Country Link
EP (1) EP0499619B1 (es)
JP (2) JPH04506931A (es)
AT (1) ATE133856T1 (es)
AU (1) AU634606B2 (es)
CA (1) CA2071840C (es)
DE (1) DE69025334T2 (es)
ES (1) ES2084712T3 (es)
GR (1) GR3018939T3 (es)
WO (1) WO1991006286A1 (es)

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US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
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Also Published As

Publication number Publication date
AU634606B2 (en) 1993-02-25
CA2071840C (en) 1997-02-04
DE69025334D1 (de) 1996-03-21
DE69025334T2 (de) 1996-08-01
JP2711231B2 (ja) 1998-02-10
EP0499619B1 (en) 1996-02-07
EP0499619A1 (en) 1992-08-26
GR3018939T3 (en) 1996-05-31
ATE133856T1 (de) 1996-02-15
JPH04506931A (ja) 1992-12-03
CA2071840A1 (en) 1991-05-07
WO1991006286A1 (en) 1991-05-16
AU6756290A (en) 1991-05-31
JPH0853369A (ja) 1996-02-27

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