HUT50347A - Process for production of cefalosporin-salts and injectable compositions containing them as active sobstance - Google Patents

Process for production of cefalosporin-salts and injectable compositions containing them as active sobstance

Info

Publication number
HUT50347A
HUT50347A HU89185A HU18589A HUT50347A HU T50347 A HUT50347 A HU T50347A HU 89185 A HU89185 A HU 89185A HU 18589 A HU18589 A HU 18589A HU T50347 A HUT50347 A HU T50347A
Authority
HU
Hungary
Prior art keywords
salts
sobstance
cefalosporin
active
production
Prior art date
Application number
HU89185A
Other languages
English (en)
Other versions
HU205940B (en
Inventor
Murray A Kaplan
Robert W Hudyma
Robert A Lipper
Kun M Shih
Susan D Boettger
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22510643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT50347(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HUT50347A publication Critical patent/HUT50347A/hu
Publication of HU205940B publication Critical patent/HU205940B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
HU89185A 1988-01-19 1989-01-18 Process for producing 7-alpha-/2-amino-thiazol-4-yl/-alpha-/z/-methoxy-imino-acetamido-3-/1-methyl-1-pyrrolidino/-methyl-3-cepheme-4-carboxylate dihydrochloride hydrate and pharmaceutical compositions containing them HU205940B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/144,899 US4910301A (en) 1985-08-05 1988-01-19 Cefepime cephalosporin salts

Publications (2)

Publication Number Publication Date
HUT50347A true HUT50347A (en) 1990-01-29
HU205940B HU205940B (en) 1992-07-28

Family

ID=22510643

Family Applications (1)

Application Number Title Priority Date Filing Date
HU89185A HU205940B (en) 1988-01-19 1989-01-18 Process for producing 7-alpha-/2-amino-thiazol-4-yl/-alpha-/z/-methoxy-imino-acetamido-3-/1-methyl-1-pyrrolidino/-methyl-3-cepheme-4-carboxylate dihydrochloride hydrate and pharmaceutical compositions containing them

Country Status (32)

Country Link
US (1) US4910301A (hu)
JP (1) JPH0725768B2 (hu)
KR (1) KR950003612B1 (hu)
AT (1) AT399878B (hu)
AU (1) AU615509B2 (hu)
BE (1) BE1002749A5 (hu)
CA (1) CA1298288C (hu)
CY (1) CY1663A (hu)
CZ (1) CZ281602B6 (hu)
DD (2) DD283397A5 (hu)
DE (1) DE3901359A1 (hu)
DK (1) DK162054C (hu)
EG (1) EG18749A (hu)
ES (1) ES2012948A6 (hu)
FI (1) FI86854C (hu)
FR (1) FR2626003B1 (hu)
GB (1) GB2213819B (hu)
GR (1) GR1001218B (hu)
HK (1) HK72292A (hu)
HU (1) HU205940B (hu)
IE (1) IE67447B1 (hu)
IT (1) IT1229528B (hu)
LU (1) LU87432A1 (hu)
NL (1) NL192266C (hu)
NZ (1) NZ227605A (hu)
OA (1) OA09227A (hu)
PT (1) PT89474B (hu)
SE (1) SE505258C2 (hu)
SG (1) SG75492G (hu)
SK (1) SK281768B6 (hu)
YU (1) YU221188A (hu)
ZA (1) ZA89407B (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244891A (en) * 1985-08-05 1993-09-14 Bristol-Myers Squibb Company Injectable compositions of cefepime dihydrochloride hydrate
DE68917574T2 (de) * 1988-12-27 1994-12-15 Chugai Pharmaceutical Co Ltd Reinigungsverfahren für 1,2-Bis(nicotinamido)propan.
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
MY108872A (en) * 1991-09-10 1996-11-30 Bristol Myers Squibb Co Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate.
US5594129A (en) * 1991-09-10 1997-01-14 Bristol-Myers Squibb Company Process for the preparation of a cephalosporin antibiotic
US5698703A (en) * 1991-09-10 1997-12-16 Bristol-Myers Squibb Company Syn-isomer of thiazolyl intermediate and process for the preparation thereof
TW232695B (hu) * 1992-07-24 1994-10-21 Bristol Myers Squibb Co
US5391729A (en) * 1992-09-08 1995-02-21 Bristol-Myers Squibb Company Crystalline dihydrate of a cephalosporin salt
CA2101571A1 (en) * 1992-09-08 1994-03-09 Elizabeth A. Garofalo Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
US5401842A (en) * 1992-09-08 1995-03-28 Bristol-Myers Squibb Company Injectable compositions of a cephalosporin dihydrate salt
JPH0840907A (ja) 1994-08-03 1996-02-13 Meiji Seika Kaisha Ltd セファロスポリン注射剤
WO2005094800A2 (en) * 2004-03-31 2005-10-13 Lupin Ltd. A co-precipitated cefepime composition and process for preparation thereof
EP1773845A1 (en) * 2004-07-16 2007-04-18 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
ITMI20051684A1 (it) * 2005-09-13 2007-03-14 Harvest Lodge Ltd Procedimento per la produzione del dicloridrato di amminoacidi
ITMI20060422A1 (it) * 2006-03-09 2007-09-10 Harvest Lodge Ltd Procedimento diretto per la produzione del dicloridrato di un amminoacido
US8151846B2 (en) * 2006-12-15 2012-04-10 Center Line Wheel Corporation Wheel having inner bead-lock
TWI400243B (zh) * 2009-07-20 2013-07-01 Intervet Int Bv 製造西喹諾（ｃｅｆｑｕｉｎｏｍｅ）粒子的方法
CN103304580B (zh) * 2013-06-09 2014-07-09 四川省惠达药业有限公司 一种盐酸头孢吡肟化合物、其制备方法及其药物组合物
AU2016367284C1 (en) * 2015-12-10 2018-09-20 Naeja-Rgm Pharmaceuticals Ulc Cephem compounds, their production and use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
JPS55151588A (en) * 1979-05-14 1980-11-26 Takeda Chem Ind Ltd Preparation of cephalosporin salt crystal
JPS5612397A (en) * 1979-05-25 1981-02-06 Glaxo Group Ltd Intermediate for manufacture of cephalosporin antibiotic
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
CA1213882A (en) * 1982-03-04 1986-11-12 Jun Okumura Cephalosporins
US4406899A (en) * 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
US4751295A (en) * 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
US4749694A (en) * 1984-04-26 1988-06-07 Merck & Co., Inc. Novel lysine esters used as absorption
FR2585705B1 (fr) * 1985-08-05 1989-01-13 Bristol Myers Co Sels de cephalosporine et compositions injectables
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
US4791196A (en) * 1986-09-26 1988-12-13 Sankyo Company Limited Crystalline cephem carboxylic acid addition salt

Also Published As

Publication number Publication date
OA09227A (fr) 1992-06-30
GB2213819B (en) 1991-11-27
NZ227605A (en) 1991-06-25
NL192266B (nl) 1996-12-02
US4910301A (en) 1990-03-20
IE67447B1 (en) 1996-04-03
DD284807A5 (de) 1990-11-28
LU87432A1 (fr) 1989-08-30
SG75492G (en) 1992-10-02
HU205940B (en) 1992-07-28
GB2213819A (en) 1989-08-23
BE1002749A5 (fr) 1991-05-28
FI890213A (fi) 1989-07-20
EG18749A (en) 1993-12-30
FI86854C (fi) 1992-10-26
FR2626003B1 (fr) 1992-10-16
CA1298288C (en) 1992-03-31
JPH029885A (ja) 1990-01-12
KR890011895A (ko) 1989-08-23
AU2862389A (en) 1989-07-20
DK20789A (da) 1989-07-20
DK162054C (da) 1992-02-10
IT1229528B (it) 1991-09-04
GR1001218B (el) 1993-06-21
SK24389A3 (en) 2000-12-11
NL192266C (nl) 1997-04-03
DK162054B (da) 1991-09-09
IE890144L (en) 1989-07-19
SE8900173L (en) 1989-01-18
ATA8589A (de) 1994-12-15
JPH0725768B2 (ja) 1995-03-22
HK72292A (en) 1992-10-02
PT89474B (pt) 1993-12-31
DE3901359A1 (de) 1989-10-05
NL8900111A (nl) 1989-08-16
PT89474A (pt) 1990-02-08
SE8900173D0 (sv) 1989-01-18
GB8901073D0 (en) 1989-03-15
SK281768B6 (sk) 2001-07-10
YU221188A (en) 1990-04-30
FI86854B (fi) 1992-07-15
IT8947539A0 (it) 1988-01-17
AT399878B (de) 1995-08-25
ES2012948A6 (es) 1990-04-16
DE3901359C2 (hu) 1992-04-30
KR950003612B1 (ko) 1995-04-17
FI890213A0 (fi) 1989-01-16
DD283397A5 (de) 1990-10-10
FR2626003A1 (fr) 1989-07-21
SE505258C2 (sv) 1997-07-21
AU615509B2 (en) 1991-10-03
CZ281602B6 (cs) 1996-11-13
ZA89407B (en) 1989-09-27
CY1663A (en) 1993-05-14
DK20789D0 (da) 1989-01-18
CZ24389A3 (en) 1996-08-14

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