CY1113221T1 - Διεργασια για την παρασκευη ενος φαρμακου - Google Patents

Διεργασια για την παρασκευη ενος φαρμακου

Info

Publication number
CY1113221T1
CY1113221T1 CY20111100440T CY111100440T CY1113221T1 CY 1113221 T1 CY1113221 T1 CY 1113221T1 CY 20111100440 T CY20111100440 T CY 20111100440T CY 111100440 T CY111100440 T CY 111100440T CY 1113221 T1 CY1113221 T1 CY 1113221T1
Authority
CY
Cyprus
Prior art keywords
agglomerate
active ingredient
primary particles
preparing
carrier
Prior art date
Application number
CY20111100440T
Other languages
English (en)
Inventor
Zeng Xian-Ming
Kee Tee Sean
Original Assignee
Norton Healthcare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113221(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Norton Healthcare Limited filed Critical Norton Healthcare Limited
Publication of CY1113221T1 publication Critical patent/CY1113221T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μια διεργασία για την παρασκευή ενός σωματιδιακού φαρμάκου που έχει μεγαλύτερη ομοιογένεια και χαμηλότερη πρόσφυση μεταξύ των σωματιδίων του ενεργού συστατικού και του φορέα. Η διεργασία περιλαμβάνει τα στάδια: (a) συνδυασμού ενός φαρμακευτικώς ενεργού συστατικού με τη μορφή ενός συσσωματώματος πρωτογενών σωματιδίων που έχουν ένα μέγεθος σωματιδίων συσσωματώματος τέτοιο ώστε το συσσωμάτωμα να είναι ικανό διέλευσης μέσω ενός κοσκινού που έχει οπή 50-3.000 μm με έναν φαρμακευτικώς αποδεκτό σωματιδιακό φορέα, και (b) ανάμιξης του προκύπτοντος υλικού σε έναν αναμικτήρα προς διάσπαση του συσσωματώματος σε πρωτογενή σωματίδια διεσπαρμένα στο φαρμακευτικώς αποδεκτό σωματιδιακό φορέα έτσι ώστε 90% ή περισσότερο από το φαρμακευτικώς ενεργό συστατικό να υπάρχει ως πρωτογενή σωματίδια που έχουν ένα μέγεθος σωματιδίων 50 μm ή λιγότερο.
CY20111100440T 2003-09-02 2011-05-06 Διεργασια για την παρασκευη ενος φαρμακου CY1113221T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49958203P 2003-09-02 2003-09-02
EP04782768A EP1699434B1 (en) 2003-09-02 2004-09-01 Process for preparing a medicament

Publications (1)

Publication Number Publication Date
CY1113221T1 true CY1113221T1 (el) 2016-04-13

Family

ID=34272843

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100440T CY1113221T1 (el) 2003-09-02 2011-05-06 Διεργασια για την παρασκευη ενος φαρμακου

Country Status (12)

Country Link
US (3) US9345664B2 (el)
EP (1) EP1699434B1 (el)
AT (1) ATE498394T1 (el)
CA (1) CA2575957C (el)
CY (1) CY1113221T1 (el)
DE (1) DE602004031459D1 (el)
DK (1) DK1699434T3 (el)
ES (1) ES2362038T3 (el)
PL (1) PL1699434T3 (el)
PT (1) PT1699434E (el)
SI (1) SI1699434T1 (el)
WO (1) WO2005020963A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001903A (es) * 2002-08-21 2005-04-28 Norton Healthcare Ltd Composicion para inhalacion.
GB0219511D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
GB0327723D0 (en) 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
JP2007510723A (ja) * 2003-11-03 2007-04-26 ノートン　ヘルスケアー　リミテッド ドライパウダー吸入器で使用するためのソフトステロイド組成物
CA2597942A1 (en) * 2005-02-16 2006-08-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions comprising anticholinergics and etiprednol

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957965A (en) * 1967-08-08 1976-05-18 Fisons Limited Sodium chromoglycate inhalation medicament
GB1242211A (en) 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
GB1569611A (en) 1976-01-23 1980-06-18 Fisons Ltd Pelletised or granular medicament formulation
US4161516A (en) 1975-07-25 1979-07-17 Fisons Limited Composition for treating airway disease
GB9027234D0 (en) 1990-12-15 1991-02-06 Harris Pharma Ltd An inhalation device
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
IS1736B (is) 1993-10-01 1999-12-30 Astra Ab Aðferð og tæki sem stuðla að aukinni samloðun agna
SE9400335D0 (sv) 1994-02-02 1994-02-02 Astra Ab Powder mixing
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
ATE247948T1 (de) * 1996-04-29 2003-09-15 Dura Pharma Inc Verfahren zum inhalieren trockener pulver
SE9700135D0 (sv) 1997-01-20 1997-01-20 Astra Ab New formulation
DE10043509A1 (de) * 2000-09-01 2002-03-14 Asta Medica Ag Feste Peptidzubereitungen für die Inhalation und deren Herstellung
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
DE10141376A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
WO2003024396A2 (en) * 2001-09-17 2003-03-27 Glaxo Group Limited Dry powder medicament formulations
GB0219512D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Inhalation compositions with high drug ratios
MXPA05001903A (es) 2002-08-21 2005-04-28 Norton Healthcare Ltd Composicion para inhalacion.
US20050158248A1 (en) 2002-08-21 2005-07-21 Xian-Ming Zeng Method of preparing dry powder inhalation compositions

Also Published As

Publication number Publication date
EP1699434A1 (en) 2006-09-13
US20080131518A1 (en) 2008-06-05
EP1699434B1 (en) 2011-02-16
ES2362038T3 (es) 2011-06-27
US9616024B2 (en) 2017-04-11
US9987229B2 (en) 2018-06-05
US20170172925A1 (en) 2017-06-22
CA2575957A1 (en) 2005-03-10
US9345664B2 (en) 2016-05-24
US20160235678A1 (en) 2016-08-18
PL1699434T3 (pl) 2011-09-30
ATE498394T1 (de) 2011-03-15
SI1699434T1 (sl) 2011-06-30
CA2575957C (en) 2010-11-30
DE602004031459D1 (de) 2011-03-31
EP1699434A4 (en) 2009-04-29
WO2005020963A1 (en) 2005-03-10
DK1699434T3 (da) 2011-05-30
PT1699434E (pt) 2011-05-03

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