CO5070672A1 - Polipeptido de proteina c humana - Google Patents

Polipeptido de proteina c humana

Info

Publication number
CO5070672A1
CO5070672A1 CO99034013A CO99034013A CO5070672A1 CO 5070672 A1 CO5070672 A1 CO 5070672A1 CO 99034013 A CO99034013 A CO 99034013A CO 99034013 A CO99034013 A CO 99034013A CO 5070672 A1 CO5070672 A1 CO 5070672A1
Authority
CO
Colombia
Prior art keywords
polypeptide
human protein
nucleic acid
acid according
vector
Prior art date
Application number
CO99034013A
Other languages
English (en)
Inventor
Huang Lihua
Ralph Meridith Riggin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5070672A1 publication Critical patent/CO5070672A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un polipéptido de proteína C humana que comprende: una cadena liviana y una cadena pesada truncada.Una molécula de ADN recombinante que codifica el polipéptido de proteína C humana de la Reivindicación 1. Un vector que comprende un ácido nucléico de acuerdo con la Reivindicación 2. Una célula huésped que comprende un ácido nucléico aislado de acuerdo con la Reivindicación 2.
CO99034013A 1998-06-01 1999-06-01 Polipeptido de proteina c humana CO5070672A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8758598P 1998-06-01 1998-06-01

Publications (1)

Publication Number Publication Date
CO5070672A1 true CO5070672A1 (es) 2001-08-28

Family

ID=22206075

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99034013A CO5070672A1 (es) 1998-06-01 1999-06-01 Polipeptido de proteina c humana

Country Status (25)

Country Link
US (1) US20040038288A1 (es)
EP (1) EP1084235A4 (es)
JP (1) JP2002517191A (es)
KR (1) KR20010043941A (es)
CN (1) CN1303428A (es)
AR (1) AR020082A1 (es)
AU (1) AU4409399A (es)
BR (1) BR9910858A (es)
CA (1) CA2330171A1 (es)
CO (1) CO5070672A1 (es)
DZ (1) DZ2803A1 (es)
EA (1) EA200001254A1 (es)
HR (1) HRP20000826A2 (es)
HU (1) HUP0102014A3 (es)
ID (1) ID27282A (es)
IL (1) IL139595A0 (es)
NO (1) NO20006091L (es)
NZ (1) NZ507982A (es)
PE (1) PE20000561A1 (es)
PL (1) PL344349A1 (es)
SK (1) SK17502000A3 (es)
SV (1) SV1999000067A (es)
TR (1) TR200003552T2 (es)
WO (1) WO1999063070A1 (es)
ZA (1) ZA200006647B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8821884B2 (en) * 2004-07-27 2014-09-02 The Regents Of The University Of California Compositions and methods using MD-2 mutants and chimeric proteins
CN108159399B (zh) * 2017-12-29 2020-07-24 华中科技大学同济医学院附属同济医院 一种凝血蛋白酶aPC在防治糖尿病心肌病药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2728240B2 (ja) * 1988-07-26 1998-03-18 ヘキスト薬品工業株式会社 ヒトプロテインｃ変異体及びその製造方法
EP0506821B1 (en) * 1989-12-29 1998-02-04 Zymogenetics, Inc. Hybrid protein c
JPH05506354A (ja) * 1990-02-09 1993-09-22 ザイモジェネティクス，インコーポレイティド 端が切り取られた軽鎖を有する活性プロテインｃ
JPH0564588A (ja) * 1991-08-14 1993-03-19 Teijin Ltd 短い重鎖を有するヒトプロテインｃおよび活性化ヒトプロテインｃ

Also Published As

Publication number Publication date
CA2330171A1 (en) 1999-12-09
HUP0102014A3 (en) 2003-09-29
JP2002517191A (ja) 2002-06-18
EA200001254A1 (ru) 2001-06-25
NO20006091L (no) 2001-01-31
AU4409399A (en) 1999-12-20
PL344349A1 (en) 2001-11-05
CN1303428A (zh) 2001-07-11
EP1084235A4 (en) 2002-03-27
KR20010043941A (ko) 2001-05-25
HUP0102014A2 (hu) 2001-10-28
NO20006091D0 (no) 2000-11-30
SK17502000A3 (sk) 2001-09-11
US20040038288A1 (en) 2004-02-26
WO1999063070A1 (en) 1999-12-09
AR020082A1 (es) 2002-04-10
BR9910858A (pt) 2001-03-06
HRP20000826A2 (en) 2001-10-31
PE20000561A1 (es) 2000-07-22
TR200003552T2 (tr) 2001-05-21
NZ507982A (en) 2004-01-30
ID27282A (id) 2001-03-22
EP1084235A1 (en) 2001-03-21
ZA200006647B (en) 2001-11-15
DZ2803A1 (fr) 2003-12-01
SV1999000067A (es) 2000-07-06
IL139595A0 (en) 2002-02-10

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