DE60232739D1 - Aktivator des peroxisomproliferator-aktivierten rezeptors delta - Google Patents
Aktivator des peroxisomproliferator-aktivierten rezeptors deltaInfo
- Publication number
- DE60232739D1 DE60232739D1 DE60232739T DE60232739T DE60232739D1 DE 60232739 D1 DE60232739 D1 DE 60232739D1 DE 60232739 T DE60232739 T DE 60232739T DE 60232739 T DE60232739 T DE 60232739T DE 60232739 D1 DE60232739 D1 DE 60232739D1
- Authority
- DE
- Germany
- Prior art keywords
- activator
- peroxisomproliferator
- activated receptor
- receptor delta
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001315694 | 2001-10-12 | ||
PCT/JP2002/010472 WO2003033493A1 (fr) | 2001-10-12 | 2002-10-09 | Activateur du recepteur $g(d) active par le proliferateur de peroxisome |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60232739D1 true DE60232739D1 (de) | 2009-08-06 |
Family
ID=19133818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60232739T Expired - Lifetime DE60232739D1 (de) | 2001-10-12 | 2002-10-09 | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
Country Status (17)
Country | Link |
---|---|
US (2) | US7119104B2 (de) |
EP (1) | EP1445258B1 (de) |
JP (1) | JP4276074B2 (de) |
KR (1) | KR100933652B1 (de) |
CN (1) | CN1293076C (de) |
AT (1) | ATE434616T1 (de) |
AU (1) | AU2002335231B2 (de) |
BR (1) | BRPI0213243B8 (de) |
CA (1) | CA2463569C (de) |
CY (1) | CY1110355T1 (de) |
DE (1) | DE60232739D1 (de) |
DK (1) | DK1445258T3 (de) |
ES (1) | ES2326411T3 (de) |
IL (2) | IL161351A0 (de) |
MX (1) | MXPA04003398A (de) |
PT (1) | PT1445258E (de) |
WO (1) | WO2003033493A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04003398A (es) * | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
US20070037882A1 (en) * | 2003-04-22 | 2007-02-15 | Astellas Pharma Inc. | Remedy for cerebral neurodegenerative diseases using ppar agonist |
CN1882533B (zh) | 2003-09-19 | 2010-06-09 | 詹森药业有限公司 | 4-((苯氧基烷基)硫基)-苯氧基乙酸及其类似物 |
WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
US8053598B2 (en) | 2004-05-05 | 2011-11-08 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
US7968723B2 (en) | 2004-05-05 | 2011-06-28 | High Point Pharmaceuticals, Llc | Compounds, their preparation and use |
KR20070053243A (ko) * | 2004-09-11 | 2007-05-23 | 사노피-아벤티스 도이칠란트 게엠베하 | 7-아자인돌 및 ppar 작용제로서의 이의 용도 |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
JP5052511B2 (ja) | 2005-06-30 | 2012-10-17 | ハイ ポイント ファーマシューティカルズ,エルエルシー | Pparデルタ活性化因子としてのフェノキシ酢酸 |
US20100029949A1 (en) * | 2005-07-06 | 2010-02-04 | Shogo Sakuma | Activator for Peroxisome Proliferator Activated Receptor |
US20080234349A1 (en) * | 2005-09-07 | 2008-09-25 | Jack Lin | PPAR active compounds |
JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
EP1979311B1 (de) | 2005-12-22 | 2012-06-13 | High Point Pharmaceuticals, LLC | Phenoxyessigsäuren als ppar-delta-aktivatoren |
EP1999098A2 (de) | 2006-03-09 | 2008-12-10 | High Point Pharmaceuticals, LLC | Verbindungen, die die ppar-aktivität modulieren, ihre herstellung und ihre verwendung |
UY30288A1 (es) | 2006-04-18 | 2007-08-31 | Janssen Pharmaceutica Nv | Derivados del ácido benzoazepin-oxi-acético como agonistas de ppar-delta usados para aumentar hdl-c. reducir ldl-c y reducir colesterol |
DK2014652T3 (da) * | 2006-04-18 | 2014-10-13 | Nippon Chemiphar Co | Aktiveringsmiddel til peroxisom-proliferator-aktiveret receptor |
JPWO2008016175A1 (ja) * | 2006-08-03 | 2009-12-24 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
WO2008143254A1 (ja) | 2007-05-21 | 2008-11-27 | Senju Pharmaceutical Co., Ltd. | PPARδアゴニスト含有医薬 |
WO2008154023A1 (en) * | 2007-06-11 | 2008-12-18 | Cerenis Therapeutics S.A. | Novel uses of ppar delta agonists |
NZ588612A (en) * | 2008-04-15 | 2012-08-31 | Nippon Chemiphar Co | Benzothiophen derivatives as activators of peroxisome proliferator activated receptor (PPAR) |
AU2009307884B2 (en) | 2008-10-22 | 2014-07-31 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
EP2362731B1 (de) | 2008-10-31 | 2016-04-06 | Merck Sharp & Dohme Corp. | Neue nützlich anti-diabetische mittel mit zyklische benzimidazol-derivate |
WO2011020001A2 (en) | 2009-08-14 | 2011-02-17 | Cerenis Therapeutics S.A. | Use of ppar delta ligands for the treatment or prevention of inflammation or energy metabolism/production related diseases |
BR112012007137A2 (pt) | 2009-09-30 | 2015-09-15 | Harvard College | metodos para modulacao da autofagia por meio da modulacao de produtos genicos inibidores da autofagia |
JP2013006769A (ja) * | 2009-10-08 | 2013-01-10 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
EA201690035A1 (ru) | 2011-02-25 | 2016-05-31 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
RU2662067C2 (ru) | 2013-01-31 | 2018-07-23 | Сэндзю Фармасьютикал Ко., Лтд. | Прозрачный водный раствор |
BR112015017708A2 (pt) | 2013-01-31 | 2017-07-11 | Senju Pharma Co | solução aquosa estável |
EP2958562A4 (de) | 2013-02-22 | 2016-08-10 | Merck Sharp & Dohme | Antidiabetische bicyclische verbindungen |
EP2970119B1 (de) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Neuartige indolderivate als antidiabetika |
WO2015035171A1 (en) | 2013-09-09 | 2015-03-12 | High Point Pharmaceuticals, Llc | Use of a ppar-delta agonist for treating muscle atrophy |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US20190255022A1 (en) * | 2016-05-12 | 2019-08-22 | Nippon Chemiphar Co., Ltd. | Wound-healing agent |
EP3551176A4 (de) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Antidiabetische heterocyclische verbindungen |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
EP3563388A2 (de) * | 2016-12-30 | 2019-11-06 | NuScale Power, LLC | Steuerstabantriebsmechanismus (crdm) mit ferntrennmechanismus |
US11634387B2 (en) | 2019-09-26 | 2023-04-25 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
CN113912547B (zh) | 2020-07-10 | 2024-04-30 | 成都凡诺西生物医药科技有限公司 | 取代苯丙咪唑类衍生物及其应用 |
WO2022189856A1 (en) * | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
CN115215856A (zh) * | 2022-08-19 | 2022-10-21 | 沈阳药科大学 | 一种PPARδ激动剂福那德帕及其中间体的制备方法 |
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US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
US5089541A (en) | 1990-11-23 | 1992-02-18 | Shell Oil Company | Removal of hydrogenation catalyst from polymer solutions by contact with activated carbon |
GB9027023D0 (en) | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
HUT64023A (en) | 1991-03-22 | 1993-11-29 | Sandoz Ag | Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds |
GB9426448D0 (en) | 1994-12-30 | 1995-03-01 | Wellcome Found | Process |
US6043264A (en) * | 1995-01-06 | 2000-03-28 | Toray Industries, Inc. | Benzene-condensed heterocyclic derivatives and their uses |
CA2171702A1 (en) * | 1995-03-14 | 1996-09-15 | Takashi Sohda | Benzofuran compounds and their use |
WO1996035688A1 (fr) | 1995-05-08 | 1996-11-14 | Nippon Chemiphar Co., Ltd. | Derives de 2,4-thiazolidinedione ou d'oxazolidinedione et agent hypoglycemique |
ATE263561T1 (de) | 1996-01-22 | 2004-04-15 | Fujisawa Pharmaceutical Co | Thiazolylbenzofuranderivate und ihre verwendung als srs-a- und leukotrien-antagonisten |
DE69723680T9 (de) | 1996-02-02 | 2004-11-04 | Merck & Co., Inc. | Antidiabetische mittel |
US20020032330A1 (en) * | 1996-12-24 | 2002-03-14 | Yutaka Nomura | Propionic acid derivatives |
EP1023907B1 (de) * | 1997-07-24 | 2009-01-21 | Astellas Pharma Inc. | Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung |
US6589969B1 (en) * | 1998-10-16 | 2003-07-08 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
JP2001354671A (ja) * | 2000-04-14 | 2001-12-25 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
DE60131001T2 (de) * | 2000-08-23 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Oxazolylarylpropionsäure derivate und ihre verwendung als ppar agonisten |
GB0031109D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
EP1345916A1 (de) * | 2000-12-20 | 2003-09-24 | Glaxo Group Limited | Substituierte oxazole und thiazole als hppar alpha agonisten |
US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
GB0113231D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
KR100901683B1 (ko) * | 2001-08-10 | 2009-06-08 | 닛뽕 케미파 가부시키가이샤 | 퍼옥시좀 증식제 응답성 수용체 δ의 활성화제 |
MXPA04003398A (es) | 2001-10-12 | 2004-11-22 | Nippon Chemiphar Co | Activador para el receptor o activado con el proliferador de peroxisoma. |
US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
-
2002
- 2002-10-09 MX MXPA04003398A patent/MXPA04003398A/es active IP Right Grant
- 2002-10-09 WO PCT/JP2002/010472 patent/WO2003033493A1/ja active Application Filing
- 2002-10-09 PT PT02801515T patent/PT1445258E/pt unknown
- 2002-10-09 DK DK02801515T patent/DK1445258T3/da active
- 2002-10-09 ES ES02801515T patent/ES2326411T3/es not_active Expired - Lifetime
- 2002-10-09 EP EP02801515A patent/EP1445258B1/de not_active Expired - Lifetime
- 2002-10-09 CN CNB028202422A patent/CN1293076C/zh not_active Expired - Fee Related
- 2002-10-09 CA CA2463569A patent/CA2463569C/en not_active Expired - Lifetime
- 2002-10-09 JP JP2003536232A patent/JP4276074B2/ja not_active Expired - Fee Related
- 2002-10-09 US US10/491,935 patent/US7119104B2/en not_active Expired - Lifetime
- 2002-10-09 BR BRPI0213243A patent/BRPI0213243B8/pt not_active IP Right Cessation
- 2002-10-09 IL IL16135102A patent/IL161351A0/xx unknown
- 2002-10-09 AU AU2002335231A patent/AU2002335231B2/en not_active Ceased
- 2002-10-09 KR KR1020047005398A patent/KR100933652B1/ko active IP Right Grant
- 2002-10-09 AT AT02801515T patent/ATE434616T1/de active
- 2002-10-09 DE DE60232739T patent/DE60232739D1/de not_active Expired - Lifetime
-
2004
- 2004-04-13 IL IL161351A patent/IL161351A/en active IP Right Grant
-
2006
- 2006-10-06 US US11/544,505 patent/US7402597B2/en active Active
-
2009
- 2009-08-06 CY CY20091100833T patent/CY1110355T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK1445258T3 (da) | 2009-10-12 |
BR0213243A (pt) | 2005-01-04 |
ES2326411T3 (es) | 2009-10-09 |
KR100933652B1 (ko) | 2009-12-23 |
PT1445258E (pt) | 2009-07-02 |
CY1110355T1 (el) | 2015-04-29 |
JP4276074B2 (ja) | 2009-06-10 |
WO2003033493A1 (fr) | 2003-04-24 |
EP1445258A1 (de) | 2004-08-11 |
CN1293076C (zh) | 2007-01-03 |
CA2463569A1 (en) | 2003-04-24 |
KR20040053164A (ko) | 2004-06-23 |
AU2002335231B2 (en) | 2008-05-08 |
EP1445258A4 (de) | 2006-01-04 |
IL161351A (en) | 2012-12-31 |
US20050096363A1 (en) | 2005-05-05 |
ATE434616T1 (de) | 2009-07-15 |
US20070027196A1 (en) | 2007-02-01 |
US7402597B2 (en) | 2008-07-22 |
BRPI0213243B8 (pt) | 2021-05-25 |
MXPA04003398A (es) | 2004-11-22 |
US7119104B2 (en) | 2006-10-10 |
CN1568323A (zh) | 2005-01-19 |
JPWO2003033493A1 (ja) | 2005-02-03 |
CA2463569C (en) | 2012-05-15 |
IL161351A0 (en) | 2004-09-27 |
BRPI0213243B1 (pt) | 2021-03-16 |
EP1445258B1 (de) | 2009-06-24 |
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