IE56262B1 - Analogs of mevalolactone and derivatives thereof,processes for their production,pharmaceutical compositions containing them and their use as pharmaceuticals - Google Patents

Analogs of mevalolactone and derivatives thereof,processes for their production,pharmaceutical compositions containing them and their use as pharmaceuticals

Info

Publication number
IE56262B1
IE56262B1 IE2713/83A IE271383A IE56262B1 IE 56262 B1 IE56262 B1 IE 56262B1 IE 2713/83 A IE2713/83 A IE 2713/83A IE 271383 A IE271383 A IE 271383A IE 56262 B1 IE56262 B1 IE 56262B1
Authority
IE
Ireland
Prior art keywords
hydrogen
compound
fluoro
benzyloxy
alkyl
Prior art date
Application number
IE2713/83A
Other languages
English (en)
Other versions
IE832713L (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE832713L publication Critical patent/IE832713L/xx
Publication of IE56262B1 publication Critical patent/IE56262B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IE2713/83A 1982-11-22 1983-11-21 Analogs of mevalolactone and derivatives thereof,processes for their production,pharmaceutical compositions containing them and their use as pharmaceuticals IE56262B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44366882A 1982-11-22 1982-11-22
US54885083A 1983-11-04 1983-11-04

Publications (2)

Publication Number Publication Date
IE832713L IE832713L (en) 1984-05-22
IE56262B1 true IE56262B1 (en) 1991-06-05

Family

ID=27033614

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2713/83A IE56262B1 (en) 1982-11-22 1983-11-21 Analogs of mevalolactone and derivatives thereof,processes for their production,pharmaceutical compositions containing them and their use as pharmaceuticals

Country Status (18)

Country Link
EP (1) EP0114027B1 (OSRAM)
JP (1) JPH0347167A (OSRAM)
AT (1) ATE31718T1 (OSRAM)
AU (1) AU570021B2 (OSRAM)
CA (1) CA1210405A (OSRAM)
CY (1) CY1579A (OSRAM)
DE (2) DE19475017I2 (OSRAM)
DK (2) DK359284A (OSRAM)
FI (1) FI77228C (OSRAM)
GR (1) GR79042B (OSRAM)
HK (1) HK11191A (OSRAM)
HU (1) HU204253B (OSRAM)
IE (1) IE56262B1 (OSRAM)
IL (1) IL70286A (OSRAM)
LU (1) LU88670I2 (OSRAM)
NL (1) NL950022I2 (OSRAM)
NZ (1) NZ206338A (OSRAM)
WO (1) WO1984002131A1 (OSRAM)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
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US4751235A (en) * 1986-12-23 1988-06-14 Sandoz Pharm. Corp. Anti-atherosclerotic indolizine derivatives
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US5185328A (en) * 1987-08-20 1993-02-09 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones useful for treating hyperlipidemia, hyperlipoproteinemia or atherosclerosis
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Also Published As

Publication number Publication date
DK97890D0 (da) 1990-04-19
FI77228B (fi) 1988-10-31
NL950022I1 (OSRAM) 1996-01-02
GR79042B (OSRAM) 1984-10-02
HU204253B (en) 1991-12-30
FI77228C (fi) 1989-02-10
DK359284D0 (da) 1984-07-20
JPH0440343B2 (OSRAM) 1992-07-02
NL950022I2 (nl) 1996-12-02
ATE31718T1 (de) 1988-01-15
LU88670I2 (fr) 1996-04-29
DK97890A (da) 1990-04-19
IE832713L (en) 1984-05-22
CY1579A (en) 1991-12-20
DE3375137D1 (en) 1988-02-11
DK165244B (da) 1992-10-26
FI842615A7 (fi) 1984-06-28
AU2261283A (en) 1984-06-18
NZ206338A (en) 1987-08-31
DE19475017I2 (de) 2003-02-20
IL70286A0 (en) 1984-02-29
AU570021B2 (en) 1988-03-03
DK359284A (da) 1984-07-20
EP0114027A1 (en) 1984-07-25
IL70286A (en) 1987-08-31
WO1984002131A1 (fr) 1984-06-07
FI842615A0 (fi) 1984-06-28
HK11191A (en) 1991-02-13
HUT35642A (en) 1985-07-29
CA1210405A (en) 1986-08-26
EP0114027B1 (en) 1988-01-07
DK165244C (da) 1993-03-22
JPH0347167A (ja) 1991-02-28

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