ES2150908T3 - Preparacion de agentes diagnosticos. - Google Patents
Preparacion de agentes diagnosticos.Info
- Publication number
- ES2150908T3 ES2150908T3 ES92303236T ES92303236T ES2150908T3 ES 2150908 T3 ES2150908 T3 ES 2150908T3 ES 92303236 T ES92303236 T ES 92303236T ES 92303236 T ES92303236 T ES 92303236T ES 2150908 T3 ES2150908 T3 ES 2150908T3
- Authority
- ES
- Spain
- Prior art keywords
- microcapsules
- wall
- preparation
- forming material
- diagnostic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 239000003094 microcapsule Substances 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
- Y10S516/928—Mixing combined with non-mixing operation or step, successively or simultaneously, e.g. heating, cooling, ph change, ageing, milling
Abstract
Un proceso de formación de un polvo esterilizado compuesto de microcápsulas huecas que son suspensibles en un medio inyectable parenteralmente para formar una suspensión apropiada para imágenes ultrasónicas cuando se administra en vía intravenosa, comprendiendo dicho proceso: (a) producción de una solución o dispersión de material formador de membrana en un líquido; (b) atomización de dicha solución o dispersión en un gas calentado de modo que dicho líquido se evapora formando así microcápsulas huecas de dicho material formador de membrana; (c) calentamiento de dichas microcápsulas para reducir la solubilidad en agua de dicho material formador de membrana obteniéndose así dichas microcápsulas como un polvo; y (d) haciendo dicho polvo esterilizado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919107628A GB9107628D0 (en) | 1991-04-10 | 1991-04-10 | Preparation of diagnostic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2150908T3 true ES2150908T3 (es) | 2000-12-16 |
Family
ID=10693031
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99203198T Expired - Lifetime ES2242355T3 (es) | 1991-04-10 | 1992-04-10 | Preparacion de agentes de diagnostico. |
ES92303236T Expired - Lifetime ES2150908T3 (es) | 1991-04-10 | 1992-04-10 | Preparacion de agentes diagnosticos. |
ES95110723T Expired - Lifetime ES2203626T3 (es) | 1991-04-10 | 1992-04-10 | Preparacion de agentes de diagnostico. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99203198T Expired - Lifetime ES2242355T3 (es) | 1991-04-10 | 1992-04-10 | Preparacion de agentes de diagnostico. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95110723T Expired - Lifetime ES2203626T3 (es) | 1991-04-10 | 1992-04-10 | Preparacion de agentes de diagnostico. |
Country Status (24)
Country | Link |
---|---|
US (3) | US5518709A (es) |
EP (6) | EP0972526B1 (es) |
JP (2) | JP2865866B2 (es) |
KR (1) | KR0129861B1 (es) |
CN (1) | CN1066977A (es) |
AT (3) | ATE246519T1 (es) |
AU (2) | AU655016B2 (es) |
CA (1) | CA2083260A1 (es) |
DE (3) | DE69233148T2 (es) |
DK (3) | DK0681843T3 (es) |
ES (3) | ES2242355T3 (es) |
FI (1) | FI925600A (es) |
GB (2) | GB9107628D0 (es) |
GR (1) | GR3034462T3 (es) |
HK (1) | HK1006538A1 (es) |
HU (1) | HUT62805A (es) |
IE (1) | IE921140A1 (es) |
IL (2) | IL101564A (es) |
MX (1) | MX9201694A (es) |
NZ (1) | NZ242328A (es) |
PT (2) | PT681843E (es) |
RU (1) | RU2109521C1 (es) |
WO (1) | WO1992018164A1 (es) |
ZA (1) | ZA922636B (es) |
Families Citing this family (188)
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US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
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US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
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US6428844B1 (en) * | 1993-02-03 | 2002-08-06 | Rohm And Haas Company | Reduction of microfoam in a spray-applied waterborne composition |
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- 1992-04-10 NZ NZ242328A patent/NZ242328A/en not_active IP Right Cessation
- 1992-04-10 MX MX9201694A patent/MX9201694A/es unknown
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- 1992-04-10 CN CN92103376A patent/CN1066977A/zh active Pending
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1994
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