DE69127556D1 - Antiatherosklerotische arylverbindungen - Google Patents
Antiatherosklerotische arylverbindungenInfo
- Publication number
- DE69127556D1 DE69127556D1 DE69127556T DE69127556T DE69127556D1 DE 69127556 D1 DE69127556 D1 DE 69127556D1 DE 69127556 T DE69127556 T DE 69127556T DE 69127556 T DE69127556 T DE 69127556T DE 69127556 D1 DE69127556 D1 DE 69127556D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- atoms
- group
- alkoxy
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 3
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 229920000570 polyether Polymers 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000005085 alkoxycarbonylalkoxy group Chemical group 0.000 abstract 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229920001774 Perfluoroether Polymers 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000005010 perfluoroalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027023A GB9027023D0 (en) | 1990-12-12 | 1990-12-12 | Anti-atherosclerotic aryl compounds |
| PCT/GB1991/002195 WO1992010468A1 (en) | 1990-12-12 | 1991-12-11 | Anti-atherosclerotic aryl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69127556D1 true DE69127556D1 (de) | 1997-10-09 |
Family
ID=10686924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69127556T Expired - Lifetime DE69127556D1 (de) | 1990-12-12 | 1991-12-11 | Antiatherosklerotische arylverbindungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5658944A (de) |
| EP (1) | EP0639178B1 (de) |
| JP (1) | JP2951402B2 (de) |
| KR (1) | KR930703246A (de) |
| AT (1) | ATE157651T1 (de) |
| AU (1) | AU647859B2 (de) |
| CA (1) | CA2098122C (de) |
| DE (1) | DE69127556D1 (de) |
| GB (1) | GB9027023D0 (de) |
| HU (1) | HUT64514A (de) |
| IE (1) | IE914304A1 (de) |
| IL (1) | IL100331A (de) |
| NZ (1) | NZ240935A (de) |
| TW (1) | TW275065B (de) |
| WO (1) | WO1992010468A1 (de) |
| ZA (1) | ZA919773B (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
| SE9401353D0 (sv) * | 1994-04-21 | 1994-04-21 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
| HRP950558A2 (en) * | 1994-11-15 | 1997-12-31 | Scott M. Wilhelm | Substituted 4-biarylbutric or biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
| DE4443891A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
| GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| US5866609A (en) * | 1996-08-09 | 1999-02-02 | Ss Pharmaceutical Co., Ltd. | Substituted vinylurea derivatives and medicine containing the same |
| KR100610578B1 (ko) | 1999-04-28 | 2006-08-09 | 닥터 레디스 레보러터리즈 리미티드 | 치환된 이원 헤테로고리, 비만증 및 고콜레스테롤증치료제로서의 그 용도 |
| AU2001277723A1 (en) | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
| AU2002224139A1 (en) * | 2000-12-05 | 2002-06-18 | Nippon Chemiphar Co. Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
| MXPA03007284A (es) * | 2001-02-15 | 2003-12-04 | Pfizer Prod Inc | Agonistas de receptor activador del proliferador de peroxisomas. |
| WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
| US6548538B2 (en) | 2001-05-22 | 2003-04-15 | Bayer Aktiengesellschaft | Propionic acid derivatives |
| EP1399426A2 (de) * | 2001-06-12 | 2004-03-24 | Active Pass Pharmaceuticals, Inc. | VERBINDUNGEN, ZUSAMMENSTELLUNGEN UND METHODE FüR DIE BETA-AMYLOIDE MODULATION |
| US20030191144A1 (en) * | 2001-06-12 | 2003-10-09 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| PT1424330E (pt) | 2001-08-10 | 2011-12-22 | Nippon Chemiphar Co | Activador do receptor ä responsivo a proliferadores peroxissomais |
| DE60232739D1 (de) | 2001-10-12 | 2009-08-06 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
| US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
| CA2488972A1 (en) | 2002-06-19 | 2003-12-31 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| EP1388352A1 (de) | 2002-08-08 | 2004-02-11 | Laboratoires Fournier S.A. | Verwendung eines ppar-alpha-Agonisten zur Behandlung von Patienten, die an mit ppar-gamma-Agonisten-Behandlung assozierter Fettleibigkeit leiden |
| RS52079B (sr) | 2002-10-21 | 2012-06-30 | Janssen Pharmaceutica N.V. | Supstituisani tetralini i indani i njihova primena |
| CA2507465C (en) | 2002-11-26 | 2009-04-28 | Pfizer Products Inc. | Phenyl substituted piperidine compounds for use as ppar activators |
| US7399866B2 (en) | 2003-01-14 | 2008-07-15 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US6987118B2 (en) | 2003-05-21 | 2006-01-17 | Pfizer Inc. | Tetrahydroisoquinoline derivatives as PPAR-alpha activators |
| US8110595B2 (en) | 2004-06-17 | 2012-02-07 | Cytokinetics, Inc. | Ureas and their use in the treatment of heart failure |
| US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
| ES2419007T3 (es) | 2005-12-15 | 2013-08-19 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y procedimientos |
| US7718657B2 (en) | 2005-12-16 | 2010-05-18 | Cytokinetics, Inc. | Certain indanyl urea modulators of the cardiac sarcomere |
| EP1962852B1 (de) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Verbindungen, zusammensetzungen und verfahren |
| CN101466687B (zh) | 2006-04-18 | 2012-04-11 | 日本化学医药株式会社 | 过氧化物酶体增殖剂激活受体δ的激活剂 |
| CA2721339C (en) | 2008-04-15 | 2017-01-24 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor |
| US9187411B2 (en) | 2012-01-10 | 2015-11-17 | Eli Lilly And Company | Leukotriene B4 antagonist compound |
| WO2013169648A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2614045A1 (de) * | 1976-04-01 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
| US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| JPH02503797A (ja) * | 1987-06-15 | 1990-11-08 | ラレザリ、イラジ | 脂質の減少、酸素に対するヘモグロビンの親和力の修正ならびに血小板凝集の抑制を行うための化合物、組成物および方法 |
| US4921997A (en) * | 1988-06-15 | 1990-05-01 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
-
1990
- 1990-12-12 GB GB909027023A patent/GB9027023D0/en active Pending
-
1991
- 1991-12-11 WO PCT/GB1991/002195 patent/WO1992010468A1/en active IP Right Grant
- 1991-12-11 ZA ZA919773A patent/ZA919773B/xx unknown
- 1991-12-11 JP JP4501716A patent/JP2951402B2/ja not_active Expired - Lifetime
- 1991-12-11 CA CA002098122A patent/CA2098122C/en not_active Expired - Fee Related
- 1991-12-11 AT AT92900716T patent/ATE157651T1/de not_active IP Right Cessation
- 1991-12-11 IL IL10033191A patent/IL100331A/en not_active IP Right Cessation
- 1991-12-11 NZ NZ240935A patent/NZ240935A/en unknown
- 1991-12-11 DE DE69127556T patent/DE69127556D1/de not_active Expired - Lifetime
- 1991-12-11 AU AU90560/91A patent/AU647859B2/en not_active Ceased
- 1991-12-11 EP EP92900716A patent/EP0639178B1/de not_active Expired - Lifetime
- 1991-12-11 IE IE430491A patent/IE914304A1/en unknown
- 1991-12-11 HU HU9301709A patent/HUT64514A/hu unknown
- 1991-12-11 KR KR1019930701756A patent/KR930703246A/ko not_active Application Discontinuation
-
1992
- 1992-01-24 TW TW081100492A patent/TW275065B/zh active
-
1995
- 1995-04-14 US US08/421,997 patent/US5658944A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0639178A1 (de) | 1995-02-22 |
| JPH06507151A (ja) | 1994-08-11 |
| TW275065B (de) | 1996-05-01 |
| AU647859B2 (en) | 1994-03-31 |
| JP2951402B2 (ja) | 1999-09-20 |
| CA2098122C (en) | 2003-09-23 |
| US5658944A (en) | 1997-08-19 |
| ATE157651T1 (de) | 1997-09-15 |
| HU9301709D0 (en) | 1993-09-28 |
| GB9027023D0 (en) | 1991-01-30 |
| CA2098122A1 (en) | 1992-06-13 |
| WO1992010468A1 (en) | 1992-06-25 |
| IE914304A1 (en) | 1992-06-17 |
| KR930703246A (ko) | 1993-11-29 |
| IL100331A (en) | 1996-09-12 |
| IL100331A0 (en) | 1992-09-06 |
| ZA919773B (en) | 1993-06-11 |
| EP0639178B1 (de) | 1997-09-03 |
| NZ240935A (en) | 1994-11-25 |
| HUT64514A (en) | 1994-01-28 |
| AU9056091A (en) | 1992-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: UNIVERSITY OF SOUTH CAROLINA, COLUMBIA, S.C., US |
|
| 8332 | No legal effect for de |