AP942A - Process for preparing 2- azadihydroxybicyclo[2.2.1]heptane compounds and the L - tartaric acid salt of the compound. - Google Patents

Process for preparing 2- azadihydroxybicyclo[2.2.1]heptane compounds and the L - tartaric acid salt of the compound. Download PDF

Info

Publication number
AP942A
AP942A APAP/P/1999/001486A AP9901486A AP942A AP 942 A AP942 A AP 942A AP 9901486 A AP9901486 A AP 9901486A AP 942 A AP942 A AP 942A
Authority
AP
ARIPO
Prior art keywords
compound
mol
formula
heptane
azadihydroxybicyclo
Prior art date
Application number
APAP/P/1999/001486A
Other languages
English (en)
Other versions
AP9901486A0 (en
Inventor
Michael K O'brien
Patrick Leon
Dennis Largeau
Matthew R Powers
Thierry Durand
Original Assignee
Aventis Pharmaceuticals Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Products Inc filed Critical Aventis Pharmaceuticals Products Inc
Publication of AP9901486A0 publication Critical patent/AP9901486A0/xx
Application granted granted Critical
Publication of AP942A publication Critical patent/AP942A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
APAP/P/1999/001486A 1996-10-16 1997-10-15 Process for preparing 2- azadihydroxybicyclo[2.2.1]heptane compounds and the L - tartaric acid salt of the compound. AP942A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/732,024 US5684159A (en) 1995-05-30 1996-10-16 L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
PCT/US1997/018365 WO1998016510A1 (en) 1996-10-16 1997-10-15 Process for preparing 2-azadihydroxybicyclo[2.2.1]heptane compounds and the l-tartaric acid salt of the compound

Publications (2)

Publication Number Publication Date
AP9901486A0 AP9901486A0 (en) 1999-03-31
AP942A true AP942A (en) 2001-02-16

Family

ID=24941881

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1999/001486A AP942A (en) 1996-10-16 1997-10-15 Process for preparing 2- azadihydroxybicyclo[2.2.1]heptane compounds and the L - tartaric acid salt of the compound.

Country Status (22)

Country Link
US (4) US5684159A (hu)
EP (1) EP0934268A4 (hu)
JP (1) JP2001502329A (hu)
KR (1) KR20000049195A (hu)
CN (2) CN1094927C (hu)
AP (1) AP942A (hu)
AU (1) AU721965B2 (hu)
BG (2) BG64701B1 (hu)
BR (1) BR9711910A (hu)
CA (1) CA2268652A1 (hu)
CZ (1) CZ291387B6 (hu)
EA (3) EA002438B1 (hu)
HK (1) HK1022475A1 (hu)
HU (1) HUP9903583A3 (hu)
IL (1) IL129231A (hu)
NO (2) NO320332B1 (hu)
OA (1) OA11112A (hu)
PL (1) PL332827A1 (hu)
SK (1) SK43799A3 (hu)
UA (1) UA52702C2 (hu)
WO (1) WO1998016510A1 (hu)
ZA (1) ZA979268B (hu)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
ES2216252T3 (es) * 1997-12-25 2004-10-16 Kuraray Co., Ltd. Procedimiento de preparacion y metodo de cristalizacion de 2-azabiciclo (2.2.1) hepta-5-en-3-ona.
TW396337B (en) * 1998-02-13 2000-07-01 Mediatek Inc The automatic regulating device of cdrom optimum focusing spot and the method thereof
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
DE69920045T2 (de) 1998-12-31 2005-09-29 Aventis Pharmaceuticals Inc. Verfahren zur herstellung von n6-substituierten deaza-adenosinderivaten
US6387033B1 (en) 2000-11-22 2002-05-14 Council Of Scientific And Industrial Research Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols
EP1392690A2 (en) * 2001-05-10 2004-03-03 Aventis Pharma Deutschland GmbH Novel processes for the preparation of adenosine compounds and intermediates thereto
EP1574508A1 (de) * 2004-01-30 2005-09-14 Lonza AG Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen
KR101088669B1 (ko) * 2006-10-11 2011-12-01 닛뽕소다 가부시키가이샤 아자비시클로알칸올 유도체의 제조 방법
CN102311440B (zh) * 2010-07-02 2015-01-07 无锡药明康德生物技术有限公司 1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7513818A (nl) * 1974-12-13 1976-06-15 Merck & Co Inc Werkwijze voor het scheiden van enantiomere 1-tert.butylamino 2.3-dihydroxypropanen.
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US5284769A (en) * 1989-10-16 1994-02-08 Chiros Ltd. Process for preparing a single enantiomer of a lactam using lactamase
EP0433036A3 (en) * 1989-12-13 1992-01-22 Noristan Holdings Limited Polycyclic nitrile compounds and pharmaceutical compositions thereof
JP2891740B2 (ja) * 1990-03-30 1999-05-17 塩野義製薬株式会社 光学活性ノルボルナン系アミン誘導体の製造方法
AU654507B2 (en) * 1990-09-25 1994-11-10 Rhone-Poulenc Rorer International (Holdings) Inc. Compounds having antihypertensive and anti-ischemic properties
US5700895A (en) * 1993-08-23 1997-12-23 Sumitomo Chemical Company, Limited Ethylene-α-olefin copolymer and molded article thereof
US5670649A (en) * 1995-05-30 1997-09-23 Rhone-Poulenc Rorer S.A. Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
FR2734822B1 (fr) * 1995-05-30 1997-07-04 Rhone Poulenc Rorer Sa Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
US5856497A (en) * 1995-12-11 1999-01-05 Boehringer Ingelheim Pharmaceuticals, Inc. Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NONE *

Also Published As

Publication number Publication date
EA002438B1 (ru) 2002-04-25
CN1233239A (zh) 1999-10-27
HK1022475A1 (en) 2000-08-11
AU721965B2 (en) 2000-07-20
JP2001502329A (ja) 2001-02-20
EA199900382A1 (ru) 1999-10-28
HUP9903583A2 (hu) 2000-04-28
NO991800L (no) 1999-06-15
NO20051757D0 (no) 2005-04-08
US5684159A (en) 1997-11-04
BG64701B1 (bg) 2005-12-30
ZA979268B (en) 1998-07-27
NO991800D0 (no) 1999-04-15
IL129231A0 (en) 2000-02-17
CN1094927C (zh) 2002-11-27
NO20051757L (no) 1999-06-15
CN1385422A (zh) 2002-12-18
US5808093A (en) 1998-09-15
AU4816097A (en) 1998-05-11
US5831096A (en) 1998-11-03
OA11112A (en) 2003-04-04
BG64733B1 (bg) 2006-01-31
BG103296A (en) 2000-11-30
CZ131299A3 (cs) 2000-06-14
AP9901486A0 (en) 1999-03-31
NO320332B1 (no) 2005-11-21
EA200100660A1 (ru) 2001-12-24
CA2268652A1 (en) 1998-04-23
UA52702C2 (uk) 2003-01-15
CZ291387B6 (cs) 2003-02-12
IL129231A (en) 2003-07-06
EA200100661A1 (ru) 2001-12-24
EP0934268A1 (en) 1999-08-11
SK43799A3 (en) 2000-04-10
US5886192A (en) 1999-03-23
BR9711910A (pt) 1999-08-24
PL332827A1 (en) 1999-10-11
WO1998016510A1 (en) 1998-04-23
HUP9903583A3 (en) 2000-10-30
KR20000049195A (ko) 2000-07-25
EP0934268A4 (en) 2001-04-18

Similar Documents

Publication Publication Date Title
AP942A (en) Process for preparing 2- azadihydroxybicyclo[2.2.1]heptane compounds and the L - tartaric acid salt of the compound.
FR2654726A1 (fr) Nouveaux derives de l'isoindolone et leur preparation.
IL200692A (en) Method of preparing a desired diastereomer of a tetrahydro-beta-carboline and use thereof for preparing an indole-1,4-dione derivative
FR2676443A1 (fr) Nouveaux derives de perhydroisoindole et leur preparation.
JP2007519710A (ja) １−（２Ｓ，３Ｓ）−２−ベンズヒドリル−Ｎ−（５−ｔｅｒｔ−ブチル−２−メトキシベンジル）キヌクリジン−３−アミンの製造方法
Quirante et al. Synthesis of 2-azabicyclo [3.3. 1] nonanes by means of (carbamoyl) dichloromethyl radical cyclization
KR101864805B1 (ko) 거울상이성질체적으로 순수한 아민
JPH02292288A (ja) ２，７‐ジアザビシクロ［３．３．０］オクタン類
JP5199865B2 (ja) ２−アザビシクロ［３．３．０］オクタン−３−カルボン酸誘導体の製造方法
JPH0331260A (ja) フコシダーゼ阻害剤
Bravo et al. Stereoselective Total Synthesis of Enantiomerically Pure 1‐Trifluoromethyl Tetrahydroisoquinoline Alkaloids
US5912365A (en) Derivatives of 2-azabicyclo 2.2.1! heptane, their preparation and their application
AU617328B2 (en) A process for the preparation of bicyclic amino carboxylic acids, intermediates in this process, and their use
AP973A (en) 2-Azabicyclo {2.2.1} heptane derivatives preparation and application thereof.
KR20160008873A (ko) 신규의 베타-술핀아미노 말로네이트 유도체 및 이의 제조방법, 그리고 이를 이용한 시타글립틴의 제조방법
Johnston tt: f, Je~~~ itiou ot Ketet-ot]! clit~ mines to
Johnston The addition of heterocyclic amines to a nitro-alkene: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science at Massey University
Ashraf Studies towards the synthesis of fumitremorgin C and a mechanistic study of the Pictet-Spengler reaction
Mendelson USE OF THE 2-AZONIA-(3, 3)-SIGMATROPIC REARRANGEMENT IN ALKALOID SYNTHESIS
MXPA97008995A (en) New derivatives of 2-azabiciclo [2.2.1] heptano, its preparation and its application