MXPA03009626A - Construcciones y metodo para la expresion de proteinas recombinantes de la envoltura viral de hcv. - Google Patents
Construcciones y metodo para la expresion de proteinas recombinantes de la envoltura viral de hcv.Info
- Publication number
- MXPA03009626A MXPA03009626A MXPA03009626A MXPA03009626A MXPA03009626A MX PA03009626 A MXPA03009626 A MX PA03009626A MX PA03009626 A MXPA03009626 A MX PA03009626A MX PA03009626 A MXPA03009626 A MX PA03009626A MX PA03009626 A MXPA03009626 A MX PA03009626A
- Authority
- MX
- Mexico
- Prior art keywords
- hcv envelope
- methods
- expression
- envelope proteins
- constructs
- Prior art date
Links
- 101710091045 Envelope protein Proteins 0.000 title abstract 4
- 101710188315 Protein X Proteins 0.000 title abstract 4
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 4
- 241000271566 Aves Species 0.000 abstract 3
- 102000016943 Muramidase Human genes 0.000 abstract 3
- 108010014251 Muramidase Proteins 0.000 abstract 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 3
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 3
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 3
- 229960000274 lysozyme Drugs 0.000 abstract 3
- 235000010335 lysozyme Nutrition 0.000 abstract 3
- 239000004325 lysozyme Substances 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 241000235648 Pichia Species 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24223—Virus like particles [VLP]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invencion se relaciona con vectores y metodos para la expresion eficaz de las proteinas de la envoltura del HCV en celulas eucarioticas. Mas en particular, los vectores comprenden la secuencia codificadora para un peptido de senal de lisozima de ave o un equivalente funcional del mismo, unido a una proteina de la envoltura del HCV o una parte de la misma. El peptido de senal de lisozima de ave es removido de manera eficaz cuando la proteina que comprende el peptido de senal de lisozima de ave unido a una proteina de la envoltura del HCV o una parte de la misma, es expresado en una celula eucariotica. Las celulas eucarioticas adecuadas incluyen celulas de la levadura tales como las celulas de Saccharomyces o Hansenula.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01870088 | 2001-04-24 | ||
| US30560401P | 2001-07-17 | 2001-07-17 | |
| PCT/BE2002/000062 WO2002085932A2 (en) | 2001-04-24 | 2002-04-24 | Constructs and methods for expression of recombinant hcv envelope proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03009626A true MXPA03009626A (es) | 2004-06-30 |
Family
ID=34072546
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03009632A MXPA03009632A (es) | 2001-04-24 | 2002-04-24 | Proteinas de la envoltura de vhc glucosiladas en la estructura central. |
| MXPA03009626A MXPA03009626A (es) | 2001-04-24 | 2002-04-24 | Construcciones y metodo para la expresion de proteinas recombinantes de la envoltura viral de hcv. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03009632A MXPA03009632A (es) | 2001-04-24 | 2002-04-24 | Proteinas de la envoltura de vhc glucosiladas en la estructura central. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7314925B2 (es) |
| EP (3) | EP1381671A2 (es) |
| JP (2) | JP4261195B2 (es) |
| KR (1) | KR100950104B1 (es) |
| CN (1) | CN1636050A (es) |
| AR (3) | AR035867A1 (es) |
| AU (3) | AU2002257392B2 (es) |
| BR (2) | BR0209034A (es) |
| CA (3) | CA2443781A1 (es) |
| CZ (1) | CZ20032853A3 (es) |
| HU (1) | HUP0303924A2 (es) |
| MX (2) | MXPA03009632A (es) |
| NZ (2) | NZ529019A (es) |
| OA (1) | OA13092A (es) |
| PL (1) | PL366621A1 (es) |
| RU (1) | RU2274643C2 (es) |
| SK (1) | SK13142003A3 (es) |
| WO (3) | WO2002085932A2 (es) |
| YU (1) | YU84103A (es) |
| ZA (3) | ZA200308274B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040185061A1 (en) * | 1994-07-29 | 2004-09-23 | Innogenetics N.V. | Redox reversible HCV proteins with native-like conformation |
| WO2002085932A2 (en) * | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Constructs and methods for expression of recombinant hcv envelope proteins |
| DE10143490C2 (de) * | 2001-09-05 | 2003-12-11 | Gsf Forschungszentrum Umwelt | Rekombinantes MVA mit der Fähigkeit zur Expression von HCV Struktur-Antigenen |
| AU2003283365A1 (en) * | 2002-11-08 | 2004-06-07 | Innogenetics N.V. | HCV vaccine compositions comprising E1 and NS3 peptides |
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| JP4371739B2 (ja) * | 2003-09-02 | 2009-11-25 | 株式会社東芝 | シリアルａｔａインタフェースを持つ電子機器及びシリアルａｔａバスのパワーセーブ方法 |
| EP1574517A1 (en) * | 2004-03-09 | 2005-09-14 | Innogenetics N.V. | HCV E1 comprising specific disulfide bridges |
| EP1602664A1 (en) * | 2004-03-08 | 2005-12-07 | Innogenetics N.V. | HCV E1 comprising specific disulfide bridges |
| JP4885476B2 (ja) * | 2004-05-21 | 2012-02-29 | 株式会社日本触媒 | タンパク質及び／又はペプチドの細胞内導入方法 |
| AU2011254055B2 (en) * | 2004-10-18 | 2012-12-20 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| EP1809773B1 (en) * | 2004-10-18 | 2014-07-16 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis c infection |
| US20060234360A1 (en) * | 2005-04-13 | 2006-10-19 | Paola Branduardi | Ascorbic acid production from D-glucose in yeast |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| PE20070796A1 (es) * | 2005-10-24 | 2007-08-15 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
| CA2651456A1 (en) | 2006-05-19 | 2007-11-29 | Glycofi, Inc. | Recombinant vectors |
| AU2015234338C1 (en) * | 2006-07-28 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
| EP2061805B1 (en) * | 2006-08-25 | 2020-02-12 | Macfarlane Burnet Institute for Medical Research and Public Health Limited | Recombinant hcv e2 glycoprotein |
| EP2331125A4 (en) | 2008-09-19 | 2013-03-27 | Globeimmune Inc | IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS |
| WO2010039224A2 (en) | 2008-09-30 | 2010-04-08 | University Of Massachusetts Medical School | Respiratory syncytial virus (rsv) sequences for protein expression and vaccines |
| US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
| DE102009044224A1 (de) * | 2009-10-09 | 2011-04-28 | PomBio Tech GmbH Starterzentrum der Universität des Saarlandes Campus Geb. A1-1 | Methode zur Produktion von HCV Virus-ähnlichen Partikeln |
| DK2654785T3 (da) | 2010-12-22 | 2019-06-24 | Bayer Ip Gmbh | Forøget immunrespons hos kvægracer |
| US20140155469A1 (en) | 2011-04-19 | 2014-06-05 | The Research Foundation Of State University Of New York | Adeno-associated-virus rep sequences, vectors and viruses |
| US9534039B2 (en) | 2011-05-09 | 2017-01-03 | Ablynx N.V. | Method for the production of immunoglobulin single variable domains |
| MX2016010993A (es) * | 2014-02-28 | 2017-05-01 | Bayer Animal Health Gmbh | Plasmidos inmunoestimuladores. |
| JP2019504638A (ja) * | 2015-11-13 | 2019-02-21 | マメドフ、タルラン | Ｅｎｄｏ ｈとの同時発現によってインビボｎ−脱グルコシル化組換えタンパク質の産生 |
| EP3184642B1 (de) * | 2015-12-22 | 2019-05-08 | bisy e.U. | Hefezelle |
| AU2017332854A1 (en) | 2016-09-21 | 2019-04-11 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4395395A (en) | 1979-05-21 | 1983-07-26 | The United States Of America As Represented By The Department Of Health And Human Services | Detection of non-A, non-B hepatitis associated antigen |
| EP0288198A3 (en) * | 1987-04-20 | 1989-03-29 | Takeda Chemical Industries, Ltd. | Production of peptide |
| US5135854A (en) | 1987-10-29 | 1992-08-04 | Zymogenetics, Inc. | Methods of regulating protein glycosylation |
| US5683864A (en) | 1987-11-18 | 1997-11-04 | Chiron Corporation | Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| US5698390A (en) | 1987-11-18 | 1997-12-16 | Chiron Corporation | Hepatitis C immunoassays |
| JP2791418B2 (ja) * | 1987-12-02 | 1998-08-27 | 株式会社ミドリ十字 | 異種蛋白質の製造方法、組換えｄｎａ、形質転換体 |
| NO177065C (no) * | 1988-09-26 | 1995-07-12 | Labofina Sa | Framgangsmåte for framstilling av enzymatisk aktivt humant lysozym |
| US5747239A (en) | 1990-02-16 | 1998-05-05 | United Biomedical, Inc. | Synthetic peptides specific for the detection of antibodies to HCV, diagnosis of HCV infection and preventions thereof as vaccines |
| US5712087A (en) | 1990-04-04 | 1998-01-27 | Chiron Corporation | Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens |
| WO1992001800A1 (en) * | 1990-07-20 | 1992-02-06 | Chiron Corporation | Method for integrative transformation of yeast using dispersed repetitive elements |
| CA2047792C (en) | 1990-07-26 | 2002-07-02 | Chang Y. Wang | Synthetic peptides specific for the detection of antibodies to hcv, diagnosis of hcv infection and prevention thereof as vaccines |
| ES2188583T3 (es) | 1991-06-24 | 2003-07-01 | Chiron Corp | Polipeptidos para el virus de la hepatitis c (hcv). |
| AU4659993A (en) | 1992-07-07 | 1994-01-31 | Merck & Co., Inc. | Vaccine comprising mixed pres1+pres2+s and core particle |
| DK0992580T3 (da) | 1993-11-04 | 2005-07-11 | Innogenetics Nv | Epitoper på human T-celler, som er immundominante for hepatitis C-virus |
| ES2174957T5 (es) * | 1994-07-29 | 2006-12-16 | Innogenetics N.V. | Proteinas purificadas de envoltura de virus de la hepatitis c para uso diagnostico y terapeutico. |
| ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
| US5935824A (en) * | 1996-01-31 | 1999-08-10 | Technologene, Inc. | Protein expression system |
| DE69735242T2 (de) * | 1996-12-20 | 2006-09-21 | Novo Nordisk A/S | N-terminal verlängerte proteine exprimiert in hefe |
| AU752131C (en) | 1997-11-06 | 2003-12-04 | Innogenetics N.V. | Multi-mer peptides derived from hepatitis C virus envelope proteins for diagnostic use and vaccination purposes |
| AU2149899A (en) * | 1998-01-23 | 1999-08-09 | Novo Nordisk A/S | Process for making desired polypeptides in yeast |
| TR200003024T2 (tr) | 1998-04-17 | 2000-12-21 | Innogenetics N.V. | İndirgeme ajanlarını kullanarak geliştirilen immünodiagnostik tahliller. |
| NZ508797A (en) * | 1998-06-24 | 2004-02-27 | Innogenetics N | Particles of HCV envelope proteins: use for vaccination |
| CA2387666A1 (en) | 1999-10-27 | 2001-05-03 | Innogenetics N.V. | Redox reversible hcv proteins with native-like conformation |
| WO2002055548A2 (en) | 2001-01-11 | 2002-07-18 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
| WO2002085932A2 (en) * | 2001-04-24 | 2002-10-31 | Innogenetics N.V. | Constructs and methods for expression of recombinant hcv envelope proteins |
| RU2319505C2 (ru) | 2001-12-18 | 2008-03-20 | Иннодженетикс Н.В. | Очищенные оболочечные белки вируса гепатита с для диагностического и терапевтического применения |
| AU2003283365A1 (en) | 2002-11-08 | 2004-06-07 | Innogenetics N.V. | HCV vaccine compositions comprising E1 and NS3 peptides |
-
2002
- 2002-04-24 WO PCT/BE2002/000062 patent/WO2002085932A2/en active IP Right Grant
- 2002-04-24 YU YU84103A patent/YU84103A/sh unknown
- 2002-04-24 BR BR0209034-1A patent/BR0209034A/pt not_active IP Right Cessation
- 2002-04-24 EP EP02764023A patent/EP1381671A2/en not_active Withdrawn
- 2002-04-24 RU RU2003130955/13A patent/RU2274643C2/ru not_active IP Right Cessation
- 2002-04-24 CA CA002443781A patent/CA2443781A1/en not_active Abandoned
- 2002-04-24 CA CA002443740A patent/CA2443740A1/en not_active Abandoned
- 2002-04-24 CZ CZ20032853A patent/CZ20032853A3/cs unknown
- 2002-04-24 JP JP2002583615A patent/JP4261195B2/ja not_active Expired - Fee Related
- 2002-04-24 AR ARP020101493A patent/AR035867A1/es unknown
- 2002-04-24 MX MXPA03009632A patent/MXPA03009632A/es not_active Application Discontinuation
- 2002-04-24 CN CNA028126076A patent/CN1636050A/zh active Pending
- 2002-04-24 NZ NZ529019A patent/NZ529019A/en unknown
- 2002-04-24 US US10/128,587 patent/US7314925B2/en not_active Expired - Fee Related
- 2002-04-24 AR ARP020101494A patent/AR035868A1/es unknown
- 2002-04-24 BR BR0209033-3A patent/BR0209033A/pt not_active IP Right Cessation
- 2002-04-24 EP EP02721875A patent/EP1414942A2/en not_active Withdrawn
- 2002-04-24 MX MXPA03009626A patent/MXPA03009626A/es not_active Application Discontinuation
- 2002-04-24 WO PCT/BE2002/000064 patent/WO2002086101A2/en active IP Right Grant
- 2002-04-24 OA OA1200500194A patent/OA13092A/en unknown
- 2002-04-24 AR ARP020101495A patent/AR035869A1/es unknown
- 2002-04-24 KR KR1020037013778A patent/KR100950104B1/ko not_active IP Right Cessation
- 2002-04-24 AU AU2002257392A patent/AU2002257392B2/en not_active Ceased
- 2002-04-24 WO PCT/BE2002/000063 patent/WO2002086100A2/en active Application Filing
- 2002-04-24 PL PL02366621A patent/PL366621A1/xx not_active Application Discontinuation
- 2002-04-24 AU AU2002252856A patent/AU2002252856A1/en not_active Abandoned
- 2002-04-24 AU AU2002308449A patent/AU2002308449B2/en not_active Ceased
- 2002-04-24 EP EP02727059A patent/EP1417298A2/en not_active Withdrawn
- 2002-04-24 NZ NZ529324A patent/NZ529324A/en unknown
- 2002-04-24 US US10/128,578 patent/US7048930B2/en not_active Expired - Fee Related
- 2002-04-24 US US10/128,590 patent/US7238356B2/en not_active Expired - Fee Related
- 2002-04-24 HU HU0303924A patent/HUP0303924A2/hu unknown
- 2002-04-24 JP JP2002583616A patent/JP4173741B2/ja not_active Expired - Fee Related
- 2002-04-24 SK SK1314-2003A patent/SK13142003A3/sk unknown
- 2002-04-24 CA CA002444006A patent/CA2444006A1/en not_active Abandoned
-
2003
- 2003-10-23 ZA ZA200308274A patent/ZA200308274B/en unknown
- 2003-10-23 ZA ZA200308272A patent/ZA200308272B/en unknown
- 2003-10-23 ZA ZA200308277A patent/ZA200308277B/en unknown
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