HUP0500871A2 - 5-Ariltetrazol-vegyületek, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

5-Ariltetrazol-vegyületek, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0500871A2
HUP0500871A2 HU0500871A HUP0500871A HUP0500871A2 HU P0500871 A2 HUP0500871 A2 HU P0500871A2 HU 0500871 A HU0500871 A HU 0500871A HU P0500871 A HUP0500871 A HU P0500871A HU P0500871 A2 HUP0500871 A2 HU P0500871A2
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Hungary
Prior art keywords
alkyl
nhc
benzyl
independently
nhr5
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HU0500871A
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English (en)
Inventor
Alex Nivorozhkin
John Duzer
Andrew Salzman
Garry Southan
Siya Ram
Qi Zeng
Csaba Szabo
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Inotek Pharmaceuticals Corporation
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Application filed by Inotek Pharmaceuticals Corporation filed Critical Inotek Pharmaceuticals Corporation
Publication of HUP0500871A2 publication Critical patent/HUP0500871A2/hu
Publication of HUP0500871A3 publication Critical patent/HUP0500871A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány (Ia) általános képletű 5-ariltetrazol-vegyületekre, afenti 5-ariltetrazol-vegyületeket hatásos mennyiségben tartalmazógyógyszerkészítményekre vonatkozik. A találmány tárgya továbbá a fentivegyületek alkalmazása gyulladásos betegsegek, reperfúziós betegségekvagy hiperuricemia kezelésére alkalmas gyógyszerkészítményekalkalmazására. A képletben R1 jelentése CO2R4, R2 jelentése egymástólfüggetlenül halogénatom, -NO2, -CN, -OH, -N(R5)(R5), -OR5, -C(O)R5, -OC(O)R5, -C(O)NHC(O)R5, -(C1-C10)al- kil, -(C2-C10)alkenil, -(C2-C10)alkinil, -(C3-C10)cikloalkil, -(C8-C14)bi- cikloalkil, -(C5-C10)cikloalkenil, -(C3-C10)heterolociklus, -fenil, -naftil, -benzil, -CO2R5, -C(O)OCH(R5)(R5), -NHC(O)R5, -NHC(O)-NHR5, -C(O)NHR5, -OC(O)R5,-OC(O)OR5, -SR5, -S(O)R5, vagy -S(O)2R5, R3 jelentése -H, -halogénatom, -NO2, -CN, -OH, -N(R5)(R5), -O(CH2)mR5, -C(O)R5, -C(O)NR5R5, -C(O)NH(CH2)m(R5), -OCF3, -benzil, -CO2CH(R5)(R5), -(C1-C10)alkil, -(C2-C10)alkenil, -(C2-C10)alkinil, -(C3-C10)cikloalkil, -(C8-C14)bicikloalkil, -(C5-C10)cikloalkenil, -naftil, -(C3-C10)heterociklus, -CO2(CH2)mR5, -NHC(O)R5, -N(R5)C(O)R5, -NHC(O)NHR5,-OC(O)(CH2)mCHR5R5, -CO2(CH2)mCHR5R5, -OC(O)OR5, -SR5, -S(O)R5, -S(O)2R5, -S(O2)NHR5, vagy R4 jelentése -(C5)heteroaril, -(C6)heteroaril, fenil, naftil, vagy benzil, R5 jelentése egymástólfüggetlenül -H, -CF3, -(C1-C10)alkil, -benzil, -adamantil, -morfolinil, -pirrolidil, -piridiloxid, -pirrolidinildion, -piperidil,-(C2-C10)alkenil, -(C2-C10)alkinil, -(C3-C10)cikloalkil, -(C8-C14)bicikloalkil, -(C3-C10)heterociklus, vagy R6 jelentése egymástólfüggetlenül -H, -halogénatom, -NO2, -CN, -OH, -CO2H, -N((C1-C10)alkil-(C1-C10)alkil, -O(C1-C10)alkil, -C(O)(C1-C10)alkil, -C(O)NH(CH2)- (C1-C10)alkil, -OCF3, -benzil, -CO2(CH2)mCH((C1-C10)alkil-(C1-C10)alkil),-C(O)H, -CO2(C1-C10)alkil, -(C1-C10)alkil, -(C2-C10)alkenil, -(C2-C10)alkinil, -(C3-C10)cikloalkil, -(C8-C14)bicikloalkil, -(C5-C10)cikloalkenil, -(C5)heteroaril, -(C6)heteroaril, -fenil, naftil, -(C3-C10)heterociklus, -CO2(CH2)m(C1-C10)alkil, -CO2(CH2)mH, -NHC(O)-(C1-C10)alkil, -NHC(O)NH(C1-C10)alkil, -OC(O)(C1-C10)alkil, -OC(O)O(C1-C10)alkil, -SO2NHR5, vagy -SO2NH2, n jelentése 0-4 értékűegész szám, m jelentése egymástól függetlenül 0-8 értékű egész szám ésp jelentése egymástól függetlenül 0-5 értékű egész szám.
HU0500871A 2002-07-18 2003-07-17 5-aryltetrazole compounds, compositions thereof and their use HUP0500871A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/197,609 US7078423B2 (en) 2002-07-18 2002-07-18 5-Aryltetrazole compounds, compositions thereof, and uses therefor
PCT/US2003/022462 WO2004009563A1 (en) 2002-07-18 2003-07-17 5-aryltetrazole compounds, compositions thereof, and uses therefor

Publications (2)

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HUP0500871A2 true HUP0500871A2 (hu) 2005-12-28
HUP0500871A3 HUP0500871A3 (en) 2006-11-28

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US (1) US7078423B2 (hu)
EP (1) EP1542980A1 (hu)
JP (1) JP2005535678A (hu)
KR (1) KR20050028038A (hu)
CN (1) CN1694875A (hu)
AU (1) AU2003249313A1 (hu)
BR (1) BR0312768A (hu)
CA (1) CA2492847A1 (hu)
HU (1) HUP0500871A3 (hu)
IL (1) IL166331A0 (hu)
MX (1) MXPA05000765A (hu)
NZ (1) NZ538313A (hu)
PL (1) PL374833A1 (hu)
RU (1) RU2005104429A (hu)
WO (1) WO2004009563A1 (hu)
ZA (1) ZA200501431B (hu)

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US20040019208A1 (en) 2004-01-29
ZA200501431B (en) 2006-02-22
PL374833A1 (en) 2005-10-31
CA2492847A1 (en) 2004-01-29
BR0312768A (pt) 2005-05-10
KR20050028038A (ko) 2005-03-21
CN1694875A (zh) 2005-11-09
MXPA05000765A (es) 2005-10-19
IL166331A0 (en) 2006-01-16
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RU2005104429A (ru) 2005-08-27
US7078423B2 (en) 2006-07-18

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