HUP0303030A2 - Eljárás 20(S)-kamptotecin tisztítására - Google Patents

Eljárás 20(S)-kamptotecin tisztítására

Info

Publication number
HUP0303030A2
HUP0303030A2 HU0303030A HUP0303030A HUP0303030A2 HU P0303030 A2 HUP0303030 A2 HU P0303030A2 HU 0303030 A HU0303030 A HU 0303030A HU P0303030 A HUP0303030 A HU P0303030A HU P0303030 A2 HUP0303030 A2 HU P0303030A2
Authority
HU
Hungary
Prior art keywords
camptothecin
crystals
purifying
acidifying
hydrogenated
Prior art date
Application number
HU0303030A
Other languages
English (en)
Inventor
Armin Rapp
Rainer Sobotta
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of HUP0303030A2 publication Critical patent/HUP0303030A2/hu
Publication of HUP0303030A3 publication Critical patent/HUP0303030A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya eljárás az általános képletű - ahol R1 etilcsoport- 20(S)-kamptotecin tisztítására. Az eljárás szerint (a) a 20(S)-kamptotecint tartalmazó kiindulási anyagot egy vizes bázissalelegyítve a 20(S)-kamptotecin laktongyűrűjét karboxilátsóvá alakítják;(b) az így kapott elegyet valamilyen átmeneti fém-katalizátorjelenlétében hidrogénezi; (c) a vizes fázist savanyítva kamptotecin-kristályokat nyernek; (d) valamilyen poláros aprotikus oldószert adnakhozzá; és (e) a kamptotecinkristályokat elválasztják. Ó
HU0303030A 2001-02-15 2002-02-09 Method for purifying 20(s)-camptothecin HUP0303030A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10106969A DE10106969C1 (de) 2001-02-15 2001-02-15 Verfahren zur Reinigung und zur Herstellung von 20(S)-Camptothecin
PCT/EP2002/001375 WO2002064597A2 (de) 2001-02-15 2002-02-09 Verfahren zur reinigung von 20(s)-camptothecin

Publications (2)

Publication Number Publication Date
HUP0303030A2 true HUP0303030A2 (hu) 2003-12-29
HUP0303030A3 HUP0303030A3 (en) 2004-11-29

Family

ID=7674093

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303030A HUP0303030A3 (en) 2001-02-15 2002-02-09 Method for purifying 20(s)-camptothecin

Country Status (27)

Country Link
EP (1) EP1362051B1 (hu)
JP (1) JP4467884B2 (hu)
KR (1) KR100813087B1 (hu)
CN (1) CN1228340C (hu)
AT (1) ATE301124T1 (hu)
AU (1) AU2002244711B2 (hu)
BG (1) BG108064A (hu)
BR (1) BR0207261A (hu)
CA (1) CA2435372C (hu)
CZ (1) CZ300671B6 (hu)
DE (2) DE10106969C1 (hu)
EA (1) EA005618B1 (hu)
EE (1) EE05131B1 (hu)
ES (1) ES2246389T3 (hu)
HK (1) HK1064092A1 (hu)
HR (1) HRP20030654A2 (hu)
HU (1) HUP0303030A3 (hu)
IL (2) IL157148A0 (hu)
MX (1) MXPA03007194A (hu)
NO (1) NO328106B1 (hu)
NZ (1) NZ528039A (hu)
PL (1) PL202135B1 (hu)
RS (1) RS50496B (hu)
SK (1) SK10192003A3 (hu)
UA (1) UA74874C2 (hu)
WO (1) WO2002064597A2 (hu)
ZA (1) ZA200305364B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI396690B (zh) * 2006-04-27 2013-05-21 Yakult Honsha Kk 喜樹鹼衍生物的製造方法
ES2425621T3 (es) * 2008-05-29 2013-10-16 Microbiopharm Japan Co., Ltd. Métodos para producir derivados de camptotecina

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Also Published As

Publication number Publication date
NO20033614D0 (no) 2003-08-14
MXPA03007194A (es) 2003-12-04
DE50203824D1 (de) 2005-09-08
EE05131B1 (et) 2009-02-16
PL202135B1 (pl) 2009-06-30
DE10106969C1 (de) 2002-10-02
NO20033614L (no) 2003-08-14
CN1491228A (zh) 2004-04-21
WO2002064597A2 (de) 2002-08-22
BG108064A (bg) 2005-04-30
EP1362051A2 (de) 2003-11-19
AU2002244711B2 (en) 2007-05-31
CN1228340C (zh) 2005-11-23
HK1064092A1 (en) 2005-01-21
CZ300671B6 (cs) 2009-07-15
JP4467884B2 (ja) 2010-05-26
ES2246389T3 (es) 2006-02-16
IL157148A (en) 2008-08-07
IL157148A0 (en) 2004-02-08
KR20030076674A (ko) 2003-09-26
BR0207261A (pt) 2004-06-15
CA2435372A1 (en) 2002-08-22
RS50496B (sr) 2010-03-02
WO2002064597A3 (de) 2002-10-24
PL362128A1 (en) 2004-10-18
ATE301124T1 (de) 2005-08-15
YU61403A (sh) 2006-05-25
UA74874C2 (en) 2006-02-15
EA200300837A1 (ru) 2003-12-25
CZ20032211A3 (cs) 2003-12-17
NZ528039A (en) 2006-02-24
EP1362051B1 (de) 2005-08-03
HRP20030654A2 (en) 2005-06-30
EE200300389A (et) 2003-12-15
SK10192003A3 (sk) 2004-01-08
HUP0303030A3 (en) 2004-11-29
JP2004521909A (ja) 2004-07-22
CA2435372C (en) 2010-04-20
KR100813087B1 (ko) 2008-03-17
NO328106B1 (no) 2009-12-07
ZA200305364B (en) 2004-04-28
EA005618B1 (ru) 2005-04-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees