HUP0303030A2 - Eljárás 20(S)-kamptotecin tisztítására - Google Patents
Eljárás 20(S)-kamptotecin tisztításáraInfo
- Publication number
- HUP0303030A2 HUP0303030A2 HU0303030A HUP0303030A HUP0303030A2 HU P0303030 A2 HUP0303030 A2 HU P0303030A2 HU 0303030 A HU0303030 A HU 0303030A HU P0303030 A HUP0303030 A HU P0303030A HU P0303030 A2 HUP0303030 A2 HU P0303030A2
- Authority
- HU
- Hungary
- Prior art keywords
- camptothecin
- crystals
- purifying
- acidifying
- hydrogenated
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 6
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 2
- 229940127093 camptothecin Drugs 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 1
- -1 carboxylate salt Chemical class 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002596 lactones Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya eljárás az általános képletű - ahol R1 etilcsoport- 20(S)-kamptotecin tisztítására. Az eljárás szerint (a) a 20(S)-kamptotecint tartalmazó kiindulási anyagot egy vizes bázissalelegyítve a 20(S)-kamptotecin laktongyűrűjét karboxilátsóvá alakítják;(b) az így kapott elegyet valamilyen átmeneti fém-katalizátorjelenlétében hidrogénezi; (c) a vizes fázist savanyítva kamptotecin-kristályokat nyernek; (d) valamilyen poláros aprotikus oldószert adnakhozzá; és (e) a kamptotecinkristályokat elválasztják. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10106969A DE10106969C1 (de) | 2001-02-15 | 2001-02-15 | Verfahren zur Reinigung und zur Herstellung von 20(S)-Camptothecin |
| PCT/EP2002/001375 WO2002064597A2 (de) | 2001-02-15 | 2002-02-09 | Verfahren zur reinigung von 20(s)-camptothecin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303030A2 true HUP0303030A2 (hu) | 2003-12-29 |
| HUP0303030A3 HUP0303030A3 (en) | 2004-11-29 |
Family
ID=7674093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303030A HUP0303030A3 (en) | 2001-02-15 | 2002-02-09 | Method for purifying 20(s)-camptothecin |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1362051B1 (hu) |
| JP (1) | JP4467884B2 (hu) |
| KR (1) | KR100813087B1 (hu) |
| CN (1) | CN1228340C (hu) |
| AT (1) | ATE301124T1 (hu) |
| AU (1) | AU2002244711B2 (hu) |
| BG (1) | BG108064A (hu) |
| BR (1) | BR0207261A (hu) |
| CA (1) | CA2435372C (hu) |
| CZ (1) | CZ300671B6 (hu) |
| DE (2) | DE10106969C1 (hu) |
| EA (1) | EA005618B1 (hu) |
| EE (1) | EE05131B1 (hu) |
| ES (1) | ES2246389T3 (hu) |
| HK (1) | HK1064092A1 (hu) |
| HR (1) | HRP20030654A2 (hu) |
| HU (1) | HUP0303030A3 (hu) |
| IL (2) | IL157148A0 (hu) |
| MX (1) | MXPA03007194A (hu) |
| NO (1) | NO328106B1 (hu) |
| NZ (1) | NZ528039A (hu) |
| PL (1) | PL202135B1 (hu) |
| RS (1) | RS50496B (hu) |
| SK (1) | SK10192003A3 (hu) |
| UA (1) | UA74874C2 (hu) |
| WO (1) | WO2002064597A2 (hu) |
| ZA (1) | ZA200305364B (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI396690B (zh) * | 2006-04-27 | 2013-05-21 | Yakult Honsha Kk | 喜樹鹼衍生物的製造方法 |
| CN102046634B (zh) * | 2008-05-29 | 2013-04-24 | 日本迈科洛生物制药有限公司 | 喜树碱衍生物的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
2001
- 2001-02-15 DE DE10106969A patent/DE10106969C1/de not_active Expired - Fee Related
-
2002
- 2002-02-09 IL IL15714802A patent/IL157148A0/xx active IP Right Grant
- 2002-02-09 BR BR0207261-0A patent/BR0207261A/pt not_active Expired - Fee Related
- 2002-02-09 EP EP02712902A patent/EP1362051B1/de not_active Expired - Lifetime
- 2002-02-09 SK SK1019-2003A patent/SK10192003A3/sk unknown
- 2002-02-09 CA CA2435372A patent/CA2435372C/en not_active Expired - Lifetime
- 2002-02-09 AT AT02712902T patent/ATE301124T1/de active
- 2002-02-09 PL PL362128A patent/PL202135B1/pl not_active IP Right Cessation
- 2002-02-09 NZ NZ528039A patent/NZ528039A/en unknown
- 2002-02-09 WO PCT/EP2002/001375 patent/WO2002064597A2/de active IP Right Grant
- 2002-02-09 AU AU2002244711A patent/AU2002244711B2/en not_active Ceased
- 2002-02-09 KR KR1020037010605A patent/KR100813087B1/ko not_active IP Right Cessation
- 2002-02-09 MX MXPA03007194A patent/MXPA03007194A/es active IP Right Grant
- 2002-02-09 CZ CZ20032211A patent/CZ300671B6/cs not_active IP Right Cessation
- 2002-02-09 HU HU0303030A patent/HUP0303030A3/hu unknown
- 2002-02-09 EA EA200300837A patent/EA005618B1/ru not_active IP Right Cessation
- 2002-02-09 DE DE50203824T patent/DE50203824D1/de not_active Expired - Lifetime
- 2002-02-09 ES ES02712902T patent/ES2246389T3/es not_active Expired - Lifetime
- 2002-02-09 CN CNB028049918A patent/CN1228340C/zh not_active Expired - Fee Related
- 2002-02-09 EE EEP200300389A patent/EE05131B1/xx not_active IP Right Cessation
- 2002-02-09 RS YUP-614/03A patent/RS50496B/sr unknown
- 2002-02-09 JP JP2002564528A patent/JP4467884B2/ja not_active Expired - Lifetime
- 2002-09-02 UA UA2003098461A patent/UA74874C2/uk unknown
-
2003
- 2003-07-11 ZA ZA200305364A patent/ZA200305364B/en unknown
- 2003-07-29 IL IL157148A patent/IL157148A/en not_active IP Right Cessation
- 2003-08-06 BG BG108064A patent/BG108064A/bg active Pending
- 2003-08-13 HR HR20030654A patent/HRP20030654A2/hr not_active Application Discontinuation
- 2003-08-14 NO NO20033614A patent/NO328106B1/no not_active IP Right Cessation
-
2004
- 2004-09-08 HK HK04106806A patent/HK1064092A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |