ZA93652B - Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them. - Google Patents
Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them.Info
- Publication number
- ZA93652B ZA93652B ZA93652A ZA93652A ZA93652B ZA 93652 B ZA93652 B ZA 93652B ZA 93652 A ZA93652 A ZA 93652A ZA 93652 A ZA93652 A ZA 93652A ZA 93652 B ZA93652 B ZA 93652B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- tetrahydropyrimidine derivatives
- tetrahydropyrimidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The present invention relates to purified tetrahydropyrimidine derivatives and to pharmaceutical compositions comprising them. The tetrahydropyrimidine derivatives are useful for DNA protection from damaging by DNA-binding drugs, chemical carcinogens and mutagens and from irradiation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10081092A IL100810A (en) | 1992-01-30 | 1992-01-30 | Pharmaceutical compositions comprising 2-methyl-4-carboxy-5-hydroxy-tetrahydropyrimidine and/or 2-methyl-4-carboxy-tetrahydropyrimidine methods for the isolation and purification of said compounds and substantially pure 2-methyl-4-carboxy-5-hydroxy-3, 4, 5, 6-tetrahydropyrimidine salts 5-ethers and 5-esters thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA93652B true ZA93652B (en) | 1993-09-02 |
Family
ID=11063323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA93652A ZA93652B (en) | 1992-01-30 | 1993-01-29 | Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5789414A (en) |
EP (2) | EP0553884B1 (en) |
JP (1) | JPH0717864A (en) |
CN (1) | CN1080172A (en) |
AT (1) | ATE169339T1 (en) |
AU (1) | AU3213993A (en) |
CA (1) | CA2088390A1 (en) |
DE (1) | DE69320075T2 (en) |
HU (1) | HUT67711A (en) |
IL (1) | IL100810A (en) |
NZ (1) | NZ245797A (en) |
ZA (1) | ZA93652B (en) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4244580A1 (en) * | 1992-12-31 | 1994-07-07 | Galinski Erwin A | Process for the in vivo extraction of ingredients from cells |
DE4342560A1 (en) * | 1993-12-14 | 1995-06-22 | Marbert Gmbh | Use of 1,4,5,6-tetra:hydro-4-pyrimidine carboxylic acid derivs. in cosmetics |
DE19711082A1 (en) * | 1997-03-18 | 1998-09-24 | Degussa | Process for the separation of tetrahydropyrimidines from aqueous solutions |
IL123256A0 (en) | 1998-02-10 | 1998-09-24 | Yeda Res & Dev | Methods for dna amplification and sequencing |
DE19821378A1 (en) * | 1998-05-13 | 1999-11-18 | Degussa | Process for the separation of tetrahydropyrimidine derivatives |
DE19834816A1 (en) * | 1998-08-01 | 2000-02-03 | Merck Patent Gmbh | Use of ectoin or ectoin derivatives in cosmetic formulations |
US20030157040A1 (en) * | 1998-08-01 | 2003-08-21 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives in cosmetic formulations |
US20040047828A1 (en) * | 1998-08-01 | 2004-03-11 | Merck Patent Gmbh | Ectoin or ection derivatives and surfactants |
EP1183047B1 (en) * | 1999-06-12 | 2003-08-27 | bitop Aktiengesellschaft für biotechnische Optimierung | Pharmaceutical preparation |
DE19957470A1 (en) * | 1999-11-24 | 2001-06-21 | Actinodrug Pharmaceuticals Gmb | Tetrahydropyrimidine dioxygenase gene and method for enzymatic in vivo and in vitro production of hydroxylated tetrahydropyrimidines |
DE10002725A1 (en) * | 2000-01-11 | 2001-07-12 | Beiersdorf Ag | Treatment and prevention of undesired skin pigmentation, e.g. to prevent tanning or to remove freckles, using an ectoin compound, especially ectoin or hydroxyectoin |
DE10043456A1 (en) * | 2000-09-04 | 2002-03-14 | Merck Patent Gmbh | Use of ectoin or ectoin derivatives to stabilize p53 |
US7048910B2 (en) * | 2000-09-07 | 2006-05-23 | Merck Patent Gmbh | Use of ectoine or ectoine derivatives for oral care |
DE10047444A1 (en) * | 2000-09-21 | 2002-04-11 | Bitop Gmbh | Process for the separation and high-purity isolation of low-molecular, structurally similar compounds, in particular of tetrahydropyrimidine derivatives such as e.g. 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acids (ectoins) and their cleavage products |
DE10214257A1 (en) * | 2002-03-28 | 2003-10-16 | Merck Patent Gmbh | Use of compatible solutes to inhibit the release of ceramides |
RU2418633C2 (en) * | 2004-04-08 | 2011-05-20 | Байоматрика, Инк. | Integration of specimens storage and control in biomedical sciences |
EP1858519B1 (en) * | 2005-03-12 | 2013-02-20 | Bitop Aktiengesellschaft Für Biotechnische Optimierung | Ectoin and/or hydroxyectoin for the prevention and treatment of inflammatory bowel diseases |
FR2896990B1 (en) * | 2006-02-03 | 2008-05-02 | Lvmh Rech | PROTECTIVE AND REGENERATIVE COMPOSITION |
DE102007052380A1 (en) * | 2007-10-31 | 2009-05-07 | Bitop Ag | Osmolyte-containing preparations for use in dry mucous membranes |
ES2700613T3 (en) * | 2008-07-16 | 2019-02-18 | Bitop Ag | Synthesis of cyclic amidines |
DE102008039231A1 (en) | 2008-08-22 | 2010-02-25 | Bitop Ag | Use of glucosylglycerol |
EP2168570B1 (en) | 2008-09-30 | 2013-12-25 | Symrise AG | Extracts of isochrysis sp. |
EP3348255B1 (en) | 2008-12-05 | 2021-11-10 | Symrise AG | Extracts of tetraselmis sp. for cosmetic and therapeutic purposes |
US8519125B2 (en) * | 2009-05-11 | 2013-08-27 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US9845489B2 (en) | 2010-07-26 | 2017-12-19 | Biomatrica, Inc. | Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
CN102225067B (en) * | 2011-04-29 | 2012-10-03 | 济南环肽医药科技有限公司 | Pharmaceutical composition for treating stomach cancer |
CN102240298B (en) * | 2011-04-29 | 2012-07-04 | 济南环肽医药科技有限公司 | Pharmaceutical composition for resisting tumors |
CN102258526B (en) * | 2011-04-29 | 2012-10-31 | 山东大学 | Anticancer medicinal composition |
CN102210868A (en) * | 2011-04-29 | 2011-10-12 | 济南环肽医药科技有限公司 | Application of tetrahydropyrimidine and derivatives thereof in preparing oral absorption enhancers |
CN102617707B (en) * | 2011-09-19 | 2014-01-29 | 江苏师范大学 | Preparation method of new homologue 2-methyl-actinomycin D of actinomycin D |
EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | Formulations and methods for stabilizing pcr reagents |
ES2701758T3 (en) | 2013-02-27 | 2019-02-25 | Symrise Ag | Ginger extract for the protection of stem cells |
EP2862852B1 (en) | 2013-10-18 | 2018-07-04 | Symrise AG | Urea derivatives for the protection of stem cells |
EP2921157B1 (en) | 2014-03-18 | 2017-08-16 | Symrise AG | Coated titanium dioxide to reduce whitening effect on skin |
ES2819207T3 (en) | 2014-04-29 | 2021-04-15 | Symrise Ag | Active mixes |
EP3154338B1 (en) | 2014-06-10 | 2020-01-29 | Biomatrica, INC. | Stabilization of thrombocytes at ambient temperatures |
EP3045161A1 (en) | 2015-01-18 | 2016-07-20 | Symrise AG | Active compositions comprising 1,2-hexanediol and 1,2-octanediol |
EP4242628A3 (en) | 2015-12-08 | 2023-11-08 | Biomatrica, INC. | Reduction of erythrocyte sedimentation rate |
CN105669560B (en) * | 2016-01-12 | 2019-02-19 | 天津科技大学 | A method of the separation and Extraction tetrahydropyrimidine from fermentation liquid |
CN106361764A (en) * | 2016-08-29 | 2017-02-01 | 沂水县人民医院 | Liver cancer surgical incision flushing liquid |
CN109053587A (en) * | 2018-08-31 | 2018-12-21 | 山东福田药业有限公司 | A method of the separation and Extraction tetrahydropyrimidine from halophilic microorganism fermentation liquid |
CN110982843B (en) * | 2019-10-31 | 2021-12-28 | 温州大学 | Application of tetrahydropyrimidine in regulating DNA (deoxyribonucleic acid) coagulation strength |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4261995A (en) * | 1979-08-31 | 1981-04-14 | Syntex (U.S.A.) Inc. | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives |
-
1992
- 1992-01-30 IL IL10081092A patent/IL100810A/en not_active IP Right Cessation
-
1993
- 1993-01-28 US US08/011,668 patent/US5789414A/en not_active Expired - Fee Related
- 1993-01-29 ZA ZA93652A patent/ZA93652B/en unknown
- 1993-01-29 AU AU32139/93A patent/AU3213993A/en not_active Abandoned
- 1993-01-29 CA CA002088390A patent/CA2088390A1/en not_active Abandoned
- 1993-01-29 HU HU9300251A patent/HUT67711A/en unknown
- 1993-01-29 NZ NZ245797A patent/NZ245797A/en unknown
- 1993-01-30 CN CN93102524A patent/CN1080172A/en active Pending
- 1993-02-01 JP JP5051221A patent/JPH0717864A/en active Pending
- 1993-02-01 AT AT93101515T patent/ATE169339T1/en not_active IP Right Cessation
- 1993-02-01 EP EP93101515A patent/EP0553884B1/en not_active Expired - Lifetime
- 1993-02-01 EP EP97122337A patent/EP0845539A1/en not_active Withdrawn
- 1993-02-01 DE DE69320075T patent/DE69320075T2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ245797A (en) | 1995-07-26 |
CA2088390A1 (en) | 1993-07-31 |
AU3213993A (en) | 1993-08-05 |
DE69320075T2 (en) | 1999-04-22 |
HUT67711A (en) | 1995-04-28 |
ATE169339T1 (en) | 1998-08-15 |
DE69320075D1 (en) | 1998-09-10 |
IL100810A0 (en) | 1992-09-06 |
EP0553884B1 (en) | 1998-08-05 |
US5789414A (en) | 1998-08-04 |
CN1080172A (en) | 1994-01-05 |
JPH0717864A (en) | 1995-01-20 |
HU9300251D0 (en) | 1993-04-28 |
EP0845539A1 (en) | 1998-06-03 |
EP0553884A1 (en) | 1993-08-04 |
IL100810A (en) | 1996-12-05 |
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