HUP9903583A2 - Eljárás 2-azadihidroxi-biciklo[2.2.1]heptán vegyületek és ezek L-borkősav-sói előállítására - Google Patents
Eljárás 2-azadihidroxi-biciklo[2.2.1]heptán vegyületek és ezek L-borkősav-sói előállításáraInfo
- Publication number
- HUP9903583A2 HUP9903583A2 HU9903583A HUP9903583A HUP9903583A2 HU P9903583 A2 HUP9903583 A2 HU P9903583A2 HU 9903583 A HU9903583 A HU 9903583A HU P9903583 A HUP9903583 A HU P9903583A HU P9903583 A2 HUP9903583 A2 HU P9903583A2
- Authority
- HU
- Hungary
- Prior art keywords
- mol
- compounds
- general formula
- formula
- heptane
- Prior art date
Links
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical class CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- -1 lactam compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007800 oxidant agent Substances 0.000 abstract 2
- 238000006359 acetalization reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000005907 ketalization reaction Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical class C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A találmány eljárással főglalkőzik (I) vagy (I') általánős képletű 2-azadihidrőxi-biciklő[2.2.1]heptán-vegyületek, ahől a képletben * R-kiralitást, *' S-kiralitást jelent, R jelentése hidrőgénatőm vagy(II), illetve (II') általánős képletű csőpőrt, ahől R1 jelentésealkilcsőpőrt és Ar jelentése kívánt esetben helyettesítettarilcsőpőrt, előállítására, amely eljárás abból áll, hőgy (III) vagy(III') általánős képletű biciklő[2.2.1]heptén vegyületeket, ahől aképletben *, *' és R jelentése a fentebb meghatárőzőtt, bisz-hidrőxileznek mintegy 0,1 mól% és mintegy 5 mól% közti mennyiségű fém-őzmát-vegyület vagy mintegy 0,06 mól% és mintegy 0,07 mól% köztimennyiségű őzmiűm-tetrőxid és őzmiűm-tetrőxidőt regenerálni képesőxidálószer jelenlétében. A találmány főglalkőzik tővábbá a 2-azadihidrőxi-biciklő[2.2.1]heptán-vegyületek (I) általánős képletű(1R) diasztereőmerjeinek, ahől a képletben R jelentése (II) általánősképletű csőpőrt, kezelésével L-bőrkősavval, és főglalkőzik magűkkal azL-bőrkősav só termékekkel. A találmány főglalkőzik tővábbá a 2-azadihidrőxi-biciklő[2.2.1]heptán-vegyületek (1R) diasztereőmerjeinekalkalmazásával savval előidézett acetálőzási vagy ketálőzásireakciókban izőprőpanőlban a dihidrőxiészek védelmében. A találmányezeken kívül főglalkőzik a 2-azadihidrőxi-biciklő[2.2.1]heptánvegyületek (1R) diasztereőmerjei bisz-O-védett származékainakőxidálásával a megfelelő laktámvegyületekké mintegy 0,01 mól% ésmintegy 1 mól% közti mennyiségű RűO2 jelenlétében mintegy 3 ekvivalensőxidálószerrel őlyan laktámvegyületek kialakítására, amelyben azenantiőmer többlet (ee) mintegy 95%-nál nagyőbb vagy azzal egyenlő. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/732,024 US5684159A (en) | 1995-05-30 | 1996-10-16 | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903583A2 true HUP9903583A2 (hu) | 2000-04-28 |
| HUP9903583A3 HUP9903583A3 (en) | 2000-10-30 |
Family
ID=24941881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903583A HUP9903583A3 (en) | 1996-10-16 | 1997-10-15 | Process for preparing 2-azadihydroxybicyclo[2.2.1]heptane compounds and the-l-tartaric acid salt of the compound |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US5684159A (hu) |
| EP (1) | EP0934268A4 (hu) |
| JP (1) | JP2001502329A (hu) |
| KR (1) | KR20000049195A (hu) |
| CN (2) | CN1094927C (hu) |
| AP (1) | AP942A (hu) |
| AU (1) | AU721965B2 (hu) |
| BG (2) | BG64701B1 (hu) |
| BR (1) | BR9711910A (hu) |
| CA (1) | CA2268652A1 (hu) |
| CZ (1) | CZ291387B6 (hu) |
| EA (3) | EA002438B1 (hu) |
| HK (1) | HK1022475A1 (hu) |
| HU (1) | HUP9903583A3 (hu) |
| IL (1) | IL129231A (hu) |
| NO (2) | NO320332B1 (hu) |
| OA (1) | OA11112A (hu) |
| PL (1) | PL332827A1 (hu) |
| SK (1) | SK43799A3 (hu) |
| UA (1) | UA52702C2 (hu) |
| WO (1) | WO1998016510A1 (hu) |
| ZA (1) | ZA979268B (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
| ES2216252T3 (es) * | 1997-12-25 | 2004-10-16 | Kuraray Co., Ltd. | Procedimiento de preparacion y metodo de cristalizacion de 2-azabiciclo (2.2.1) hepta-5-en-3-ona. |
| TW396337B (en) * | 1998-02-13 | 2000-07-01 | Mediatek Inc | The automatic regulating device of cdrom optimum focusing spot and the method thereof |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
| DE69920045T2 (de) | 1998-12-31 | 2005-09-29 | Aventis Pharmaceuticals Inc. | Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten |
| US6387033B1 (en) | 2000-11-22 | 2002-05-14 | Council Of Scientific And Industrial Research | Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols |
| EP1392690A2 (en) * | 2001-05-10 | 2004-03-03 | Aventis Pharma Deutschland GmbH | Novel processes for the preparation of adenosine compounds and intermediates thereto |
| EP1574508A1 (de) * | 2004-01-30 | 2005-09-14 | Lonza AG | Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen |
| KR101088669B1 (ko) * | 2006-10-11 | 2011-12-01 | 닛뽕소다 가부시키가이샤 | 아자비시클로알칸올 유도체의 제조 방법 |
| CN102311440B (zh) * | 2010-07-02 | 2015-01-07 | 无锡药明康德生物技术有限公司 | 1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7513818A (nl) * | 1974-12-13 | 1976-06-15 | Merck & Co Inc | Werkwijze voor het scheiden van enantiomere 1-tert.butylamino 2.3-dihydroxypropanen. |
| US4508911A (en) * | 1982-06-21 | 1985-04-02 | The Upjohn Company | Amine intermediates for analgesic compounds |
| US5284769A (en) * | 1989-10-16 | 1994-02-08 | Chiros Ltd. | Process for preparing a single enantiomer of a lactam using lactamase |
| EP0433036A3 (en) * | 1989-12-13 | 1992-01-22 | Noristan Holdings Limited | Polycyclic nitrile compounds and pharmaceutical compositions thereof |
| JP2891740B2 (ja) * | 1990-03-30 | 1999-05-17 | 塩野義製薬株式会社 | 光学活性ノルボルナン系アミン誘導体の製造方法 |
| AU654507B2 (en) * | 1990-09-25 | 1994-11-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
| US5700895A (en) * | 1993-08-23 | 1997-12-23 | Sumitomo Chemical Company, Limited | Ethylene-α-olefin copolymer and molded article thereof |
| US5670649A (en) * | 1995-05-30 | 1997-09-23 | Rhone-Poulenc Rorer S.A. | Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application |
| US5684159A (en) * | 1995-05-30 | 1997-11-04 | Rhone-Poulenc Rorer S.A. | L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds |
| FR2734822B1 (fr) * | 1995-05-30 | 1997-07-04 | Rhone Poulenc Rorer Sa | Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application |
| US5856497A (en) * | 1995-12-11 | 1999-01-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines |
-
1996
- 1996-10-16 US US08/732,024 patent/US5684159A/en not_active Expired - Fee Related
-
1997
- 1997-06-10 US US08/873,285 patent/US5808093A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,096 patent/US5886192A/en not_active Expired - Fee Related
- 1997-06-10 US US08/873,284 patent/US5831096A/en not_active Expired - Fee Related
- 1997-10-15 EA EA199900382A patent/EA002438B1/ru not_active IP Right Cessation
- 1997-10-15 WO PCT/US1997/018365 patent/WO1998016510A1/en not_active Application Discontinuation
- 1997-10-15 UA UA99052680A patent/UA52702C2/uk unknown
- 1997-10-15 AU AU48160/97A patent/AU721965B2/en not_active Ceased
- 1997-10-15 EA EA200100661A patent/EA200100661A1/ru unknown
- 1997-10-15 CA CA002268652A patent/CA2268652A1/en not_active Abandoned
- 1997-10-15 EP EP97910894A patent/EP0934268A4/en not_active Withdrawn
- 1997-10-15 EA EA200100660A patent/EA200100660A1/ru unknown
- 1997-10-15 AP APAP/P/1999/001486A patent/AP942A/en active
- 1997-10-15 BR BR9711910A patent/BR9711910A/pt not_active Application Discontinuation
- 1997-10-15 IL IL12923197A patent/IL129231A/xx unknown
- 1997-10-15 CN CN97198783A patent/CN1094927C/zh not_active Expired - Fee Related
- 1997-10-15 CZ CZ19991312A patent/CZ291387B6/cs not_active IP Right Cessation
- 1997-10-15 HU HU9903583A patent/HUP9903583A3/hu unknown
- 1997-10-15 SK SK437-99A patent/SK43799A3/sk unknown
- 1997-10-15 PL PL97332827A patent/PL332827A1/xx not_active IP Right Cessation
- 1997-10-15 JP JP10518472A patent/JP2001502329A/ja not_active Ceased
- 1997-10-15 KR KR1019990703293A patent/KR20000049195A/ko active IP Right Grant
- 1997-10-16 ZA ZA979268A patent/ZA979268B/xx unknown
-
1999
- 1999-03-30 BG BG103296A patent/BG64701B1/bg unknown
- 1999-03-30 BG BG108906A patent/BG64733B1/bg unknown
- 1999-04-09 OA OA9900080A patent/OA11112A/en unknown
- 1999-04-15 NO NO19991800A patent/NO320332B1/no unknown
-
2000
- 2000-03-03 HK HK00101370A patent/HK1022475A1/xx not_active IP Right Cessation
-
2002
- 2002-06-05 CN CN02122409A patent/CN1385422A/zh active Pending
-
2005
- 2005-04-08 NO NO20051757A patent/NO20051757D0/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9903583A2 (hu) | Eljárás 2-azadihidroxi-biciklo[2.2.1]heptán vegyületek és ezek L-borkősav-sói előállítására | |
| TW369533B (en) | Quinoline compounds, process for preparing them and pharmaceutical composition containing them | |
| CA2333322A1 (en) | Nitric oxide synthase inhibitors | |
| MX9704646A (es) | Derivados del acido 3-aril-tetronico, su obtencion y su empleo como agentes pesticidas. | |
| ES8200879A1 (es) | Procedimiento para la obtencion de triazolilmetil-terc.-bu- til-carbinoles sustituidos | |
| DK0727418T3 (da) | Fremgangsmåde til fremstilling af 1-amino-1,2,3-triazol | |
| IE780214L (en) | Herbicidal n-substituted halogenoacetanilides | |
| CA2149872A1 (en) | Diabetes prevention and treatment | |
| AU550315B2 (en) | Substituted 2:-phenyl-ethyl-1h-1,24-triazole | |
| MX9702203A (es) | Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida. | |
| ES8200878A1 (es) | Procedimiento para la obtencion de triazolilmetil-terc.-bu- til-cetonas sustituidas | |
| ES8700242A1 (es) | Un procedimiento para preparar un derivado de dihidropirida-zinona | |
| AU9157082A (en) | (1,2,4-)/(1,3-) azole compounds | |
| DK0683165T3 (da) | Fremgangsmåde til fremstilling af N-alkyl-N-pyridinyl-1H-indol-1-aminer | |
| ES8303393A1 (es) | Un procedimiento para preparar derivados del acido ascorbico. | |
| CA2289013A1 (en) | Chemical process for the reduction of 1-substituted-3-hydroxymethyl-4-(4-fluorophenyl)tetrahydropyridines | |
| IE42758L (en) | Fungicidal agents | |
| ES8500255A1 (es) | "un procedimiento para preparar nuevas furfuril-amidas de acidos fenoxifenoxialcanoicos" | |
| ES2085234A1 (es) | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. | |
| WO2000053581A3 (en) | Heterocyclic compounds having antitumor activity | |
| ES479027A1 (es) | Procedimiento de preparacion de nuevos derivados de tiazol. | |
| JPS6434963A (en) | Carbostyril derivative | |
| NZ314517A (en) | 1-substituted phenyl-4,5-dihydro-3H-2,3-benzodiazepine derivatives and pharmaceutical compositions thereof | |
| ES8105716A1 (es) | Un procedimiento para preparar nuevos derivados de 3h-nafto (1-2-d) imidazol | |
| ES8203812A1 (es) | Un metodo para preparar eteres fluorovinilicos |