TW275065B - - Google Patents
Info
- Publication number
- TW275065B TW275065B TW081100492A TW81100492A TW275065B TW 275065 B TW275065 B TW 275065B TW 081100492 A TW081100492 A TW 081100492A TW 81100492 A TW81100492 A TW 81100492A TW 275065 B TW275065 B TW 275065B
- Authority
- TW
- Taiwan
- Prior art keywords
- alkyl
- atoms
- group
- alkoxy
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909027023A GB9027023D0 (en) | 1990-12-12 | 1990-12-12 | Anti-atherosclerotic aryl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
TW275065B true TW275065B (zh) | 1996-05-01 |
Family
ID=10686924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW081100492A TW275065B (zh) | 1990-12-12 | 1992-01-24 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5658944A (zh) |
EP (1) | EP0639178B1 (zh) |
JP (1) | JP2951402B2 (zh) |
KR (1) | KR930703246A (zh) |
AT (1) | ATE157651T1 (zh) |
AU (1) | AU647859B2 (zh) |
CA (1) | CA2098122C (zh) |
DE (1) | DE69127556D1 (zh) |
GB (1) | GB9027023D0 (zh) |
HU (1) | HUT64514A (zh) |
IE (1) | IE914304A1 (zh) |
IL (1) | IL100331A (zh) |
NZ (1) | NZ240935A (zh) |
TW (1) | TW275065B (zh) |
WO (1) | WO1992010468A1 (zh) |
ZA (1) | ZA919773B (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
SE9401353D0 (sv) * | 1994-04-21 | 1994-04-21 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
IL115995A0 (en) * | 1994-11-15 | 1996-01-31 | Bayer Ag | Substituted 4-biarylbutyric or 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors |
DE4443891A1 (de) * | 1994-12-09 | 1996-06-13 | Bayer Ag | Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide |
GB9606805D0 (en) * | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
US5866609A (en) * | 1996-08-09 | 1999-02-02 | Ss Pharmaceutical Co., Ltd. | Substituted vinylurea derivatives and medicine containing the same |
CA2371757A1 (en) * | 1999-04-28 | 2000-11-09 | Dr. Reddy's Research Foundation | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents |
AU2001277723A1 (en) * | 2000-08-11 | 2002-02-25 | Nippon Chemiphar Co., Ltd. | Ppardelta activators |
AU2002224139A1 (en) * | 2000-12-05 | 2002-06-18 | Nippon Chemiphar Co. Ltd. | Ppar (peroxisome proliferator activated receptor) activators |
EP1360172A1 (en) | 2001-02-15 | 2003-11-12 | Pfizer Products Inc. | Ppar agonists |
WO2002064130A1 (en) * | 2001-02-15 | 2002-08-22 | Pfizer Products Inc. | Proliferative activator receptor (ppar) compounds |
US6548538B2 (en) | 2001-05-22 | 2003-04-15 | Bayer Aktiengesellschaft | Propionic acid derivatives |
US20030191144A1 (en) * | 2001-06-12 | 2003-10-09 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
WO2002100836A2 (en) * | 2001-06-12 | 2002-12-19 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
ATE526319T1 (de) | 2001-08-10 | 2011-10-15 | Nippon Chemiphar Co | Aktivator für den peroxisome proliferator- responsiven rezeptor delta |
IL161351A0 (en) | 2001-10-12 | 2004-09-27 | Nippon Chemiphar Co | ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR delta |
US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
CN1662487A (zh) | 2002-06-19 | 2005-08-31 | 伊莱利利公司 | 酰胺连接基过氧化物酶体增殖物激活受体调节剂 |
EP1388352A1 (en) | 2002-08-08 | 2004-02-11 | Laboratoires Fournier S.A. | Use of a ppar-alpha agonist to treat patients suffering from weight gain associated with a ppar-gamma agonist treatment |
PT1554240E (pt) | 2002-10-21 | 2009-06-17 | Janssen Pharmaceutica Nv | Tetralinas e indanos substituídos e sua utilização |
PL378268A1 (pl) * | 2002-11-26 | 2006-03-20 | Pfizer Products Inc. | Aktywatory PPAR |
JP4613157B2 (ja) | 2003-01-14 | 2011-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
US6987118B2 (en) | 2003-05-21 | 2006-01-17 | Pfizer Inc. | Tetrahydroisoquinoline derivatives as PPAR-alpha activators |
PL1765327T3 (pl) | 2004-06-17 | 2015-01-30 | Cytokinetics Inc | Związki, kompozycje i sposoby |
US7538223B2 (en) | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
WO2007070683A2 (en) | 2005-12-15 | 2007-06-21 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
US7825120B2 (en) | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
EP1959962A2 (en) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
US7989455B2 (en) | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
PL2014652T3 (pl) | 2006-04-18 | 2015-02-27 | Nippon Chemiphar Co | Czynnik aktywujący receptor aktywowany przez proliferatory peroksysomów |
JP5474769B2 (ja) | 2008-04-15 | 2014-04-16 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
JP2015509917A (ja) | 2012-01-10 | 2015-04-02 | イーライ リリー アンド カンパニー | ロイコトリエンb4アンタゴニスト化合物 |
WO2013169648A1 (en) | 2012-05-07 | 2013-11-14 | Novartis Ag | Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2614045A1 (de) * | 1976-04-01 | 1977-10-06 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
JPH02503797A (ja) * | 1987-06-15 | 1990-11-08 | ラレザリ、イラジ | 脂質の減少、酸素に対するヘモグロビンの親和力の修正ならびに血小板凝集の抑制を行うための化合物、組成物および方法 |
US4921997A (en) * | 1988-06-15 | 1990-05-01 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
-
1990
- 1990-12-12 GB GB909027023A patent/GB9027023D0/en active Pending
-
1991
- 1991-12-11 WO PCT/GB1991/002195 patent/WO1992010468A1/en active IP Right Grant
- 1991-12-11 EP EP92900716A patent/EP0639178B1/en not_active Expired - Lifetime
- 1991-12-11 ZA ZA919773A patent/ZA919773B/xx unknown
- 1991-12-11 NZ NZ240935A patent/NZ240935A/en unknown
- 1991-12-11 IE IE430491A patent/IE914304A1/en unknown
- 1991-12-11 HU HU9301709A patent/HUT64514A/hu unknown
- 1991-12-11 IL IL10033191A patent/IL100331A/en not_active IP Right Cessation
- 1991-12-11 DE DE69127556T patent/DE69127556D1/de not_active Expired - Lifetime
- 1991-12-11 CA CA002098122A patent/CA2098122C/en not_active Expired - Fee Related
- 1991-12-11 KR KR1019930701756A patent/KR930703246A/ko not_active Application Discontinuation
- 1991-12-11 AT AT92900716T patent/ATE157651T1/de not_active IP Right Cessation
- 1991-12-11 JP JP4501716A patent/JP2951402B2/ja not_active Expired - Lifetime
- 1991-12-11 AU AU90560/91A patent/AU647859B2/en not_active Ceased
-
1992
- 1992-01-24 TW TW081100492A patent/TW275065B/zh active
-
1995
- 1995-04-14 US US08/421,997 patent/US5658944A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2951402B2 (ja) | 1999-09-20 |
DE69127556D1 (de) | 1997-10-09 |
US5658944A (en) | 1997-08-19 |
AU647859B2 (en) | 1994-03-31 |
IL100331A0 (en) | 1992-09-06 |
IE914304A1 (en) | 1992-06-17 |
AU9056091A (en) | 1992-07-08 |
ZA919773B (en) | 1993-06-11 |
JPH06507151A (ja) | 1994-08-11 |
NZ240935A (en) | 1994-11-25 |
HUT64514A (en) | 1994-01-28 |
CA2098122C (en) | 2003-09-23 |
CA2098122A1 (en) | 1992-06-13 |
EP0639178B1 (en) | 1997-09-03 |
WO1992010468A1 (en) | 1992-06-25 |
HU9301709D0 (en) | 1993-09-28 |
IL100331A (en) | 1996-09-12 |
GB9027023D0 (en) | 1991-01-30 |
ATE157651T1 (de) | 1997-09-15 |
EP0639178A1 (en) | 1995-02-22 |
KR930703246A (ko) | 1993-11-29 |
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