HUT64514A - Process for producing arylic comdounds with anti-atherosclerotic effect - Google Patents
Process for producing arylic comdounds with anti-atherosclerotic effect Download PDFInfo
- Publication number
- HUT64514A HUT64514A HU9301709A HU170993A HUT64514A HU T64514 A HUT64514 A HU T64514A HU 9301709 A HU9301709 A HU 9301709A HU 170993 A HU170993 A HU 170993A HU T64514 A HUT64514 A HU T64514A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- alkoxy
- methyl
- group
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Indole Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027023A GB9027023D0 (en) | 1990-12-12 | 1990-12-12 | Anti-atherosclerotic aryl compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9301709D0 HU9301709D0 (en) | 1993-09-28 |
| HUT64514A true HUT64514A (en) | 1994-01-28 |
Family
ID=10686924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9301709A HUT64514A (en) | 1990-12-12 | 1991-12-11 | Process for producing arylic comdounds with anti-atherosclerotic effect |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5658944A (https=) |
| EP (1) | EP0639178B1 (https=) |
| JP (1) | JP2951402B2 (https=) |
| KR (1) | KR930703246A (https=) |
| AT (1) | ATE157651T1 (https=) |
| AU (1) | AU647859B2 (https=) |
| CA (1) | CA2098122C (https=) |
| DE (1) | DE69127556D1 (https=) |
| GB (1) | GB9027023D0 (https=) |
| HU (1) | HUT64514A (https=) |
| IE (1) | IE914304A1 (https=) |
| IL (1) | IL100331A (https=) |
| NZ (1) | NZ240935A (https=) |
| TW (1) | TW275065B (https=) |
| WO (1) | WO1992010468A1 (https=) |
| ZA (1) | ZA919773B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
| SE9401353D0 (sv) * | 1994-04-21 | 1994-04-21 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
| AR002945A1 (es) * | 1994-11-15 | 1998-05-27 | Bayer Corp | Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos |
| DE4443891A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
| GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| US5866609A (en) * | 1996-08-09 | 1999-02-02 | Ss Pharmaceutical Co., Ltd. | Substituted vinylurea derivatives and medicine containing the same |
| PL351987A1 (en) * | 1999-04-28 | 2003-07-14 | Reddys Lab Ltd Dr | Substitution bicyclic-heterocyclic compounds, method of obtaining thereof, and use of such compounds to control adiposis and to reduce the level of cholesterol |
| US6787552B2 (en) * | 2000-08-11 | 2004-09-07 | Nippon Chemiphar Co., Ltd. | PPAR delta activators |
| WO2002046176A1 (en) * | 2000-12-05 | 2002-06-13 | Nippon Chemiphar Co., Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
| EP1360172A1 (en) | 2001-02-15 | 2003-11-12 | Pfizer Products Inc. | Ppar agonists |
| WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
| US6548538B2 (en) | 2001-05-22 | 2003-04-15 | Bayer Aktiengesellschaft | Propionic acid derivatives |
| US20030125338A1 (en) * | 2001-06-12 | 2003-07-03 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| US20030191144A1 (en) * | 2001-06-12 | 2003-10-09 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| AU2002323776B2 (en) | 2001-08-10 | 2008-07-31 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-responsive receptor Delta |
| MXPA04003398A (es) | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
| US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
| EP1517882A1 (en) | 2002-06-19 | 2005-03-30 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| EP1388352A1 (en) | 2002-08-08 | 2004-02-11 | Laboratoires Fournier S.A. | Use of a ppar-alpha agonist to treat patients suffering from weight gain associated with a ppar-gamma agonist treatment |
| EA009554B1 (ru) | 2002-10-21 | 2008-02-28 | Янссен Фармацевтика Н.В. | Замещённые тетралины и инданы и их применение |
| EA008928B1 (ru) * | 2002-11-26 | 2007-08-31 | Пфайзер Продактс Инк. | Активаторы рецепторов, активируемых пролифератором пероксисом (ppar ) |
| CA2511970C (en) | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Urea derivatives useful in the treatment of heart failure |
| US6987118B2 (en) | 2003-05-21 | 2006-01-17 | Pfizer Inc. | Tetrahydroisoquinoline derivatives as PPAR-alpha activators |
| JP5080970B2 (ja) | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
| EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| CN101466687B (zh) | 2006-04-18 | 2012-04-11 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
| MX2010011252A (es) | 2008-04-15 | 2010-11-30 | Nippon Chemiphar Co | Activador para el receptor activado por el proliferador de peroxisoma. |
| BR112014016450A2 (pt) | 2012-01-10 | 2019-09-24 | Lilly Co Eli | composto antagonista de leucotrieno b4 |
| WO2013169648A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2614045A1 (de) * | 1976-04-01 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
| US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| WO1988010113A1 (en) * | 1987-06-15 | 1988-12-29 | Iraj Lalezari | Compound, composition and method for the reduction of lipids the modification of the affinity of hemoglobin for oxygen and the prevention of platelet aggregation |
| US4921997A (en) * | 1988-06-15 | 1990-05-01 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
-
1990
- 1990-12-12 GB GB909027023A patent/GB9027023D0/en active Pending
-
1991
- 1991-12-11 DE DE69127556T patent/DE69127556D1/de not_active Expired - Lifetime
- 1991-12-11 JP JP4501716A patent/JP2951402B2/ja not_active Expired - Lifetime
- 1991-12-11 HU HU9301709A patent/HUT64514A/hu unknown
- 1991-12-11 IL IL10033191A patent/IL100331A/en not_active IP Right Cessation
- 1991-12-11 AU AU90560/91A patent/AU647859B2/en not_active Ceased
- 1991-12-11 ZA ZA919773A patent/ZA919773B/xx unknown
- 1991-12-11 EP EP92900716A patent/EP0639178B1/en not_active Expired - Lifetime
- 1991-12-11 KR KR1019930701756A patent/KR930703246A/ko not_active Withdrawn
- 1991-12-11 IE IE430491A patent/IE914304A1/en unknown
- 1991-12-11 NZ NZ240935A patent/NZ240935A/en unknown
- 1991-12-11 CA CA002098122A patent/CA2098122C/en not_active Expired - Fee Related
- 1991-12-11 WO PCT/GB1991/002195 patent/WO1992010468A1/en not_active Ceased
- 1991-12-11 AT AT92900716T patent/ATE157651T1/de not_active IP Right Cessation
-
1992
- 1992-01-24 TW TW081100492A patent/TW275065B/zh active
-
1995
- 1995-04-14 US US08/421,997 patent/US5658944A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL100331A (en) | 1996-09-12 |
| GB9027023D0 (en) | 1991-01-30 |
| WO1992010468A1 (en) | 1992-06-25 |
| AU647859B2 (en) | 1994-03-31 |
| IE914304A1 (en) | 1992-06-17 |
| EP0639178A1 (en) | 1995-02-22 |
| EP0639178B1 (en) | 1997-09-03 |
| DE69127556D1 (de) | 1997-10-09 |
| JPH06507151A (ja) | 1994-08-11 |
| CA2098122C (en) | 2003-09-23 |
| IL100331A0 (en) | 1992-09-06 |
| ZA919773B (en) | 1993-06-11 |
| KR930703246A (ko) | 1993-11-29 |
| HU9301709D0 (en) | 1993-09-28 |
| AU9056091A (en) | 1992-07-08 |
| US5658944A (en) | 1997-08-19 |
| NZ240935A (en) | 1994-11-25 |
| CA2098122A1 (en) | 1992-06-13 |
| JP2951402B2 (ja) | 1999-09-20 |
| TW275065B (https=) | 1996-05-01 |
| ATE157651T1 (de) | 1997-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT64514A (en) | Process for producing arylic comdounds with anti-atherosclerotic effect | |
| HU184959B (en) | Process for producing new amino-ethanel derivatives | |
| LU85856A1 (fr) | Composes de phenethanolamine | |
| PL154186B1 (en) | Method for manufacturing arylic derivatives of the hydroxamic acid | |
| FR2536749A1 (fr) | (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique | |
| FR2491467A1 (fr) | Nouveaux n-alkyl inferieur)-3-phenoxy-1-azetidinecarboxamides possedant notamment une activite sur le systeme nerveux central, et leur procede de preparation | |
| FR2527204A1 (fr) | Nouveaux composes utiles comme medicaments anti-allergiques et procede et intermediaires pour leur separation | |
| LU86002A1 (fr) | Composes d'aminophenol | |
| DE2332837A1 (de) | Amine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel | |
| EP0051077A1 (de) | Substituierte Oxocarbonsäuren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Arzneimittel | |
| EP1001944B1 (fr) | Derives de pyrazine, leur preparation et les medicaments les contenant | |
| US5422373A (en) | Anti-atherosclerotic aryl compounds | |
| FR2461699A1 (fr) | Nouveaux derives de type methylene-3 azetidine utiles comme medicaments et compositions therapeutiques les contenant | |
| EP0143016B1 (fr) | Dérivés de 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin-1-yl-N-phényl acétamide, leur préparation et leur application en thérapeutique | |
| US3856951A (en) | Substituted benzoic acid hypoliphemic agents | |
| CH646425A5 (fr) | Composes heterocycliques azotes therapeutiquement actifs, et medicament les contenant. | |
| JPS6270335A (ja) | ２環性アリルエ−テル誘導体、その製法および用途 | |
| HK123396A (en) | New bronchospasmolytic compounds and process for their preparation | |
| JPH06503839A (ja) | 経口活性抗ウィルス化合物 | |
| JPH02292213A (ja) | 制癌剤 | |
| FR2690917A1 (fr) | Aminoesters, leur procédé de préparation et leur application en thérapeutique. | |
| FR2632641A1 (fr) | ((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif | |
| FR2544313A1 (fr) | Les n-cycloalcoyl methyl-2 oxo-3 diaryl 5-6 as triazines, leur procede de fabrication et leur utilisation en tant que medicament | |
| US4124706A (en) | Esters of bis-(hydroxyalkylthio)-alkanes | |
| US4024259A (en) | 3-Anilino-2,4-diazabicyclo[3.2.1]octenes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary protection due to refusal |