CY1113221T1 - Διεργασια για την παρασκευη ενος φαρμακου - Google Patents
Διεργασια για την παρασκευη ενος φαρμακουInfo
- Publication number
- CY1113221T1 CY1113221T1 CY20111100440T CY111100440T CY1113221T1 CY 1113221 T1 CY1113221 T1 CY 1113221T1 CY 20111100440 T CY20111100440 T CY 20111100440T CY 111100440 T CY111100440 T CY 111100440T CY 1113221 T1 CY1113221 T1 CY 1113221T1
- Authority
- CY
- Cyprus
- Prior art keywords
- agglomerate
- active ingredient
- primary particles
- preparing
- carrier
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει μια διεργασία για την παρασκευή ενός σωματιδιακού φαρμάκου που έχει μεγαλύτερη ομοιογένεια και χαμηλότερη πρόσφυση μεταξύ των σωματιδίων του ενεργού συστατικού και του φορέα. Η διεργασία περιλαμβάνει τα στάδια: (a) συνδυασμού ενός φαρμακευτικώς ενεργού συστατικού με τη μορφή ενός συσσωματώματος πρωτογενών σωματιδίων που έχουν ένα μέγεθος σωματιδίων συσσωματώματος τέτοιο ώστε το συσσωμάτωμα να είναι ικανό διέλευσης μέσω ενός κοσκινού που έχει οπή 50-3.000 μm με έναν φαρμακευτικώς αποδεκτό σωματιδιακό φορέα, και (b) ανάμιξης του προκύπτοντος υλικού σε έναν αναμικτήρα προς διάσπαση του συσσωματώματος σε πρωτογενή σωματίδια διεσπαρμένα στο φαρμακευτικώς αποδεκτό σωματιδιακό φορέα έτσι ώστε 90% ή περισσότερο από το φαρμακευτικώς ενεργό συστατικό να υπάρχει ως πρωτογενή σωματίδια που έχουν ένα μέγεθος σωματιδίων 50 μm ή λιγότερο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49958203P | 2003-09-02 | 2003-09-02 | |
EP04782768A EP1699434B1 (en) | 2003-09-02 | 2004-09-01 | Process for preparing a medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113221T1 true CY1113221T1 (el) | 2016-04-13 |
Family
ID=34272843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100440T CY1113221T1 (el) | 2003-09-02 | 2011-05-06 | Διεργασια για την παρασκευη ενος φαρμακου |
Country Status (12)
Country | Link |
---|---|
US (3) | US9345664B2 (el) |
EP (1) | EP1699434B1 (el) |
AT (1) | ATE498394T1 (el) |
CA (1) | CA2575957C (el) |
CY (1) | CY1113221T1 (el) |
DE (1) | DE602004031459D1 (el) |
DK (1) | DK1699434T3 (el) |
ES (1) | ES2362038T3 (el) |
PL (1) | PL1699434T3 (el) |
PT (1) | PT1699434E (el) |
SI (1) | SI1699434T1 (el) |
WO (1) | WO2005020963A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101369631B1 (ko) * | 2002-08-21 | 2014-03-05 | 노턴 헬스케어 리미티드 | 흡입용 조성물 |
GB0219511D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
AU2004285592B2 (en) * | 2003-11-03 | 2010-02-18 | Norton Healthcare, Ltd. | Soft steroid compositions for use in dry powder inhalers |
WO2006087316A1 (en) * | 2005-02-16 | 2006-08-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions comprising anticholinergics and etiprednol |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3957965A (en) | 1967-08-08 | 1976-05-18 | Fisons Limited | Sodium chromoglycate inhalation medicament |
GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
GB1569611A (en) | 1976-01-23 | 1980-06-18 | Fisons Ltd | Pelletised or granular medicament formulation |
US4161516A (en) | 1975-07-25 | 1979-07-17 | Fisons Limited | Composition for treating airway disease |
GB9027234D0 (en) | 1990-12-15 | 1991-02-06 | Harris Pharma Ltd | An inhalation device |
IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
TW402506B (en) * | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
IS1736B (is) | 1993-10-01 | 1999-12-30 | Astra Ab | Aðferð og tæki sem stuðla að aukinni samloðun agna |
SE9400335D0 (sv) | 1994-02-02 | 1994-02-02 | Astra Ab | Powder mixing |
AR002009A1 (es) * | 1994-12-22 | 1998-01-07 | Astra Ab | Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco. |
NZ332669A (en) * | 1996-04-29 | 1999-02-25 | Dura Pharma Inc | A dry power inhalation system which is flow rate independent |
SE9700135D0 (sv) | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
DE10043509A1 (de) * | 2000-09-01 | 2002-03-14 | Asta Medica Ag | Feste Peptidzubereitungen für die Inhalation und deren Herstellung |
UA75375C2 (en) | 2000-10-12 | 2006-04-17 | Boehringer Ingelheim Pharma | Method for producing powdery preparations for inhaling |
DE10141376A1 (de) | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Inhalationspulvern |
AU2002333644A1 (en) * | 2001-09-17 | 2003-04-01 | Glaxo Group Limited | Dry powder medicament formulations |
US20050158248A1 (en) | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
GB0219512D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions with high drug ratios |
KR101369631B1 (ko) | 2002-08-21 | 2014-03-05 | 노턴 헬스케어 리미티드 | 흡입용 조성물 |
-
2004
- 2004-09-01 DE DE602004031459T patent/DE602004031459D1/de active Active
- 2004-09-01 US US10/594,473 patent/US9345664B2/en active Active
- 2004-09-01 SI SI200431668T patent/SI1699434T1/sl unknown
- 2004-09-01 PL PL04782768T patent/PL1699434T3/pl unknown
- 2004-09-01 EP EP04782768A patent/EP1699434B1/en not_active Revoked
- 2004-09-01 ES ES04782768T patent/ES2362038T3/es active Active
- 2004-09-01 WO PCT/US2004/028345 patent/WO2005020963A1/en active Application Filing
- 2004-09-01 AT AT04782768T patent/ATE498394T1/de active
- 2004-09-01 PT PT04782768T patent/PT1699434E/pt unknown
- 2004-09-01 DK DK04782768.8T patent/DK1699434T3/da active
- 2004-09-01 CA CA2575957A patent/CA2575957C/en not_active Expired - Fee Related
-
2011
- 2011-05-06 CY CY20111100440T patent/CY1113221T1/el unknown
-
2016
- 2016-04-25 US US15/137,671 patent/US9616024B2/en active Active
-
2017
- 2017-03-09 US US15/453,940 patent/US9987229B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2575957A1 (en) | 2005-03-10 |
PT1699434E (pt) | 2011-05-03 |
PL1699434T3 (pl) | 2011-09-30 |
US20160235678A1 (en) | 2016-08-18 |
EP1699434A1 (en) | 2006-09-13 |
US9616024B2 (en) | 2017-04-11 |
ATE498394T1 (de) | 2011-03-15 |
CA2575957C (en) | 2010-11-30 |
EP1699434B1 (en) | 2011-02-16 |
WO2005020963A1 (en) | 2005-03-10 |
DK1699434T3 (da) | 2011-05-30 |
US9987229B2 (en) | 2018-06-05 |
SI1699434T1 (sl) | 2011-06-30 |
US9345664B2 (en) | 2016-05-24 |
US20080131518A1 (en) | 2008-06-05 |
US20170172925A1 (en) | 2017-06-22 |
EP1699434A4 (en) | 2009-04-29 |
DE602004031459D1 (de) | 2011-03-31 |
ES2362038T3 (es) | 2011-06-27 |
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