TW275065B - - Google Patents

Info

Publication number
TW275065B
TW275065B TW081100492A TW81100492A TW275065B TW 275065 B TW275065 B TW 275065B TW 081100492 A TW081100492 A TW 081100492A TW 81100492 A TW81100492 A TW 81100492A TW 275065 B TW275065 B TW 275065B
Authority
TW
Taiwan
Prior art keywords
alkyl
atoms
group
alkoxy
optionally substituted
Prior art date
Application number
TW081100492A
Other languages
English (en)
Original Assignee
Wellcome Found
Univ South Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Univ South Carolina filed Critical Wellcome Found
Application granted granted Critical
Publication of TW275065B publication Critical patent/TW275065B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
TW081100492A 1990-12-12 1992-01-24 TW275065B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027023A GB9027023D0 (en) 1990-12-12 1990-12-12 Anti-atherosclerotic aryl compounds

Publications (1)

Publication Number Publication Date
TW275065B true TW275065B (zh) 1996-05-01

Family

ID=10686924

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081100492A TW275065B (zh) 1990-12-12 1992-01-24

Country Status (16)

Country Link
US (1) US5658944A (zh)
EP (1) EP0639178B1 (zh)
JP (1) JP2951402B2 (zh)
KR (1) KR930703246A (zh)
AT (1) ATE157651T1 (zh)
AU (1) AU647859B2 (zh)
CA (1) CA2098122C (zh)
DE (1) DE69127556D1 (zh)
GB (1) GB9027023D0 (zh)
HU (1) HUT64514A (zh)
IE (1) IE914304A1 (zh)
IL (1) IL100331A (zh)
NZ (1) NZ240935A (zh)
TW (1) TW275065B (zh)
WO (1) WO1992010468A1 (zh)
ZA (1) ZA919773B (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
SE9401353D0 (sv) * 1994-04-21 1994-04-21 Pharmacia Ab Novel antitumour compounds with antimitotic activity
AR002945A1 (es) * 1994-11-15 1998-05-27 Bayer Corp Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos
DE4443891A1 (de) * 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
GB9606805D0 (en) * 1996-03-30 1996-06-05 Glaxo Wellcome Inc Medicaments
US5866609A (en) * 1996-08-09 1999-02-02 Ss Pharmaceutical Co., Ltd. Substituted vinylurea derivatives and medicine containing the same
RU2278114C2 (ru) * 1999-04-28 2006-06-20 Др.Редди З Лабораториз Лимитед Замещенные бициклические гетероциклические соединения, способ их получения (варианты) и применение в качестве средств против ожирения и гиперхолестеринемии
ATE542805T1 (de) 2000-08-11 2012-02-15 Nippon Chemiphar Co Ppar-delta aktivatoren
AU2002224139A1 (en) * 2000-12-05 2002-06-18 Nippon Chemiphar Co. Ltd. Ppar (peroxisome proliferator activated receptor) activators
EP1372632A1 (en) * 2001-02-15 2004-01-02 Pfizer Products Inc. Proliferative activator receptor (ppar) compounds
MXPA03007284A (es) 2001-02-15 2003-12-04 Pfizer Prod Inc Agonistas de receptor activador del proliferador de peroxisomas.
US6548538B2 (en) 2001-05-22 2003-04-15 Bayer Aktiengesellschaft Propionic acid derivatives
US20030191144A1 (en) * 2001-06-12 2003-10-09 Active Pass Pharmaceuticals, Inc. Compounds, compositions and methods for modulating beta-amyloid production
EP1399426A2 (en) * 2001-06-12 2004-03-24 Active Pass Pharmaceuticals, Inc. Compounds, compositions and methods for modulating beta-amyloid production
IL160304A0 (en) 2001-08-10 2004-07-25 Nippon Chemiphar Co ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR delta
KR100933652B1 (ko) 2001-10-12 2009-12-23 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 응답성 수용체 δ의 활성화제
US7015345B2 (en) * 2002-02-21 2006-03-21 Asahi Kasei Pharma Corporation Propionic acid derivatives
CN1662487A (zh) 2002-06-19 2005-08-31 伊莱利利公司 酰胺连接基过氧化物酶体增殖物激活受体调节剂
EP1388352A1 (en) 2002-08-08 2004-02-11 Laboratoires Fournier S.A. Use of a ppar-alpha agonist to treat patients suffering from weight gain associated with a ppar-gamma agonist treatment
PT1554240E (pt) 2002-10-21 2009-06-17 Janssen Pharmaceutica Nv Tetralinas e indanos substituídos e sua utilização
SI1567493T1 (sl) * 2002-11-26 2009-06-30 Pfizer Prod Inc S fenilom substituirane piperidinske spojine za uporabo kot aktivatorji PPAR
CA2511970C (en) 2003-01-14 2012-06-26 Cytokinetics, Inc. Urea derivatives useful in the treatment of heart failure
US6987118B2 (en) 2003-05-21 2006-01-17 Pfizer Inc. Tetrahydroisoquinoline derivatives as PPAR-alpha activators
RS53600B1 (en) 2004-06-17 2015-02-27 Cytokinetics, Inc. UNITS, PREPARATIONS AND METHODS
US7538223B2 (en) 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
WO2007070683A2 (en) 2005-12-15 2007-06-21 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US7825120B2 (en) 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US7718657B2 (en) 2005-12-16 2010-05-18 Cytokinetics, Inc. Certain indanyl urea modulators of the cardiac sarcomere
WO2007078839A2 (en) 2005-12-19 2007-07-12 Cytokinetics, Inc. Compounds, compositions and methods
KR101507173B1 (ko) 2006-04-18 2015-03-30 닛뽕 케미파 가부시키가이샤 페록시좀 증식제 활성화 수용체 δ 의 활성화제
RU2501794C2 (ru) 2008-04-15 2013-12-20 Ниппон Кемифар Ко., Лтд. Активирующий агент для рецептора, активируемого стимулирующими рост пероксисом агентами
JP2015509917A (ja) 2012-01-10 2015-04-02 イーライ リリー アンド カンパニー ロイコトリエンb4アンタゴニスト化合物
WO2013169648A1 (en) 2012-05-07 2013-11-14 Novartis Ag Pharmaceutical combinations comprising a dgat1 inhibtor and a triglyceride lowering drug

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2614045A1 (de) * 1976-04-01 1977-10-06 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben
US4387106A (en) * 1982-01-26 1983-06-07 American Cyanamid Company Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4397868A (en) * 1982-01-26 1983-08-09 American Cyanamid Company Method of treating atherosclerosis with trisubstituted ureas
EP0358724A4 (en) * 1987-06-15 1990-06-05 Iraj Lalezari COMPOSITION, COMPOUND AND METHOD FOR REDUCING LIPIDS, MODIFYING THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND PREVENTING THE BLOOD LEVEL.
US4921997A (en) * 1988-06-15 1990-05-01 Montefiore Medical Center Method of synthesis and novel compounds for pharmaceutical uses
GB8827152D0 (en) * 1988-11-21 1988-12-29 Wellcome Found Anti-atherosclerotic diaryl compounds

Also Published As

Publication number Publication date
ATE157651T1 (de) 1997-09-15
JPH06507151A (ja) 1994-08-11
DE69127556D1 (de) 1997-10-09
CA2098122C (en) 2003-09-23
US5658944A (en) 1997-08-19
JP2951402B2 (ja) 1999-09-20
IL100331A (en) 1996-09-12
IE914304A1 (en) 1992-06-17
ZA919773B (en) 1993-06-11
EP0639178A1 (en) 1995-02-22
HUT64514A (en) 1994-01-28
AU647859B2 (en) 1994-03-31
WO1992010468A1 (en) 1992-06-25
NZ240935A (en) 1994-11-25
KR930703246A (ko) 1993-11-29
EP0639178B1 (en) 1997-09-03
CA2098122A1 (en) 1992-06-13
IL100331A0 (en) 1992-09-06
HU9301709D0 (en) 1993-09-28
GB9027023D0 (en) 1991-01-30
AU9056091A (en) 1992-07-08

Similar Documents

Publication Publication Date Title
TW275065B (zh)
CA2282890A1 (en) Therapeutic heterocyclic compounds
TW330202B (en) Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals
GR3020510T3 (en) Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them
MY102866A (en) Amide derivatives.
ATE79376T1 (de) Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ZA935276B (en) 3-(hydroxybenzylidenyl)-indolin-2-ones processes for their preparation and pharmaceutical compositions containing them
EP0222693A3 (en) 3-oxadiazolyl and 3-carboxylic-acid beta-carboline derivatives, their preparation and their use as medicaments
AU582043B2 (en) Phenoxyalkylcarboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
GR3000565T3 (en) 2-thiazolyl imidazo û1,2-a¨ pyrimidines and their salts, process for their preparation, their use as medicaments and compositions containing them
ES8501410A1 (es) Un procedimiento para la preparacion de nuevos derivados de fosfolipidos.
FR2709306B1 (fr) Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ZA906301B (en) Novel 2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,pharmaceutical compositions containing them and process for preparing same
HK56597A (en) 3-aminochromane derivatives procedure for their preparation and pharmaceutical compositions containing them
IE893956L (en) Novel compounds
IL79233A0 (en) 11-substituted 5,11-dihydro-6h-pyrido(2,3-b)(1,4)benzodiazepin-6-ones,their preparation and pharmaceutical compositions containing them
ATE92315T1 (de) Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate.
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
EP0090681A3 (en) Novel 1,2-dihydropyrido-(3,4-b)pyrazines
ES8701176A1 (es) Un procedimiento para preparar nuevas amidas de acidos indo-lo-quinolizin-carboxilicos
ES2002427A6 (es) Procedimient para la preparacion de nuevos analogos de gonadoliberina
ES8202797A1 (es) Procedimiento para la obtencion de fenoxiacetatos sustitui- dos de aminas ciclicas