ATE434616T1 - Aktivator des peroxisomproliferator-aktivierten rezeptors delta - Google Patents
Aktivator des peroxisomproliferator-aktivierten rezeptors deltaInfo
- Publication number
- ATE434616T1 ATE434616T1 AT02801515T AT02801515T ATE434616T1 AT E434616 T1 ATE434616 T1 AT E434616T1 AT 02801515 T AT02801515 T AT 02801515T AT 02801515 T AT02801515 T AT 02801515T AT E434616 T1 ATE434616 T1 AT E434616T1
- Authority
- AT
- Austria
- Prior art keywords
- activated receptor
- peroxisome proliferator
- receptor delta
- alkyl
- delta activator
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001315694 | 2001-10-12 | ||
PCT/JP2002/010472 WO2003033493A1 (fr) | 2001-10-12 | 2002-10-09 | Activateur du recepteur $g(d) active par le proliferateur de peroxisome |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE434616T1 true ATE434616T1 (de) | 2009-07-15 |
Family
ID=19133818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02801515T ATE434616T1 (de) | 2001-10-12 | 2002-10-09 | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
Country Status (17)
Country | Link |
---|---|
US (2) | US7119104B2 (de) |
EP (1) | EP1445258B1 (de) |
JP (1) | JP4276074B2 (de) |
KR (1) | KR100933652B1 (de) |
CN (1) | CN1293076C (de) |
AT (1) | ATE434616T1 (de) |
AU (1) | AU2002335231B2 (de) |
BR (1) | BRPI0213243B8 (de) |
CA (1) | CA2463569C (de) |
CY (1) | CY1110355T1 (de) |
DE (1) | DE60232739D1 (de) |
DK (1) | DK1445258T3 (de) |
ES (1) | ES2326411T3 (de) |
IL (2) | IL161351A0 (de) |
MX (1) | MXPA04003398A (de) |
PT (1) | PT1445258E (de) |
WO (1) | WO2003033493A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60232739D1 (de) * | 2001-10-12 | 2009-08-06 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
US20070037882A1 (en) * | 2003-04-22 | 2007-02-15 | Astellas Pharma Inc. | Remedy for cerebral neurodegenerative diseases using ppar agonist |
EA012241B1 (ru) | 2003-09-19 | 2009-08-28 | Янссен Фармацевтика, Н.В. | 4-((феноксиалкил)тио)феноксиуксусные кислоты и их аналоги |
US20050203151A1 (en) * | 2003-12-19 | 2005-09-15 | Kalypsys, Inc. | Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions |
EP2305352A1 (de) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-Reduktaseinhibitoren zur Behandlung von Stoffwechsel- und anthropometrischen Störungen |
DE602005024384D1 (de) | 2004-05-05 | 2010-12-09 | High Point Pharmaceuticals Llc | Neue verbindungen, ihre herstellung und verwendung |
WO2005105736A1 (en) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Novel compounds, their preparation and use |
BRPI0515168A (pt) | 2004-09-11 | 2008-07-08 | Sanofi Aventis Deutschland | 7-azaindóis, processos para sua preparação e seu uso como fármacos |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
ES2449618T3 (es) | 2005-06-30 | 2014-03-20 | High Point Pharmaceuticals, Llc | Ácidos fenoxiacéticos como activadores de PPAR-delta |
EP1916247A4 (de) * | 2005-07-06 | 2009-07-15 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator- aktivierten rezeptors |
JP2009509932A (ja) * | 2005-09-07 | 2009-03-12 | プレキシコン,インコーポレーテッド | Ppar活性化合物 |
JO3006B1 (ar) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
EP2386540A1 (de) | 2005-12-22 | 2011-11-16 | High Point Pharmaceuticals, LLC | Neue Verbindungen, ihre Herstellung und Verwendung |
EP1999098A2 (de) | 2006-03-09 | 2008-12-10 | High Point Pharmaceuticals, LLC | Verbindungen, die die ppar-aktivität modulieren, ihre herstellung und ihre verwendung |
SI2014652T1 (sl) * | 2006-04-18 | 2014-12-31 | Nippon Chemiphar Co., Ltd. | Aktivacijsko sredstvo za peroksisomski proliferatorski aktivirani receptor |
PE20080188A1 (es) | 2006-04-18 | 2008-03-10 | Janssen Pharmaceutica Nv | Derivados del acido benzoazepin-oxi-acetico como agonistas de ppar-delta usados para aumentar hdl-c, reducir ldl-c y reducir colesterol |
WO2008016175A1 (fr) * | 2006-08-03 | 2008-02-07 | Nippon Chemiphar Co., Ltd. | Agent activant de récepteur activé par les proliférateurs des peroxysomes |
PT2151438E (pt) | 2007-05-21 | 2012-11-15 | Senju Pharma Co | Produto farmacêutico contendo agonista de ppar |
WO2008154023A1 (en) * | 2007-06-11 | 2008-12-18 | Cerenis Therapeutics S.A. | Novel uses of ppar delta agonists |
CN102083810B (zh) | 2008-04-15 | 2014-10-29 | 日本化学医药株式会社 | 过氧化物酶体增殖剂活化受体的活化剂 |
CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
MX2012001932A (es) * | 2009-08-14 | 2012-03-14 | Nippon Chemiphar Co | Uso de ligandos ppar delta para el tratamiento o prevencion de enfermedades relacionadas con metabolismo/produccion de inflamacion o energia. |
EP2483407A2 (de) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Verfahren zur autophagie-modulation durch modulation autophagie-verstärkender genprodukte |
JP2013006769A (ja) * | 2009-10-08 | 2013-01-10 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤活性化受容体の活性化剤 |
JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
MA34916B1 (fr) | 2011-02-25 | 2014-02-01 | Merck Sharp & Dohme | Nouveaux dérivés d'azabenzimidazole cyclique utiles en tant qu'agents antidiabétiques |
CA2880901A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
KR20150110773A (ko) | 2013-01-31 | 2015-10-02 | 센주 세이야꾸 가부시키가이샤 | 징명한 수성 액제 |
CA2899292A1 (en) | 2013-01-31 | 2014-08-07 | Senju Pharmaceutical Co., Ltd. | Stable aqueous solution |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
US9487493B2 (en) | 2013-09-09 | 2016-11-08 | Vtv Therapeutics Llc | Use of a PPAR-delta agonist for treating muscle atrophy |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
EP3456327A4 (de) * | 2016-05-12 | 2019-12-25 | Nippon Chemiphar Co., Ltd. | Wundheilender wirkstoff |
EP3551176A4 (de) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Antidiabetische heterocyclische verbindungen |
EP3558298A4 (de) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | Antidiabetische spirochromanverbindungen |
CN110114837B (zh) * | 2016-12-30 | 2023-10-10 | 纽斯高动力有限责任公司 | 具有远程断开机构的控制棒驱动机构(crdm) |
US11634387B2 (en) | 2019-09-26 | 2023-04-25 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
CN113912547A (zh) | 2020-07-10 | 2022-01-11 | 成都凡诺西生物医药科技有限公司 | 取代苯丙咪唑类衍生物及其应用 |
WO2022189856A1 (en) * | 2021-03-08 | 2022-09-15 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
CN115215856A (zh) * | 2022-08-19 | 2022-10-21 | 沈阳药科大学 | 一种PPARδ激动剂福那德帕及其中间体的制备方法 |
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ATE216384T1 (de) | 1996-01-22 | 2002-05-15 | Fujisawa Pharmaceutical Co | Thiazolylbenzofuranderivate und pharmazeutische zusammensetzungen die sie enthalten |
ATE245622T1 (de) | 1996-02-02 | 2003-08-15 | Merck & Co Inc | Antidiabetische mittel |
US20020032330A1 (en) | 1996-12-24 | 2002-03-14 | Yutaka Nomura | Propionic acid derivatives |
JP4427825B2 (ja) | 1997-07-24 | 2010-03-10 | アステラス製薬株式会社 | コレステロール低下作用を有する医薬組成物 |
US6589969B1 (en) | 1998-10-16 | 2003-07-08 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
JP2001354671A (ja) * | 2000-04-14 | 2001-12-25 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
EP1313717B1 (de) * | 2000-08-23 | 2007-10-17 | Eli Lilly And Company | Oxazolylarylpropionsäure derivate und ihre verwendung als ppar agonisten |
EP1345916A1 (de) * | 2000-12-20 | 2003-09-24 | Glaxo Group Limited | Substituierte oxazole und thiazole als hppar alpha agonisten |
US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
GB0031109D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
GB0113231D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
AU2002323776B2 (en) * | 2001-08-10 | 2008-07-31 | Nippon Chemiphar Co., Ltd. | Activator for peroxisome proliferator-responsive receptor Delta |
DE60232739D1 (de) | 2001-10-12 | 2009-08-06 | Nippon Chemiphar Co | Aktivator des peroxisomproliferator-aktivierten rezeptors delta |
US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
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2002
- 2002-10-09 DE DE60232739T patent/DE60232739D1/de not_active Expired - Lifetime
- 2002-10-09 EP EP02801515A patent/EP1445258B1/de not_active Expired - Lifetime
- 2002-10-09 US US10/491,935 patent/US7119104B2/en not_active Expired - Lifetime
- 2002-10-09 PT PT02801515T patent/PT1445258E/pt unknown
- 2002-10-09 CA CA2463569A patent/CA2463569C/en not_active Expired - Lifetime
- 2002-10-09 KR KR1020047005398A patent/KR100933652B1/ko active IP Right Grant
- 2002-10-09 DK DK02801515T patent/DK1445258T3/da active
- 2002-10-09 JP JP2003536232A patent/JP4276074B2/ja not_active Expired - Fee Related
- 2002-10-09 AU AU2002335231A patent/AU2002335231B2/en not_active Ceased
- 2002-10-09 ES ES02801515T patent/ES2326411T3/es not_active Expired - Lifetime
- 2002-10-09 IL IL16135102A patent/IL161351A0/xx unknown
- 2002-10-09 BR BRPI0213243A patent/BRPI0213243B8/pt not_active IP Right Cessation
- 2002-10-09 WO PCT/JP2002/010472 patent/WO2003033493A1/ja active Application Filing
- 2002-10-09 AT AT02801515T patent/ATE434616T1/de active
- 2002-10-09 MX MXPA04003398A patent/MXPA04003398A/es active IP Right Grant
- 2002-10-09 CN CNB028202422A patent/CN1293076C/zh not_active Expired - Fee Related
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2004
- 2004-04-13 IL IL161351A patent/IL161351A/en active IP Right Grant
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2006
- 2006-10-06 US US11/544,505 patent/US7402597B2/en active Active
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Also Published As
Publication number | Publication date |
---|---|
DK1445258T3 (da) | 2009-10-12 |
ES2326411T3 (es) | 2009-10-09 |
JPWO2003033493A1 (ja) | 2005-02-03 |
CY1110355T1 (el) | 2015-04-29 |
EP1445258A4 (de) | 2006-01-04 |
CN1568323A (zh) | 2005-01-19 |
IL161351A (en) | 2012-12-31 |
CA2463569A1 (en) | 2003-04-24 |
DE60232739D1 (de) | 2009-08-06 |
KR20040053164A (ko) | 2004-06-23 |
BRPI0213243B1 (pt) | 2021-03-16 |
WO2003033493A1 (fr) | 2003-04-24 |
BR0213243A (pt) | 2005-01-04 |
MXPA04003398A (es) | 2004-11-22 |
CA2463569C (en) | 2012-05-15 |
US7402597B2 (en) | 2008-07-22 |
EP1445258B1 (de) | 2009-06-24 |
US20070027196A1 (en) | 2007-02-01 |
US7119104B2 (en) | 2006-10-10 |
US20050096363A1 (en) | 2005-05-05 |
JP4276074B2 (ja) | 2009-06-10 |
IL161351A0 (en) | 2004-09-27 |
CN1293076C (zh) | 2007-01-03 |
KR100933652B1 (ko) | 2009-12-23 |
BRPI0213243B8 (pt) | 2021-05-25 |
AU2002335231B2 (en) | 2008-05-08 |
PT1445258E (pt) | 2009-07-02 |
EP1445258A1 (de) | 2004-08-11 |
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