HUP0401099A2 - Eljárás 4-halogénalkilnikotinnitril-származékok előállítására - Google Patents

Eljárás 4-halogénalkilnikotinnitril-származékok előállítására

Info

Publication number
HUP0401099A2
HUP0401099A2 HU0401099A HUP0401099A HUP0401099A2 HU P0401099 A2 HUP0401099 A2 HU P0401099A2 HU 0401099 A HU0401099 A HU 0401099A HU P0401099 A HUP0401099 A HU P0401099A HU P0401099 A2 HUP0401099 A2 HU P0401099A2
Authority
HU
Hungary
Prior art keywords
hal
general formula
reaction
haloalkyl
producing
Prior art date
Application number
HU0401099A
Other languages
English (en)
Inventor
Sergiy Pazenok
Henricus Maria Martinus Bastiaans
Original Assignee
Bayer Cropscience Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000161967 external-priority patent/DE10061967A1/de
Priority claimed from DE2001120819 external-priority patent/DE10120819A1/de
Priority claimed from DE2001144411 external-priority patent/DE10144411A1/de
Application filed by Bayer Cropscience Gmbh filed Critical Bayer Cropscience Gmbh
Publication of HUP0401099A2 publication Critical patent/HUP0401099A2/hu
Publication of HUP0401099A3 publication Critical patent/HUP0401099A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya eljárás (I) általános képletű 4-halogénalkilnikotinnitrilek előállítására, ahol RF jelentése 1-4szénatomos halogénalkil-, előnyösen trifluormetil-csoport, az eljárástúgy végzik, hogy a) egy (II) általános képletű 3-amino-1-halogénalkil-2-propén-1-ont RF-C(O)-CH=CH-NH2 (II) kondenzációsreakcióval reagáltatják (III)-(VII) általános képletű vegyületekkel,(R1Z)CH=CH-CN (III) (R1Z)2CH-CH2-CN (IV)Hal-CH=CH-CN (V) Ha12CH-CH2CN (VI) HC<C-CN (VII) ahol R1 jelentése alkil, Hal jelentése klór- vagybrómatom és Z jelentése egymástól függetlenül O, S, NR1 vagy OCOcsoport, a reakcióban (VIII), (IX) és/vagy (X) általános képletűvegyület keletkezik, RF-C(O)-CH=CH-NH-CH=CH-CN (VIII)RF-C(O)-CH=CH-NH-CH(ZR1)-CH2-CN (IX) RF-C(O)-CH=CH-NH-CH(Hal)-CH2-CN (X) ahol RF, R1, Z és Hal jelentése a fenti,majd a reakcióterméket b) gyűrűzárási reakciónak vetik alá. Avegyületek hasznos intermedierek kártevők elleni szerekelőállításánál. Ó
HU0401099A 2000-12-13 2001-12-12 Method for producing 4-haloalkyl nicotine nitriles HUP0401099A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2000161967 DE10061967A1 (de) 2000-12-13 2000-12-13 Verfahren zur Herstellung von 4-Trifluormethylnicotinnitril
DE2001120819 DE10120819A1 (de) 2001-04-27 2001-04-27 Verfahren zur Herstellung von 4-Trifluormethylnicotinnitril
DE2001144411 DE10144411A1 (de) 2001-09-11 2001-09-11 Verfahren zur Herstellung von 3-(Haloalkyl-3-oxo-1-butenylamino)acrylnitrilen
PCT/EP2001/014584 WO2002048111A2 (de) 2000-12-13 2001-12-12 Verfahren zur herstellung von 4-haloalkylnicotinnitrilen

Publications (2)

Publication Number Publication Date
HUP0401099A2 true HUP0401099A2 (hu) 2004-09-28
HUP0401099A3 HUP0401099A3 (en) 2007-02-28

Family

ID=27214195

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401099A HUP0401099A3 (en) 2000-12-13 2001-12-12 Method for producing 4-haloalkyl nicotine nitriles

Country Status (14)

Country Link
US (2) US6541640B2 (hu)
EP (1) EP1345906A2 (hu)
JP (1) JP2004525091A (hu)
KR (1) KR100845376B1 (hu)
CN (1) CN1244560C (hu)
AR (1) AR031658A1 (hu)
AU (1) AU2002235770A1 (hu)
BR (1) BR0116124A (hu)
CZ (1) CZ20031662A3 (hu)
HU (1) HUP0401099A3 (hu)
IL (3) IL156359A0 (hu)
MX (1) MXPA03005258A (hu)
TW (1) TWI222442B (hu)
WO (1) WO2002048111A2 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL207756B1 (pl) 2001-11-21 2011-01-31 Sankyo Agro Co Ltd Pochodna amidu kwasu N-heteroarylonikotynowego i insektycyd zawierający tą pochodną
DE10223274A1 (de) * 2002-05-24 2003-12-04 Bayer Cropscience Gmbh Verfahren zur Herstellung von 4-Haloalkylnicotinsäureamiden
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
FR2985857B1 (fr) 2012-01-17 2014-01-03 Hutchinson Cathode pour cellule de batterie lithium-ion, son procede de fabrication et cette batterie l'incorporant.
RU2016142722A (ru) 2014-04-01 2018-05-04 Клокс Текнолоджиз Инк. Композиции наполнителей для тканей и способы их применения
JP2022036351A (ja) * 2018-10-30 2022-03-08 日本曹達株式会社 ３－シアノ－４－トリフルオロメチルピリジン若しくはその塩を含有する、土壌処理剤、水田処理剤又は種子処理剤
CN109851552A (zh) * 2018-12-28 2019-06-07 京博农化科技有限公司 一种n-氰甲基-4-（三氟甲基）烟酰胺的合成方法
CN113816901B (zh) * 2021-08-27 2023-08-15 淮北龙溪生物科技有限公司 一种4－三氟甲基烟酰胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2994182B2 (ja) * 1992-07-23 1999-12-27 石原産業株式会社 アミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
JPH0710841A (ja) * 1993-06-21 1995-01-13 Ishihara Sangyo Kaisha Ltd ４−トリフルオロメチルピリジン−３−カルボキサミド系化合物又はその塩、それらの製造方法及びそれらを含有する有害動物防除剤
EP0744400B1 (en) * 1995-05-26 2002-09-11 Ishihara Sangyo Kaisha, Ltd. Process for producing 4-trifluoromethylnicotinic acid
DE19725450A1 (de) 1997-06-16 1998-12-17 Hoechst Schering Agrevo Gmbh 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclylpyrimidine, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
WO1999059993A1 (fr) * 1998-05-18 1999-11-25 Sumitomo Chemical Company, Limited Compose heterocyclique
DE10014006A1 (de) * 2000-03-22 2001-09-27 Aventis Cropscience Gmbh Heterocyclische Acylsulfimine, Verfahren zu ihrer Herstellung , sie enthalten Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
GB0022697D0 (en) * 2000-09-15 2000-11-01 Basf Ag Azo disperse dye mixtures

Also Published As

Publication number Publication date
IL187126A0 (en) 2008-02-09
BR0116124A (pt) 2003-12-09
AU2002235770A1 (en) 2002-06-24
US20030109711A1 (en) 2003-06-12
HUP0401099A3 (en) 2007-02-28
CN1244560C (zh) 2006-03-08
CN1479723A (zh) 2004-03-03
KR20030060116A (ko) 2003-07-12
US20020087004A1 (en) 2002-07-04
WO2002048111A2 (de) 2002-06-20
CZ20031662A3 (cs) 2003-09-17
WO2002048111A3 (de) 2003-03-27
IL156359A (en) 2009-05-04
US6541640B2 (en) 2003-04-01
US6864385B2 (en) 2005-03-08
IL187126A (en) 2009-08-03
KR100845376B1 (ko) 2008-07-09
AR031658A1 (es) 2003-09-24
EP1345906A2 (de) 2003-09-24
IL156359A0 (en) 2004-01-04
JP2004525091A (ja) 2004-08-19
MXPA03005258A (es) 2003-09-25
TWI222442B (en) 2004-10-21

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