CA2247336A1 - Parapoxviruses containing foreign dna, their production and their use in vaccines - Google Patents

Parapoxviruses containing foreign dna, their production and their use in vaccines

Info

Publication number
CA2247336A1
CA2247336A1 CA002247336A CA2247336A CA2247336A1 CA 2247336 A1 CA2247336 A1 CA 2247336A1 CA 002247336 A CA002247336 A CA 002247336A CA 2247336 A CA2247336 A CA 2247336A CA 2247336 A1 CA2247336 A1 CA 2247336A1
Authority
CA
Canada
Prior art keywords
parapoxviruses
vaccines
production
foreign dna
containing foreign
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002247336A
Other languages
French (fr)
Other versions
CA2247336C (en
Inventor
Norbert Schmeer
Walter Strube
Mathias Buttner
Hans-Joachim Rziha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19639601A external-priority patent/DE19639601A1/en
Application filed by Individual filed Critical Individual
Publication of CA2247336A1 publication Critical patent/CA2247336A1/en
Application granted granted Critical
Publication of CA2247336C publication Critical patent/CA2247336C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24211—Parapoxvirus, e.g. Orf virus
    • C12N2710/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24211—Parapoxvirus, e.g. Orf virus
    • C12N2710/24241—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to recombinantly prepared parapoxviruses which carry, in their genomes, deletions or insertions in the form of foreign hereditary information and contain hereditary information, to the preparation of such constructs and to their use in vaccines.
CA002247336A 1996-02-28 1997-02-17 Parapoxviruses containing foreign dna, their production and their use in vaccines Expired - Lifetime CA2247336C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19607458 1996-02-28
DE19639601.8 1996-09-26
DE19607458.4 1996-09-26
DE19639601A DE19639601A1 (en) 1996-02-28 1996-09-26 Parapox viruses that contain foreign DNA, their production and their use in vaccines
PCT/EP1997/000729 WO1997032029A1 (en) 1996-02-28 1997-02-17 Parapoxviruses containing foreign dna, their production and their use in vaccines

Publications (2)

Publication Number Publication Date
CA2247336A1 true CA2247336A1 (en) 1997-09-04
CA2247336C CA2247336C (en) 2008-06-17

Family

ID=26023280

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247336A Expired - Lifetime CA2247336C (en) 1996-02-28 1997-02-17 Parapoxviruses containing foreign dna, their production and their use in vaccines

Country Status (19)

Country Link
US (1) US6365393B1 (en)
EP (1) EP0886679B1 (en)
JP (1) JP2000507092A (en)
CN (1) CN1217027A (en)
AT (1) ATE364090T1 (en)
AU (1) AU718141B2 (en)
BR (1) BR9707785A (en)
CA (1) CA2247336C (en)
DE (1) DE59712852D1 (en)
DK (1) DK0886679T3 (en)
ES (1) ES2287949T3 (en)
HU (1) HUP9901035A3 (en)
IL (1) IL125797A0 (en)
NO (1) NO983946L (en)
NZ (1) NZ331556A (en)
PL (1) PL190401B1 (en)
SK (1) SK120098A3 (en)
TR (1) TR199801702T2 (en)
WO (1) WO1997032029A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037031A1 (en) * 1996-03-29 1997-10-09 University Of Otago Parapoxvirus vectors
EP1064382B1 (en) * 1998-03-17 2008-08-20 Genentech, Inc. Polypeptides homologous to vegf and bmp1
ATE324902T1 (en) * 1998-11-02 2006-06-15 Ludwig Inst Cancer Res A VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN FROM ORF VIRUS NZ10 BINDS AND ACTIVATES THE MAMMAL VEGF RECEPTOR-2
IL153643A0 (en) * 2000-07-11 2003-07-06 Bayer Ag Use of strains of the parapox ovis virus for producing antiviral pharmaceuticals and anticancer pharmaceuticals
US6844000B2 (en) 2001-12-07 2005-01-18 Bayer Pharmaceuticals Corporation Use of Parapox B2L protein to treat cancer and modify immune responses
US6752995B2 (en) * 2002-04-15 2004-06-22 Board Of Regents, The University Of Texas System Nucleic acid and polypeptide sequences useful as adjuvants
CN1984666A (en) * 2004-07-13 2007-06-20 爱库里斯股份有限两合公司 Parapoxviruses in combination with other antiviral agents for the treatment of HIV/AIDS
CA2795308A1 (en) * 2010-04-29 2011-11-03 Riemser Arzneimittel Ag Parapoxvirus expressing the vp60 major capsid protein of the rabbit haemorrhagic disease virus
AU2011254315B2 (en) * 2010-05-21 2015-05-14 Zoetis Services Llc Parapoxvirus vectors containing rabies virus antigen
BR112013001379A2 (en) * 2010-07-20 2016-05-17 Ah Usa 42 Llc parapoxvirus vectors.
JP2015524268A (en) 2012-07-19 2015-08-24 ゾエティス・エルエルシー Bovine influenza virus composition
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
DE102015111756A1 (en) * 2015-07-20 2017-01-26 Eberhard Karls Universität Tübingen Medizinische Fakultät Recombinant Orf virus vector
ES2933623T3 (en) 2015-08-14 2023-02-10 Zoetis Services Llc Compositions of Mycoplasma Bovis
EP3432922B1 (en) 2016-03-21 2020-02-19 South Dakota Board of Regents Orf virus-based platform for vaccine delivery
AU2019229653B2 (en) * 2018-03-07 2025-09-11 Transgene Parapoxvirus vectors
WO2024062098A1 (en) 2022-09-23 2024-03-28 Transgene Recombinant pseudocowpox virus encoding an interleukin-12

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4405841C1 (en) * 1994-02-23 1995-01-05 Mayr Anton Prof Dr Med Vet Dr Multipotent non-specific immunity inducers based on combinations of poxvirus components, processes for their preparation and their use as pharmaceuticals
DK0758397T3 (en) * 1994-04-29 2005-10-10 Baxter Healthcare Sa Recombinant poxviruses with foreign polynucleotides in essential regions

Also Published As

Publication number Publication date
TR199801702T2 (en) 1998-12-21
CN1217027A (en) 1999-05-19
HUP9901035A2 (en) 1999-07-28
EP0886679B1 (en) 2007-06-06
CA2247336C (en) 2008-06-17
NO983946D0 (en) 1998-08-27
DK0886679T3 (en) 2007-09-24
ATE364090T1 (en) 2007-06-15
NZ331556A (en) 2000-05-26
BR9707785A (en) 1999-07-27
AU718141B2 (en) 2000-04-06
WO1997032029A1 (en) 1997-09-04
DE59712852D1 (en) 2007-07-19
EP0886679A1 (en) 1998-12-30
NO983946L (en) 1998-10-22
PL190401B1 (en) 2005-12-30
IL125797A0 (en) 1999-04-11
PL328870A1 (en) 1999-03-01
HUP9901035A3 (en) 2001-01-29
US6365393B1 (en) 2002-04-02
AU1725797A (en) 1997-09-16
ES2287949T3 (en) 2007-12-16
SK120098A3 (en) 1999-03-12
JP2000507092A (en) 2000-06-13

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Effective date: 20170217