DE3582274D1 - Menschliche monoklonale antikoerper gegen serotypische lipopolysaccharidische determinanten von gram-negativen bakterien und ihre produktion. - Google Patents

Menschliche monoklonale antikoerper gegen serotypische lipopolysaccharidische determinanten von gram-negativen bakterien und ihre produktion.

Info

Publication number
DE3582274D1
DE3582274D1 DE8585303642T DE3582274T DE3582274D1 DE 3582274 D1 DE3582274 D1 DE 3582274D1 DE 8585303642 T DE8585303642 T DE 8585303642T DE 3582274 T DE3582274 T DE 3582274T DE 3582274 D1 DE3582274 D1 DE 3582274D1
Authority
DE
Germany
Prior art keywords
crl
gram
monoclonal antibodies
human monoclonal
determinants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE8585303642T
Other languages
English (en)
Inventor
Anthony W Siadak
Mark E Lostrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Systems Corp
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24460190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3582274(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Application granted granted Critical
Publication of DE3582274D1 publication Critical patent/DE3582274D1/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/803—Antibody or antigen-binding fragment thereof that binds gram-negative bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/806—Drug, bio-affecting and body treating compositions involving IgM
    • Y10S424/807—Monoclonal
    • Y10S424/808—Human
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
    • Y10S530/864—Monoclonal
    • Y10S530/865—Human

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8585303642T 1984-05-25 1985-05-23 Menschliche monoklonale antikoerper gegen serotypische lipopolysaccharidische determinanten von gram-negativen bakterien und ihre produktion. Revoked DE3582274D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61418484A 1984-05-25 1984-05-25

Publications (1)

Publication Number Publication Date
DE3582274D1 true DE3582274D1 (de) 1991-05-02

Family

ID=24460190

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585303642T Revoked DE3582274D1 (de) 1984-05-25 1985-05-23 Menschliche monoklonale antikoerper gegen serotypische lipopolysaccharidische determinanten von gram-negativen bakterien und ihre produktion.

Country Status (16)

Country Link
US (1) US4834975A (de)
EP (1) EP0163493B1 (de)
JP (1) JPS6169796A (de)
KR (1) KR850008282A (de)
AT (1) ATE62021T1 (de)
AU (1) AU600222B2 (de)
DE (1) DE3582274D1 (de)
DK (1) DK233385A (de)
ES (1) ES8702792A1 (de)
FI (1) FI89278C (de)
GR (1) GR851234B (de)
HU (1) HU202927B (de)
IE (1) IE58411B1 (de)
IL (1) IL75277A (de)
NO (1) NO167758C (de)
ZA (1) ZA853888B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria
JPS61155398A (ja) * 1984-12-28 1986-07-15 Teijin Ltd 抗緑膿菌ヒトモノクロ−ナル抗体及びその製造法並びにそれを有効成分とする治療剤
EP0233289B1 (de) * 1984-12-26 1993-03-10 Teijin Limited Humaner monoklonaler antikörper gegen pseudomonas aeruginosagegen pseudomonas aeruginosa produzierende hybridomen
JPS61152280A (ja) * 1984-12-26 1986-07-10 Teijin Ltd 抗緑膿菌ヒト抗体を産生する形質転換細胞及びその製造法並びにその使用方法
EP0215131B1 (de) * 1985-03-11 1992-06-17 Teijin Limited E87ag-antigen des pseudomonas aeruginosa, monoklonale antikörper dagegen und hybridom
US5179001A (en) * 1985-09-27 1993-01-12 The Regents Of The University Of California Detection and monitoring of chronic and gram-negative infection
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
US4777136A (en) * 1985-09-27 1988-10-11 The Regents Of The University Of California Monoclonal antibody reactive with Pseudomonas Aeruginosa
EP0494085A1 (de) 1985-09-27 1992-07-08 The Regents Of The University Of California Monoklonale Antikörper, die Determinanten von Gram-negativen Bakterien binden
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
US4970070A (en) * 1986-02-07 1990-11-13 Genetic Systems Corporation Protective monoclonal antibody compositions for infections due to group B streptococcus
IL81370A (en) * 1986-02-07 1991-06-30 Genetic Systems Corp Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions
ZA87863B (en) * 1986-02-07 1987-09-30 Genetic Systems Corp Cross-protective human monoclonal antibody compositions
ES2009365A6 (es) * 1986-04-24 1989-09-16 Univ California Procedimiento de otencion de anticuerpos monoclonales para bacterias gram-negativas.
GB8610202D0 (en) * 1986-04-25 1986-05-29 Technology Licence Co Ltd Monoclonal antibodies
EP0256713A3 (de) * 1986-08-06 1989-02-15 Merck & Co. Inc. Therapeutische, menschliche Antipseudomonas-Aeruginosa-Antikörper
ZA878610B (en) * 1986-11-20 1989-06-28 Minnesota Mining & Mfg Method for the evaluation of oral microbes
US5521085A (en) * 1986-12-15 1996-05-28 Mitsui Toatsu Chemicals, Inc. Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes
AU1807188A (en) * 1987-04-10 1988-11-04 Xoma Corporation Human monoclonal antibodies binding determinants of gram negative bacteria
ES2045027T3 (es) * 1987-08-10 1994-01-16 Miles Inc Igm purificadas.
JPH01197500A (ja) * 1988-01-29 1989-08-09 Sumitomo Chem Co Ltd ヒトモノクローナル抗体
GB2218703B (en) * 1988-05-10 1992-10-28 Sumitomo Chemical Co Human monoclonal antibody to p.aeruginosa: its production and use
US5439665A (en) * 1988-07-29 1995-08-08 Immunomedics Detection and treatment of infectious and inflammatory lesions
CA1341375C (en) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions and methods for the treatment and prevention of gram-negative bacterial infections
US4939176A (en) * 1988-12-20 1990-07-03 Miles Inc. Viral inactivation process
JPH02283294A (ja) * 1989-04-24 1990-11-20 Sumitomo Chem Co Ltd ヒトモノクローナル抗体
US5233024A (en) * 1991-04-09 1993-08-03 The Brigham & Women's Hospital Anti-idiotypic monoclonal antibodies for mucoid pseudomonas aeruginosa, their preparation and use
US5824310A (en) * 1991-10-22 1998-10-20 The United States Of America As Represented By The Department Of Health And Human Services Lipopplysaccharide conjugate vaccines
CA2085448C (en) * 1991-12-24 2003-11-18 Masakazu Tsuchiya Process for extracting endotoxin
US5610031A (en) * 1993-10-27 1997-03-11 The General Hospital Corporation B1k chain of laminin and methods of use
US5562902A (en) * 1994-03-14 1996-10-08 Arp Biomed, Inc. Immunotherapeutic method of treating cancerous diseases by administration of intravenous immunoglobulin
US5807694A (en) * 1995-09-07 1998-09-15 Economic Innovation And Technology Council, University Of Manitoba Detection of salmonella enteritidis and other pathogenic microorganisms and monoclonal antibody useful therefor
US6818222B1 (en) * 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
ATE339964T1 (de) * 1997-05-15 2006-10-15 Trillium Therapeutics Inc Verfahren um immunkoagulation zu modulieren
US6790661B1 (en) 1999-07-16 2004-09-14 Verax Biomedical, Inc. System for detecting bacteria in blood, blood products, and fluids of tissues
WO2001061305A2 (en) * 2000-02-15 2001-08-23 Fit Biotech Oyj Plc Immunoassays detecting or making use of at least two rubber latexallergens
ATE458006T1 (de) * 2003-05-14 2010-03-15 Kenta Biotech Ag Humaner monoklonaler antikörper spezifisch für lipopolysacchariden (lps) des serotyps iats o6 von pseudomonas aeruginosa
US20120114657A1 (en) 2009-04-09 2012-05-10 Kenta Biotech Ag Human Monoclonal Antibody Specific for Lipopolysaccharides (LPS) of Serotype IATS 01 of Pseudomonas Aeruginosa
KR20130048199A (ko) * 2010-02-18 2013-05-09 심포젠 에이/에스 녹농균의 혈청형 ｅ 지질다당류에 대한 항체
EP2361989A1 (de) * 2010-02-26 2011-08-31 Kenta Biotech AG Verfahren und Kits zur Serotypisierung von Pseudomonas aeruginosa und Oligonukleotidsequenzen zur Verwendung in solchen Methoden und Kits

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU530649B2 (en) * 1981-01-28 1983-07-21 Coats Patons Plc Method of manufacturing monoclonal antibodies and capable of manufacturing such antibodies
US4464465A (en) * 1982-04-05 1984-08-07 Genetic Systems Corporation Cell-driven viral transfer in eukaryotes
JPS5929622A (ja) * 1982-08-10 1984-02-16 Meiji Seika Kaisha Ltd モノクロ−ナル抗体、その製造法およびその用途
CA1262238C (en) * 1982-09-30 1989-10-10 HUMAN MONOCLONAL ANTIBODIES AGAINST BACTERIAL TOXINS
JPH0776240B2 (ja) * 1983-05-06 1995-08-16 ベロス グル−プ エンドトキシンコア−と反応性のモノクロ−ナル抗体
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria

Also Published As

Publication number Publication date
JPS6169796A (ja) 1986-04-10
EP0163493B1 (de) 1991-03-27
EP0163493A3 (en) 1986-07-02
FI89278C (fi) 1993-09-10
ES543474A0 (es) 1987-01-16
NO167758B (no) 1991-08-26
IE851302L (en) 1985-11-25
ES8702792A1 (es) 1987-01-16
ZA853888B (en) 1986-01-29
FI852029A0 (fi) 1985-05-21
KR850008282A (ko) 1985-12-16
IL75277A (en) 1990-02-09
HU202927B (en) 1991-04-29
ATE62021T1 (de) 1991-04-15
AU4285885A (en) 1985-11-28
AU600222B2 (en) 1990-08-09
GR851234B (de) 1985-07-01
FI89278B (fi) 1993-05-31
US4834975A (en) 1989-05-30
DK233385A (da) 1985-11-26
NO167758C (no) 1991-12-04
DK233385D0 (da) 1985-05-24
FI852029L (fi) 1985-11-26
IE58411B1 (en) 1993-09-22
NO852093L (no) 1985-11-26
HUT38123A (en) 1986-04-28
IL75277A0 (en) 1985-09-29
EP0163493A2 (de) 1985-12-04

Similar Documents

Publication Publication Date Title
ATE62021T1 (de) Menschliche monoklonale antikoerper gegen serotypische lipopolysaccharidische determinanten von gram-negativen bakterien und ihre produktion.
SE8605295D0 (sv) Monoclonal antibodies cross-reactive and crossprotective against p. aeruginosa serotypes
NO162613C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive diarylacetylener.
IL79719A (en) Pharmaceutical composition comprising monoclonal antibodies binding determinants of gram negative bacteria and hybridoma cell lines producing the antibodies
DE69501591D1 (de) Lactobazillusstämme menschlichen ursprungs, ihre zusammensetzung und deren verwendung
IL112778A0 (en) Substituted heterocycles, their preparation and pharmaceutical compositions containing them
IT1210589B (it) Procedimento per la preparazione dicomposti pirimidinici dotati di attivita' farmacologica particolarmente per il trattamento di infezioni batteriche loro intermedi prodotto ottenuto e composizioni farmaceutiche che li contengono
DE3688038D1 (de) Verwendung von buspiron zur herstellung von pharmazeutischen zusammensetzungen zur linderung von krankhaften angst.
FI972308A0 (fi) 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi
SE8700467D0 (sv) Cross-protective human monoclonal antibody compositions
ATE39694T1 (de) (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung.
DE59507578D1 (de) Neuer peptidischer wirkstoff und dessen herstellung
IT8721657A0 (it) Eteri e tioeteri ad attivita'terapeutica, loro preparazione e composizioni che li contengono.
FR2568585B1 (fr) Nouvelles cellules hybrides secretant des anticorps anti-idiotypiques, nouveaux anticorps monoclonaux secretes par lesdites cellules hybrides, leur preparation et leur application
IT1194677B (it) Composizione farmaceutica ad attivita' antiflogistica,antipiretica e antalgica
DE3583015D1 (de) Phospholipidkonjugate und deren herstellung.
OA06185A (fr) Nouvelles compositions pharmaceutiques à base d'enzyme bactérien.
ATE86634T1 (de) Humaner monoklonaler antikoerper gegen pseudomonas aeruginosagegen pseudomonas aeruginosa produzierende hybridomen.
IT8348050A0 (it) Sostanze ss 12538 fisiologicamente attive, loro preparazione e microorganismo che le produce
SU1075674A1 (ru) 2,3,2,3-Тетрагидро-3,3-тетрацианметилен-5,5-бис-as-триазин, обладающий противовоспалительной и анальгетической активностью
IT8219456A0 (it) Composto ad attivita'analgesica e antiinfiammatoria ad azione protratta, procedimento per la sua preparazione e relative composizioni farmaceutiche.
IT7820098A0 (it) Composti ad attivita'disinfettante, deodorante e disinquinante e composizioni farmaceutiche che li contengono.
ATE38666T1 (de) Diaminopyrimidine und deren herstellung.
IT8224116A0 (it) Composti ad attivita'antiinfiammatoria, processo per laloro preparazione e composizioni farmaceutiche relative.
IT7927837A0 (it) Procedimento migliorato per la fermentazione dell'etanolo.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation