IL100810A - Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods - Google Patents

Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Info

Publication number
IL100810A
IL100810A IL10081092A IL10081092A IL100810A IL 100810 A IL100810 A IL 100810A IL 10081092 A IL10081092 A IL 10081092A IL 10081092 A IL10081092 A IL 10081092A IL 100810 A IL100810 A IL 100810A
Authority
IL
Israel
Prior art keywords
thp
tetrahydropyrimidine
dna
carboxy
act
Prior art date
Application number
IL10081092A
Other languages
English (en)
Hebrew (he)
Other versions
IL100810A0 (en
Inventor
Aviva Lapidot
Livia Inbar
Yosef Aloni
Edna Ben-Asher
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL10081092A priority Critical patent/IL100810A/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of IL100810A0 publication Critical patent/IL100810A0/xx
Priority to US08/011,668 priority patent/US5789414A/en
Priority to AU32139/93A priority patent/AU3213993A/en
Priority to ZA93652A priority patent/ZA93652B/xx
Priority to HU9300251A priority patent/HUT67711A/hu
Priority to NZ245797A priority patent/NZ245797A/en
Priority to CA002088390A priority patent/CA2088390A1/en
Priority to CN93102524A priority patent/CN1080172A/zh
Priority to AT93101515T priority patent/ATE169339T1/de
Priority to JP5051221A priority patent/JPH0717864A/ja
Priority to EP93101515A priority patent/EP0553884B1/de
Priority to DE69320075T priority patent/DE69320075T2/de
Priority to EP97122337A priority patent/EP0845539A1/de
Publication of IL100810A publication Critical patent/IL100810A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL10081092A 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods IL100810A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IL10081092A IL100810A (en) 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods
US08/011,668 US5789414A (en) 1992-01-30 1993-01-28 Pharmaceutical compositions comprising tetrahydropyrimidine derivates
AU32139/93A AU3213993A (en) 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them
ZA93652A ZA93652B (en) 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them.
HU9300251A HUT67711A (en) 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions comprising them
NZ245797A NZ245797A (en) 1992-01-30 1993-01-29 Substantially pure 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine and/or the 5-hydroxy derivative; analogues, pharmaceutical compositions, and isolation thereof from streptomyces culture
CA002088390A CA2088390A1 (en) 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them
CN93102524A CN1080172A (zh) 1992-01-30 1993-01-30 纯化的四氢嘧啶衍生物及包含它们的药用组合物
EP97122337A EP0845539A1 (de) 1992-01-30 1993-02-01 Isolierung und Reinigung von Tetrahydropyrimidinderivaten
AT93101515T ATE169339T1 (de) 1992-01-30 1993-02-01 Mindestens ein tetrahydropyrimidinderivat (thp(a) oder thp(b)) enthaltende pharmazeutische zusammensetzungen
JP5051221A JPH0717864A (ja) 1992-01-30 1993-02-01 精製テトラヒドロピリミジン誘導体
EP93101515A EP0553884B1 (de) 1992-01-30 1993-02-01 Mindestens ein Tetrahydropyrimidinderivat (THP(A) oder THP(B)) enthaltende pharmazeutische Zusammensetzungen
DE69320075T DE69320075T2 (de) 1992-01-30 1993-02-01 Mindestens ein Tetrahydropyrimidinderivat (THP(A) oder THP(B)) enthaltende pharmazeutische Zusammensetzungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10081092A IL100810A (en) 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Publications (2)

Publication Number Publication Date
IL100810A0 IL100810A0 (en) 1992-09-06
IL100810A true IL100810A (en) 1996-12-05

Family

ID=11063323

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10081092A IL100810A (en) 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Country Status (12)

Country Link
US (1) US5789414A (de)
EP (2) EP0553884B1 (de)
JP (1) JPH0717864A (de)
CN (1) CN1080172A (de)
AT (1) ATE169339T1 (de)
AU (1) AU3213993A (de)
CA (1) CA2088390A1 (de)
DE (1) DE69320075T2 (de)
HU (1) HUT67711A (de)
IL (1) IL100810A (de)
NZ (1) NZ245797A (de)
ZA (1) ZA93652B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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DE4244580A1 (de) * 1992-12-31 1994-07-07 Galinski Erwin A Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen
DE4342560A1 (de) * 1993-12-14 1995-06-22 Marbert Gmbh Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
DE19711082A1 (de) * 1997-03-18 1998-09-24 Degussa Verfahren zur Abtrennung von Tetrahydropyrimidinen aus wäßrigen Lösungen
IL123256A0 (en) * 1998-02-10 1998-09-24 Yeda Res & Dev Methods for dna amplification and sequencing
DE19821378A1 (de) * 1998-05-13 1999-11-18 Degussa Verfahren zur Auftrennung von Tetrahydropyrimidinderivaten
US20030157040A1 (en) * 1998-08-01 2003-08-21 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
DE19834816A1 (de) * 1998-08-01 2000-02-03 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen
US20040047828A1 (en) * 1998-08-01 2004-03-11 Merck Patent Gmbh Ectoin or ection derivatives and surfactants
ES2204640T3 (es) * 1999-06-12 2004-05-01 Bitop Aktiengesellschaft Fur Biotechnische Optimierung Preparado farmaceutico con contenido en proteinas.
DE19957470A1 (de) * 1999-11-24 2001-06-21 Actinodrug Pharmaceuticals Gmb Tetrahydropyrimidin-Dioxygenase-Gen sowie Verfahren zur enzymatischen in vivo und in vitro Produktion von hydroxylierten Tetrahydropyrimidinen
DE10002725A1 (de) * 2000-01-11 2001-07-12 Beiersdorf Ag Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening)
DE10043456A1 (de) * 2000-09-04 2002-03-14 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten zur Stabilisierung von p53
US7048910B2 (en) * 2000-09-07 2006-05-23 Merck Patent Gmbh Use of ectoine or ectoine derivatives for oral care
DE10047444A1 (de) * 2000-09-21 2002-04-11 Bitop Gmbh Verfahren zur Trennung und hochreinen Isolierung von niedermolekularen, strukturell ähnlichen Verbindungen insbesondere von Tetrahydropyrimidinderivaten wie z.B. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsäuren (Ectoine) und deren Spaltprodukte
DE10214257A1 (de) * 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
EP3167961A1 (de) * 2004-04-08 2017-05-17 Biomatrica, Inc. Integration von probenlagerung und probenverwaltung für biowissenschaften
JP2008537734A (ja) * 2005-03-12 2008-09-25 ビトップ アクツィエンゲゼルシャフト フュール ビオテヒニシェ オプティミールング 経口で用いられる適合溶質を含む薬剤
FR2896990B1 (fr) * 2006-02-03 2008-05-02 Lvmh Rech Composition protectrice et regenerante
DE102007052380A1 (de) * 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
EP2303847B1 (de) * 2008-07-16 2018-09-05 Bitop AG Synthese von zyklischen amidinen
DE102008039231A1 (de) 2008-08-22 2010-02-25 Bitop Ag Verwendung von Glucosylglycerol
EP2168570B1 (de) 2008-09-30 2013-12-25 Symrise AG Extrakte von Isochrysis sp.
EP2193785B1 (de) 2008-12-05 2018-07-18 Symrise AG Extrakte von Tetraselmis sp. für kosmetische und therapeutische Zwecke
US8519125B2 (en) * 2009-05-11 2013-08-27 Biomatrica, Inc. Compositions and methods for biological sample storage
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
EP2598660B1 (de) 2010-07-26 2017-03-15 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in blut- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CN102240298B (zh) * 2011-04-29 2012-07-04 济南环肽医药科技有限公司 一种抗肿瘤的药物组合物
CN102258526B (zh) * 2011-04-29 2012-10-31 山东大学 一种抗肿瘤药物组合物
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
CN102210868A (zh) * 2011-04-29 2011-10-12 济南环肽医药科技有限公司 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用
CN102617707B (zh) * 2011-09-19 2014-01-29 江苏师范大学 放线菌素d新同系物2-甲基-放线菌素d的制备方法
EP3249054A1 (de) 2012-12-20 2017-11-29 Biomatrica, INC. Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
ES2701758T3 (es) 2013-02-27 2019-02-25 Symrise Ag Extracto de jengibre para la protección de citoblastos
EP2862852B1 (de) 2013-10-18 2018-07-04 Symrise AG Harnstoffderivate für den Schutz von Stammzellen
ES2643590T3 (es) 2014-03-18 2017-11-23 Symrise Ag Dióxido de titanio revestido para reducir el efecto de blanqueamiento en la piel
ES2819207T3 (es) 2014-04-29 2021-04-15 Symrise Ag Mezclas activas
EP3154338B1 (de) 2014-06-10 2020-01-29 Biomatrica, INC. Stabilisierung von thrombozyten bei umgebungstemperatur
EP3045161A1 (de) 2015-01-18 2016-07-20 Symrise AG Aktive Zusammensetzung enthaltend 1,2-Hexandiol und 1,2-Octandiol
WO2017100212A1 (en) 2015-12-08 2017-06-15 Biomatrica, Inc. Reduction of erythrocyte sedimentation rate
CN105669560B (zh) * 2016-01-12 2019-02-19 天津科技大学 一种从发酵液中分离提取四氢嘧啶的方法
CN106361764A (zh) * 2016-08-29 2017-02-01 沂水县人民医院 一种肝癌手术切口用冲洗液
CN109053587A (zh) * 2018-08-31 2018-12-21 山东福田药业有限公司 一种从嗜盐微生物发酵液中分离提取四氢嘧啶的方法
CN110982843B (zh) * 2019-10-31 2021-12-28 温州大学 四氢嘧啶用于调节dna凝聚强弱的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

Also Published As

Publication number Publication date
AU3213993A (en) 1993-08-05
ZA93652B (en) 1993-09-02
CN1080172A (zh) 1994-01-05
CA2088390A1 (en) 1993-07-31
EP0845539A1 (de) 1998-06-03
HUT67711A (en) 1995-04-28
NZ245797A (en) 1995-07-26
DE69320075D1 (de) 1998-09-10
DE69320075T2 (de) 1999-04-22
EP0553884A1 (de) 1993-08-04
ATE169339T1 (de) 1998-08-15
EP0553884B1 (de) 1998-08-05
HU9300251D0 (en) 1993-04-28
JPH0717864A (ja) 1995-01-20
US5789414A (en) 1998-08-04
IL100810A0 (en) 1992-09-06

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