ATE462413T1 - Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln - Google Patents

Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln

Info

Publication number
ATE462413T1
ATE462413T1 AT01902059T AT01902059T ATE462413T1 AT E462413 T1 ATE462413 T1 AT E462413T1 AT 01902059 T AT01902059 T AT 01902059T AT 01902059 T AT01902059 T AT 01902059T AT E462413 T1 ATE462413 T1 AT E462413T1
Authority
AT
Austria
Prior art keywords
agent
particles
mixture
drug
macromolecular
Prior art date
Application number
AT01902059T
Other languages
English (en)
Inventor
Edith Mathiowitz
Yong Jong
Jules Jacob
Original Assignee
Univ Brown Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown Res Found filed Critical Univ Brown Res Found
Application granted granted Critical
Publication of ATE462413T1 publication Critical patent/ATE462413T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
AT01902059T 2000-01-14 2001-01-12 Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln ATE462413T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17619300P 2000-01-14 2000-01-14
PCT/US2001/001183 WO2001051032A2 (en) 2000-01-14 2001-01-12 Micronized freeze-dried particles

Publications (1)

Publication Number Publication Date
ATE462413T1 true ATE462413T1 (de) 2010-04-15

Family

ID=22643372

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01902059T ATE462413T1 (de) 2000-01-14 2001-01-12 Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln

Country Status (7)

Country Link
EP (1) EP1246609B1 (de)
JP (1) JP2003519651A (de)
AT (1) ATE462413T1 (de)
AU (1) AU773735B2 (de)
CA (1) CA2397404C (de)
DE (1) DE60141680D1 (de)
WO (1) WO2001051032A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809309B1 (fr) * 2000-05-23 2004-06-11 Mainelab Microspheres a liberation prolongee pour administration injectable
CA2456806C (en) 2001-08-08 2011-10-18 Brown University Research Foundation Methods for micronization of hydrophobic drugs
WO2003049701A2 (en) * 2001-12-10 2003-06-19 Spherics, Inc. Methods and products useful in the formation and isolation of microparticles
AU2003221497A1 (en) * 2002-03-13 2003-09-22 Novartis Ag Pharmaceutical microparticles
SI21222A (sl) * 2002-05-28 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo nanodelcev
US7670627B2 (en) * 2002-12-09 2010-03-02 Salvona Ip Llc pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients
JP2006199589A (ja) * 2003-09-03 2006-08-03 Ltt Bio-Pharma Co Ltd 生理活性タンパク質またはペプチドを含有するナノ粒子およびその製造方法、ならびに当該ナノ粒子からなる外用剤
AU2004298719B8 (en) 2003-12-19 2011-04-07 Alk-Abello A/S Cryogranulation and storage method for active pharmaceutical agents
DE602004032262D1 (de) * 2003-12-19 2011-05-26 Alk Abello As Verfahren zur kryogranulierung und lagerung von allergenen
CA2596011C (en) * 2005-02-17 2013-05-14 Medivas, Llc Polymer particle delivery compositions and methods of use
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP2026771B1 (de) * 2006-01-23 2009-10-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Mikrokügelchen mit nanokapseln, die ein lipophiles arzneimittel enthalten
US10722468B2 (en) 2014-08-14 2020-07-28 Brown University Compositions for stabilizing and delivering proteins
CN108379243A (zh) * 2018-03-22 2018-08-10 福州大学 一种载基因多孔磁性微球的制备方法
CN115005320B (zh) * 2022-05-07 2023-09-05 中国农业大学 一种具有长效饱腹感的酪蛋白粉的制备方法及所得产物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225162B1 (de) * 1985-11-27 1992-01-22 Ethicon, Inc. Hemmung der postoperativen Adhäsionsbildung durch topische Verabreichung eines entzündungshemmenden nichtsteroiden Wirkstoffs
ATE76311T1 (de) * 1986-08-19 1992-06-15 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen.
WO1997003702A1 (en) * 1995-07-21 1997-02-06 Brown University Research Foundation A method for gene therapy using nucleic acid loaded polymeric microparticles
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6190702B1 (en) * 1996-03-28 2001-02-20 Takeda Chemical Industries, Ltd. Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase
ATE252375T1 (de) * 1997-04-17 2003-11-15 Amgen Inc Bioabbaubare mikropartikeln mit verzögerter wirkstofffreisetzung
JP3918248B2 (ja) * 1997-09-26 2007-05-23 ソニー株式会社 固体撮像素子およびその駆動方法

Also Published As

Publication number Publication date
AU2790201A (en) 2001-07-24
DE60141680D1 (de) 2010-05-12
CA2397404C (en) 2008-12-02
CA2397404A1 (en) 2001-07-19
WO2001051032A2 (en) 2001-07-19
EP1246609B1 (de) 2010-03-31
WO2001051032A3 (en) 2002-03-28
AU773735B2 (en) 2004-06-03
EP1246609A2 (de) 2002-10-09
JP2003519651A (ja) 2003-06-24

Similar Documents

Publication Publication Date Title
ATE462413T1 (de) Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln
CN1232411A (zh) 用超临界流体进行微囊包封的方法
Rill et al. Properties of nuclease-resistant fragments of calf thymus chromatin
EP0625069B1 (de) Verfahren zur herstellung von mikrokapseln
DE69220317T2 (de) Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
ES2084712T3 (es) Metodo para producir microesferas proteicas.
Kim et al. Microencapsulation of dissociable human growth hormone aggregates within poly (D, L-lactic-co-glycolic acid) microparticles for sustained release
DE502006005846D1 (de) Verfahren zur schonenden herstellung hochfeiner partikelsuspensionen und hochfeiner partikel sowie deren verwendung
NO20000913L (no) Sfæriske mikropartikler inneholdende lineære polysakkarider
JP5373618B2 (ja) 微粒化方法
ES8501978A1 (es) Un procedimiento para preparar un agente anti-inflamatorio
ATE204469T1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln
KR920003962A (ko) 서방형 제제 및 그의 제조 방법
PT1158962E (pt) Processo para a preparacao de formas de dosagem solidas que contem ciclodextrina
JPH09504026A (ja) 流動床乾燥工程を含んでなるミクロスフェアの製造方法
RU2000113730A (ru) Гранулы на полиэтиленгликолевой матрице для жирных, маслянистых или клейких лекарственных веществ
DE60030999D1 (de) Verfahren zur herstellung von teilchen
JP2017522394A5 (de)
IE58245B1 (en) Micro-encapsulation of medicaments
CY1113221T1 (el) Διεργασια για την παρασκευη ενος φαρμακου
US6482518B1 (en) Excipient for the lyophilization of aqueous suspensions of microparticles
CN101485904A (zh) 含载药可注射硫酸钙基缓释植入组份及应用
JP2017520593A (ja) 微小インスリン、微小インスリン類似体及びそれらの製造方法
Symecko et al. Binder functionality in tabletted systems
NZ201494A (en) Microencapsulation of an aqueous amine solution

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties