HUP0303924A2 - Core-glikozilált HCV-burokproteinek - Google Patents

Core-glikozilált HCV-burokproteinek

Info

Publication number
HUP0303924A2
HUP0303924A2 HU0303924A HUP0303924A HUP0303924A2 HU P0303924 A2 HUP0303924 A2 HU P0303924A2 HU 0303924 A HU0303924 A HU 0303924A HU P0303924 A HUP0303924 A HU P0303924A HU P0303924 A2 HUP0303924 A2 HU P0303924A2
Authority
HU
Hungary
Prior art keywords
glycosylated
core
envelope proteins
hcv envelope
sites
Prior art date
Application number
HU0303924A
Other languages
English (en)
Inventor
Alfons Bosman
Erik Depla
Geert Deschamps
Erwin Sablon
Isabelle Samson
Manfred Suckow
Gert Verheyden
Original Assignee
Innogenetics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics N.V. filed Critical Innogenetics N.V.
Publication of HUP0303924A2 publication Critical patent/HUP0303924A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24223—Virus like particles [VLP]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A találmány tárgyát HCV-burokproteinek vagy legalább egy N-glikozilációs helyet tartalmazó fragmenseik képezik, melyek eukariótasejtekben végzett expresszáltatás termékei. Közelebbről a HCV-burokproteinek N-glikozilációs helyeinek átlagosan legfeljebb 80 %-a<core<-glikozilált. Ezek az N-glikozilációs helyeknek több, mint 70%-a8-10 mannózt tartalmazó oligomannózzal van glikozilálva. Ezenkívül aMan(7)-GlcNAc(2) szerkezetű oligomannózzal <core<-glikozilált helyekszámának Man(8)-G1cNAc(2) szerkezetű oligomannózzal <core<-glikozilálthelyek számához viszonyított aránya legfeljebb 0,45. A <core<-glikozilált helyek 10%-nál kevesebb láncvégi a1,3-mannózt tartalmazóoligomannózzal vannak glikozilálva. A találmány szerinti HCV-burokproteinek különösen alkalmasak diagnosztikai, profilaktikus ésterápiás célokra. A találmány szerinti HCV-burokproteinekelőállítására alkalmas eukarióta sejt Hansenula sejt. Ó
HU0303924A 2001-04-24 2002-04-24 Core-glikozilált HCV-burokproteinek HUP0303924A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01870088 2001-04-24
US30560401P 2001-07-17 2001-07-17
PCT/BE2002/000064 WO2002086101A2 (en) 2001-04-24 2002-04-24 Core-glycosylated hcv envelope proteins

Publications (1)

Publication Number Publication Date
HUP0303924A2 true HUP0303924A2 (hu) 2004-03-01

Family

ID=34072546

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303924A HUP0303924A2 (hu) 2001-04-24 2002-04-24 Core-glikozilált HCV-burokproteinek

Country Status (20)

Country Link
US (3) US7314925B2 (hu)
EP (3) EP1381671A2 (hu)
JP (2) JP4261195B2 (hu)
KR (1) KR100950104B1 (hu)
CN (1) CN1636050A (hu)
AR (3) AR035867A1 (hu)
AU (3) AU2002257392B2 (hu)
BR (2) BR0209034A (hu)
CA (3) CA2443781A1 (hu)
CZ (1) CZ20032853A3 (hu)
HU (1) HUP0303924A2 (hu)
MX (2) MXPA03009632A (hu)
NZ (2) NZ529019A (hu)
OA (1) OA13092A (hu)
PL (1) PL366621A1 (hu)
RU (1) RU2274643C2 (hu)
SK (1) SK13142003A3 (hu)
WO (3) WO2002085932A2 (hu)
YU (1) YU84103A (hu)
ZA (3) ZA200308274B (hu)

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US20040185061A1 (en) * 1994-07-29 2004-09-23 Innogenetics N.V. Redox reversible HCV proteins with native-like conformation
WO2002085932A2 (en) * 2001-04-24 2002-10-31 Innogenetics N.V. Constructs and methods for expression of recombinant hcv envelope proteins
DE10143490C2 (de) * 2001-09-05 2003-12-11 Gsf Forschungszentrum Umwelt Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen
AU2003283365A1 (en) * 2002-11-08 2004-06-07 Innogenetics N.V. HCV vaccine compositions comprising E1 and NS3 peptides
US7439042B2 (en) * 2002-12-16 2008-10-21 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
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EP1574517A1 (en) * 2004-03-09 2005-09-14 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
EP1602664A1 (en) * 2004-03-08 2005-12-07 Innogenetics N.V. HCV E1 comprising specific disulfide bridges
JP4885476B2 (ja) * 2004-05-21 2012-02-29 株式会社日本触媒 タンパク質及び／又はペプチドの細胞内導入方法
AU2011254055B2 (en) * 2004-10-18 2012-12-20 Globeimmune, Inc. Yeast-based therapeutic for chronic hepatitis C infection
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US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
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CA2651456A1 (en) 2006-05-19 2007-11-29 Glycofi, Inc. Recombinant vectors
AU2015234338C1 (en) * 2006-07-28 2017-07-20 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
EP2061805B1 (en) * 2006-08-25 2020-02-12 Macfarlane Burnet Institute for Medical Research and Public Health Limited Recombinant hcv e2 glycoprotein
EP2331125A4 (en) 2008-09-19 2013-03-27 Globeimmune Inc IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS
WO2010039224A2 (en) 2008-09-30 2010-04-08 University Of Massachusetts Medical School Respiratory syncytial virus (rsv) sequences for protein expression and vaccines
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DK2654785T3 (da) 2010-12-22 2019-06-24 Bayer Ip Gmbh Forøget immunrespons hos kvægracer
US20140155469A1 (en) 2011-04-19 2014-06-05 The Research Foundation Of State University Of New York Adeno-associated-virus rep sequences, vectors and viruses
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MX2016010993A (es) * 2014-02-28 2017-05-01 Bayer Animal Health Gmbh Plasmidos inmunoestimuladores.
JP2019504638A (ja) * 2015-11-13 2019-02-21 マメドフ、タルラン Ｅｎｄｏ ｈとの同時発現によってインビボｎ−脱グルコシル化組換えタンパク質の産生
EP3184642B1 (de) * 2015-12-22 2019-05-08 bisy e.U. Hefezelle
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Also Published As

Publication number Publication date
MXPA03009632A (es) 2004-06-30
CA2443781A1 (en) 2002-10-31
US20030108561A1 (en) 2003-06-12
EP1414942A2 (en) 2004-05-06
SK13142003A3 (en) 2004-11-03
KR100950104B1 (ko) 2010-03-30
JP2004532029A (ja) 2004-10-21
AR035868A1 (es) 2004-07-21
JP4261195B2 (ja) 2009-04-30
MXPA03009626A (es) 2004-06-30
NZ529019A (en) 2004-05-28
JP2004536052A (ja) 2004-12-02
NZ529324A (en) 2005-08-26
KR20030094359A (ko) 2003-12-11
US20030211597A1 (en) 2003-11-13
WO2002085932A3 (en) 2003-03-13
ZA200308274B (en) 2005-01-24
AR035869A1 (es) 2004-07-21
AU2002252856A1 (en) 2002-11-05
BR0209034A (pt) 2005-02-01
WO2002086100A3 (en) 2004-02-19
CN1636050A (zh) 2005-07-06
JP4173741B2 (ja) 2008-10-29
RU2003130955A (ru) 2005-04-20
AR035867A1 (es) 2004-07-21
WO2002086101A3 (en) 2004-02-19
PL366621A1 (en) 2005-02-07
US7238356B2 (en) 2007-07-03
WO2002086100A2 (en) 2002-10-31
RU2274643C2 (ru) 2006-04-20
CZ20032853A3 (cs) 2004-08-18
ZA200308272B (en) 2005-01-24
EP1417298A2 (en) 2004-05-12
AU2002308449B2 (en) 2008-05-29
WO2002085932A2 (en) 2002-10-31
YU84103A (sh) 2006-05-25
US7048930B2 (en) 2006-05-23
OA13092A (en) 2006-11-10
US7314925B2 (en) 2008-01-01
WO2002086101A2 (en) 2002-10-31
US20030152940A1 (en) 2003-08-14
ZA200308277B (en) 2004-07-08
AU2002257392B2 (en) 2007-05-10
BR0209033A (pt) 2005-01-11
CA2443740A1 (en) 2002-10-31
EP1381671A2 (en) 2004-01-21
CA2444006A1 (en) 2002-10-31

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