ZA93652B - Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them. - Google Patents

Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them.

Info

Publication number
ZA93652B
ZA93652B ZA93652A ZA93652A ZA93652B ZA 93652 B ZA93652 B ZA 93652B ZA 93652 A ZA93652 A ZA 93652A ZA 93652 A ZA93652 A ZA 93652A ZA 93652 B ZA93652 B ZA 93652B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical compositions
compositions containing
tetrahydropyrimidine derivatives
tetrahydropyrimidine
derivatives
Prior art date
Application number
ZA93652A
Other languages
English (en)
Inventor
Aviva Lapidot
Livia Inbar
Yosef Aloni
Edna Ben-Asher
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of ZA93652B publication Critical patent/ZA93652B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA93652A 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them. ZA93652B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL10081092A IL100810A (en) 1992-01-30 1992-01-30 Pharmaceutical preparations including 2 - methyl - carboxy - 5 - hydroxy - tetrahydropyrimidine and / or 2 - methyl - 4 - carboxy - tetrahydropyrimidine, plywood methods

Publications (1)

Publication Number Publication Date
ZA93652B true ZA93652B (en) 1993-09-02

Family

ID=11063323

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA93652A ZA93652B (en) 1992-01-30 1993-01-29 Tetrahydropyrimidine derivatives and pharmaceutical compositions containing them.

Country Status (12)

Country Link
US (1) US5789414A (xx)
EP (2) EP0845539A1 (xx)
JP (1) JPH0717864A (xx)
CN (1) CN1080172A (xx)
AT (1) ATE169339T1 (xx)
AU (1) AU3213993A (xx)
CA (1) CA2088390A1 (xx)
DE (1) DE69320075T2 (xx)
HU (1) HUT67711A (xx)
IL (1) IL100810A (xx)
NZ (1) NZ245797A (xx)
ZA (1) ZA93652B (xx)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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DE4244580A1 (de) * 1992-12-31 1994-07-07 Galinski Erwin A Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen
DE4342560A1 (de) * 1993-12-14 1995-06-22 Marbert Gmbh Ectoin und Ectoinderivate als Feuchtigkeitsspender in Kosmetikprodukten
DE19711082A1 (de) * 1997-03-18 1998-09-24 Degussa Verfahren zur Abtrennung von Tetrahydropyrimidinen aus wäßrigen Lösungen
IL123256A0 (en) * 1998-02-10 1998-09-24 Yeda Res & Dev Methods for dna amplification and sequencing
DE19821378A1 (de) * 1998-05-13 1999-11-18 Degussa Verfahren zur Auftrennung von Tetrahydropyrimidinderivaten
DE19834816A1 (de) * 1998-08-01 2000-02-03 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten in kosmetischen Formulierungen
US20030157040A1 (en) * 1998-08-01 2003-08-21 Merck Patent Gmbh Use of ectoine or ectoine derivatives in cosmetic formulations
US20040047828A1 (en) * 1998-08-01 2004-03-11 Merck Patent Gmbh Ectoin or ection derivatives and surfactants
AU5812800A (en) * 1999-06-12 2001-01-02 Stefan Barth Pharmaceutical preparation
DE19957470A1 (de) 1999-11-24 2001-06-21 Actinodrug Pharmaceuticals Gmb Tetrahydropyrimidin-Dioxygenase-Gen sowie Verfahren zur enzymatischen in vivo und in vitro Produktion von hydroxylierten Tetrahydropyrimidinen
DE10002725A1 (de) * 2000-01-11 2001-07-12 Beiersdorf Ag Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening)
DE10043456A1 (de) * 2000-09-04 2002-03-14 Merck Patent Gmbh Verwendung von Ectoin oder Ectoin-Derivaten zur Stabilisierung von p53
US7048910B2 (en) * 2000-09-07 2006-05-23 Merck Patent Gmbh Use of ectoine or ectoine derivatives for oral care
DE10047444A1 (de) * 2000-09-21 2002-04-11 Bitop Gmbh Verfahren zur Trennung und hochreinen Isolierung von niedermolekularen, strukturell ähnlichen Verbindungen insbesondere von Tetrahydropyrimidinderivaten wie z.B. 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsäuren (Ectoine) und deren Spaltprodukte
DE10214257A1 (de) * 2002-03-28 2003-10-16 Merck Patent Gmbh Verwendung von kompatiblen Soluten zur Inhibierung der Freisetzung von Ceramiden
CA2560513A1 (en) * 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
JP2008537734A (ja) * 2005-03-12 2008-09-25 ビトップ アクツィエンゲゼルシャフト フュール ビオテヒニシェ オプティミールング 経口で用いられる適合溶質を含む薬剤
FR2896990B1 (fr) * 2006-02-03 2008-05-02 Lvmh Rech Composition protectrice et regenerante
DE102007052380A1 (de) * 2007-10-31 2009-05-07 Bitop Ag Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten
JP5781928B2 (ja) * 2008-07-16 2015-09-24 ビトップ アーゲーｂｉｔｏｐ ＡＧ 環状アミジンの合成
DE102008039231A1 (de) 2008-08-22 2010-02-25 Bitop Ag Verwendung von Glucosylglycerol
EP2168570B1 (en) 2008-09-30 2013-12-25 Symrise AG Extracts of isochrysis sp.
EP3348255B1 (en) 2008-12-05 2021-11-10 Symrise AG Extracts of tetraselmis sp. for cosmetic and therapeutic purposes
WO2010132508A2 (en) * 2009-05-11 2010-11-18 Biomatrica, Inc. Compositions and methods for biological sample storage
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
CN102240298B (zh) * 2011-04-29 2012-07-04 济南环肽医药科技有限公司 一种抗肿瘤的药物组合物
CN102210868A (zh) * 2011-04-29 2011-10-12 济南环肽医药科技有限公司 四氢嘧啶及其衍生物在制备口服吸收促进剂中的应用
CN102258526B (zh) * 2011-04-29 2012-10-31 山东大学 一种抗肿瘤药物组合物
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
CN102617707B (zh) * 2011-09-19 2014-01-29 江苏师范大学 放线菌素d新同系物2-甲基-放线菌素d的制备方法
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
ES2701758T3 (es) 2013-02-27 2019-02-25 Symrise Ag Extracto de jengibre para la protección de citoblastos
EP2862852B1 (en) 2013-10-18 2018-07-04 Symrise AG Urea derivatives for the protection of stem cells
ES2643590T3 (es) 2014-03-18 2017-11-23 Symrise Ag Dióxido de titanio revestido para reducir el efecto de blanqueamiento en la piel
ES2819207T3 (es) 2014-04-29 2021-04-15 Symrise Ag Mezclas activas
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
EP3045161A1 (en) 2015-01-18 2016-07-20 Symrise AG Active compositions comprising 1,2-hexanediol and 1,2-octanediol
KR20230145258A (ko) 2015-12-08 2023-10-17 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CN105669560B (zh) * 2016-01-12 2019-02-19 天津科技大学 一种从发酵液中分离提取四氢嘧啶的方法
CN106361764A (zh) * 2016-08-29 2017-02-01 沂水县人民医院 一种肝癌手术切口用冲洗液
CN109053587A (zh) * 2018-08-31 2018-12-21 山东福田药业有限公司 一种从嗜盐微生物发酵液中分离提取四氢嘧啶的方法
CN110982843B (zh) * 2019-10-31 2021-12-28 温州大学 四氢嘧啶用于调节dna凝聚强弱的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261995A (en) * 1979-08-31 1981-04-14 Syntex (U.S.A.) Inc. 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

Also Published As

Publication number Publication date
EP0845539A1 (en) 1998-06-03
IL100810A0 (en) 1992-09-06
US5789414A (en) 1998-08-04
ATE169339T1 (de) 1998-08-15
EP0553884A1 (en) 1993-08-04
IL100810A (en) 1996-12-05
AU3213993A (en) 1993-08-05
NZ245797A (en) 1995-07-26
CN1080172A (zh) 1994-01-05
DE69320075T2 (de) 1999-04-22
JPH0717864A (ja) 1995-01-20
HUT67711A (en) 1995-04-28
HU9300251D0 (en) 1993-04-28
DE69320075D1 (de) 1998-09-10
EP0553884B1 (en) 1998-08-05
CA2088390A1 (en) 1993-07-31

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