NO20051757L - Fremgangsmate ved fremstilling av 2-azadihydroksy-bicyklo [2.2.2]-heptanderivater - Google Patents

Fremgangsmate ved fremstilling av 2-azadihydroksy-bicyklo [2.2.2]-heptanderivater

Info

Publication number
NO20051757L
NO20051757L NO20051757A NO20051757A NO20051757L NO 20051757 L NO20051757 L NO 20051757L NO 20051757 A NO20051757 A NO 20051757A NO 20051757 A NO20051757 A NO 20051757A NO 20051757 L NO20051757 L NO 20051757L
Authority
NO
Norway
Prior art keywords
formula
compound
azadihydroxy
bicyclo
preparation
Prior art date
Application number
NO20051757A
Other languages
English (en)
Other versions
NO20051757D0 (no
Inventor
Patrick Leon
Michael K O'brien
Denis Largeau
Matthew Powers
Thierry Durand
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20051757L publication Critical patent/NO20051757L/no
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO20051757D0 publication Critical patent/NO20051757D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Fremgangsmåte ved fremstilling av en forbindelse. Fremgangsmåte ved frenstilling av en forbindelse av formel i" VXD"-" hvor R er hydrogen eller henholdsvis en gruppe av formel R, Ri hvor Ri er alkyl og Ar er eventuelt substituert aryl, Rj. og Rj'. er hydrogen, alkyl eller fenyl eller Rv og Rb-' tatt sammen med karbonatomet til hvilket de er bundet danner cykloalkyl omfattende syreassistert acetaliserir.g eller ketalisering av en forbindelse av formel hvor alkoksy, eller tatt sammen .med karbon- atom.et til hvilket de er bundet danner karbonyl med (IR) diastereomeren av 2-azadlhydrcksybicyklo[2.2.1j heptanfor- bindc-lson ifølge formel HOk HO 1- V-N-f (1) elltjr salt derav i isopcopanol.
NO20051757A 1996-10-16 2005-04-08 Fremgangsmõte ved fremstilling av 2-azadihydroksybicyklo [2.2.2]-heptanforbindelser samt L-tartarsyresalter av forbindelsene NO20051757D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/732,024 US5684159A (en) 1995-05-30 1996-10-16 L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
PCT/US1997/018365 WO1998016510A1 (en) 1996-10-16 1997-10-15 Process for preparing 2-azadihydroxybicyclo[2.2.1]heptane compounds and the l-tartaric acid salt of the compound

Publications (2)

Publication Number Publication Date
NO20051757L true NO20051757L (no) 1999-06-15
NO20051757D0 NO20051757D0 (no) 2005-04-08

Family

ID=24941881

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19991800A NO320332B1 (no) 1996-10-16 1999-04-15 Fremgangsmate ved fremstilling av 2-azadihydroksybicyklo [2.2.2]-heptanforbindelser samt L-tartarsyresalter av forbindelsene
NO20051757A NO20051757D0 (no) 1996-10-16 2005-04-08 Fremgangsmõte ved fremstilling av 2-azadihydroksybicyklo [2.2.2]-heptanforbindelser samt L-tartarsyresalter av forbindelsene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19991800A NO320332B1 (no) 1996-10-16 1999-04-15 Fremgangsmate ved fremstilling av 2-azadihydroksybicyklo [2.2.2]-heptanforbindelser samt L-tartarsyresalter av forbindelsene

Country Status (22)

Country Link
US (4) US5684159A (no)
EP (1) EP0934268A4 (no)
JP (1) JP2001502329A (no)
KR (1) KR20000049195A (no)
CN (2) CN1094927C (no)
AP (1) AP942A (no)
AU (1) AU721965B2 (no)
BG (2) BG64701B1 (no)
BR (1) BR9711910A (no)
CA (1) CA2268652A1 (no)
CZ (1) CZ291387B6 (no)
EA (3) EA200100660A1 (no)
HK (1) HK1022475A1 (no)
HU (1) HUP9903583A3 (no)
IL (1) IL129231A (no)
NO (2) NO320332B1 (no)
OA (1) OA11112A (no)
PL (1) PL332827A1 (no)
SK (1) SK43799A3 (no)
UA (1) UA52702C2 (no)
WO (1) WO1998016510A1 (no)
ZA (1) ZA979268B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
EP0926136B1 (en) * 1997-12-25 2004-05-12 Kuraray Co., Ltd. Process for producing and method of crystallizing 2-azabicyclo(2.2.1)hept-5-en-3-one
TW396337B (en) * 1998-02-13 2000-07-01 Mediatek Inc The automatic regulating device of cdrom optimum focusing spot and the method thereof
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
US6057446A (en) 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
AU2187100A (en) 1998-12-31 2000-07-24 Aventis Pharmaceuticals Products Inc. Process for preparing n6-substituted deaza-adenosine derivatives
US6387033B1 (en) 2000-11-22 2002-05-14 Council Of Scientific And Industrial Research Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols
EP1392690A2 (en) * 2001-05-10 2004-03-03 Aventis Pharma Deutschland GmbH Novel processes for the preparation of adenosine compounds and intermediates thereto
EP1574508A1 (de) * 2004-01-30 2005-09-14 Lonza AG Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen
JP5118053B2 (ja) * 2006-10-11 2013-01-16 日本曹達株式会社 アザビシクロアルカノール誘導体の製造方法
CN102311440B (zh) * 2010-07-02 2015-01-07 无锡药明康德生物技术有限公司 1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK532575A (da) * 1974-12-13 1976-06-14 Merck & Co Inc Fremgangsmade til racematspaltning af organiske forbindelser
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US5284769A (en) * 1989-10-16 1994-02-08 Chiros Ltd. Process for preparing a single enantiomer of a lactam using lactamase
AU641712B2 (en) * 1989-12-13 1993-09-30 Noristan Holdings Limited Polycyclic nitrile compounds and pharmaceutical compositions thereof
JP2891740B2 (ja) * 1990-03-30 1999-05-17 塩野義製薬株式会社 光学活性ノルボルナン系アミン誘導体の製造方法
ATE147074T1 (de) * 1990-09-25 1997-01-15 Rhone Poulenc Rorer Int Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen
US5700895A (en) * 1993-08-23 1997-12-23 Sumitomo Chemical Company, Limited Ethylene-α-olefin copolymer and molded article thereof
FR2734822B1 (fr) * 1995-05-30 1997-07-04 Rhone Poulenc Rorer Sa Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
US5670649A (en) * 1995-05-30 1997-09-23 Rhone-Poulenc Rorer S.A. Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application
US5856497A (en) * 1995-12-11 1999-01-05 Boehringer Ingelheim Pharmaceuticals, Inc. Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines

Also Published As

Publication number Publication date
HUP9903583A2 (hu) 2000-04-28
BG64701B1 (bg) 2005-12-30
EA002438B1 (ru) 2002-04-25
CN1233239A (zh) 1999-10-27
KR20000049195A (ko) 2000-07-25
AU4816097A (en) 1998-05-11
NO991800L (no) 1999-06-15
CN1094927C (zh) 2002-11-27
IL129231A (en) 2003-07-06
EP0934268A4 (en) 2001-04-18
SK43799A3 (en) 2000-04-10
OA11112A (en) 2003-04-04
NO991800D0 (no) 1999-04-15
PL332827A1 (en) 1999-10-11
AU721965B2 (en) 2000-07-20
EA200100661A1 (ru) 2001-12-24
AP9901486A0 (en) 1999-03-31
US5886192A (en) 1999-03-23
US5831096A (en) 1998-11-03
WO1998016510A1 (en) 1998-04-23
EA199900382A1 (ru) 1999-10-28
AP942A (en) 2001-02-16
US5808093A (en) 1998-09-15
CZ131299A3 (cs) 2000-06-14
ZA979268B (en) 1998-07-27
HUP9903583A3 (en) 2000-10-30
EP0934268A1 (en) 1999-08-11
BG64733B1 (bg) 2006-01-31
CN1385422A (zh) 2002-12-18
CA2268652A1 (en) 1998-04-23
BR9711910A (pt) 1999-08-24
JP2001502329A (ja) 2001-02-20
CZ291387B6 (cs) 2003-02-12
NO320332B1 (no) 2005-11-21
NO20051757D0 (no) 2005-04-08
US5684159A (en) 1997-11-04
HK1022475A1 (en) 2000-08-11
BG103296A (en) 2000-11-30
UA52702C2 (uk) 2003-01-15
EA200100660A1 (ru) 2001-12-24
IL129231A0 (en) 2000-02-17

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