ATE99358T1 - Alpha-1-antitrypsinmutante und dafuer kodierende dns und herstellung derselben, und solche mutante verwendende therapeutische zusammensetzungen und ihre herstellung. - Google Patents
Alpha-1-antitrypsinmutante und dafuer kodierende dns und herstellung derselben, und solche mutante verwendende therapeutische zusammensetzungen und ihre herstellung.Info
- Publication number
- ATE99358T1 ATE99358T1 AT85301790T AT85301790T ATE99358T1 AT E99358 T1 ATE99358 T1 AT E99358T1 AT 85301790 T AT85301790 T AT 85301790T AT 85301790 T AT85301790 T AT 85301790T AT E99358 T1 ATE99358 T1 AT E99358T1
- Authority
- AT
- Austria
- Prior art keywords
- mutants
- production
- alpha
- dna encoding
- therapeutic compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58941084A | 1984-03-14 | 1984-03-14 | |
US06/709,382 US4711848A (en) | 1984-03-14 | 1985-03-07 | Site specific mutagenesis in alpha-1-antitrypsin |
EP85301790A EP0155188B1 (de) | 1984-03-14 | 1985-03-14 | Alpha-1-Antitrypsinmutante und dafür kodierende DNS und Herstellung derselben, und solche Mutante verwendende therapeutische Zusammensetzungen und ihre Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE99358T1 true ATE99358T1 (de) | 1994-01-15 |
Family
ID=27080550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85301790T ATE99358T1 (de) | 1984-03-14 | 1985-03-14 | Alpha-1-antitrypsinmutante und dafuer kodierende dns und herstellung derselben, und solche mutante verwendende therapeutische zusammensetzungen und ihre herstellung. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4711848A (de) |
EP (2) | EP0566158A1 (de) |
JP (3) | JP2539781B2 (de) |
AT (1) | ATE99358T1 (de) |
AU (1) | AU593766B2 (de) |
CA (1) | CA1341219C (de) |
DE (1) | DE3587703D1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA8410063B (en) * | 1984-01-30 | 1985-10-30 | Smith Kline Rit | Expression of human alpha-1-antitrypsin in yeast |
DE3585969D1 (de) * | 1984-06-14 | 1992-06-11 | Chiron Corp | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
US4732973A (en) * | 1984-06-14 | 1988-03-22 | Chiron Corporation | Active site modified protease α-1-antitrypsin inhibitors |
WO1986000337A1 (fr) * | 1984-06-19 | 1986-01-16 | Transgene S.A. | DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION |
US5422090A (en) * | 1984-08-13 | 1995-06-06 | Biotechnology Australia, Pty., Ltd. | Human PAI-2 |
CA1299120C (en) * | 1984-10-22 | 1992-04-21 | Glenn Kawasaki | Stable dna constructs for expression of alpha-1-antitrypsin |
US6291662B1 (en) | 1984-12-05 | 2001-09-18 | Amgen Inc. | Recombinant methods for production of serine protease inhibitors and DNA sequences |
US5871956A (en) * | 1984-12-06 | 1999-02-16 | Amgen Inc. | Recombinant methods for production of serine inhibitors and DNA sequences useful for same |
AU591474B2 (en) * | 1984-12-06 | 1989-12-07 | Amgen, Inc. | Serine protease inhibitors and methods for isolation of same |
US6132990A (en) * | 1984-12-06 | 2000-10-17 | Amgen Boulder Inc. | Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same |
AU590238B2 (en) * | 1984-12-06 | 1989-11-02 | Amgen, Inc. | Recombinant methods for production of serine protease inhibitors and dna sequences useful for same |
US5900400A (en) * | 1984-12-06 | 1999-05-04 | Amgen Inc. | Serine protease inhibitor analogs |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
DK171161B1 (da) * | 1985-03-28 | 1996-07-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve |
AU6469886A (en) * | 1985-11-08 | 1987-05-14 | Smithkline Beckman Corporation | Mutant alpha-1-antitryosin and dna sequence therefor |
FR2599752B1 (fr) * | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
EP0253193B1 (de) * | 1986-07-08 | 1992-10-28 | Abbott Laboratories | Verfahren für die Mutagenese durch eine oligonukleotidgeleitete Reparatur eines Strangbruchs |
JP2656944B2 (ja) * | 1987-04-30 | 1997-09-24 | クーパー ラボラトリーズ | タンパク質性治療剤のエアロゾール化 |
NZ226543A (en) * | 1987-10-22 | 1992-02-25 | Merck & Co Inc | Recombinant mutant acidic fibroblast growth factor |
US5648254A (en) * | 1988-01-15 | 1997-07-15 | Zymogenetics, Inc. | Co-expression in eukaryotic cells |
US5622845A (en) * | 1988-02-17 | 1997-04-22 | The Upjohn Company | Fermentation method for producing norleucine |
US5180667A (en) * | 1988-03-07 | 1993-01-19 | Ciba-Geigy Corporation | Genes encoding eglin C mutants |
EP0332576B1 (de) * | 1988-03-07 | 1994-04-06 | Ciba-Geigy Ag | Modifizierte Proteine |
DE3901917A1 (de) * | 1989-01-24 | 1990-07-26 | Behringwerke Ag | Mutanten von humanem antithrombin iii |
DK0401508T3 (da) * | 1989-05-13 | 1995-05-15 | Bayer Ag | Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf |
US5518907A (en) * | 1989-06-07 | 1996-05-21 | Center For Innovative Technology | Cloning and expression in Escherichia coli of the Alcaligenes eutrophus H16 poly-beta-hydroxybutyrate biosynthetic pathway |
US5334520A (en) * | 1990-05-25 | 1994-08-02 | Center For Innovative Technology | Production of poly-beta-hydroxybutyrate in transformed escherichia coli |
US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
AU7168591A (en) * | 1989-12-29 | 1991-07-24 | Zymogenetics Inc. | Hybrid protein c |
US6869925B1 (en) * | 1992-09-09 | 2005-03-22 | Amgen Inc. | Inhibition of retrovirus infection |
CA2170030A1 (en) * | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
US6017880A (en) * | 1994-03-09 | 2000-01-25 | Amgen Inc. | Inhibition of retrovirus infection |
WO1996010638A1 (en) * | 1994-09-30 | 1996-04-11 | Ppl Therapeutics (Scotland) Ltd. | Alpha-1-antitrypsin and antithrombine-iii variants |
US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US6315995B1 (en) * | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
US6316403B1 (en) | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
AU743025B2 (en) | 1997-03-12 | 2002-01-17 | Applera Corporation | DNA polymerases having improved labeled nucleotide incorporation properties |
WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
AU3511500A (en) | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
US6849605B1 (en) * | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
US20050250688A1 (en) * | 1999-04-01 | 2005-11-10 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
WO2002086088A2 (en) * | 2001-04-24 | 2002-10-31 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
US20050042629A1 (en) | 2002-09-13 | 2005-02-24 | Applera Corporation | Thermus scotoductus nucleic acid polymerases |
WO2003048308A2 (en) | 2001-11-30 | 2003-06-12 | Applera Corporation | Thermus brockianus nucleic acid polymerases |
US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
EP1660661A2 (de) * | 2003-08-08 | 2006-05-31 | Arriva Pharmaceuticals, Inc. | Verfahren zur proteinproduktion in hefe |
EP2520654B8 (de) | 2003-08-26 | 2017-04-19 | The Regents of the University of Colorado, a body corporate | Serinprotease-Hemmer und deren Verwendung in Verfahren und Zusammensetzungen für die Behandlung bakterieller Infektionen |
SI1684719T1 (sl) | 2003-11-14 | 2012-07-31 | Baxter Int | Sestavki alfa antitripsina in postopki zdravljenja ob uporabi takih sestavkov |
US20070105768A1 (en) * | 2004-11-10 | 2007-05-10 | Rajiv Nayar | Dry recombinant human alpha 1-antitrypsin formulation |
GB2446550B (en) * | 2005-11-28 | 2010-12-08 | Proteomtech Inc | Methods for production of recombinant alpha1-antitrypsin |
CA2672651C (en) | 2006-12-15 | 2014-03-11 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
US8133484B2 (en) | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
KR100992526B1 (ko) * | 2007-11-21 | 2010-11-05 | 한국과학기술연구원 | 이황화결합을 이용한 내열성의 알파-1-안티트립신 뮤테인및 그의 제조방법 |
US20110112573A1 (en) * | 2008-06-18 | 2011-05-12 | Orahn Preiss Bloom | Methods and devices for use with sealants |
EP2303341A2 (de) * | 2008-06-18 | 2011-04-06 | Lifebond Ltd | Verfahren zur enzymatischen vernetzung eines proteins |
US8367388B2 (en) | 2008-06-18 | 2013-02-05 | Lifebond Ltd. | Cross-linked compositions |
EP2496246B1 (de) | 2009-11-03 | 2018-06-27 | Grifols Therapeutics LLC | Zusammensetzung, verfahren und kit für einen alpha-1-proteasehmmer |
CA2781120C (en) | 2009-11-24 | 2015-01-27 | Jianxin Guo | Lyophilization methods, compositions, and kits |
JP5796860B2 (ja) | 2009-12-22 | 2015-10-21 | ライフボンド リミテッドLifebond Ltd | 架橋マトリックスの特性を調節するための酵素的架橋剤の改変 |
CA2807012A1 (en) | 2010-08-05 | 2012-02-09 | Lifebond Ltd. | Dry composition wound dressings and adhesives |
EP2668201A2 (de) | 2011-01-28 | 2013-12-04 | Sanofi Pasteur SA | Immunologische zusammensetzungen mit hiv-gp41-polypeptidderivaten |
EP2723370A4 (de) | 2011-06-24 | 2015-06-03 | Univ Colorado Regents | Zusammensetzungen, verfahren und verwendung für alpha-1-antitrypsin-fusionsmoleküle |
ES2656150T3 (es) * | 2011-11-14 | 2018-02-23 | Universitätsklinikum Jena | Diagnóstico de la sepsis y del síndrome de respuesta inflamatoria sistémica |
MY166314A (en) | 2011-12-30 | 2018-06-25 | Grifols Sa | Alpha1-proteinase inhibitor for delaying the onset or progression of pulmonary exacerbations |
KR102348985B1 (ko) | 2012-01-10 | 2022-01-12 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
EP2978442B1 (de) | 2013-03-29 | 2020-03-18 | The Regents of the University of Colorado, a body corporate | Alpha 1 antitrypsin zur vorbereitung eines patienten auf ein transplantat |
GB201322091D0 (en) | 2013-12-13 | 2014-01-29 | Cambridge Entpr Ltd | Modified serpins for the treatment of bleeding disorders |
EP3397274A1 (de) | 2015-12-31 | 2018-11-07 | The Regents of the University of Colorado, a body corporate | Verfahren und verwendungen für alpha-1-antitrypsin oder rekombinante formen davon auf steroid-refraktärer graft-versus-host-krankheit mit gastrointestinalen komplikationen |
WO2018183705A1 (en) * | 2017-03-29 | 2018-10-04 | Cornell University | Oxidation-resistant aat gene therapy |
SE1750774A1 (en) * | 2017-06-19 | 2018-12-11 | Hepgene Medical Ab | Novel nucleic acid molecules and their use in therapy |
EP3723790B1 (de) | 2017-12-12 | 2024-03-13 | Kamada Ltd | Verfahren zur induzierung der immuntoleranz und zur verminderung der antiinflammatorischen antikörperreaktion |
WO2023083859A1 (en) | 2021-11-09 | 2023-05-19 | Danmarks Tekniske Universitet | Variants of alpha-1-antitrypsin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4351901A (en) * | 1980-03-24 | 1982-09-28 | Cetus Corporation | Method for single nucleotide alteration |
CA1303530C (en) * | 1983-01-21 | 1992-06-16 | Michael Courtney | EXPRESSION VECTORS AND THEIR USE FOR THE PREPARATION OF A PROTEIN HAVING HUMAN .alpha. -ANTITRYPSIN ACTIVITY |
JPS60186290A (ja) * | 1983-08-10 | 1985-09-21 | チモ−ジエネテイツクス インコ−ポレ−テツド | アルフア−1−アンチトリプシンを細菌に表現させる方法 |
AU3145184A (en) * | 1983-08-16 | 1985-02-21 | Zymogenetics Inc. | High expression of foreign genes in schizosaccharomyces pombe |
ZA8410063B (en) * | 1984-01-30 | 1985-10-30 | Smith Kline Rit | Expression of human alpha-1-antitrypsin in yeast |
DE3585969D1 (de) * | 1984-06-14 | 1992-06-11 | Chiron Corp | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
WO1986000337A1 (fr) * | 1984-06-19 | 1986-01-16 | Transgene S.A. | DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION |
-
1985
- 1985-03-07 US US06/709,382 patent/US4711848A/en not_active Expired - Lifetime
- 1985-03-13 AU AU39819/85A patent/AU593766B2/en not_active Expired
- 1985-03-13 CA CA000476337A patent/CA1341219C/en not_active Expired - Fee Related
- 1985-03-14 AT AT85301790T patent/ATE99358T1/de not_active IP Right Cessation
- 1985-03-14 DE DE85301790T patent/DE3587703D1/de not_active Expired - Lifetime
- 1985-03-14 EP EP93107971A patent/EP0566158A1/de not_active Withdrawn
- 1985-03-14 JP JP60051553A patent/JP2539781B2/ja not_active Expired - Fee Related
- 1985-03-14 EP EP85301790A patent/EP0155188B1/de not_active Expired - Lifetime
-
1993
- 1993-04-06 JP JP5115129A patent/JP2750257B2/ja not_active Expired - Fee Related
-
1997
- 1997-10-08 JP JP9275648A patent/JPH10113193A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH06105689A (ja) | 1994-04-19 |
EP0155188A3 (en) | 1986-08-13 |
DE3587703D1 (de) | 1994-02-10 |
EP0155188A2 (de) | 1985-09-18 |
EP0566158A1 (de) | 1993-10-20 |
AU3981985A (en) | 1985-09-19 |
JP2539781B2 (ja) | 1996-10-02 |
CA1341219C (en) | 2001-05-01 |
AU593766B2 (en) | 1990-02-22 |
JPH10113193A (ja) | 1998-05-06 |
EP0155188B1 (de) | 1993-12-29 |
JP2750257B2 (ja) | 1998-05-13 |
JPS6112289A (ja) | 1986-01-20 |
US4711848A (en) | 1987-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |